Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF   uncultured organism AAN27792.1
 ORF (fragment)   uncultured organism AGU11696.1    
 ORF, partial   uncultured organism AGU11902.1    
 ORF, partial   uncultured organism AGU11902.1    
 Sequence 8 from patent US 7485308   unidentified ACN05175.1    
 Sequence 12 from patent US 6846913   unidentified AAX04116.1    
 Sequence 12 from patent US 6846913   unidentified AAX04116.1    
 Sequence 5 from patent US 6939698 (fragment)   unidentified ABA38427.1    
 Sequence 6 from patent US 6939698 (fragment)   unidentified ABA38428.1    
 Sequence 274 from patent US 7247715   unidentified ABU38998.1    
 Sequence 274 from patent US 7247715   unidentified ABU38998.1    

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