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Glycoside Hydrolase Family 5 / Subf 40

Activities in Sub FamilyEndo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (226); Uniprot accession (1);
Summary
Download GH5_40 (222) Taxonomic display Characterized (1)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 NYE86_05980   Actinacidiphila bryophytorum DS3 UWE08315.1     40
 V6738_12850   Actinomadura luteofluorescens YN2 WWV98017.1     40
 LUW74_10065 (fragment)   Actinomadura madurae MRC005 URN03637.1     40
 LUW76_00305 (fragment)   Actinomadura madurae MRC008 URM92909.1     40
 HUT06_19455   Actinomadura sp. NAK00032 QKW35943.1     40
 Aiant_19970   Actinoplanes ianthinogenes NBRC 13996 BCJ41340.1     40
 ACTOB_004929   Actinoplanes oblitus NRRL 3884 WIN00853.1     40
 ACTOB_006605   Actinoplanes oblitus NRRL 3884 WIM94572.1     40
 L3i22_086010   Actinoplanes sp. L3-i22 BCY13513.1     40
 L083_3363 (CelA)   Actinoplanes sp. N902-109 AGL16873.1     40
 ACWT_6205   Actinoplanes sp. SE50 ATO85620.1     40
 ACPL_6337 (CelA)   Actinoplanes sp. SE50/110 AEV87219.1
SLM03033.1		     40
 TPMA0078_72040   Actinoplanes sp. TPMA0078 BFD55800.1     40
 ISP_008389   Amycolatopsis mediterranei ISP5501 UZF74842.1     40
 B737_8016   Amycolatopsis mediterranei RB AGT88677.1     40
 RAM_41810   Amycolatopsis mediterranei S699 AEK46829.1
AFO81548.1		     40
 AMED_8139   Amycolatopsis mediterranei U32 ADJ49840.1     40
 QRX60_40120   Amycolatopsis mongoliensis 4-36 WIY00208.1     40
 SD37_26450   Amycolatopsis orientalis B-37 ANN22051.1     40
 QRY02_30205   Amycolatopsis sp. DG1A-15b WIX85492.1     40
 HUT10_33755   Amycolatopsis sp. Hca4 QKV78197.1     40
 MUY22_38780   Amycolatopsis sp. WQ 127309 UOZ04733.1     40
 YIM_32705 (Cela1)   Amycolatopsis sp. YIM 10 QFU91702.1     40
 Caci_3718   Catenulispora acidiphila DSM 44928 ACU72620.1     40
 Caci_6685   Catenulispora acidiphila DSM 44928 ACU75531.1     40
 IE160_02535   Chryseoglobus sp. 28M-23 QOD94131.1     40
 COUCH_25850   Couchioplanes caeruleus TL65 UQU62445.1     40
 GA0004736_3138   Curtobacterium sp. 9128 SBN64180.1     40
 DEJ13_12705   Curtobacterium sp. MCLR17_007 WIB59299.1     40
 Dmats_24655   Dactylosporangium matsuzakiense NRRL B-16293 UWZ40923.1     40
 Dmats_12150   Dactylosporangium matsuzakiense NRRL B-16293 UWZ47080.1     40
 GCM10020063_064510   Dactylosporangium thailandense JCM 3084 BFE61925.1     40
 Dvina_12580   Dactylosporangium vinaceum NRRL B-16297 UAB98830.1     40
 Dvina_29445   Dactylosporangium vinaceum NRRL B-16297 UAB92472.1     40
 GCM10025732_31020 (fragment)   Glycomyces mayteni JCM 16217 BFF25137.1     40
 K3N28_15535   Glycomyces sp. TRM65418 QZD54162.1     40
 KPHV_83940 (fragment)   Kitasatospora purpeofusca HV058 BEK71167.1     40
 KSE_56690   Kitasatospora setae KM-6054 BAJ31442.1     40
 O1G21_01805   Kitasatospora sp. HUAS 3-15 WBP84706.1     40
 CFP65_7265   Kitasatospora sp. MMS16-BH015 AUG81852.1     40
