Activities in Sub Family	Endoglycosylceramidase (EC 3.2.1.123);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (4); Uniprot accession (2); PDB accession (6); 3D entries (1); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
V6738_31260		Actinomadura luteofluorescens YN2	WWW01515.1			28
HUT06_37340		Actinomadura sp. NAK00032	QKW38997.1			28
F7P10_25690		Actinomadura sp. WMMB499	QFG27299.1			28
ACTIVE_6803		Actinomadura verrucosospora NRRL:B18236	QKG25152.1			28
SAMN04489737_0244		Arcanobacterium phocae DSM 10002	SDU77936.1			28
JTE88_00990		Arcanobacterium phocisimile DSM 26142	QRV02371.1			28
CUC43_32110		Bacillus thuringiensis LM1212	AXY11283.1			28
BVH75_30260		Bacillus thuringiensis YGD22-03	ARX70213.1			28
FJR70_30715		Bacillus tropicus LM1212-W3	QDF27186.1			28
HDN1F_20130		gamma proteobacterium HdN1	CBL45596.1			28
L2X98_03535		Microbacterium elymi KUDC0405	UJP13739.1			28
HQM25_01085		Microbacterium hominis PA2F3	QKJ18144.1			28
MNR00_01470		Microbacterium sp. H1-D42	UNK71144.1			28
L2X99_15905		Microbacterium sp. KUDC0406	UJP09841.1			28
B005_1763		Nocardiopsis alba ATCC BAA-2165	AFR06036.1			28
KGD84_01185		Nocardiopsis changdeensis Mg02	QUX23054.1			28
NE857_33290		Nocardiopsis exhalans JCM11759T	USY20045.1			28
HUT17_01340		Nocardiopsis flavescens NA01583	QKW31762.1			28
CDO52_02365		Nocardiopsis gilva YIM 90087	ASU81787.1			28
K1J57_10640		Nocardiopsis sp. MT53	QYX38999.1			28
P9209_25210 (fragment)		Prescottella defluvii SampleD3_15	WFR74703.1			28
REQ_13700		Prescottella equi 103S	CBH47454.1			28
SCD75_07080		Prescottella equi 134979_2019	WQB75242.1			28
KAREA_15200		Prescottella equi ATCC 33701	BDC71605.1			28
C7H75_07755		Prescottella equi DSSKP-R-001	AVP67853.1			28
RE9414_14400		Prescottella equi JCM94-14	BCN43160.1			28
RE9416_13830		Prescottella equi JCM94-16	BCN48082.1			28
RE9425_15410		Prescottella equi JCM94-25	BCN53151.1			28
RE9427_14170		Prescottella equi JCM94-27	BCN58047.1			28
RE943_13980		Prescottella equi JCM94-3	BCN67925.1			28
RE9431_14340		Prescottella equi JCM94-31	BCN62979.1			28
RE0327_14310		Prescottella equi JID03-27	BCN72832.1			28
RE0346_14900		Prescottella equi JID03-46	BCN77830.1			28
RE0356_14830		Prescottella equi JID03-56	BCN82842.1			28
GS533_016195		Prescottella equi lh_12	UPH34954.1			28
MPC38_07340		Prescottella equi P2117036	UNQ41061.1			28
MPC39_07170		Prescottella equi P2120831	UNQ36377.1			28
MWT96_05515		Prescottella equi PAM2287	UPH42608.1			28
REA19_13860		Prescottella equi U19	BDE58370.1			28
P9990_25585		Prescottella equi WH99	WJJ14566.1			28
P9990_16960		Prescottella equi WH99	WJJ10260.1			28
FNU77_02835		Prescottella equi WY	QDP08738.1			28
G6O69_19060		Pseudenhygromyxa sp. WMMC2535	QII76704.1			28
XU06_27470		Rhodococcus erythropolis BG43	AKE01030.1			28
O5Y_27195		Rhodococcus erythropolis CCM2595	AGT95256.1			28
ITJ47_29785 (fragment)		Rhodococcus erythropolis CERE8	UKO86234.1			28
D4768_28140		Rhodococcus erythropolis D310-1	UJC81142.1			28
RE2895_55370 (fragment)		Rhodococcus erythropolis JCM 2895	BBE48606.1			28
G9444_5959		Rhodococcus erythropolis KB1	QIP43202.1			28
QIE55_27995		Rhodococcus erythropolis MGMM8	WGV49324.2 WGV49324.1			28
RER_56930		Rhodococcus erythropolis PR4	BAH36401.1			28
H351_05000		Rhodococcus erythropolis R138	ALU68549.1			28
JXX30_27295		Rhodococcus erythropolis R85	QSE40966.1			28
F6X56_30770		Rhodococcus erythropolis X5	QEX13806.1			28
WDS21_26975		Rhodococcus qingshengii 190158	WXH52868.1			28
IM699_16455		Rhodococcus qingshengii 7B	QOS61013.1			28
R0122_08890		Rhodococcus qingshengii A29-k1	WOI88861.1			28
J6K27_005480		Rhodococcus qingshengii CL-05	QTS00178.1			28
