Carbohydrate-Binding Module Family 40

Activities in FamilyModules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the β-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294).
3D Structure Statuslectin-like
External resourcesHOMSTRAD;
Statistics GenBank accession (304); Uniprot accession (83); PDB accession (66); 3D entries (7); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 sialidase (CpNanI;CPF_0721) 3.2.1.18 Clostridium perfringens ATCC 13124 ABG83208.1 Q0TT67
5FRA[A,B,C,D,E,F] α-D-Neup5Ac
α-D-Neup5Ac-(2-6)-β-D-Galp
2.00
5FRE[A,B,C] α-D-Neup5Ac-(2-3)-β-D-Galp
1.90
 exo-α-sialidase (NanJ;CPE0553) 3.2.1.18 Clostridium perfringens str. 13 BAB80259.1
NP_561469.1
Q8XMY5
2V73[A,B] α-D-Neup5Ac
2.2
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
4C1W[A] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-α-D-Glcp
1.84
4C1X[A] α-D-Neup5Ac-(2-6)-β-D-Galp-(1-4)-β-D-Glcp
1.84
4ZXK[A,B] 1.84
 neuraminidase (NanC) 3.2.1.18 Streptococcus pneumoniae G54 ACF56230.1 B5E561
4YW0[A,B] 2.05
4YW1[A,B] α-D-Neup5Ac
<carb_like_DAN>
2.25
4YW2[A,B] α-D-Neup5Ac-(2-6)-β-D-Galp
2.00
4YW3[A,B] α-D-Neup5Ac
<carb_like_DAN>
2.05
4YW4[A,B] 2.20
4YW5[A,B] <carb_like_G39>
2.30
4YZ1[A,B] 1.97
4YZ2[A,B] <carb_like_DAN>
2.06
4YZ3[A,B] <carb_like_G39>
2.38
4YZ4[A,B] α-D-Neup5Ac
2.15
4YZ5[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp
<carb_like_DAN>
2.27
5F9T[A,B] α-L-Manp3F5Ac-(2-0)-TYR
2.05
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727
2JKB[A] 1.54
2VW0[A] 2.3
2VW1[A] <carb_like_DAN>
2.39
2VW2[A] 1.7
4FOQ[A] 1.99
4FOV[A] 2.29
4FOW[A] 2.10
4FOY[A] 1.84
4FP2[A] 2.05
4FP3[A] 2.74
4FPC[A] 2.32
4FPE[A] 2.18
4FPF[A] 2.23
4FPG[A] 2.58
4FPH[A] 1.94
4FPJ[A] 1.98
4FPK[A] 2.40
4FPL[A] 2.10
4FPO[B] 2.59
4FPY[A] 2.18
4FQ4[A] 1.84
4XE9[A] 1.84
4XHB[A] 1.88
4XHX[A] 2.10
4XIK[A] 1.91
4XIL[A] 1.90
4XIO[A] 1.80
4XJ8[A] 2.75
4XJ9[A] 1.98
4XJA[A] 1.98
4XJU[A] 1.94
4XJW[A] 1.53
4XJZ[A] 1.56
4XMA[A] 2.09
4XMI[A] 1.97
4XOG[A] <carb_like_DAN>
2.09
4XYX[A] 2.10
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1
AAA27547.1
P37060
1KIT[A] 2.30
1W0O[A] α-D-Neup5Ac
<carb_like_DAN>
1.9
1W0P[A] α-D-Neup5Ac
1.6
2W68[A,B,C] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.50
6EKS[A] <carb_like_G39>
1.87
6EKU[A] <carb_like_ZMR>
1.75
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 Macrobdella decora AAC47263.1 Q27701
1SLI[A] <carb_like_DAN>
2.00
1SLL[A] 2.00
2SLI[A] 1.80
3SLI[A] 1.80
4SLI[A] <carb_like_CNP>
1.80
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