Glycoside Hydrolase Family 5 / Subf 37

Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); Cellobiohydrolase (EC 3.2.1.91);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (62); Uniprot accession (14); PDB accession (3); 3D entries (1); cryst (0)

Summary

Download GH5_37 (62) Taxonomic display Structure (1) Characterized (15)


Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
endo-β-1,4-glucanase C (CelC)	3.2.1.4	doi	Acetivibrio thermocellus F7	CAC27410.1	Q9AL36		37
endo-β-1,4-glucanase C (LC2;CelC;EgC) (Cel5B)	3.2.1.4	pubmed	Acetivibrio thermocellus NCIB 10682EL	AAA23220.1	P07985 P0C2S3	1CEC[A] 1CEN[A] 1CEO[A]	37
endo-β-1,4-glucanase C307 (CelC307)	3.2.1.4	pubmed	Clostridium sp. F1	BAA00793.1	P23340		37
lichenase (Ra0453;CUS_6741) (β-1,3-specific;cellobiose releasing)	3.2.1.73	pubmed	Ruminococcus albus 8	EGC02962.1	E9SCY7		37
cellodextrinase (CelA)	3.2.1.74	doi	Ruminococcus flavefaciens FD-1	CAA36207.1	P16169		37
endo-β-1,4-glucanase / acidic cellulase (En1;CMC01D10-ORF18)	3.2.1.4	pubmed	uncultured bacterium	AEV59734.1	G9BYB5		37
cellobiohydrolase (Scaffold00024.3;En4)	3.2.1.91	pubmed	uncultured bacterium	AEV59731.1	G9BYB2		37
endoglucanase	3.2.1.4	pubmed	uncultured bacterium Contig15	AHF23845.1	W0FLK6		37
endo-β-1,4-glucanase (CelA;Cel)	3.2.1.4	pubmed	unidentified bacterium	AAA91966.1	Q60054		37
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
endoglucanase (umCel5N)	3.2.1.4	doi	uncultured microorganism	ACH67609.1	B5LZ80		37
endo-β-1,4-glucanase (cel3623)	3.2.1.4	pubmed	uncultured microorganism	AOA60286.1			37
endo-β-1,4-glucanase (cel7482)	3.2.1.4	pubmed	uncultured microorganism	AOA60285.1			37
β-glucanase (M8-2)	3.2.1.73	pubmed	uncultured microorganism	ACA61165.1	B1PLK8		37
β-glucanase	3.2.1.6	pubmed	uncultured organism	ADD61786.1	D9ZEN2		37
SARM_0068 / 3004993_158220 / TW-3	3.2.1.4	pubmed	uncultured organism	ADX05739.1	E9NSP4		37
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