 HUT16_26455   Kitasatospora sp. NA04385 QKW22140.1     40
 KitaXyl93_03630   Kitasatospora sp. Xyl93 BFD89003.1     40
 OU787_24580   Kitasatospora sp. YST-16 WAL74393.1     40
 ccbrp13_25920   Ktedonobacteria bacterium brp13 BCL80127.1     40
 ccbrp13_02760   Ktedonobacteria bacterium brp13 BCL77811.1     40
 EPA93_26970 (fragment)   Ktedonosporobacter rubrisoli SCAWS-G2 QBD83602.1     40
 Q4V64_45880   Kutzneria buriramensis DSM 45791 WKX14453.1     40
 JJ691_23550   Kutzneria sp. CA-103260 QUQ64634.1     40
 H2LOC_007145   Methylocystis heyeri H2 QGM45488.1     40
 OVN18_07945   Microcella daejeonensis MMS21-STM12 WAB80505.1     40
 NNL39_02410   Microcella humidisoli MMS21-STM10 UTT62979.1     40
 OVN20_06060   Microcella sp. MMS21-STM26 WAB85111.1     40
 HZU44_14145   Micromonospora carbonacea africana QLK01021.1     40
 HXZ27_04145   Micromonospora carbonacea aurantiaca QLD23503.1     40
 GA0070618_5384   Micromonospora echinospora DSM 43816 SCF33320.1     40
 Jiend_55470 (fragment)   Micromonospora endophytica NBRC 109090 BCJ62125.1     40
 Q3V37_00785 (fragment)   Micromonospora profundi TRM95458 WLS45862.1     40
 endo-β-1,4-mannanase (GA0070623_1484) 3.2.1.78 Micromonospora rifamycinica DSM 44983 SCG47572.1 A0A120F9Z2   40
 FJK98_13340   Micromonospora sp. HM134 QDY08022.1     40
 Q2K16_08380   Micromonospora sp. HUAS LYJ1 WKU07053.1     40
 O7604_20205 (fragment)   Micromonospora sp. WMMA1947 WBC07533.1     40
 O7602_10285   Micromonospora sp. WMMD1128 WBB75865.1     40
 O7633_23905   Micromonospora sp. WMMD712 WFE59709.1     40
 O7625_18760   Micromonospora sp. WMMD714 WFE65191.1     40
 O7613_13435   Micromonospora sp. WMMD975 WFE36346.1     40
 O7612_12175   Micromonospora sp. WMMD987 WFE97573.1     40
 O7619_21615   Micromonospora sp. WMMD998 WFE40917.1     40
 H7F38_25130 (fragment)   Nakamurella sp. PAMC28650 QNK81265.1     40
 ENKNEFLB_00753 (CelE)   Nocardioides aquaticus KCTC 9944 QVT78376.1     40
 I601_0711 (EgL)   Nocardioides dokdonensis FR1436 ANH37161.1     40
 HPC71_02990   Nocardioides marmotae zg-579 QKE00161.1     40
 SAMN04488570_0245   Nocardioides scoriae DSM 22127 SDR74715.1     40
 OSR43_03455   Nocardioides sp. Arc9.136 WKN49196.1     40
 Noca_0723   Nocardioides sp. JS614 ABL80248.1     40
 KM427_07130   Nocardioides sp. LMS-CY QWF23484.1     40
 KM427_04825   Nocardioides sp. LMS-CY QWF23058.1     40
 GBF35_48915   Nonomuraea nitratireducens WYY166 QFY13444.1     40
 C7M71_019420   Peterkaempfera bronchialis DSM 106435 AXI79261.1     40
 IOD16_19435   Saccharothrix sp. 6-C QQQ73473.1     40
 EKG83_21690   Saccharothrix syringae NRRL B-16468 QFZ19695.1     40
 O7608_25265   Solwaraspora sp. WMMA2056 WJK39730.1     40
 O7623_00425   Solwaraspora sp. WMMD791 WFE27719.1     40
 GXP74_25270   Streptacidiphilus sp. P02-A3a QMU71041.1     40
 SCAT_p0083   Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488 CCB71109.1     40
 SCATT_p16620   Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488 AEW99855.1     40
