CAZy ~ Carbohydrate-Active enZymes


   
Polysaccharide Lyase Family 8
  
Known Activitieshyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20)
 
3D Structure StatusFold: ( / ) 6 barrel + anti-parallel -sheet
 
Relevant LinksInterPro   PFAM   
 
StatisticsCAZy Entries (140);  GenBank/GenPept (188);  Uniprot (27);  3D(8) : PDB(41); cryst(1);
 
TaxonomyBacteria(140);  
 
3D DisplayPL8_3D
 
        
        Bacteria          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
chondroitin AC lyase 4.2.2.1

4.2.2.5
Arthrobacter aurescens   1RW9
1RWA
1RWC
1RWF
1RWG
1RWH
[A]
[A]
[A]
[A]
[A]
[A]
AAur_3068 n.d.Arthrobacter aurescens TC1CP000474
ABM09726.1
   
Arth_1698 n.d.Arthrobacter sp. FB24CP000454
ABK03092.1
   
pE33L466_0352 n.d.Bacillus cereus E33LCP000040
AAY60495.1
   
heparinase (Hep) n.d.Bacillus circulansAB073927
BAB91369.1
Q8KKH9
  
xanthan lyase (Xly) 4.2.2.12
Bacillus sp. GL1AB037178
BAB21059.1
Q9AQS0
1J0M
1J0N
1X1H
1X1I
1X1J
2E22
2E24
A
A
[A]
[A]
[A]
[A]
[A]
BF1599 n.d.Bacteroides fragilis NCTC 9343 ATCC 25285 = NCTC 9343CR626927
CAH07300.1
   
BF1585 n.d.Bacteroides fragilis YCH46AP006841
BAD48335.1
   
chondroitin sulfate lyase AC (CslA) 4.2.2.5
Bacteroides stercoris HJ-15EU091268
ABW87764.1
   
lyase 2 (CsuB;BT3350) n.d.Bacteroides thetaiotaomicron VPI-5482L42367
AE016940
NC_004663
AAA99039.1
AAO78456.1
NP_812262.1
Q45773
  
BT3324 n.d.Bacteroides thetaiotaomicron VPI-5482AE016940
NC_004663
AAO78430.1
NP_812236.1
   
BT2964 n.d.Bacteroides thetaiotaomicron VPI-5482AE016938
NC_004663
AAO78070.1
NP_811876.1
   
chondroitin sulfate lyase ABC 4.2.2.20
Bacteroides thetaiotaomicron WAL2926   2Q1F
[A]
CPF_0394 n.d.Clostridium perfringens ATCC 13124CP000246
ABG84856.1
   
CPR_0390 n.d.Clostridium perfringens SM101CP000312
ABG85527.1
   
Sequence 326 from patent US 6448043 (fragment) n.d.Enterococcus faecalis EF040-
-
-
AAN89116.1
AAN89118.1
AAN89120.1
   
EF3023 n.d.Enterococcus faecalis V583AE016956
-
-
NC_004668
AAO82707.1
AAR57166.1
AAR57723.1
NP_816637.1
   
EF0818 n.d.Enterococcus faecalis V583AE016949
-
NC_004668
AAO80631.1
AAR59670.1
NP_814561.1
   
Sequence 326 from patent US 6913907 (fragment) n.d.Enterococcus faecalis V586-
-
-
ABA13212.1
ABA13214.1
ABA13216.1
   
chondroitin AC lyase (CslA) 4.2.2.5
Flavobacterium columnare G4AY912281
AAX07421.1
   
LSEI_2687 n.d.Lactobacillus casei ATCC 334CP000423
ABJ71405.1
   
LCABL_28750 (XalA) n.d.Lactobacillus casei BL23FM177140
CAQ67925.1
   
Oter_4325 n.d.Opitutus terrae PB90-1CP001032
ACB77597.1
   
XalB n.d.Paenibacillus alginolyticus XL-1AF318176
AAG42262.1
Q9EYM9
  
xanthan lyase (XalA) 4.2.2.12
Paenibacillus alginolyticus XL-1AF242413
AAG24953.1
Q9F8Q9
  
chondroitin AC lyase 4.2.2.5
Pedobacter heparinusU27583
AAC83383.1
Q59288
1CB8
1HM2
1HM3
1HMU
1HMW
[A]
[A]
[A]
[A]
[A]
PBPRB0153 n.d.Photobacterium profundum SS9CR378675
CAG22026.1
   
hyaluronate lyase (Hyase) 4.2.2.1
Propionibacterium acnesU15927
AAA51650.1
Q59634
  
