Glycoside Hydrolase Family 172

Activities in Family	α-D-arabinofuranosidase (EC 3.2.1.-); α-D-fructofuranosidase (EC 3.2.1.-); Exo-α-1,5-D-arabinofuranosidase (EC 3.2.1.-); Difructose-anhydride-I synthase (EC 4.2.1.179);
Mechanism	Retaining a
3D Structure Status	β-jelly roll
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Created after (Kashima et al., JBC, 2021) [PMID=34688653] who demonstrated the difructose dianhydride I synthase/hydrolase activity of aFFase1 protein in Bifidobacterium dentium JCM 1195 = DSM 20436
External resources	CAZypedia;
Statistics	GenBank accession (1910); Uniprot accession (1); PDB accession (6); 3D entries (4); cryst (0)


Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
difructose dianhydride I synthase/hydrolase (aFFase1; BBDE_2040)	3.2.1.- 3.2.1.-	pubmed pubmed pubmed pubmed	Bifidobacterium dentium JCM 1195 = DSM 20436	BAQ28034.1	A0A6L9SN29	7V1V[A,B,C,D,E,F] 7V1W[A,B,C,D,E,F] 7V1X[A,B,C,D,E,F]
exo-α-1,5-D-arabinofuranosidase (MycGH172; GII36_05205)	3.2.1.-	pubmed	Candidatus Mycosynbacter amalyticus JR1	QHN43218.1
exo-α-1,5-L-arabinofuranosidase (DgGH172a; HMPREF9455_02467)	3.2.1.-	pubmed	Dysgonomonas gadei ATCC BAA-286	EGK01275.1
exo-α-1,5-D-arabinofuranosidase (DgGH172b; HMPREF9455_02471)	3.2.1.-	pubmed	Dysgonomonas gadei ATCC BAA-286	EGK01279.1
exo-α-1,5-D-arabinofuranosidase (DgGH172c; HMPREF9455_02479)	3.2.1.-	pubmed	Dysgonomonas gadei ATCC BAA-286	EGK01287.1		8AH3[A]
exo-α-D-arabinofuranosidase (ExoMA1; MIAR_33200)	3.2.1.-	pubmed	Microbacterium arabinogalactanolyticum JCM 9171	GLC86735.1		8IC8[A,B,C,D,E,F,G,H,I,J,K,L]
DFA-I 2',1-α-D-Fructofuranosidase (MfDFA-Iase;J0P97_13010)	3.2.1.-	pubmed	Microbacterium flavum DSM 18909	MBT8798982.1
exo-α-1,5-D-arabinofuranosidase (NocGH172; O3I_017420)	3.2.1.-	pubmed	Nocardia brasiliensis ATCC 700358 HUJEG-1	AFU01445.1
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