 H9W91_31030   Streptomyces alfalfae XN-04 QUI36170.1     40
 QR300_27230   Streptomyces antimycoticus FIM95-F1 WJD99381.1     40
 HKX69_05250   Streptomyces argyrophyllae Jing01 QJS14177.1     40
 G9272_36370   Streptomyces asoensis H2S5 QJT07245.1     40
 BV401_17870   Streptomyces autolyticus CGMCC0516 AQA12038.1     40
 SAV1854 (CelA2)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69565.1
NP_823030.1		     40
 SAVMC3_22060   Streptomyces avermitilis MC3 BBJ49577.1     40
 SBI_06900 (Cela1)   Streptomyces bingchenggensis BCW-1 ADI10020.1     40
 GQF42_34735   Streptomyces broussonetiae T44 QHA07782.1     40
 EJC51_45495   Streptomyces brunneus CR22 AZP22675.1     40
 OG925_10880   Streptomyces canus NBC_01585 WSD84759.1     40
 NRO40_10380   Streptomyces changanensis HL-66 UUS31205.1     40
 CP983_07815   Streptomyces chartreusis ATCC 14922 QEV66587.1     40
 HUT05_09120   Streptomyces chartreusis NA02069 QKZ17494.1     40
 CP977_29665   Streptomyces cinereoruber ATCC 19740 QEV35824.1     40
 HGI09_09470   Streptomyces collinus L2 UJA13648.1     40
 HGI10_54630   Streptomyces collinus SQ UJA11486.1     40
 B446_30100 (probable fragment)   Streptomyces collinus Tu 365 AGS72824.1     40
 S1361_32550 (fragment)   Streptomyces cyanogenus S136 QTE02108.1     40
 S1361_32545 (fragment)   Streptomyces cyanogenus S136 QTE02107.1     40
 N8I84_32600   Streptomyces cynarae HUAS 13-4 UXY22918.1     40
 D9753_05755   Streptomyces dangxiongensis Z022 AYN38507.1     40
 M4V62_37310   Streptomyces durmitorensis MS405 UQT60272.1     40
 D3X13_05440   Streptomyces fradiae NKZ-259 AYA20982.1     40
 H4W23_33570   Streptomyces gardneri ATCC 15439 QPK49084.1     40
 SGFS_029450   Streptomyces graminofaciens A-8890 BBC31651.1     40
 SGFS_100530 (fragment)   Streptomyces graminofaciens A-8890 BBC38759.1     40
 DWG14_08412 (Cela_1)   Streptomyces griseorubiginosus 3E-1 AYC44104.1     40
 ELQ87_06455   Streptomyces griseoviridis F1-27 AZS83978.1     40
 DDJ31_32900   Streptomyces griseoviridis K61 QCN89169.1     40
 J2N69_31470   Streptomyces huasconensis D23 UFQ19135.1     40
 DWB77_07127 (CelA)   Streptomyces hundungensis BH38 AYG84912.1     40
 SHJG_7499 (partial)   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92766.1     40
 SHJGH_7259   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF66921.1     40
 SHL15_6376   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO97412.1     40
 SHXM_04453   Streptomyces hygroscopicus XM201 AQW50990.1     40
 SIRAN6226   Streptomyces iranensis CDR09620.1     40
 SLA_0107   Streptomyces laurentii ATCC 31255 BAU81062.1     40
 J3S85_33870   Streptomyces lavenduligriseus Tu901 WDM16038.1     40
 Sle_18090   Streptomyces leeuwenhoekii C34 (= DSM 42122 = NRRL B-24963) CQR61271.1     40
 SMALA_2845   Streptomyces malaysiensis DSM 4137 ATL83079.1
QDL72732.1		     40
 SMIR_03290   Streptomyces mirabilis P16B-1 QUW78287.1     40
