Glycoside Hydrolase Family 5 / Subf 28

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (21); Uniprot accession (8); PDB accession (6); 3D entries (1); cryst (0)
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMN04489737_0244   Arcanobacterium phocae DSM 10002 SDU77936.1     28
 BVH75_30260   Bacillus thuringiensis YGD22-03 ARX70213.1     28
 HDN1F_20130   gamma proteobacterium HdN1 CBL45596.1 E1VLA4   28
 B005_1763   Nocardiopsis alba ATCC BAA-2165 AFR06036.1     28
 CDO52_02365   Nocardiopsis gilva YIM 90087 ASU81787.1     28
 XU06_27470   Rhodococcus erythropolis BG43 AKE01030.1     28
 O5Y_27195   Rhodococcus erythropolis CCM2595 AGT95256.1     28
 RER_56930   Rhodococcus erythropolis PR4 BAH36401.1 C0ZTY5   28
 H351_05000   Rhodococcus erythropolis R138 ALU68549.1     28
 REQ_13700   Rhodococcus hoagii 103S CBH47454.1 E4WEV0   28
 AOT96_08730   Rhodococcus sp. 008 ANQ74830.1     28
 A0W34_27420   Rhodococcus sp. BH4 ARE37572.1     28
 endoglycoceramidase I (EGCase I) Rhodococcus sp. C9 BAB17317.1 Q9FAC7   28
 CPI83_01720   Rhodococcus sp. H-CA8f ATI35656.1     28
 endoglycoceramidase II (EGCase II) Rhodococcus sp. M-777 AAB67050.1 O33853 2OSW[A,B]
 BTZ20_5019   Rhodococcus sp. MTM3W5.2 AQA22291.1     28
 BTZ20_4323   Rhodococcus sp. MTM3W5.2 AQA22644.1     28
 SACE_3752   Saccharopolyspora erythraea NRRL 2338 CAM03023.1 A4FG48   28
 Snas_0664   Stackebrandtia nassauensis DSM 44728 ADD40377.1 D3Q6X8   28
 KY5_5124   Streptomyces formicae KY5 ATL30142.1     28
 Sros_1713   Streptosporangium roseum DSM 43021 ACZ84704.1 D2AS25   28

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