Activities in Sub Family	Endoglycosylceramidase (EC 3.2.1.123);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (4); Uniprot accession (2); PDB accession (6); 3D entries (1); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
V6738_31260		Actinomadura luteofluorescens YN2	WWW01515.1			28
HUT06_37340		Actinomadura sp. NAK00032	QKW38997.1			28
F7P10_25690		Actinomadura sp. WMMB499	QFG27299.1			28
ACTIVE_6803		Actinomadura verrucosospora NRRL:B18236	QKG25152.1			28
SAMN04489737_0244		Arcanobacterium phocae DSM 10002	SDU77936.1			28
JTE88_00990		Arcanobacterium phocisimile DSM 26142	QRV02371.1			28
CUC43_32110		Bacillus thuringiensis LM1212	AXY11283.1			28
BVH75_30260		Bacillus thuringiensis YGD22-03	ARX70213.1			28
FJR70_30715		Bacillus tropicus LM1212-W3	QDF27186.1			28
HDN1F_20130		gamma proteobacterium HdN1	CBL45596.1			28
L2X98_03535		Microbacterium elymi KUDC0405	UJP13739.1			28
HQM25_01085		Microbacterium hominis PA2F3	QKJ18144.1			28
MNR00_01470		Microbacterium sp. H1-D42	UNK71144.1			28
L2X99_15905		Microbacterium sp. KUDC0406	UJP09841.1			28
B005_1763		Nocardiopsis alba ATCC BAA-2165	AFR06036.1			28
KGD84_01185		Nocardiopsis changdeensis Mg02	QUX23054.1			28
NE857_33290		Nocardiopsis exhalans JCM11759T	USY20045.1			28
HUT17_01340		Nocardiopsis flavescens NA01583	QKW31762.1			28
CDO52_02365		Nocardiopsis gilva YIM 90087	ASU81787.1			28
K1J57_10640		Nocardiopsis sp. MT53	QYX38999.1			28
P9209_25210 (fragment)		Prescottella defluvii SampleD3_15	WFR74703.1			28
REQ_13700		Prescottella equi 103S	CBH47454.1			28
SCD75_07080		Prescottella equi 134979_2019	WQB75242.1			28
KAREA_15200		Prescottella equi ATCC 33701	BDC71605.1			28
C7H75_07755		Prescottella equi DSSKP-R-001	AVP67853.1			28
RE9414_14400		Prescottella equi JCM94-14	BCN43160.1			28
RE9416_13830		Prescottella equi JCM94-16	BCN48082.1			28
RE9425_15410		Prescottella equi JCM94-25	BCN53151.1			28
RE9427_14170		Prescottella equi JCM94-27	BCN58047.1			28
RE943_13980		Prescottella equi JCM94-3	BCN67925.1			28
RE9431_14340		Prescottella equi JCM94-31	BCN62979.1			28
RE0327_14310		Prescottella equi JID03-27	BCN72832.1			28
RE0346_14900		Prescottella equi JID03-46	BCN77830.1			28
RE0356_14830		Prescottella equi JID03-56	BCN82842.1			28
GS533_016195		Prescottella equi lh_12	UPH34954.1			28
MPC38_07340		Prescottella equi P2117036	UNQ41061.1			28
MPC39_07170		Prescottella equi P2120831	UNQ36377.1			28
MWT96_05515		Prescottella equi PAM2287	UPH42608.1			28
REA19_13860		Prescottella equi U19	BDE58370.1			28
P9990_25585		Prescottella equi WH99	WJJ14566.1			28
P9990_16960		Prescottella equi WH99	WJJ10260.1			28
FNU77_02835		Prescottella equi WY	QDP08738.1			28
G6O69_19060		Pseudenhygromyxa sp. WMMC2535	QII76704.1			28
XU06_27470		Rhodococcus erythropolis BG43	AKE01030.1			28
O5Y_27195		Rhodococcus erythropolis CCM2595	AGT95256.1			28
ITJ47_29785 (fragment)		Rhodococcus erythropolis CERE8	UKO86234.1			28
D4768_28140		Rhodococcus erythropolis D310-1	UJC81142.1			28
RE2895_55370 (fragment)		Rhodococcus erythropolis JCM 2895	BBE48606.1			28
G9444_5959		Rhodococcus erythropolis KB1	QIP43202.1			28
QIE55_27995		Rhodococcus erythropolis MGMM8	WGV49324.2 WGV49324.1			28