PPA0380 (hyaluronate lyase) 4.2.2.1
Propionibacterium acnes KPA171202AE017283
AAT82132.1
   
Sequence 7112 from patent US 6605709 n.d.Proteus mirabilis-
AAR43842.1
   
Sequence 7181 from patent US 6605709 n.d.Proteus mirabilis-
AAR43911.1
   
PMI2127 n.d.Proteus mirabilis HI4320AM942759
CAR44246.1
   
PMI2128 n.d.Proteus mirabilis HI4320AM942759
CAR44248.1
   
chondroitin ABC lyase II 4.2.2.20
Proteus vulgaris-
AAB43333.1
 cryst 
chondroitin ABC lyase I 4.2.2.20
Proteus vulgaris-
-
1095454
ABE23097.1
P59807
1HN0
A
PSPPH_1510 n.d.Pseudomonas syringae pv. phaseolicola 1448A; BAA-978CP000058
AAZ36518.1
   
SARI_02380 n.d.Salmonella enterica subsp. arizonae serovar 62:z4,z23:-- RSK2980CP000880
ABX22243.1
   
hyaluronate lyase (HysA) 4.2.2.1
Staphylococcus aureus 8325-4U21221
AAA82984.1
Q59801
  
HysA n.d.Staphylococcus aureus N315AP003136
NC_002745
BAB43294.1
NP_375315.1
   
SAB1663 n.d.Staphylococcus aureus RF122AJ938182
CAI81352.1
   
SAB2082 n.d.Staphylococcus aureus RF122AJ938182
CAI81771.1
   
SA2194 n.d.Staphylococcus aureus subsp. aureus COLCP000046
AAW37070.1
   
ORF n.d.Staphylococcus aureus subsp. aureus JH1CP000736
ABR53099.1
   
SaurJH9_2232 n.d.Staphylococcus aureus subsp. aureus JH9CP000703
ABQ50013.1
   
SAR1892 (HysA1) n.d.Staphylococcus aureus subsp. aureus MRSA252BX571856
CAG40881.1
   
SAR2292 (HysA2) n.d.Staphylococcus aureus subsp. aureus MRSA252BX571856
CAG41271.1
   
SAS2103 n.d.Staphylococcus aureus subsp. aureus MSSA476BX571857
CAG43912.1
   
SAHV_2186 n.d.Staphylococcus aureus subsp. aureus Mu3AP009324
BAF79069.1
   
SAV2202 (HysA) n.d.Staphylococcus aureus subsp. aureus Mu50AP003364
AP003364
NC_002758
BAB45130.1
BAB58364.1
NP_372726.1
   
HysA n.d.Staphylococcus aureus subsp. aureus MW2AP004829
NC_003923
BAB95994.1
NP_646946.1
Q8NVC3
  
SAOUHSC_02463 n.d.Staphylococcus aureus subsp. aureus NCTC 8325CP000253
ABD31483.1
   
NWMN_2106 n.d.Staphylococcus aureus subsp. aureus str. NewmanAP009351
CP000730
BAF68378.1
ABX30190.1
   
SAUSA300_2161 n.d.Staphylococcus aureus subsp. aureus USA300; FPR3757CP000255
ABD22109.1
   
USA300HOU_2197 n.d.Staphylococcus aureus subsp. aureus USA300_TCH1516CP000730
ABX30190.1
   
SAG1197 n.d.Streptococcus agalactiae 2603V/RAE014246
NC_004116
AAN00079.1
NP_688206.1
   
hyaluronate lyase (HylB) 4.2.2.1
Streptococcus agalactiae 4755Y15903
CAA75865.1
O86478
  
