Carbohydrate-Binding Module Family 32

Activities in FamilyBinding to galactose and lactose has been demonstrated for the module of Micromonospora viridifaciens sialidase (PMID: 16239725). Binding to polygalacturonic acid has been shown for a Yersinia member (PMID: 17292916). Binding to LacNAc (β-D-galactosyl-1,4-β-D-N-acetylglucosamine) has been shown for an N-acetylglucosaminidase from Clostridium perfingens (PMID: 16990278).
3D Structure Statusβ-sandwich
NoteFormerly known as X56 modules. Distantly related to CBM6 modules and to Anguilla anguilla agglutinin.
External resourcesCAZypedia;
Statistics GenBank accession (12800); Uniprot accession (83); PDB accession (92); 3D entries (31); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 BF3579   Bacteroides fragilis NCTC 9343 CAH09262.1  
3F2Z[A] 1.30
 Btheta7330_02495 (Nagj_2)   Bacteroides thetaiotaomicron 7330 ALJ42041.1  
6OE2[A] 3.00
 K6V27_03665   Bacteroides thetaiotaomicron BFG-55 UBD12722.1  
7BLG[A] β-D-Galp
1.18
7BLH[A]
7BLJ[A] 1.76
7BLK[A] 1.06
 BT0290   Bacteroides thetaiotaomicron VPI-5482 AAO75397.1
NP_809203.1
 
6EON[A] α-D-Galp
1.75
 BT0865   Bacteroides thetaiotaomicron VPI-5482 AAO75972.1
NP_809778.1
 
2KD7[A] NMR
3GGL[A] 3.00
 (grape RGII active) α-L-arabinofuranosidase (BT3662;BT_3662)   Bacteroides thetaiotaomicron VPI-5482 AAO78767.1
NP_812573.1
Q8A1J9
5MSX[A,B,C] 2.10
 β-N-acetyl-6-sulfo-glucosaminidase (BbhII)   Bifidobacterium bifidum JCM 1254 BAI94823.1 D4QAP5
6YXZ[A]
6Z14[A]
7WDT[A] α-D-GlcpNAc6SO3
β-D-GlcpNAc6SO3
1.65
7WDU[A] α-D-Glcp1N2NAc6SO3-(1-1)-<non_carb>
2.23
 core 1 endo-α-N-acetylgalactosaminidase (EngBF;BLLJ_0168)   Bifidobacterium longum subsp. longum JCM 1217 BAJ65838.1
AAX44931.1
CAM83935.1
A0A413AG90
Q3T552
6QEP[A] 2.60
6QFK[A] 2.00
6SH9[B] 2.40
 exo-β-N-acetylglucosaminidase (NagH;CpGH84A;CPF_0184) (GH84A)   Clostridium perfringens ATCC 13124 ABG83307.1 A0A0H2YRL1
P26831
Q0TUP2
2LS6[A] NMR
 exo-β-N-acetylglucosaminidase (NagH;CpGH84A;CPF_0184) (GH84A)   Clostridium perfringens ATCC 13124 ABG83307.1 A0A0H2YRL1
P26831
Q0TUP2
2W1Q[A,B] 1.60
2W1S[A,B] 1.45
2W1U[A,B,C,D] β-D-GlcpNAc-(1-3)-α-D-GalpNAc
β-D-GlcpNAc-(1-3)-β-D-GalpNAc
2.00
2WDB[A,B,C,D] β-D-GlcpNAc-(1-2)-β-D-Manp
2.03
 exo-β-N-acetylglucosaminidase (NagH;CpGH84A;CPF_0184) (GH84A)   Clostridium perfringens ATCC 13124 ABG83307.1 A0A0H2YRL1
P26831
Q0TUP2
4TXW[A] 1.40
 exo-acting protein-α-N-acetylgalactosaminidase (CpGH31;CPF_1301)   Clostridium perfringens ATCC 13124 ABG84084.1 A0A0H2YST8
4LPL[A] 1.35
 exo-acting protein-α-N-acetylgalactosaminidase (CpGH31;CPF_1301)   Clostridium perfringens ATCC 13124 ABG84084.1 A0A0H2YST8
4LKS[A,C] β-D-Galp
1.50
4LQR[A] 1.58
4P5Y[A] β-D-GalpNAc
2.50
 α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)   Clostridium perfringens ATCC 13124 ABG84150.1 A0A0H2YU91
Q0TST1
Q8XM24
2VC9[A] <carb_like_NOK>
2.36
2VCA[A] β-D-GlcpNAc
2.05
2VCB[A] β-D-Glcp1N2NAc-(1-1)-<non_carb>
2.20
2VCC[A] 2.0
4A4A[A] α-D-GlcpNAc-(1-4)-β-D-Galp
1.90
7MFK[A] 2.13
7MFL[A] 2.00
 α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)   Clostridium perfringens ATCC 13124 ABG84150.1 A0A0H2YU91
Q0TST1
Q8XM24
4A42[A,B] 1.55
 α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)   Clostridium perfringens ATCC 13124 ABG84150.1 A0A0H2YU91
Q0TST1
Q8XM24
4A41[A] β-D-Galp
1.55
4A44[A] 1.70
4A45[A] β-D-GalpNAc-(1-3)-β-D-Galp
1.75
4AAX[A] β-D-GalpNAc
1.90
 α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)   Clostridium perfringens ATCC 13124 ABG84150.1 A0A0H2YU91
Q0TST1
Q8XM24
4A3Z[A] 1.55
4A6O[A,B] α-D-GlcpNAc-(1-4)-β-D-Galp
2.80
 hyaluronidase (NagJ;CpNagJ;CpOGA;CPF_1442)   Clostridium perfringens ATCC 13124 ABG84519.1 Q0TR53
2J1A[A] β-D-Galp
1.49
2J1E[A] β-D-Galp-(1-4)-α-D-GlcpNAc
2.4
2J1F[A] α-L-Fucp-(1-2)-β-D-Galp-(1-4)-α-D-GlcpNAc
2.30
2V5D[A] 3.30
 CPF_1489   Clostridium perfringens ATCC 13124 ABG82278.1  
7JFS[A] 4.60
7JNB[A] α-D-GalpNAc
2.00
7JND[A] 2.00
7JNF[A] α-D-GalpNAc
2.10
 CPF_1489   Clostridium perfringens ATCC 13124 ABG82278.1  
7JFS[A] 4.60
7JNB[A] α-D-GalpNAc
2.00
7JND[A] 2.00
7JNF[A] α-D-GalpNAc
2.10
 exo-α-sialidase (NanJ;CPE0553)   Clostridium perfringens str. 13 BAB80259.1
NP_561469.1
 
