CAZY WebSite

Gordon Conference on Cellulosomes, Cellulases, and other Carbohydrate Modifying Enzymes

bernard henrissat — 2013-03-27T06:57:52Z

The Gordon Conference on Cellulosomes, Cellulases, and other Carbohydrate Modifying Enzymes will take place August 4-9, 2013, in Proctor Academy, Andover NH, USA.

This Gordon Conference, chaired by Harry Brumer and co-chaired by Kiyohiko Igarashi, will present cutting-edge research on the enzymatic degradation of cellulose and other plant cell wall components. The Conference will feature a range of current topics that includes the biosynthesis and ultrastructure of polysaccharide substrates, the enzymology of plant structural degradation, regulation of the degradative apparatus, (meta)genomic approaches to discover new enzymes from both plants and cell wall-degrading organisms, structural and functional carbohydrate enzymology, as well as advances in applications in the biorefinery context.

17th European Carbohydrate Symposium (July 7-11, 2013)

bernard henrissat — 2013-03-27T06:43:13Z

Eurocarb17

The 17th European Carbohydrate Symposium (Eurocarb 17) will be held during 7 - 11 July 2013, in Tel Aviv, Israel at the David Intercontinental hotel and convention center.

Eurocarb 17

Eurocarb 17 aims to introduce the latest and emerging trends in all aspects of chemistry, biochemistry, biology, technology and medical applications of carbohydrates. Eurocarb 17 offers a wonderful opportunity for scientists from all relevant fields to be updated with the current state of the art and to encourage future innovation and collaborations between scientists from the various disciplines of the glycosciences.

New enzyme category in CAZy

elodie — 2013-03-21T17:28:23Z

Because lignin is invariably found together with polysaccharides in the plant cell wall and because lignin fragments are likely to act in concert with (LPMO), we have decided to join the families of lignin degradation enzymes to the LPMO families and launch a new CAZy class that we name "Auxiliary Activities" in order to accommodate a range of enzyme mechanisms and substrates related to lignocellulose conversion. Auxiliary Activities

Postdoctoral position(s) at CAZy

2013-02-05T09:00:00Z

Seeking a position in sunny south of France ?

A postdoctoral position is available to work in the Glycogenomics team that operates the CAZy database :

- Integrative glycogenomics in the context of fungal enzyme discovery for the deconstruction of plant cell walls .

The successful candidate will have to demonstrate experience in protein sequence-based bioinformatics and also in Perl scripts and SQL, preferably acquired through large scale projects or in genome sequencing centers.
The position is due to start in April or May 2013 for a duration of 18 months minimum.
If interested please contact Bernard Henrissat (bernard.henrissat@afmb.univ-mrs.fr) and provide at least two references.

10th Carbohydrate Bioengineering Meeting (CBM10) in Prague, Czech Republic - 2013/April/21-24

elodie — 2012-12-03T15:00:17Z

The 10th Carbohydrate Bioengineering Meeting is Organized by the Institute of Microbiology, Academy of Sciences of the Czech Republic. The conference will take place from April 21 to April 24, 2013 in Prague, Czech Republic at the Hotel Pyramida. About 300 – 350 participants are expected to participate.

www.cbm10.org

The main topics of this conference are: Mechanisms and structure-function relationships of carbohydrate modifying enzymes; Glycomics; Systems glycobiology and bioinformatics; Synthesis, structure and function of carbohydrates and glycoconjugates; Carbohydrate and enzyme engineering; Carbohydrates in health and medicine; New materials and nanomaterials from carbohydrates as renewable resources.

New page layout !

elodie — 2012-11-22T10:59:48Z

Tired of overly long pages and long display times ? Check out the new page layout, with 1,000 entries at a time for All/Superkingdoms/Unclassified tabs and 100 entries at a time for Structure/Characterized tabs.

- What's new

GH5 subfamilies now available !!

vlombard — 2012-11-13T14:55:43Z

A recent article by the CAZy team defines subfamilies within the large GH5 family.

