Glycoside Hydrolase Family 5 / Subf 43

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (37); Uniprot accession (9);
All (36) Bacteria (36)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMN04489716_4612   Actinoplanes derwentensis DSM 43941 SDT57550.1     43
 Amir_6164   Actinosynnema mirum DSM 43827 ACU39971.1 C6WHM2   43
 CNX65_30350   Actinosynnema pretiosum X47 ATE57059.1     43
 SAMN04489726_6883   Allokutzneria albata DSM 44149 SDN49924.1     43
 B737_2348   Amycolatopsis mediterranei RB AGT83012.1     43
 RAM_12075   Amycolatopsis mediterranei S699 AEK40905.1
AFO75883.1
    43
 AMED_2374   Amycolatopsis mediterranei U32 ADJ44170.1 D8HUX2   43
 SD37_23615   Amycolatopsis orientalis B-37 ANN18328.1     43
 HDN1F_08830   gamma proteobacterium HdN1 CBL44466.1 E1VI24   43
 KALB_5052   Kutzneria albida DSM 43870 AHH98414.1     43
 BBK82_00065   Lentzea guizhouensis DHS C013 ANZ42376.1     43
 A0128_03105   Leptospira alstonii GWTS #1 AOP35869.1     43
 LBF_2411   Leptospira biflexa serovar Patoc strain Patoc 1 (Ames) ABZ94901.1 B0SD09   43
 LEPBI_I2486   Leptospira biflexa serovar Patoc strain Patoc 1 (Paris) ABZ98573.1 B0SLI7   43
 SAV_7508   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC75219.1     43
 SBI_01663   Streptomyces bingchenggensis BCW-1 ADI04784.1 D7CFP8   43
 B446_32895   Streptomyces collinus Tu 365 AGS73383.1     43
 BN159_1009   Streptomyces davawensis JCM 4913 CCK25388.1     43
 AVL59_17735   Streptomyces griseochromogenes ATCC 14511 ANP51215.1     43
 SHXM_09064   Streptomyces hygroscopicus XM201 AQW55601.1     43
 ABB07_02795   Streptomyces incarnatus NRRL 8089 AKJ08988.1     43
 SIRAN836   Streptomyces iranensis CDR02600.1     43
 SLINC_7771   Streptomyces lincolnensis NRRL 2936 ANS69995.1     43
 SPRI_1194   Streptomyces pristinaespiralis HCCB 10218 ALC19500.1     43
 BFF78_03590   Streptomyces puniciscabiei TW1S1 AOR36861.1     43
 M271_03950   Streptomyces rapamycinicus NRRL 5491 AGP52420.1     43
 TUE45_00384   Streptomyces reticuli CUW25674.1     43
 SCAB_8561   Streptomyces scabiei 87.22 CBG68039.1 C9Z0A6   43
 CGL27_46220   Streptomyces sp. 11-1-2 ASQ99437.1     43
 SAMN05444521_0940   Streptomyces sp. 3124.6 SHH56234.1     43
 AS200_05975   Streptomyces sp. CdTB01 ALV38406.1     43
 QR97_02615   Streptomyces sp. PBH53 AKN75089.1     43
 A4E84_37985   Streptomyces sp. S10(2016) AMW15701.1     43
 Strvi_4282   Streptomyces violaceusniger Tu 4113 AEM83933.1     43
 Sros_5302   Streptosporangium roseum DSM 43021 ACZ88069.1 D2BC46   43
 Tcur_1364   Thermomonospora curvata DSM 43183 ACY96946.1 D1AA10   43
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