Activities in Family	The hyaluronan-specific binding function of the N-terminal CBM70 module of Streptococcus pneumoniae hyaluronate lyase has been demonstrated.
3D Structure Status	β-sandwich
Note	Created after Suits et al. (2014) J Biol Chem 289:27264-27277 [PMID: 25100731]
Statistics	GenBank accession (565); Uniprot accession (7); PDB accession (1); 3D entries (1); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
hyaluronidase (Hyl; HAase-B)		Bacillus sp. A50	AHB61202.1	W5RSC1
hyaluronate lyase (HysA)		Bacillus sp. CQMU-D	WFD50841.1
H1220_07235		Carnobacteriaceae bacterium zg-84	QMI85505.1
J4772_03910		Cohnella sp. LGH	QTH43589.1
PZY29_08045		Enterococcus casseliflavus ASE2	WEI93903.1
EGM182_03430		Enterococcus casseliflavus EGM182	QOG29929.1
CIRMBP1281_00096		Enterococcus cecorum isolate CIRMBP-1281	CAI3258224.1
CIRMBP1228_00080		Enterococcus cecorum isolate CIRMBP-1228	CAI3256524.1
CIRMBP1261_00123		Enterococcus cecorum isolate CIRMBP-1261	CAI3261587.1
CIRMBP1246_00018		Enterococcus cecorum isolate CIRMBP-1246	CAI3251005.1
CIRMBP1287_00040		Enterococcus cecorum isolate CIRMBP-1287	CAI3465195.1
CIRMBP1302_00018		Enterococcus cecorum isolate CIRMBP-1302	CAI3300860.1
NCTC12421_00019		Enterococcus cecorum NCTC12421	SQE53777.1
DOU32_08560		Enterococcus faecalis C54	QCX17614.1
PML87_09855		Enterococcus gallinarum K205-4a	WCG06786.1
H9Q80_00695		[Eubacterium] hominis NSJ-61	QNM12507.1
NQ540_05815		Granulicatella adiacens ATCC 49175	UWP37444.1
N8I82_05785		Granulicatella adiacens KHUD_009	UXY40727.1
HIF96_07580		Helcococcus kunzii H10	QZO76137.1
GUI37_08075		Helcococcus kunzii H13	QUY65479.1
EQF90_007695		Helcococcus ovis KG-36	WNZ01141.1
NCTC4824_01128		Lederbergia lenta NCTC4824	SQI53822.1
NCTC4824_03984		Lederbergia lenta NCTC4824	SQI63227.1
hyaluronate lyase (BniHL)		Neobacillus niacini F8	BAO57293.1
HLK66_10555		Niallia circulans GN03	QJX62049.1
C2I06_04330		Niallia circulans PK3_109	AYV66165.1
C2H98_05220		Niallia circulans PK3_138	AYV71019.1
C2I17_01805		Niallia circulans PK3_15	UQZ73390.1
PBLR_13548		Paenibacillus alvei	SYX85126.1
PBLR_11433		Paenibacillus alvei	SYX83011.1
MJA45_14235		Paenibacillus aurantius MBLB1776	WNQ08816.1
MJA45_15510		Paenibacillus aurantius MBLB1776	WNQ09054.1
PAJ34TS1_49980		Paenibacillus azoreducens J34TS1	BFH64406.1
PC41400_11260		Paenibacillus chitinolyticus KCCM 41400	QAV18210.1
PsJ27TS7_37650		Paenibacillus dendritiformis J27TS7	BFH69765.1
A3958_01915		Paenibacillus glucanolyticus 5162	ANA78826.1
WDY75_09010		Paenibacillus glucanolyticus GlSt238	WXG84339.1
C7121_14620		Paenibacillus glucanolyticus W10507	AVV57259.1
BBD41_21650		Paenibacillus ihbetae IHBB 9852	ANY74958.1
D5F53_17370		Paenibacillus lautus E7593-69	AYB44936.1
CD191_07740		Paenibacillus odorifer CBA7130	AWV32512.1
IJ21_17060		Paenibacillus sp. 32O-W	ALS27107.1
IJ21_17060		Paenibacillus sp. 32O-W	ALS27107.1
P0X86_13280		Paenibacillus sp. BR1-192	WFB61729.1
N6H14_29050 (fragment)		Paenibacillus sp. CC-CFT747	WJH33979.1
N6H14_27315 (fragment)		Paenibacillus sp. CC-CFT747	WJH33686.1
QNH28_07540		Paenibacillus sp. G2S3	WHY20831.1