 POD33_25995   Streptomyces moderatus DT446 WCH95404.1     40
 CP978_27420   Streptomyces nodosus ATCC 14899 QEV41787.1     40
 SNOD_27135   Streptomyces nodosus ATCC 14899 AJE43292.1     40
 DVK44_00900   Streptomyces paludis GSSD-12 AXG76470.1     40
 LIV37_31490   Streptomyces rapamycinicus NRRL 5491 UTP33454.1     40
 M271_31005   Streptomyces rapamycinicus NRRL 5491 AGP57633.1     40
 LJB45_26360   Streptomyces rapamycinicus SRMK07 UTO65496.1     40
 CP984_26115   Streptomyces rimosus ATCC 10970 QEV77995.1     40
 V519_030420   Streptomyces rimosus R6-500 QGY69610.1     40
 SRIM_014725   Streptomyces rimosus subsp. rimosus ATCC 10970 QST81248.1     40
 SRIMDV3_23470   Streptomyces rimosus subsp. rimosus DV3 UTJ15202.1     40
 SRIMHP_23580   Streptomyces rimosus subsp. rimosus HP126 UTH97106.1     40
 SRIMR7_26210   Streptomyces rimosus subsp. rimosus R7 UNZ05651.1     40
 FMM49_26670   Streptomyces rimosus subsp. rimosus SRI-4018v0 QTL88842.1     40
 CTZ40_26150   Streptomyces rimosus WT5260 QDA06720.1     40
 HUT11_31960   Streptomyces seoulensis A01 QKW30226.1     40
 A7J05_06405   Streptomyces silaceus ACCC40021 APY90660.1     40
 I1A49_18140   Streptomyces solisilvae HNM0141 QPI56589.1     40
 SAMN05444521_1740   Streptomyces sp. 3214.6 SHH75332.1     40
 IOD14_13275   Streptomyces sp. A2-16 QUC57692.1     40
 N7U49_38130   Streptomyces sp. AD2-2 UXX97833.1     40
 AS97_33555   Streptomyces sp. AgN23 AJZ85737.1     40
 PZB77_28310   Streptomyces sp. AM 2-1-1 WEH43094.1     40
 C2142_36630   Streptomyces sp. CB01881 AUY53494.1     40
 AS200_10470   Streptomyces sp. CdTB01 ALV32415.1     40
 Q2K21_13185   Streptomyces sp. CGMCC 4.7035 WNB98952.1     40
 HB370_40810   Streptomyces sp. DSM 40868 QIS75498.1     40
 WJM95_27335   Streptomyces sp. f51 WYH85886.1     40
 A6P39_010165   Streptomyces sp. FXJ1.172 WEO94338.1     40
 KQY30_33060   Streptomyces sp. GMY02 QXE38350.1     40
 KBP30_08245   Streptomyces sp. Go40/10 Go 40/10 UFR01166.1     40
 LUX31_06655   Streptomyces sp. GQFP UIX29742.1     40
 LUV23_18290   Streptomyces sp. HNM0561 UHH18090.1     40
 N8I87_33670   Streptomyces sp. HUAS 15-9 UXY31019.1     40
 O1G22_07930   Streptomyces sp. HUAS 2-6 WBO62750.1     40
 PGH47_35175   Streptomyces sp. HUAS 31 WCE00640.1     40
 RLT57_26880   Streptomyces sp. ITFR-21 WNI18794.1     40
 PPN52_31435   Streptomyces sp. JCM 35825 WCL88755.1     40
 NOO62_33165   Streptomyces sp. Je 1-369 WAL98905.1     40
 R9806_05780   Streptomyces sp. KN37 WPO70170.1     40
 RKE30_26035   Streptomyces sp. Li-HN-5-11 WNM33603.1     40
 RKE30_27125   Streptomyces sp. Li-HN-5-11 WNM33780.1     40
 RKE32_24540   Streptomyces sp. Li-HN-5-13 WNW40458.1     40
 CFP59_05776 (EgL)   Streptomyces sp. M56 AUA13610.1     40
 KGS77_22990   Streptomyces sp. MST-110588 UNO41881.1     40
 R2B38_35045   Streptomyces sp. N50 WOX13731.1     40
 QFW82_28980   Streptomyces sp. NA07423 WHX20785.1     40
 OG906_00825   Streptomyces sp. NBC_01426 WUX80042.1     40