2V72[A] β-D-Galp
2.25
 β-N-acetylglucosaminidase (NagJ;CpNagJ;CPE1234) (GH84C)   Clostridium perfringens str. 13 BAB80940.1
NP_562150.1
Q0TR53
Q8XL08
2J7M[A] α-L-Fucp-(1-2)-β-D-Galp-(1-4)-α-D-GlcpNAc
2.3
 sialidase (NedA)   Micromonospora viridifaciens BAA00852.1
AAQ70871.1
Q02834
1EUT[A] 2.50
1EUU[A] β-D-Galp
2.50
1W8N[A] β-D-Galp
<carb_like_DAN>
2.1
1W8O[A] β-D-Galp-(1-4)-α-D-Glcp
1.70
1WCQ[A,B,C] <carb_like_DAN>
2.1
2BER[A] β-D-Neup5Ac
1.8
2BQ9[A,B,C] β-D-Galp
2.00
2BZD[A,B,C] β-D-Galp
2.0
 chitosanase-glucanase   Paenibacillus fukuinensis D2 / IK-5 BAB64835.1 Q93IE7
2RVA[A] NMR
4ZZ5[A,B] 1.29
4ZZ8[A,B] β-D-GlcpN-(1-4)-β-D-GlcpN-(1-4)-β-D-GlcpN
1.65
 chitosanase-glucanase   Paenibacillus fukuinensis D2 / IK-5 BAB64835.1 Q93IE7
2RV9[A] NMR
4ZXE[A,B,C] 1.40
4ZY9[A,B] 1.20
 alginate lyase (AlyQ)   Persicobacter sp. CCB-QB2 WP_053404615.1 A0A3B6UEP6
5XNR[A] 2.30
7D29[A] 1.70
7D2A[A] α-L-4-deoxy-AllpA-(1-4)-α-L-GulpA
1.57
 endo-β-N-acetylglucosaminidase D (EndoD;Endo-D;Endo D;sp234)   Streptococcus pneumoniae BAB62042.1 A0A0H2UNT5
Q93HW0
2XQX[A,B] 2.01
 alginate lyase (AlyB; VsAlyB)   Vibrio splendidus OU02    
5ZU6[A] 1.40
7W12[A] α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA
2.25
5ZU5[A] 1.60
 polygalacturonic acid-binding protein (YeCBM32) (partial)   Yersinia enterocolitica ATCC 9610D    
2JD9[A] 1.8
2JDA[A] 1.35
2JDA[B] 1.35
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 galactose oxidase (GaoA;GaO)   Fusarium graminearum AAB94635.1
AAO95371.1
AAO95372.1
AAO95373.1
AAO95374.1
AAW14679.1
AAW14680.1
ABJ31020.1
ABJ31021.1
ABJ31022.1
ABJ31023.1
ABJ31024.1
ABJ31025.1
ABJ31026.1
ABJ31027.1
ABJ31028.1
ABJ31029.1
ABJ31030.1
ABJ31031.1
ABJ43047.1
ABJ43048.1
ABJ43049.1
ABJ43050.1
ABJ43051.1
ABJ43052.1
ABJ43053.1
ABJ43054.1
ABJ43055.1
ABJ43056.1
ABJ43057.1
ABJ43058.1
P0CS93
Q01745
1GOF[A] 1.70
1GOG[A] 1.90
1GOH[A] 2.20
1K3I[A] 1.40
1T2X[A] 2.30
2EIB[A] 2.10
2EIC[A] 2.80
2EID[A] 2.20
2EIE[A] 1.80
2JKX[A] 1.84
2VZ1[A] 1.91
2VZ3[A] 1.9
2WQ8[A] 2.19
6XLR[A] 1.23
6XLS[A] 1.80
6XLT[A] 1.48
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 GH29_0940 (partial)   unidentified    
5K9H[A] 2.03
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