Glycoside Hydrolase Family 5 / Subf 15

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (28); Uniprot accession (13);
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 β-1,6-glucanase (CG16) (peptide fragment) 3.2.1.75 Acremonium IMI 383068   P82288   15
 β-1,6-glucanase (BGN6.1) 3.2.1.75 Acremonium sp. OXF C13 AAT97707.1 Q68GV7   15
 β-1,6-glucanase (Anid-Bgl503;AN3777) 3.2.1.75 Aspergillus nidulans FGSC A4 EAA59985.1
ABF50867.1
C8V716
Q5B6Q3
  15
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae FL1 ABK27195.1 A0FJV0   15
 β-1,6-glucanase (GcnA) 3.2.1.75 Epichloe festucae var. lolii LP19 ABK27199.1 A0FJV4   15
 β-1,6-glucanase 3.2.1.75 Neotyphodium sp. FCB-2002 AAN04103.1 Q8NJN4   15
 endo-β-1,6-glucanase (Bgn16.2;B16-2) 3.2.1.75 Trichoderma harzianum CAA55789.1
ACM42428.1
CAA55788.1
Q12711
Q12712
  15
 β-1,6-glucanase (Bgn3) 3.2.1.75 Trichoderma virens AAL84696.1
ABV71387.1
Q8TG97   15
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