Glycoside Hydrolase Family 189

Activities in Family	β-1,2-glucan synthetase (elongation) (EC 2.4.1.391); β-1,2-glucan synthetase (cyclization) (EC 2.4.1.397);
Mechanism	Retaining e
3D Structure Status	( α / α ) ₆ barrel
Note	Created after Tanaka et al. [PMID=38300345] who demonstrated the b-glucosyltransferase activity on b-1,2-glucooligosaccharides of the multimodular protein Thit_1831 in Thermoanaerobacter italicus Ab9, that comprises an N-terminal GT84 and a C-terminal GH94. Family with remote homology to GH144/clan-S, always found in such multimodular architectures.
External resources	CAZypedia;
Statistics	GenBank accession (2828); Uniprot accession (3); PDB accession (5); 3D entries (2); cryst (0)

Bacteria

Protein Name

EC#

Organism

GenBank

Uniprot

PDB/3D

Carbohydrate Ligands

Resolution (Å)

cyclic β-1,2-glucan synthase (Atu2730;ChvB;cgs)

AAK88447.2
AAK88447.1
AAL43711.1
NP_355662.1
NP_533395.1

8RF0[A]	β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-α-D-Glcp-(1-0)-TYR β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-3)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-3)-D-1-deoxy-Glcp	3.40
8RF9[A]		3.28
8RFE[A]	β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-D-1-deoxy-Glcp	3.80
8RFG[A]	β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-D-1-deoxy-Glcp β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-D-1-deoxy-Glcp β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-β-D-Glcp-(1-2)-D-1-deoxy-Glcp	3.35

β-1,2-glucooligosaccharide:β-glucosyltransferase (Thit_1831)

3.90