SAK_1284 (HylB) n.d.Streptococcus agalactiae A909CP000114
ABA45106.1
   
Gbs1270 n.d.Streptococcus agalactiae NEM316AL766849
NC_004368
CAD46929.1
NP_735714.1
   
hyaluronate lyase 4.2.2.1
Streptococcus agalactiae type III / GBS 3502U15050
AAA56749.1
Q53591
1F1S
1I8Q
1LXM
[A]
[A]
[A]
ORF n.d.Streptococcus anginosus MAS624AY302595
AAQ73521.1
   
hyaluronate lyase 4.2.2.1
Streptococcus constellatus ATCC 27823AF385683
AAK67165.1
Q934I5
  
ORF (fragment) n.d.Streptococcus constellatus subsp. constellatus C-19AY302594
AAQ73520.1
   
ORF n.d.Streptococcus constellatus subsp. pharyngis MM9889aAY302596
AAQ73523.1
   
hyaluronidase (Hyl) n.d.Streptococcus equi subsp. zooepidemicus cvcc23362EU082206
ABV69920.1
   
hyaluronate lyase 4.2.2.1
Streptococcus intermedius ATCC 27335AF385684
AAK67167.1
Q934I4
  
Sequence 4843 from patent US 6800744 n.d.Streptococcus pneumoniae-
-
-
-
-
-
AAW09447.1
ABI03997.1
ABI09038.1
ABJ50167.1
ABJ32554.1
ABL17910.1
   
SPCG_0322 n.d.Streptococcus pneumoniae CGSP14CP001033.1
ACB89574.1
   
SPD_0287 n.d.Streptococcus pneumoniae D39CP000410
ABJ54273.1
   
SPG_0285 (HyL) n.d.Streptococcus pneumoniae G54CP001015.1
ACF54992.1
   
SPH_0426 n.d.Streptococcus pneumoniae Hungary19A-6CP000936
ACA36441.1
   
hyaluronate lyase (HysA) 4.2.2.1
Streptococcus pneumoniae R6L20670
L20670
AE008409
-
NC_003098
AAA53685.1
AAA53686.1
AAK99090.1
AAT16666.1
NP_357880.1
Q8CWU3
1W3Y
1C82
1EGU
1F9G
1LOH
1LXK
1N7N
1N7O
1N7P
1N7Q
1N7R
1OJM
1OJN
1OJO
1OJP
2BRP
2BRV
2BRW
[A]
A
A
A
A
A
A
A
A
A
A
A
A
A
A
[A]
[X]
[A]
hyaluronate lyase (SP0314) 4.2.2.1
Streptococcus pneumoniae TIGR4AE007344
NC_003028
AAK74491.1
NP_344851.1
Q54873
Q54874
  
hyaluronate lyase (HylA) 4.2.2.1
Streptococcus pyogenesAF218838
AAF29533.1
Q9L7W9
  
HylA n.d.Streptococcus pyogenes 1020EU078701
ABU63951.1
   
HylA n.d.Streptococcus pyogenes 1055EU078692
ABU63942.1
   
HylA n.d.Streptococcus pyogenes 2397EU078700
ABU63950.1
   
HylA n.d.Streptococcus pyogenes 3200EU078689
ABU63939.1
   
HylA n.d.Streptococcus pyogenes 350EU078693
ABU63943.1
   
HylA n.d.Streptococcus pyogenes 350EU078693
ABU63943.1
   
HylA n.d.Streptococcus pyogenes 3779EU078702
ABU63952.1
   
HylA n.d.Streptococcus pyogenes 422EU078694
ABU63944.1
   
HylA n.d.Streptococcus pyogenes 4282EU078697
ABU63947.1
   
HylA n.d.Streptococcus pyogenes 4283EU078690
ABU63940.1
   
HylA n.d.Streptococcus pyogenes 437EU078696
ABU63946.1
   
HylA n.d.Streptococcus pyogenes 445EU078691
ABU63941.1
   
HylA n.d.Streptococcus pyogenes 4786EU078695
ABU63945.1
   
HylA n.d.Streptococcus pyogenes 6219EU078688
ABU63938.1
   
HylA n.d.Streptococcus pyogenes 872EU078698
ABU63948.1
   
HylA n.d.Streptococcus pyogenes 94146EU078699
ABU63949.1
   
SPY1032 (HylA) n.d.Streptococcus pyogenes M1 GAS SF370AE006548
NC_002737
AAK33924.1
NP_269203.1
Q99ZX4
  
