Glycoside Hydrolase Family 5 / Subf 27

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (30); Uniprot accession (20);
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 EGX50094.1   Arthrobotrys oligospora ATCC 24927 EGX50094.1     27
 AO090012000006   Aspergillus oryzae RIB40 BAE60253.1 Q2UDW2   27
 endoglycoceramidase (EGCase) 3.2.1.123 Cyanea nozakii BAB16369.1
BAB16370.1
Q9GV15
Q9GV16
  27
 FFUJ_11407   Fusarium fujikuroi IMI 58289 CCT75388.1     27
 ORF (fragment)   Hirsutella thompsonii H3 AIK98137.1     27
 endoglycoceramidase (EGCase) 3.2.1.123 Hydra magnipapillata BAD20464.1 Q6L6S1   27
 ORF (partial)   Isaria fumosorosea Ifr AsC AIK98138.1     27
 ORF   Lagenidium giganteum ARSEF 373 AIK98135.1     27
 LRAMOSA09953   Lichtheimia ramosa CDS08592.1     27
 ORF (fragment)   Paecilomyces reniformis IndGH96 AIK98136.1     27
 SJCHGC02838   Schistosoma japonicum AAW25069.1 Q5DGI7   27
 Smp_119550 (fragment)   Schistosoma mansoni CAY19074.1 C1M2Q5   27
 Smp_120050 (fragment)   Schistosoma mansoni CAY19094.1 C1M2R9   27
 Smp_120660 or Smp_187070 (fragment)   Schistosoma mansoni CAY19124.1
CAZ38230.1
C1M2T6   27
 Smp_155570   Schistosoma mansoni CAZ33725.1 C4QE39   27
 Smp_193630 (fragment)   Schistosoma mansoni CAZ38970.1 C4QU33   27
 Smp_194220 (fragment)   Schistosoma mansoni CAZ39055.1 C4QUB8   27
 Smp_194230 (fragment)   Schistosoma mansoni CAZ39056.1 C4QUB9   27
 Smp_177700 (fragment)   Schistosoma mansoni CAZ37129.1 C4QNU2   27
 Smp_181910 (fragment)   Schistosoma mansoni CAZ37678.1 C4QQE1   27
 Smp_182090 (fragment)   Schistosoma mansoni CAZ37698.1 C4QQG1   27
 Smp_185860 (fragment)   Schistosoma mansoni CAZ38099.1 C4QRL2   27
 Smp_187010 (fragment)   Schistosoma mansoni CAZ38225.1 C4QRY8   27
 Smp_187410 (fragment)   Schistosoma mansoni CAZ38267.1 C4QS30   27
 Smp_164170 (possible fragment)   Schistosoma mansoni Puerto Rico CAZ35197.1
CCD80873.1
C4QIB1   27
 Smp_177380 (fragment)   Schistosoma mansoni Puerto Rico CAZ37094.1
CCD76693.1
C4QNQ7   27
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