CAZy Family GH84

CAZy ~ Carbohydrate-Active enZymes

Families

Glycoside Hydrolases

GlycosylTransferases

Polysaccharide Lyases

Carbohydrate Esterases

Carbohydrate-Binding Modules


Glycoside Hydrolase Family 84


Known Activities	N-acetyl -glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35)

Mechanism	Retaining

Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate

Catalytic Proton Donor	Asp

3D Structure Status	Fold: ( / ) ₈

Note	Mechanism shown in Macauley et al. (2005) JBC 280, 25313–25322

Statistics	CAZy Entries (60); GenBank/GenPept (103); Swissprot (23); 3D(3) : PDB(9);

Taxonomy	Archaea(1); Bacteria(51); Eukaryota(8);

3D Display	GH84_3D


Archaea
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
Smar_0708	n.d.	Staphylothermus marinus F1	CP000575	ABN69811.1


Bacteria
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
AM1_0334	n.d.	Acaryochloris marina MBIC11017	CP000828	ABW25393.1
AHA_1474	n.d.	Aeromonas hydrophila subsp. hydrophila ATCC 7966	CP000462	ABK39090.1
ASA_2891	n.d.	Aeromonas salmonicida subsp. salmonicida A449	CP000644	ABO90903.1
Amuc_0052	n.d.	Akkermansia muciniphila ATCC BAA-835	CP001071	ACD03898.1
BF3796	n.d.	Bacteroides fragilis NCTC 9343 ATCC 25285 = NCTC 9343	CR626927	CAH09476.1
BF4022	n.d.	Bacteroides fragilis YCH46	AP006841	BAD50764.1
-N-acetylglucosaminidase (BT4395)	3.2.1.52	Bacteroides thetaiotaomicron VPI-5482	AE016945 NC_004663	AAO79500.1 NP_813306.1		2CHN 2CHO 2J47 2J4G 2JIW 2VVN	[A] [A] [A] [A] [B] [B]
BVU_2069	n.d.	Bacteroides vulgatus ATCC 8482	CP000139	ABR39734.1
CJA_1347 - Hyl84	n.d.	Cellvibrio japonicus Ueda107	CP000934	ACE83103.1
-N-acetylglucosaminidase - Nag84A	3.2.1.52	Clostridium paraputrificum M-21	AB109099	BAC99989.1
-N-acetylglucosaminidase (NagJ;CPE1234) - GH84C	3.2.1.52	Clostridium perfringens 13	AP003189 NC_003366	BAB80940.1 NP_562150.1	Q8XL08	2CBI 2CBJ	[A] [A]
CPE1523 (NagL) - GH84E	n.d.	Clostridium perfringens 13	AP003190 NC_003366	BAB81229.1 NP_562439.1	Q8XK80
hyaluronidase (NagH;CPE0191) - GH84A	3.2.1.35	Clostridium perfringens 13	AP003185 NC_003366	BAB79897.1 NP_561107.1
CPE0881 (NagI) - GH84B	n.d.	Clostridium perfringens 13	AP003188 NC_003366	BAB80587.1 NP_561797.1	Q8XM09
CPE1279 (NagK) - GH84D	n.d.	Clostridium perfringens 13	AP003189 NC_003366	BAB80985.1 NP_562195.1	Q8XKW3
CPF_1487	n.d.	Clostridium perfringens ATCC 13124	CP000246	ABG84775.1
hyaluronidase (NagJ;CPF_1442)	n.d.	Clostridium perfringens ATCC 13124	CP000246	ABG84519.1		2J62	[A]
CPF_0875	n.d.	Clostridium perfringens ATCC 13124	CP000246	ABG84510.1
CPF_0184	n.d.	Clostridium perfringens ATCC 13124	CP000246	ABG83307.1
hyaluronidase (NagH)	3.2.1.35	Clostridium perfringens CPN50	M81878	AAA23259.1	P26831
Hyl	n.d.	Enterococcus faecium CV133	AF544400	AAN34803.1	Q8GMZ8
Maqu_3474	n.d.	Marinobacter aquaeolei VT8	CP000514	ABM20545.1
hyaluronidase (NagH)	n.d.	Mycoplasma alligatoris A21JP2	AY515698 AY515698	AAR98795.1 AAR98795.2
BDI_1142	n.d.	Parabacteroides distasonis ATCC 8503	CP000140	ABR42905.1
Plav_1649	n.d.	Parvibaculum lavamentivorans DS-1	CP000774	ABS63268.1
Pmob_0472	n.d.	Petrotoga mobilis SJ95	CP000879	ABX31208.1
RF_p56	n.d.	Rickettsia felis URRWXCal2	CP000054 CP000055	AAY62307.1 AAY62351.1
SACE_7066	n.d.	Saccharopolyspora erythraea NRRL 2338	AM420293	CAM06227.1
SACE_0529	n.d.	Saccharopolyspora erythraea NRRL 2338	AM420293	CAL99875.1
N-acetyl -glucosaminidase (SPy1600)	3.2.1.52	Streptococcus pyogenes M1 GAS SF370	AE006591 NC_002737	AAK34378.1 NP_269657.1	Q99YP8
MGAS10270_Spy1430 (hyl)	n.d.	Streptococcus pyogenes MGAS10270	CP000260	ABF34495.1
M6_Spy1332	n.d.	Streptococcus pyogenes MGAS10394	CP000003	AAT87467.1
MGAS10750_Spy1423 (hyl)	n.d.	Streptococcus pyogenes MGAS10750	CP000262	ABF38373.1
MGAS2096_Spy1335 + MGAS2096_Spy1334 (hyl)	n.d.	Streptococcus pyogenes MGAS2096	CP000261 CP000261	ABF36387.1 ABF36386.1
Hyl	n.d.	Streptococcus pyogenes MGAS315	AE014161 NC_004070	AAM79901.1 NP_665098.1	Q8K6L2
M5005_Spy_1314 (HyL)	n.d.	Streptococcus pyogenes MGAS5005	CP000017	AAZ51932.1
M28_Spy1355 (HyL)	n.d.	Streptococcus pyogenes MGAS6180	CP000056	AAX72465.1
Hyl	n.d.	Streptococcus pyogenes MGAS8232	AE010073 NC_003485	AAL98163.1 NP_607664.1	Q8P022
MGAS9429_Spy1308 (hyl)	n.d.	Streptococcus pyogenes MGAS9429	CP000259	ABF32495.1
SPs0567	n.d.	Streptococcus pyogenes SSI-1	AP005142 NC_004606	BAC63662.1 NP_801829.1
SpyM50541	n.d.	Streptococcus pyogenes str. Manfredo	AM295007	CAM29879.1
SAML0971	n.d.	Streptomyces ambofaciens ATCC 23877	AM238663	CAJ89957.1
SGR_4877	n.d.	Streptomyces griseus subsp. griseus NBRC 13350	AP009493	BAG21706.1
XAC3928	n.d.	Xanthomonas axonopodis pv. citri str. 306	AE012042 NC_003919	AAM38765.1 NP_644229.1
xcc-b100_2329	n.d.	Xanthomonas campestris pv. campestris B100	AM920689	CAP51686.1
XC_2155	n.d.	Xanthomonas campestris pv. campestris str. 8004	CP000050	AAY49211.1
XCC2028	n.d.	Xanthomonas campestris pv. campestris str. ATCC 33913	AE012308 NC_003902	AAM41317.1 NP_637393.1
XCV4043	n.d.	Xanthomonas campestris pv. vesicatoria str. 85-10	AM039952	CAJ25774.1
XOO0215	n.d.	Xanthomonas oryzae pv. oryzae KACC10331	AE013598	AAW73469.1
XOO0189	n.d.	Xanthomonas oryzae pv. oryzae MAFF 311018	AP008229	BAE66944.1
PXO_03654	n.d.	Xanthomonas oryzae pv. oryzae PXO99A	CP000967.1	ACD56872.1


