Glycoside Hydrolase Family 5 / Subf 37

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (37); Uniprot accession (15); PDB accession (3); 3D entries (1); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endo-β-1,4-glucanase C307 (CelC307) 3.2.1.4 Clostridium sp. F1 BAA00793.1 P23340   37
 endo-β-1,4-glucanase C (CelC) 3.2.1.4 Ruminiclostridium thermocellum F7 CAC27410.1 Q9AL36   37
 endo-β-1,4-glucanase C (LC2;CelC;EgC) (Cel5B) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682EL AAA23220.1 P07985
P0C2S3
1CEC[A]
1CEN[A]
1CEO[A]
37
 lichenase (Ra0453;CUS_6741) (β-1,3-specific;cellobiose releasing) 3.2.1.73 Ruminococcus albus 8 ZP_08159266.1
EGC02962.1
    37
 cellodextrinase (CelA) 3.2.1.74 Ruminococcus flavefaciens FD-1 CAA36207.1 P16169   37
 endo-β-1,4-glucanase / acidic cellulase (En1;CMC01D10-ORF18) 3.2.1.4 uncultured bacterium AEV59734.1     37
 Scaffold00024.3 (En4) 3.2.1.- uncultured bacterium AEV59731.1     37
 Exo_contig136_11 (En6) 3.2.1.- uncultured bacterium AEV59739.1     37
 endoglucanase 3.2.1.4 uncultured bacterium Contig15 AHF23845.1     37
 endo-β-1,4-glucanase (CelA;Cel) 3.2.1.4 unidentified bacterium AAA91966.1 Q60054   37
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endoglucanase (umCel5N) 3.2.1.4 uncultured microorganism ACH67609.1 B5LZ80   37
 cellulase (DM1-1) 3.2.1.- uncultured microorganism ACA61162.1 B1PLK5   37
 β-glucanase (M8-2) 3.2.1.- uncultured microorganism ACA61165.1 B1PLK8   37
 β-glucanase 3.2.1.- uncultured organism ADD61786.1 D9ZEN2   37
 SARM_0068 / 3004993_158220 / TW-3 3.2.1.4 uncultured organism ADX05739.1     37
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