PI247_27245 (fragment)		Rhodococcus qingshengii DC2	WCT02367.1			28
C1M55_29060		Rhodococcus qingshengii djl-6-2	AUS35611.1			28
JKI97_10130		Rhodococcus qingshengii F2-2	ULD43355.1			28
LRQ08_27625		Rhodococcus qingshengii J1-2	UUE24962.1			28
M0639_27710		Rhodococcus qingshengii JCM 15477 djl-6	UPU42771.1			28
RQN9TF_28820		Rhodococcus qingshengii N9T-4	BDQ23245.1			28
N6G92_27620		Rhodococcus qingshengii PM1	UXF67104.1			28
D6M20_26540		Rhodococcus qingshengii RL1	QEM30080.1			28
KSE96_27470		Rhodococcus qingshengii TG-1	QXC42749.1			28
LE551_27535		Rhodococcus qingshengii VER34	UDF20985.1			28
I1G86_01705		Rhodococcus qingshengii VKM Ac-2784D	QPG90032.1			28
LRL17_22690		Rhodococcus qingshengii VT6	UGQ50809.1			28
endoglycoceramidase II (EGCase II; M777_EGCase II)	3.2.1.123	Rhodococcus sp. (in: high G+C Gram-positive bacteria) M-777	AAB67050.1	O33853	2OSW[A,B] 2OSX[A] 2OSY[A,B] 2OYK[A,B] 2OYL[A,B] 2OYM[A,B]	28
AOT96_08730		Rhodococcus sp. 008	ANQ74830.1			28
ERC79_08785		Rhodococcus sp. ABRD24	QBJ96057.1			28
ERC79_16430		Rhodococcus sp. ABRD24	QBJ97348.1			28
A0W34_27420		Rhodococcus sp. BH4	ARE37572.1			28
KTR60_27345		Rhodococcus sp. C1	UEL32888.1			28
endoglycoceramidase I (EGCase I)	3.2.1.123	Rhodococcus sp. C9	BAB17317.1	Q9FAC7		28
RA302_27825		Rhodococcus sp. DN22 strain DN22	WVX70237.1			28
CPI83_01720		Rhodococcus sp. H-CA8f	ATI35656.1			28
BTZ20_5019		Rhodococcus sp. MTM3W5.2	AQA22291.1			28
BTZ20_4323		Rhodococcus sp. MTM3W5.2	AQA22644.1			28
I7X09_18420		Rhodococcus sp. P-2	QQM20049.1			28
P0M12_10505		Rhodococcus sp. RCBS9	WEX05832.1			28
RHP72_27580		Rhodococcus sp. SG20037	WNF41493.1			28
JQX30_19105		Saccharopolyspora erythraea NRRL 23338	QRK86981.1			28
SACE_3752		Saccharopolyspora erythraea NRRL 2338	CAM03023.1			28
HUO13_20185		Saccharopolyspora erythraea SCSIO 07745	QUH02818.1			28
Snas_0664		Stackebrandtia nassauensis DSM 44728	ADD40377.1			28
GXP74_04895		Streptacidiphilus sp. P02-A3a	QMU67663.1			28
GXW83_04505		Streptacidiphilus sp. PB12-B1b	QMU75132.1			28
GCM10020241_49030		Streptoalloteichus tenebrarius JCM 4838	BFF03228.1			28
K7396_00620		Streptomyces angustmyceticus JCM 4053	UAL65209.1			28
K7C20_35075		Streptomyces decoyicus NRRL 2666	QZY19805.1			28
KY5_5124		Streptomyces formicae KY5	ATL30142.1			28
test1122_18915		Streptomyces gobiensis 1_25	UGY93585.1			28
K9S39_38155		Streptomyces halobius 3_2	UQA98106.1			28
DWB77_02953 (fragment)		Streptomyces hundungensis BH38	AYG80815.1			28
KI385_42030		Streptomyces inhibens NRRL30439	UKY54728.1			28
CP970_15640		Streptomyces kanamyceticus ATCC 12853	QEU92146.1			28
LGI35_43485		Streptomyces longhuiensis BH-MK-02	UDM04628.1			28
A6P39_043600		Streptomyces sp. FXJ1.172	WEP00615.1			28
G7Z12_07100		Streptomyces sp. ID38640	QIK05834.1			28
NOO62_25625		Streptomyces sp. Je 1-369	WAL97577.1			28
OG522_14170		Streptomyces sp. NBC_01431	WUX60170.1			28
OIU81_32320		Streptomyces sp. NBC_01454	WUW74106.1			28
DEJ47_24130		Streptomyces venezuelae ATCC 14583	QES29108.1			28
DEJ48_14210		Streptomyces venezuelae ATCC 14584	QES34399.1			28
DEJ49_23475		Streptomyces venezuelae ATCC 14585	QES43547.1			28
V3O60_13360		Streptomyces xanthochromogenes WY144	WVT98430.1			28
Sros_1713		Streptosporangium roseum DSM 43021	ACZ84704.1			28
SG34_026280 (fragment)		Thalassomonas viridans XOM25	WDE04779.1			28
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
168790		Ramicandelaber brevisporus CBS 109374 v1 (Rambr1)				28
38619		Ramicandelaber brevisporus CBS 109374 v1 (Rambr1)				28
158399		Ramicandelaber brevisporus CBS 109374 v1 (Rambr1)				28
163434		Ramicandelaber brevisporus CBS 109374 v1 (Rambr1)				28
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