 OG627_31990   Streptomyces sp. NBC_01429 WUX71115.1     40
 OG522_35865   Streptomyces sp. NBC_01431 WUX64028.1     40
 C6376_33440   Streptomyces sp. P3 AVV45538.1     40
 V2W30_32945   Streptomyces sp. Q6 WWQ67672.1     40
 GPZ77_31470   Streptomyces sp. QHH-9511 QGZ52263.1     40
 HYQ63_16245   Streptomyces sp. Rer75 QLH21966.1     40
 HEP84_41205   Streptomyces sp. RLB1-33 QIY74572.1     40
 FNV59_42665   Streptomyces sp. RLB1-8 QDO63926.1     40
 FNV58_43680   Streptomyces sp. RLB1-9 QDO01948.1     40
 FNV62_41785   Streptomyces sp. RLB3-17 QDO43763.1     40
 FNV60_40415   Streptomyces sp. RLB3-5 QDO53681.1     40
 FNV61_43420   Streptomyces sp. RLB3-6 QDN91455.1     40
 FNV63_42290   Streptomyces sp. S1A1-3 QDO33806.1     40
 FNV64_43800   Streptomyces sp. S1A1-7 QDN81557.1     40
 FNV65_42265   Streptomyces sp. S1A1-8 QDO23680.1     40
 HEP87_42750   Streptomyces sp. S1D4-11 QIY99415.1     40
 FNV66_41935   Streptomyces sp. S1D4-14 QDN71226.1     40
 FNV67_43085   Streptomyces sp. S1D4-20 QDN61172.1     40
 FNV68_44505   Streptomyces sp. S1D4-23 QDO12280.1     40
 N6H00_15050   Streptomyces sp. S465 WAP56178.1     40
 PS467_16040   Streptomyces sp. SCA4-21 WNE96732.1     40
 RVR_3329   Streptomyces sp. SN-593 BBA97536.1     40
 U5640_06040   Streptomyces sp. SS7 WYV85261.1     40
 DMA15_31905   Streptomyces sp. WAC 01529 AZM56619.1     40
 C5L38_04485   Streptomyces sp. WAC00288 AVH94409.1     40
 StreXyl84_10680   Streptomyces sp. Xyl84 BFD81667.1     40
 SSPO_063050   Streptomyces sporoclivatus NBRC 100767 BBJ43587.1     40
 LDH80_06775   Streptomyces tanashiensis Kala UZX20432.1     40
 DEJ45_04240   Streptomyces venezuelae ATCC 10595 QES17183.1     40
 DEJ43_33070   Streptomyces venezuelae ATCC 10712 QES02637.1     40
 DEJ47_31775   Streptomyces venezuelae ATCC 14583 QES30407.1     40
 DEJ46_05260   Streptomyces venezuelae ATCC 15068 QES18568.1     40
 BN2537_3229   Streptomyces venezuelae ATCC 15439 CUM37132.1     40
 AQF52_6684   Streptomyces venezuelae ATCC 15439 ALO12277.1     40
 DEJ44_30990   Streptomyces venezuelae ATCC 21113 QES09623.1     40
 U0M97_33730   Streptomyces venezuelae SvWT WRK40578.1     40
 SVTN_32840   Streptomyces vietnamensis GIM4.0001 AJF70118.1     40
 Strvi_8131   Streptomyces violaceusniger Tu 4113 AEM87454.1     40
 BOQ63_040915   Streptomyces viridifaciens DSM 40239 UKZ10269.1     40
 KTA_21710   Thermogemmatispora argillosa A3-2 BBH93972.1     40
 KTA_18010   Thermogemmatispora argillosa A3-2 BBH93602.1     40
 RM788_05385   Umezawaea sp. Da 62-37 WNV87724.1     40
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMD00019534_038400   Acytostelium subglobosum LB1 GAM20665.1     40
 DFA_04566   Cavenderia fasciculata EGG22444.1     40
 DICPUDRAFT_47102   Dictyostelium purpureum QSDP1 EGC36482.1     40
 DICPUDRAFT_52841   Dictyostelium purpureum QSDP1 EGC39159.1     40
 GH5 cellulase (Ncsp38)   Nephotettix cincticeps BAQ94505.1     40
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