Activities in Family	Binding to galactose and lactose has been demonstrated for the module of Micromonospora viridifaciens sialidase (PMID: 16239725). Binding to polygalacturonic acid has been shown for a Yersinia member (PMID: 17292916). Binding to LacNAc (β-D-galactosyl-1,4-β-D-N-acetylglucosamine) has been shown for an N-acetylglucosaminidase from Clostridium perfingens (PMID: 16990278).
3D Structure Status	β-sandwich
Note	Formerly known as X56 modules. Distantly related to CBM6 modules and to Anguilla anguilla agglutinin.
External resources	CAZypedia;
Statistics	GenBank accession (15781); Uniprot accession (90); PDB accession (93); 3D entries (33); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
BF3579		Bacteroides fragilis NCTC 9343	CAH09262.1		3F2Z[A] 1.30
Btheta7330_02495 (Nagj_2)		Bacteroides thetaiotaomicron 7330	ALJ42041.1		6OE2[A] 3.00
K6V27_03665		Bacteroides thetaiotaomicron BFG-55	UBD12722.1		7BLG[A] β-D-Galp 1.18 7BLH[A] 7BLJ[A] 1.76 7BLK[A] 1.06
β-galactosidase (BT0290; BT_0290)		Bacteroides thetaiotaomicron VPI-5482	AAO75397.1 NP_809203.1		6EON[A] α-D-Galp 1.75
BT0865		Bacteroides thetaiotaomicron VPI-5482	AAO75972.1 NP_809778.1		2KD7[A] NMR 3GGL[A] 3.00
(grape RGII active) α-L-arabinofuranosidase (cleaves L-Araf-α-1,3-D-GalA) (BT3662;BT_3662)		Bacteroides thetaiotaomicron VPI-5482	AAO78767.1 NP_812573.1	Q8A1J9	5MSX[A,B,C] 2.10
β-N-acetyl-6-sulfo-glucosaminidase (BbhII)		Bifidobacterium bifidum JCM 1254	BAI94823.1	D4QAP5	6YXZ[A] 6Z14[A] 7WDT[A] α-D-GlcpNAc6SO3 β-D-GlcpNAc6SO3 1.65 7WDU[A] α-D-Glcp1N2NAc6SO3-(1-1)-<non_carb> 2.23
core 1 endo-α-N-acetylgalactosaminidase (EngBF;BLLJ_0168)		Bifidobacterium longum subsp. longum JCM 1217	BAJ65838.1 AAX44931.1 CAM83935.1	A0A413AG90 Q3T552	6QEP[A] 2.60 6QFK[A] 2.00 6SH9[B] 2.40
exo-β-N-acetylglucosaminidase (NagH; CpGH84A; CPF_0184) (GH84A)		Clostridium perfringens ATCC 13124	ABG83307.1	A0A0H2YRL1 P26831 Q0TUP2	2LS6[A] NMR
exo-β-N-acetylglucosaminidase (NagH; CpGH84A; CPF_0184) (GH84A)		Clostridium perfringens ATCC 13124	ABG83307.1	A0A0H2YRL1 P26831 Q0TUP2	2W1Q[A,B] 1.60 2W1S[A,B] 1.45 2W1U[A,B,C,D] β-D-GlcpNAc-(1-3)-α-D-GalpNAc β-D-GlcpNAc-(1-3)-β-D-GalpNAc 2.00 2WDB[A,B,C,D] β-D-GlcpNAc-(1-2)-β-D-Manp 2.03
exo-β-N-acetylglucosaminidase (NagH; CpGH84A; CPF_0184) (GH84A)		Clostridium perfringens ATCC 13124	ABG83307.1	A0A0H2YRL1 P26831 Q0TUP2	4TXW[A] 1.40
exo-acting protein-α-N-acetylgalactosaminidase (CpGH31; CPF_1301)		Clostridium perfringens ATCC 13124	ABG84084.1	A0A0H2YST8	4LPL[A] 1.35
exo-acting protein-α-N-acetylgalactosaminidase (CpGH31; CPF_1301)		Clostridium perfringens ATCC 13124	ABG84084.1	A0A0H2YST8	4LKS[A,C] β-D-Galp 1.50 4LQR[A] 1.58 4P5Y[A] β-D-GalpNAc 2.50
α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)		Clostridium perfringens ATCC 13124	ABG84150.1	A0A0H2YU91 Q0TST1 Q8XM24	2VC9[A] <carb_like_NOK> 2.36 2VCA[A] β-D-GlcpNAc 2.05 2VCB[A] β-D-Glcp1N2NAc-(1-1)-<non_carb> 2.20 2VCC[A] 2.0 4A4A[A] α-D-GlcpNAc-(1-4)-β-D-Galp 1.90 7MFK[A] 2.13 7MFL[A] 2.00
α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)		Clostridium perfringens ATCC 13124	ABG84150.1	A0A0H2YU91 Q0TST1 Q8XM24	4A42[A,B] 1.55
α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)		Clostridium perfringens ATCC 13124	ABG84150.1	A0A0H2YU91 Q0TST1 Q8XM24	4A41[A] β-D-Galp 1.55 4A44[A] 1.70 4A45[A] β-D-GalpNAc-(1-3)-β-D-Galp 1.75 4AAX[A] β-D-GalpNAc 1.90