Details appear in Aspeborg H, Coutinho PM, Wang Y, Brumer H, Henrissat B (2012) Evolution, substrate specificity and subfamily classification of glycoside hydrolase family 5 (GH5). BMC Evol. Biol. 12:186 [PMID: 22992189]. The GH5 subfamilies now appear online at URL http://www.cazy.org/GH5_subfamilies.html

Auxiliary Activities family classification

vlombard — 2012-11-13T14:29:14Z

Introduction

Auxiliary Activities (AA) cover redox enzymes that act in conjunction with CAZymes.

Since its inception, the carbohydrate-active enzymes database (CAZy; www.cazy.org) has described the families of enzymes that cleave or build complex carbohydrates, namely the glycoside hydrolases (GH), the polysaccharide lyases (PL), the carbohydrate esterases (CE), the glycosyltransferases (GT) and their appended non-catalytic carbohydrate-binding modules (CBM). The recent discovery that members of families CBM33 and family GH61 are in fact lytic polysaccharide mono-oxygenases (LPMO), demanded a reclassification of these families into a suitable category. Because lignin is invariably found together with polysaccharides in the plant cell wall and because lignin fragments are likely to act in concert with (LPMO)s, we have decided to join the families of lignin degradation enzymes to the LPMO families and launch a new CAZy class that we name "auxiliary activities" in order to accommodate a range of enzyme mechanisms and substrates [1]<pubmed>.

The AA class presently groups eight families of ligninolytic enzymes and two families of lytic polysaccharide mono-oxygenases. Lignin breakdown enzymes may not act on carbohydrates, but because lignin is invariably and intimately associated with carbohydrates in the plant cell wall, the lignolytic enzymes do cooperate with classical polysaccharide depolymerases. This section of the CAZy database presents a classification of these enzymes in families and subfamilies based on amino acid sequence similarities, intended to reflect structural features and to facilitate genome annotation.

Tables for Direct Access

AA Family Number

Non-Classified Sequences

AA Classification Statistics

Modules in present families	5145
Non-Classified modules	83

EC Activities found in AA families

Caution : Because of the modular nature of CAZymes, these activities may not be directly associated with the family but simply borne by adjacent modules.

1.-.-.-	9 10

1.1.1.124	3

1.1.3.4	3

1.1.3.7	3

1.1.3.9	5

1.1.3.10	3

1.1.3.12	3

1.1.3.13	3

1.1.3.16	3

1.1.3.38	4

1.1.99.-	7

1.1.99.18	3 8

1.3.3.5	NC

1.10.3.-	1

1.10.3.1	1

1.10.3.2	1 NC

1.11.1.-	2

1.11.1.5	2

1.11.1.11	2

1.11.1.13	2

1.11.1.14	2

1.11.1.16	2

3.2.1.4	9

3.2.1.78	10

[1] Levasseur A, Drula E, Lombard V, Coutinho PM, Henrissat B. Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes. Biotechnology for Biofuels, [PMID: 23514094]

12th European Training Course on Carbohydrates - 2012/Jun/3-7

2012-02-29T10:47:07Z

12th European Training Course on Carbohydrates (Summer Course in Glycosciences) in Groningen, The Netherlands, from June 3 to 7, 2012.

The Summer Course Glycosciences is a broad course in glycosciences that combines general introductions in the field of polysaccharides and glycoproteins with in-depth parallel sessions. The course is at graduate level and may be valuable for those working in research and industry that are willing to refresh their knowledge within the broad field of carbohydrates and for graduate students working on a PhD related to carbohydrate chemistry, biochemistry, biology, chemical technology or food science.

NEW ! Protein lists for genomes

2011-09-20T12:42:58Z

Important new addition
Many users have asked to provide a listing of the encoded proteins on our genome pages. This is now done. Let us know if you find it useful !

- What's new