RER_56930		Rhodococcus erythropolis PR4	BAH36401.1			28
H351_05000		Rhodococcus erythropolis R138	ALU68549.1			28
JXX30_27295		Rhodococcus erythropolis R85	QSE40966.1			28
F6X56_30770		Rhodococcus erythropolis X5	QEX13806.1			28
WDS21_26975		Rhodococcus qingshengii 190158	WXH52868.1			28
IM699_16455		Rhodococcus qingshengii 7B	QOS61013.1			28
R0122_08890		Rhodococcus qingshengii A29-k1	WOI88861.1			28
J6K27_005480		Rhodococcus qingshengii CL-05	QTS00178.1			28
PI247_27245 (fragment)		Rhodococcus qingshengii DC2	WCT02367.1			28
C1M55_29060		Rhodococcus qingshengii djl-6-2	AUS35611.1			28
JKI97_10130		Rhodococcus qingshengii F2-2	ULD43355.1			28
LRQ08_27625		Rhodococcus qingshengii J1-2	UUE24962.1			28
M0639_27710		Rhodococcus qingshengii JCM 15477 djl-6	UPU42771.1			28
RQN9TF_28820		Rhodococcus qingshengii N9T-4	BDQ23245.1			28
N6G92_27620		Rhodococcus qingshengii PM1	UXF67104.1			28
D6M20_26540		Rhodococcus qingshengii RL1	QEM30080.1			28
KSE96_27470		Rhodococcus qingshengii TG-1	QXC42749.1			28
LE551_27535		Rhodococcus qingshengii VER34	UDF20985.1			28
I1G86_01705		Rhodococcus qingshengii VKM Ac-2784D	QPG90032.1			28
LRL17_22690		Rhodococcus qingshengii VT6	UGQ50809.1			28
endoglycoceramidase II (EGCase II; M777_EGCase II)	3.2.1.123	Rhodococcus sp. (in: high G+C Gram-positive bacteria) M-777	AAB67050.1	O33853	2OSW[A,B] 2OSX[A] 2OSY[A,B] 2OYK[A,B] 2OYL[A,B] 2OYM[A,B]	28
AOT96_08730		Rhodococcus sp. 008	ANQ74830.1			28
ERC79_08785		Rhodococcus sp. ABRD24	QBJ96057.1			28
ERC79_16430		Rhodococcus sp. ABRD24	QBJ97348.1			28
A0W34_27420		Rhodococcus sp. BH4	ARE37572.1			28
KTR60_27345		Rhodococcus sp. C1	UEL32888.1			28
endoglycoceramidase I (EGCase I)	3.2.1.123	Rhodococcus sp. C9	BAB17317.1	Q9FAC7		28
RA302_27825		Rhodococcus sp. DN22 strain DN22	WVX70237.1			28
CPI83_01720		Rhodococcus sp. H-CA8f	ATI35656.1			28
BTZ20_5019		Rhodococcus sp. MTM3W5.2	AQA22291.1			28
BTZ20_4323		Rhodococcus sp. MTM3W5.2	AQA22644.1			28
I7X09_18420		Rhodococcus sp. P-2	QQM20049.1			28
P0M12_10505		Rhodococcus sp. RCBS9	WEX05832.1			28
RHP72_27580		Rhodococcus sp. SG20037	WNF41493.1			28
JQX30_19105		Saccharopolyspora erythraea NRRL 23338	QRK86981.1			28
SACE_3752		Saccharopolyspora erythraea NRRL 2338	CAM03023.1			28
HUO13_20185		Saccharopolyspora erythraea SCSIO 07745	QUH02818.1			28
Snas_0664		Stackebrandtia nassauensis DSM 44728	ADD40377.1			28
GXP74_04895		Streptacidiphilus sp. P02-A3a	QMU67663.1			28
GXW83_04505		Streptacidiphilus sp. PB12-B1b	QMU75132.1			28
GCM10020241_49030		Streptoalloteichus tenebrarius JCM 4838	BFF03228.1			28
K7396_00620		Streptomyces angustmyceticus JCM 4053	UAL65209.1			28
K7C20_35075		Streptomyces decoyicus NRRL 2666	QZY19805.1			28
KY5_5124		Streptomyces formicae KY5	ATL30142.1			28
test1122_18915		Streptomyces gobiensis 1_25	UGY93585.1			28
K9S39_38155		Streptomyces halobius 3_2	UQA98106.1			28
DWB77_02953 (fragment)		Streptomyces hundungensis BH38	AYG80815.1			28
KI385_42030		Streptomyces inhibens NRRL30439	UKY54728.1			28
CP970_15640		Streptomyces kanamyceticus ATCC 12853	QEU92146.1			28
LGI35_43485		Streptomyces longhuiensis BH-MK-02	UDM04628.1			28
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