MGAS10270_Spy0874 (HylA) n.d.Streptococcus pyogenes MGAS10270CP000260
ABF33939.1
   
M6_Spy0782 n.d.Streptococcus pyogenes MGAS10394CP000003
AAT86917.1
   
MGAS10750_Spy0909 (HylA) n.d.Streptococcus pyogenes MGAS10750CP000262
ABF37859.1
   
MGAS2096_Spy0831 + MGAS2096_Spy0830 (HylA) n.d.Streptococcus pyogenes MGAS2096CP000261
CP000261
ABF35883.1
ABF35882.1
   
HylA n.d.Streptococcus pyogenes MGAS315AE014150
NC_004070
AAM79272.1
NP_664469.1
Q8K7S1
  
M5005_Spy_0757 (HylA) n.d.Streptococcus pyogenes MGAS5005CP000017
AAZ51375.1
   
M28_Spy0736 (HylA) n.d.Streptococcus pyogenes MGAS6180CP000056
AAX71849.1
   
HylA n.d.Streptococcus pyogenes MGAS8232AE010029
NC_003485
AAL97649.1
NP_607150.1
Q8P183
  
MGAS9429_Spy0871 (HylA) n.d.Streptococcus pyogenes MGAS9429CP000259
ABF32059.1
   
SPs1188 (fragment) n.d.Streptococcus pyogenes SSI-1AP005144
NC_004606
BAC64283.1
NP_802450.1
   
hyaluronidase (HylA) n.d.Streptococcus suisAJ697918
CAG27052.1
   
hyaluronidase (HylA) n.d.Streptococcus suisAJ697934
CAG27068.1
   
hyaluronidase (HylA) n.d.Streptococcus suisAJ697919
CAG27053.1
   
SSU05_1215 + SSU05_1214 (fragments) n.d.Streptococcus suis 05ZYH33CP000407
CP000407
ABP90181.1
ABP90180.1
   
hyaluronidase (HylA) (probable fragment) n.d.Streptococcus suis 98015DQ410868
ABD74496.1
   
SSU98_1230 + SSU98_1229 (fragments) n.d.Streptococcus suis 98HAH33CP000408
CP000408
ABP92388.1
ABP92387.1
   
hyaluronidase (HylA) (fragment) n.d.Streptococcus suis Cvcc606EF492986
ABP35951.1
   
hyaluronidase (HylA) (fragment) n.d.Streptococcus suis Cvcc607EF492987
ABP35952.1
   
HylA (fragment) 4.2.2.1
Streptococcus suis P1/7AJ308330
CAC87664.1
   
HylA 4.2.2.1
Streptococcus suis P5/11/88AJ308329
CAC87663.1
   
hyaluronidase (HylA) (probable fragment) n.d.Streptococcus suis SC152DQ410867
ABD74495.1
   
hyaluronidase (HylA) (probable fragment) n.d.Streptococcus suis SC17DQ410865
ABD74493.1
   
hyaluronidase (HylA) (probable fragment) n.d.Streptococcus suis SC22DQ410866
ABD74494.1
   
hyaluronidase (HylA) n.d.Streptococcus suis serotype 2AJ697915
CAG27049.1
   
hyaluronidase (HylA) n.d.Streptococcus suis serotype 2AJ697914
CAG27048.1
   
hyaluronidase (HylA) n.d.Streptococcus suis serotype 2AJ697916
CAG27050.1
   
hyaluronidase (HylA) 4.2.2.1
Streptococcus suis serotype 7AJ308328
CAC87662.1