α-N-acetylglucosaminidase (AgnC;CpGH89;CPF_0859)		Clostridium perfringens ATCC 13124	ABG84150.1	A0A0H2YU91 Q0TST1 Q8XM24	4A3Z[A] 1.55 4A6O[A,B] α-D-GlcpNAc-(1-4)-β-D-Galp 2.80
hyaluronidase / β-N-acetylglucosaminidase 84C (NagJ; CpNagJ; CpOGA; CpGH84C; CPF_1442)		Clostridium perfringens ATCC 13124	ABG84519.1	Q0TR53	2J1A[A] β-D-Galp 1.49 2J1E[A] β-D-Galp-(1-4)-α-D-GlcpNAc 2.4 2J1F[A] α-L-Fucp-(1-2)-β-D-Galp-(1-4)-α-D-GlcpNAc 2.30 2V5D[A] 3.30
CPF_1489		Clostridium perfringens ATCC 13124	ABG82278.1		7JFS[A] 4.60 7JNB[A] α-D-GalpNAc 2.00 7JND[A] 2.00 7JNF[A] α-D-GalpNAc 2.10
CPF_1489		Clostridium perfringens ATCC 13124	ABG82278.1		7JFS[A] 4.60 7JNB[A] α-D-GalpNAc 2.00 7JND[A] 2.00 7JNF[A] α-D-GalpNAc 2.10
exo-α-sialidase (NanJ;CPE0553)		Clostridium perfringens str. 13	BAB80259.1 NP_561469.1		2V72[A] β-D-Galp 2.25
β-N-acetylglucosaminidase (NagJ;CpNagJ;CPE1234) (GH84C)		Clostridium perfringens str. 13	BAB80940.1 NP_562150.1	Q0TR53 Q8XL08	2J7M[A] α-L-Fucp-(1-2)-β-D-Galp-(1-4)-α-D-GlcpNAc 2.3
sialidase (NedA)		Micromonospora viridifaciens	BAA00852.1 AAQ70871.1	Q02834	1EUT[A] 2.50 1EUU[A] β-D-Galp 2.50 1W8N[A] β-D-Galp <carb_like_DAN> 2.1 1W8O[A] β-D-Galp-(1-4)-α-D-Glcp 1.70 1WCQ[A,B,C] <carb_like_DAN> 2.1 2BER[A] β-D-Neup5Ac 1.8 2BQ9[A,B,C] β-D-Galp 2.00 2BZD[A,B,C] β-D-Galp 2.0
exo-α-1,2-mannosidase (NnGH92)		Neobacillus novalis	CAD7619346.1	A0A7R9KAR8	7NSN[A,B] <carb_like_MVL> 2.29
exo-α-1,2-mannosidase (NnGH92)		Neobacillus novalis	CAD7619346.1	A0A7R9KAR8	7NSN[A,B] <carb_like_MVL> 2.29
chitosanase-glucanase		Paenibacillus fukuinensis D2 / IK-5	BAB64835.1	Q93IE7	2RVA[A] NMR 4ZZ5[A,B] 1.29 4ZZ8[A,B] β-D-GlcpN-(1-4)-β-D-GlcpN-(1-4)-β-D-GlcpN 1.65
chitosanase-glucanase		Paenibacillus fukuinensis D2 / IK-5	BAB64835.1	Q93IE7	2RV9[A] NMR 4ZXE[A,B,C] 1.40 4ZY9[A,B] 1.20
alginate lyase (AlyQ)		Persicobacter sp. CCB-QB2	WP_053404615.1	A0A3B6UEP6	5XNR[A] 2.30 7D29[A] 1.70 7D2A[A] α-L-4-deoxy-AllpA-(1-4)-α-L-GulpA 1.57
endo-β-N-acetylglucosaminidase D (EndoD;Endo-D;Endo D;sp234)		Streptococcus pneumoniae	BAB62042.1	A0A0H2UNT5 Q93HW0	2XQX[A,B] 2.01
alginate lyase (AlyB; VsAlyB)		Vibrio splendidus OU02			5ZU6[A] 1.40 7W12[A] α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 2.25 5ZU5[A] 1.60
polygalacturonic acid-binding protein (YeCBM32) (partial)		Yersinia enterocolitica ATCC 9610D			2JD9[A] 1.8 2JDA[A] 1.35 2JDA[B] 1.35
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
galactose oxidase (GaoA;GaO)		Fusarium graminearum	AAB94635.1 AAO95371.1 AAO95372.1 AAO95373.1 AAO95374.1 AAW14679.1 AAW14680.1 ABJ31020.1 ABJ31021.1 ABJ31022.1 ABJ31023.1 ABJ31024.1 ABJ31025.1 ABJ31026.1 ABJ31027.1 ABJ31028.1 ABJ31029.1 ABJ31030.1 ABJ31031.1 ABJ43047.1 ABJ43048.1 ABJ43049.1 ABJ43050.1 ABJ43051.1 ABJ43052.1 ABJ43053.1 ABJ43054.1 ABJ43055.1 ABJ43056.1 ABJ43057.1 ABJ43058.1	P0CS93 Q01745	1GOF[A] 1.70 1GOG[A] 1.90 1GOH[A] 2.20 1K3I[A] 1.40 1T2X[A] 2.30 2EIB[A] 2.10 2EIC[A] 2.80 2EID[A] 2.20 2EIE[A] 1.80 2JKX[A] 1.84 2VZ1[A] 1.91 2VZ3[A] 1.9 2WQ8[A] 2.19 6XLR[A] 1.23 6XLS[A] 1.80 6XLT[A] 1.48
unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
GH29_0940 (partial)		unidentified			5K9H[A] 2.03
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