DVH26_10180		Paenibacillus sp. H1-7	ULL14783.1
DVH26_30980		Paenibacillus sp. H1-7	ULL18507.1
LOZ80_05150		Paenibacillus sp. HWE-109	UKS28326.1
LOZ80_05150		Paenibacillus sp. HWE-109	UKS28326.1
LOZ80_07505		Paenibacillus sp. HWE-109	UKS28761.1
LOZ80_07505		Paenibacillus sp. HWE-109	UKS28761.1
LOZ80_07505		Paenibacillus sp. HWE-109	UKS28761.1
LOZ80_36360		Paenibacillus sp. HWE-109	UKS26877.1
LOZ80_36360		Paenibacillus sp. HWE-109	UKS26877.1
LOZ80_36360		Paenibacillus sp. HWE-109	UKS26877.1
LOZ80_36360		Paenibacillus sp. HWE-109	UKS26877.1
JNUCC32_12850		Paenibacillus sp. JNUCC32	QOT12851.1
EI981_02180		Paenibacillus sp. MBLB1234	AZS13398.1
MNQ98_03750		Paenibacillus sp. N3/727	UNK19162.1
H7F31_06225		Paenibacillus sp. PAMC21692	QNK58518.1
H7F31_07015		Paenibacillus sp. PAMC21692	QNK58643.1
H7F31_07015		Paenibacillus sp. PAMC21692	QNK58643.1
H7F31_07015		Paenibacillus sp. PAMC21692	QNK58643.1
H7F31_29305		Paenibacillus sp. PAMC21692	QNK56587.1
UNVERIFIED_ORG: hyaluronidase (HysA)		Paenibacillus sp. SH-7-A	WXC36699.1
GYMC10_2460		Paenibacillus sp. Y412MC10	ACX64738.1
NDS46_20095		Paenibacillus thiaminolyticus SY20	WCF06641.1
SAMN05661091_5261		Paenibacillus uliginis N3/975	SMF90851.1
LC071_01340		Pseudalkalibacillus hwajinpoensis KcN21-2	WLR60067.1
LC071_01340		Pseudalkalibacillus hwajinpoensis KcN21-2	WLR60067.1
NCTC11451_00695 (HylB)		Pseudomonas aeruginosa NCTC11451	VTR41759.1
HKK59_06245		Streptococcus agalactiae 01173	QJQ92957.1
BSA_12760		Streptococcus agalactiae 09mas018883	CCW38045.1
V193_05585		Streptococcus agalactiae 138P	AHN30604.1
DN94_05585		Streptococcus agalactiae 138spar	AHX75150.1
GBS222_1026 (HylB)		Streptococcus agalactiae 2-22	CCO74748.1
SAG1197		Streptococcus agalactiae 2603V/R	AAN00079.1 NP_688206.1
DKY66_06695		Streptococcus agalactiae 32790-3A	QDI66339.1
hyaluronate lyase (HylB)		Streptococcus agalactiae 4755	CAA75865.1	O86478
GRB95_06050		Streptococcus agalactiae 515	QJC65326.1
CHF17_01286		Streptococcus agalactiae 874391	ASZ01543.1
SAK_1284 (HylB)		Streptococcus agalactiae A909	ABA45106.1
CCZ24_03895		Streptococcus agalactiae B105	AWZ35997.1
CDH84_05075		Streptococcus agalactiae B507	AWZ32146.1
CDH83_05005 (fragment)		Streptococcus agalactiae B508	AWZ30048.1
CDH85_07240		Streptococcus agalactiae B509	AWZ28445.1
GT95_06720		Streptococcus agalactiae C001	ASI66297.1
GBSCOH1_1103		Streptococcus agalactiae COH1	CDN66569.1
BB161_06890		Streptococcus agalactiae CUGBS591	ASA79900.1
CUGBS08_01230 (HylB)		Streptococcus agalactiae CU_GBS_08	AMQ14781.1
CUGBS98_01167 (HylB)		Streptococcus agalactiae CU_GBS_98	AMQ16773.1
A6J82_06845		Streptococcus agalactiae FDAARGOS_254	ARC45071.1
EGX82_10455		Streptococcus agalactiae FDAARGOS_512	AYZ24217.1
FOB77_08675		Streptococcus agalactiae FDAARGOS_669	QET35740.1
FOB78_02465		Streptococcus agalactiae FDAARGOS_670	QET53184.1
A9256_06185		Streptococcus agalactiae FWL1402	ANR97234.1
AOY37_06410		Streptococcus agalactiae GBS ST-1	ALP87742.1
DK41_06360		Streptococcus agalactiae GBS1-NY	AIK71752.1
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