Glycoside Hydrolase Family 127

Activities in Family	3-C-carboxy-5-deoxy-L-xylose (aceric acid) hydrolase (EC 3.2.1.-); [retaining] α-1,3-(3,6)-anhydro-D-galactosidase (EC 3.2.1.-); β-L-arabinofuranosidase (EC 3.2.1.185);
Mechanism	Retaining a
Clan	GH-P
3D Structure Status	( α / α ) ₆ barrel
Catalytic Nucleophile/Base	zinc coordinated cysteine
Catalytic Proton Donor	Glu
Note	Created after Fujita et al. (2011) J. Biol. Chem. (PMID - 21149454) who have shown the b-L-arabinobiosidase activity of the Bifidobacterium longum enzyme.
External resources	CAZypedia;
Statistics	GenBank accession (5115); Uniprot accession (6); PDB accession (15); 3D entries (4); cryst (0)


Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
3-C-carboxy-5-deoxy-L-xylose (aceric acid) hydrolase (BT1003;BT_1003)	3.2.1.-	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76110.1	Q8A914	5MQO[A]
β-L-arabinofuranosidase (BT3674; BT_3674)	3.2.1.185	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO78779.1	Q8A1I7	6EX6[A,B]
β-1,2-L-arabinofuranosidase (HypBA1; Bll1HypBA1; BlGH127; BLLJ_0211)	3.2.1.185	pubmed	Bifidobacterium longum subsp. longum JCM 1217	BAK79118.1 BAJ65881.1	E8MGH8	3WKW[A] 3WKX[A] 3WRE[A] 3WRF[A] 3WRG[A] 7BZL[A] 7DIF[A] 7EXU[A] 7EXV[A] 7EXW[A] 8QF2[A]
β-1,3-L-arabinofuranosidase (CpAbf127B) (Abf127B)	3.2.1.185	pubmed	Caldanaerobius polysaccharolyticus ATCC BAA-17	WP_026486269.1
α-1,3-(3,6)-anhydro-D-galactosidase (Patl_0910)	3.2.1.-	doi	Pseudoalteromonas atlantica T6c	ABG39436.1
α-1,3-(3,6)-anhydro-D-galactosidase (DagA3; ZgGH127-3; zobellia_3150)	3.2.1.-	pubmed	Zobellia galactanivorans DsijT	CAZ97289.1	G0L003
α-1,3-(3,6)-anhydro-D-galactosidase (DagA2; ZgGH127-2; zobellia_3148)	3.2.1.-	pubmed	Zobellia galactanivorans DsijT	CAZ97287.1	G0L7B5
α-1,3-(3,6)-anhydro-D-galactosidase (DagA1; ZgGH127-1; zobellia_3147)	3.2.1.-	pubmed	Zobellia galactanivorans DsijT	CAZ97286.1	G0L001
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