Activities in Family	endo-β-1,4-xylanase (EC 3.2.1.8); exo-1,4-β-xylosidase (EC 3.2.1.-)
Mechanism	Retaining
Clan	GH-C
3D Structure Status	β-jelly roll
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family G
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (2699); Uniprot accession (306); PDB accession (166); 3D entries (39); cryst (2)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
xylanase (DIU60_09020)	3.2.1.8	Actinomycetia bacterium	PZN45477.1	A0A2W4QIY3	7EO6[A,B] 1.90
xylanase J (XynJ)	3.2.1.8	Bacillus sp. 41M-1	BAA82316.1 AAS31755.1	Q9RC94	2DCJ[A,B] 2.24 2DCK[A] 2.10 6KJL[A,B] 2.45 6KKA[A,B] 2.36
xylanase (ATBXYL-C;XylC1;XylC2;XylC3)	3.2.1.8	Bacillus sp. NCL 87-6-10	AEP40124.1 AEP40122.1 AEP40123.1	G4XQJ9 G4XQK0 G4XQK1 Q7SIE3	2F6B[A,B] 2.80
xylanase		Bacillus sp. NCL 87-6-10			2NQY[B] β-D-Xylp β-D-Xylp-(1-1)-<non_carb> 2.40 2NQY[A] β-D-Xylp β-D-Xylp-(1-1)-<non_carb> 2.40
xylanase (Xyn11A-LC) (Xyn11A)	3.2.1.8	Bacillus sp. SN5	AGL92443.1	V9NCQ7	4IXL[A,B] 1.49
xylanase	3.2.1.8	Bacillus subtilis B230		Q7SID8	1IGO[A] 2.20
xylanase A (XynA;BsxA;BsXynA;BSU18840)	3.2.1.8	Bacillus subtilis subsp. subtilis str. 168	CAB13776.1 AAA22897.1 AAB84458.1 AAM08359.1 ABH92520.1 ACK26682.1 ACQ19010.1 ACR92566.1 AIY93198.1 AQR81879.1 AQR86093.1 CAA84276.1 NP_389765.1	A0A6M4JHE2 P18429 Q59254 Q8RMN9	1AXK[A] 2.10 1XXN[A] 1.70 2B45[X] 2.00 2B46[X] β-D-Xylp-(1-4)-β-D-Xylp 2.21 2DCY[A,B,C,D,E] 1.40 2DCZ[A,B] 1.90 2QZ3[A,B] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.80 2Z79[A,B] 1.30 3EXU[A,B] 1.81 5K9Y[A,B] 2.20
xylanase B (XynB;XynB3;229B)	3.2.1.8	Dictyoglomus thermophilum RT46B.1	AAC46361.1	P77853	1F5J[A,B] 1.80
xylanase A (XynA)	3.2.1.8	Geobacillus stearothermophilus 236	AAB72117.1	P45705	cryst
xylanase A (XlnA;BcX)	3.2.1.8	Niallia circulans	AAS31723.1 AAM08360.1 AAS31734.1 ABH92518.1 ACK26680.1 ACQ19008.1 ACR92575.1 CAA30553.1	P09850 P18429 Q8RMN8	1BCX[A] β-D-Xylp-(1-4)-β-D-Xylp 1.81 1BVV[A] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.80 1C5H[A] 1.55 1C5I[A] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.80 1HV0[A] 1.60 1HV1[A] 1.80 1XNB[A] 1.49 1XNC[A] 1.60 2B42[B] 2.50 2BVV[A] 1.50 3HD8[B,D] 2.39 3LB9[A,B,C] 3.00 3VZJ[A,B,C,D] 2.41 3VZK[A,B] 1.55 3VZL[A,B,C,D] 2.00 3VZM[A] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.86 3VZN[A,B] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.67 3VZO[A] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.73
1,4-betα-xylanase (GH11XynB;AMS66_16445)	3.2.1.8	Paenibacillus xylanivorans	KOY15336.1	A0A0M9BNX9	7KV0[A,B] 2.50
xylanase (BadX;Xyl11)	3.2.1.8	Salipaludibacillus agaradhaerens AC13	CAB42305.1 ABE26517.1 ABE26518.1 CAA03091.1	Q7SIE2 Q7SIE3	1H4G[A,B] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.1 1H4H[A,B,C,D] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-α-D-Xylp 1.9 1QH6[A,B] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 2.00 1QH7[A,B] β-D-Xylp 1.78
xylanase B (XlnB;XlnB1;XlnB2)	3.2.1.8	Streptomyces lividans 1326	AAC06114.2 AAS31736.1 ABH92525.1 ACQ19015.1	P26515	5EJ3[A,B] 1.31
