Glycoside Hydrolase Family 5 / Subf 17

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11); Uniprot accession (7);
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 CAC0918   Clostridium acetobutylicum ATCC 824 AAK78894.1
NP_347554.1
Q97KK1   17
 SMB_G0935   Clostridium acetobutylicum DSM 1731 AEI31500.1     17
 CEA_G0930   Clostridium acetobutylicum EA 2018 ADZ19969.1     17
 mannanase K (ManK;Ccel_0736) (Man5K) 3.2.1.78 [Clostridium] cellulolyticum H10 ACL75115.1
AAG45159.1
B8I7V8
Q9EYQ3
  17
 β-mannanase A (ManA;Clocel_2818) 3.2.1.78 Clostridium cellulovorans 743B AAF06110.2
ADL52514.1
C5RQ36
D9SS67
Q9LAJ3
  17
 mannanase 5A (Man5A) 3.2.1.78 Clostridium josui BAI52931.1 D1MXA0   17
 CpapDRAFT_3432   Clostridium papyrosolvens DSM 2782 EEU57771.1     17
 Clo1100_1826   Clostridium sp. BNL1100 AEY66036.1     17
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