Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5533); Uniprot accession (902); PDB accession (143); 3D entries (56); cryst (1)
All (5278) Archaea (18) Bacteria (4665) Eukaryota (558) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 MAMA_L361   Acanthamoeba castellanii mamavirus Hal-V AEQ60476.1    
 ORF   Acanthamoeba castellanii mimivirus Mimivirus kasaii BAV61387.1    
 ORF   Acanthamoeba castellanii mimivirus Mimivirus shirakomae BAV62375.1    
 MIMI_L288   Acanthamoeba polyphaga mimivirus AAV50560.1
ADO18119.1
AEJ34527.1
E3VZN6
Q5UPX2
 
 ORF   Acanthamoeba polyphaga mimivirus Amazonia AKI80952.1    
 ORF   Acanthamoeba polyphaga mimivirus Kroon AKI80023.1    
 ORF   Acanthamoeba polyphaga mimivirus Oyster AKI79058.1    
 Catovirus_2_39   Catovirus CTV1 ARF09090.1    
 Catovirus_1_251   Catovirus CTV1 ARF08201.1    
 toxin (Ha1)   Clostridium botulinum D phage CB16 BAA75077.1   1QXM[A,B]
2EHI[A,B]
2EHM[A,B]
2EHN[A,B]
 toxin (Ha1)   Clostridium botulinum D phage CB16 BAA75077.1   1QXM[A,B]
2EHI[A,B]
2EHM[A,B]
2EHN[A,B]
 toxin (Ha1;Hα-33;Antp-33)   Clostridium botulinum phage 1C 468 CAA51311.1 P46084
Q38196
3AH1[A,B]
3AH2[A,B]
3AH4[A,B]
 toxin (Ha1;Hα-33;Antp-33)   Clostridium botulinum phage 1C 468 CAA51311.1 P46084
Q38196
3AH1[A,B]
3AH2[A,B]
3AH4[A,B]
 CST084   Clostridium phage c-st BAE47782.1 Q332E2  
 CST084   Clostridium phage c-st BAE47782.1 Q332E2  
 HIRU_S671   Hirudovirus strain Sangsue AHA45577.1    
 ORF   Mimivirus Bombay AMZ02737.1    
 ORF   Niemeyer virus ALR83869.1    
 HARRISON_30   Paenibacillus phage Harrison ALA12432.1    
 HARRISON_30   Paenibacillus phage Harrison ALA12432.1    
 PAISLEY_30   Paenibacillus phage Paisley ALA12593.1    
 PAISLEY_30   Paenibacillus phage Paisley ALA12593.1    
 IBBP123_26   Paenibacillus phage phiIBB_Pl23 AGN89341.1    
 IBBP123_26   Paenibacillus phage phiIBB_Pl23 AGN89341.1    
 β-type lectin protein   Samba virus AHJ40019.2    
 L279   Samba virus AHJ40019.1    
Top


Last update: 2017-12-01 © Copyright 1998-2017
AFMB - CNRS - Université d'Aix-Marseille