β-xylanase (SoXyn11B)	3.2.1.8	Streptomyces olivaceoviridis E-86	BCL01310.1	A0A7G1MBT0	7DFM[A,B,C,D] 2.40 7DFN[A,B,C,D] β-D-Xylp-(1-4)[α-L-Araf-(1-3)]-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 2.00 7DFO[A,B,C,D,E,F,G,H,I] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp β-D-Xylp-(1-4)-β-D-Xylp β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp β-D-Xylp-(1-4)[α-D-GlcpA4Me-(1-2)]-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 2.00
xylanase (Xyl1)	3.2.1.8	Streptomyces sp. S38	CAA67143.1	Q59962	1HIX[A] 2.0
xylanase (Xyl11;Xyl20;Tx-Xyn;TxXYN;Tx-Xyl;Tx-Xyn11;G11)	3.2.1.8	Thermobacillus xylanilyticus D3	CAJ87325.1	Q14RS0	cryst
endo-β-1,4-xylanase (Xyl11;TfGH11)	3.2.1.8	Thermobifida fusca NTU22	AAV64879.1	Q5RZ98	3ZSE[A] β-D-Xylp-(1-4)-α-D-Xylp2F-(1-4)-GLU 1.78
endo-β-1,4-xylanase (XynA;Xyn;NfXyn;NfXyn11) (Xyn11A)	3.2.1.8	Thermopolyspora flexuosa DSM43186 / ATCC35864	CAD48747.1 AAO97628.1 AAQ80269.1 AAS23965.1 ACC29940.1	Q8GMV7	1M4W[A] 2.10 3B5L[B] 1.80 3MF6[A] 1.28 3MF9[A] 1.70 3MFA[A] 1.63 3MFC[A] 1.70
glycoside hydrolase		uncultured bacterium	AMO13186.1		7AYL[A,B] 1.80 7AYP[A] 1.70 7ZSZ[A,B] 1.50
xylanase (X0012;Xyn12)	3.2.1.8	uncultured bacterium	ADD82898.1	D4PAK8	5GV1[A] 1.50 5GY8[A] 1.80 5GY9[A,B] 1.94 5GYA[A,B] 1.93 5GYB[A] 1.65 5GYC[A] 1.40 5GYE[A] 1.90 5GYF[A] 1.94 5GYG[A,B] 1.74 5GYH[A] 1.86 5GYI[A] 1.97
xylanase (EvXyn11fl) (Xyn11)	3.2.1.8	uncultured bacterium	ACB87630.1	B2LWN3	2VGD[A] β-D-Xylp-(1-4)-β-D-Xylp β-D-Xylp-(1-4)[α-L-Ribf-(1-3)]-β-D-Xylp-(1-4)-β-D-Xylp 1.80 2VUJ[A] 1.8 2VUL[A] 1.9
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
xylanase C / xylanase 3 (XynC)	3.2.1.8	Aspergillus kawachii	AAC60542.1 AAS31748.1 ABH92517.1 ACQ19007.1 BAA03576.1	P33557	1BK1[A] 2.00 3RI8[A] 2.00 3RI9[A] 2.00
endo-β-1,4-xylanase 1 (XynA;XylA;XynII;ExlA;AnxA;An14g07390)	3.2.1.8	Aspergillus niger CBS 513.88	CAA01470.1 AAZ66797.1 ABH92516.1 ACK26693.1 ACQ19006.1 ACR92608.1 CAK46731.1	A2R4D1 P55329 Q45F01	1T6G[C,D] 1.80 1UKR[A,B,C,D] 2.40 2QZ2[A] β-D-Xylp-(1-4)-β-D-Xylp β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 2.80 6QE8[A] 1.79
xylanase (Xyl2)	3.2.1.8	Fusarium oxysporum f. sp. lycopersici 4287	KNB08954.1	A0A0D2Y051 X0M5X0	5JRM[A] 1.56 5JRN[A] β-D-Xylp-(1-1)-methyl 2.84
NECHADRAFT_106153	3.2.1.8	Fusarium vanettenii 77-13-4	XP_003050975.1	C7YSL3	6Y0H[A] 1.00 7ZQ0[A] 1.90 8AF4[A] 1.51 8AF5[A] 1.63 8AF6[A] 1.70
xylanase A / 11A (XynA;XylA;Xyl11A;NpXyn11A) (Xyn11A)	3.2.1.8	Neocallimastix patriciarum	CAA46498.1 AAB23454.1 AAS31749.1 CAB58524.1 CAB58525.1 CAB58526.1 CAB58527.1 CAB58530.1 CAB58531.1 CAB58532.1	P29127	2C1F[A] 2.10 2VG9[A] 2.0
endo-β-1,4-xylanase (XynC;CDBFV;Xyn-CDBFV;XynCDBFV)	3.2.1.8	Neocallimastix patriciarum	AAF14365.1 AAE61565.1	Q9UV68	3WP4[A] 1.27 3WP5[A] 1.32 3WP6[A] β-D-Xylp-(1-4)-β-D-Xylp β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.43
xylanase	3.2.1.8	Paecilomyces variotii BAINIER	AAS31744.1	P81536	1PVX[A] 1.59
xylanase (Xyl1)	3.2.1.8	Scytalidium acidophilum	AAQ22691.1	Q6VAY1	3M4F[A,B,C,D] 1.89
endo-β-1,4-xylanase C (XynC;PfXynC)	3.2.1.8	Talaromyces funiculosus IMI-134756 / ATCC 62998 / 8/403	CAC15487.1 AAP60299.1 CAC07798.1	Q9HFH0	1TE1[B] 2.50
