Auxiliary Activity Family 14

Activities in FamilyAA14 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of xylan with oxidation of C-1 has been demonstrated for two AA14 LPMOs from Trametes coccinea (Pycnoporus coccineus); lytic xylan monooxygenase / xylan oxidase (glycosidic bond-cleaving) (EC 1.14.99.-)
Mechanism monooxygenase
NoteFamily built after Couturier et al. Nature Chem. Biol. (2018) 14:306-310 [PMID=29377002]; distantly related to other LPMO families.
External resourcesCAZypedia;
Statistics GenBank accession (41); Uniprot accession (2); PDB accession (1); 3D entries (1); cryst (0)
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 lytic polysaccharide mono-oxygenase active on xylan (PcAA14B) 1.14.99.-   Trametes coccinea CIRM-BRFM 310 AUM86167.1 A0A2I6QB00 5NO7[A,B]
 lytic polysaccharide mono-oxygenase active on xylan (PcAA14A) 1.14.99.-   Trametes coccinea CIRM-BRFM 310 AUM86166.1 A0A2I6QAZ5  
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