Eukaryota
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
ebiP6225 (EbiG6225)	n.d.	Anopheles gambiae PEST	AAAB01008799	EAA03784.2
O-GlcNAcase (OGA-1; T20B5.3)	n.d.	Caenorhabditis elegans Bristol N2	U28742 U28742 DQ407521 DQ407522 DQ407523 U28742 U28742 NM_077172	AAA68333.2 AAA68333.3 ABD85013.1 ABD85014.1 ABD85015.1 ABX00798.1 ABX00799.1 NP_509573.1	Q22602
CG5871	n.d.	Drosophila melanogaster	AE003734 AY051560 BT001727 NM_142699	AAF55867.1 AAK92984.1 AAN71482.1 NP_650956.1	Q9VDC9 Q961J2
RCJMB04_20o15 (fragment)	n.d.	Gallus gallus	AJ851715	CAH65349.1
O-GlcNAcase (meningioma expressed antigen 5;Mea5;Mgea5;NCOAT)	3.2.1.52	Homo sapiens	AF036144 AF307332 BC001343 BC039583 BC047877 AB014579 AK302626 AX878156 NM_012215	AAD05385.2 AAG21428.1 AAH01343.1 AAH39583.2 AAH47877.1 BAA31654.2 BAG63869.1 CAE90035.1 NP_036347.1	Q86WV0 Q9BVA5 Q9HAR0 O60502 O75166
O-GlcNAcase (Mgea5;NCOAT)	3.2.1.52	Mus musculus	AF132214 BC020093 BC041109 BC054821 AK012695 AK017997 AK088774 AK129188 AK145227 NM_023799	AAG43273.2 AAH20093.1 AAH41109.1 AAH54821.1 BAB28416.1 BAB31029.1 BAC40564.1 BAC97998.1 BAE26311.1 NP_076288.1	Q9CU60 Q9CSJ4 Q9EQQ9 Q8CFX2 Q8BTT2
O-GlcNAcase (Mgea5;NCOAT)	3.2.1.52	Rattus norvegicus	AY039679 NM_131904	AAK72103.1 NP_571979.1	Q8VIJ5
Unknown (MGC:184804 IMAGE:7653849)	n.d.	Xenopus tropicalis	BC161052	AAI61052.1