xylanase 11C (XylC;TcXylC)	3.2.1.8	Talaromyces pinophilus CF-2612	BAO51921.1	W8VR85	3WP3[A,B] 1.98 5HXV[A,B,C,D,E,F,G,H,I,J, 2.00
xylanase 11A (Xyn11A)	3.2.1.8	Thermochaetoides thermophila CBS730.95	AAR67679.1 AAE69548.1 AAQ73530.1 CAD48749.1	Q6UN40 Q8J1V6	1H1A[A,B] 1.75 1XNK[A,B] β-D-Xylp4S-(1-4)-β-D-Xylp4S-(1-4)-α-D-Xylp4S-(1-1)-methyl 1.55
xylanase A (XynA; XynA2; XynI; TLX)	3.2.1.8	Thermomyces lanuginosus SSBP / ATCC 46882 / DSM10635	AAB94633.1 AAE10889.1 AAS31745.1 ACR92582.1 ACY69861.1	O43097	1YNA[A] 1.55
xylanase		Trichoderma harzianum E58	AAS31741.1 ABH92529.1 ACK26691.1 ACQ19019.1 ACR92591.1		1XND[A] 2.00
xylanase II (XynII;XYNII) (partial)	3.2.1.8	Trichoderma longibrachiatum		F8W669	3AKP[A,B] 1.20 3AKQ[A] 0.97 3AKR[A] 1.10 3AKS[A] 0.97 3AKT[A,B] 1.00 2JIC[A] 1.5
xylanase 1 (Xyn1;XYNI)	3.2.1.8	Trichoderma reesei	AAE16058.1 AAS31742.1 ABH92530.1 ACK26677.1 ACQ19020.1 ACR92612.1 CAA49294.1	P36218	1XYN[A] 2.00
endo-β-1,4-xylanase 2 (Xyn2;XYNII;Xyn11;EX2;BD-11) (Xyn11A)	3.2.1.8	Trichoderma reesei RUT-C30	AAB29346.1 AAE16057.1 AAS31743.1 ABH92531.1 ABH92533.1 ABH92534.1 ABH92538.1 ABH92539.1 ABH92540.1 ABH92541.1 ACB38137.1 ACB59312.1 ACK26676.1 ACQ19021.1 ACR92589.1 ACR92590.1 ACS11409.1 CAA49293.1	B2CZF9 G0RUP7 P36217 Q02244	1ENX[A,B] 1.50 1RED[A,B] β-D-Xylp-(1-1)-<non_carb> 1.60 1REE[A,B] β-D-Xylp-(1-1)-<non_carb> 1.60 1REF[A,B] β-D-Xylp-(1-1)-<non_carb> 1.80 1XYO[A,B] 1.50 1XYP[A,B] 1.50 2D97[A] 2.01 2D98[A] 2.00 2DFB[A] 1.11 2DFC[A] 1.19 3LGR[A] 1.64 4HK8[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.15 4HK9[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.55 4HKL[A] 1.10 4HKO[A] 1.50 4HKW[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-1)-<non_carb> β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-α-D-Xylp 1.65 4S2D[A] 1.60 4S2F[A] 1.70 4S2G[A] 1.60 4S2H[A] 1.60 4XPV[A] 1.70 4XQ4[A,B] 1.25 4XQD[A,B] 1.50 4XQW[A] 1.50 5K7P[A] 2.30 5ZF3[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.20 5ZH0[A] 1.08 5ZH9[A] 1.15 5ZII[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-α-D-Xylp 1.30 5ZIW[A] 1.30 5ZKZ[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.30 5ZO0[A] 1.65 6JUG[A] 1.19 6JWB[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.15 6JXL[A] β-D-Xylp-(1-4)-β-D-Lyxp-(1-4)-β-D-Xylp 1.30 6JZP[A] 1.12 6K9O[A] 1.06 6K9R[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.30 6K9W[A] 1.10 6K9X[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.20 6KVV[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.19 6KW9[A] 1.22 6KWC[A] 1.30 6KWD[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.30 6KWE[A] 1.50 6KWF[A] β-D-Xylp β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.22 6KWG[A] β-D-Xylp-(1-4)-β-D-Lyxp-(1-4)-β-D-Xylp 1.69 6KWH[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp 1.81 7MGU[A] 1.40
unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Designed enzyme RA61		synthetic construct			7F1I[A] 1.40 7F1J[A] 1.60 7F1K[A] 1.05 7F1L[A] 1.70 7F1H[A] 1.14
exo-β-1,4-xylanase	3.2.1.37	unidentified	5VQJ_A		5VQJ[A] 1.76 7L1W[A] 1.71 7L1Y[A] β-D-Xylp-(1-4)-β-D-Xylp 1.20 7L1Z[A,B,C] 2.05
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