Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (7167); Uniprot accession (901); PDB accession (153); 3D entries (59); cryst (1)
All (7023) Archaea (27) Bacteria (6298) Eukaryota (620) Viruses (32) unclassified (46) Structure (59 - 1 cryst) Characterized (100)
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF   uncultured organism AAN27792.1
AAP87538.1
Q7TLZ3  
 ORF (fragment)   uncultured organism AGU11696.1    
 ORF, partial   uncultured organism AGU11902.1    
 ORF, partial   uncultured organism AGU11902.1    
 Sequence 8 from patent US 7485308   unidentified ACN05175.1    
 Sequence 66 from patent US 7507752.   unidentified ACQ13158.1    
 Sequence 2 from patent US 7541162.   unidentified ACS10738.1    
 EKD16_24240 (AbfB)   Streptomonospora sp. M2 QBI56592.1    
 ERC79_06225   Rhodococcus sp. ABRD24 QBJ98572.1    
 KTC_21200   Thermosporothrix sp. COM3 BBH87369.1    
 E5N77_34080   Streptomyces sp. SS52 QCB26302.1    
 E5N77_26875   Streptomyces sp. SS52 QCB25048.1    
 E5N77_01985   Streptomyces sp. SS52 QCB20734.1    
 E5N77_20670   Streptomyces sp. SS52 QCB23937.1    
 E5N77_35875   Streptomyces sp. SS52 QCB27307.1    
 E5N77_32840   Streptomyces sp. SS52 QCB26074.1    
 E5N77_16440   Streptomyces sp. SS52 QCB23226.1    
 E5N77_26880   Streptomyces sp. SS52 QCB25049.1    
 E5N77_32980   Streptomyces sp. SS52 QCB26100.1    
 E5N77_14835   Streptomyces sp. SS52 QCB22949.1    
 E5N77_03390   Streptomyces sp. SS52 QCB20971.1    
 E5N77_12355   Streptomyces sp. SS52 QCB22530.1    
 E5N77_34075   Streptomyces sp. SS52 QCB26301.1    
 E5673_05915   Sphingomonas sp. PAMC26645 QCB41811.1    
 E5225_11110   Cellulomonas sp. Z28 QCB94032.1    
 E5225_09700   Cellulomonas sp. Z28 QCB93794.1    
 E5225_17005   Cellulomonas sp. Z28 QCB95507.1    
 E5225_00255   Cellulomonas sp. Z28 QCB92217.1    
 E5225_02970   Cellulomonas sp. Z28 QCB92664.1    
 E5225_16995   Cellulomonas sp. Z28 QCB95505.1    
 E5225_00580   Cellulomonas sp. Z28 QCB92274.1    
 E5225_03115   Cellulomonas sp. Z28 QCB92691.1    
 E5225_03115   Cellulomonas sp. Z28 QCB92691.1    
 E5225_03275   Cellulomonas sp. Z28 QCB92720.1    
 E5225_00950   Cellulomonas sp. Z28 QCB92335.1    
 E7746_07620   Muribaculum sp. TLL-A4 QCD35765.1    
 FA702_20210   Novosphingobium sp. ABRDHK2 QCI96209.1    
 FCS00_01660   Elizabethkingia sp. 2-6 QCO45137.1    
 EHF32_14710   Microbacterium sp. RG1 QCQ17871.1    
 Sequence 12 from patent US 6846913   unidentified AAX04116.1    
 Sequence 12 from patent US 6846913   unidentified AAX04116.1    
 Sequence 5 from patent US 6939698 (fragment)   unidentified ABA38427.1    
 Sequence 6 from patent US 6939698 (fragment)   unidentified ABA38428.1    
 Sequence 274 from patent US 7247715   unidentified ABU38998.1    
 Sequence 274 from patent US 7247715   unidentified ABU38998.1    
 FBF33_01585   TM7 phylum sp. oral taxon 955 PM004 QCT39769.1    
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