CAZy ~ Carbohydrate-Active enZymes


   
Glycoside Hydrolase Family 7
  
Known Activitiesendoglucanase (EC 3.2.1.4); [reducing end-acting] cellobiohydrolase (EC 3.2.1.-); chitosanase (EC 3.2.1.132)
 
MechanismRetaining
 
Catalytic Nucleophile/BaseGlu (experimental)
 
Catalytic Proton DonorGlu (experimental)
 
3D Structure StatusFold: -jelly roll
 
ClanGH-B
 
Noteformerly known as cellulase family C. The cellobiohydrolases of this family act processively from the reducing ends of cellulose chains to generate cellobiose. This is markedly different from the IUBMB definition of cellobiohydrolases (EC 3.2.1.91), which act from the non-reducing ends of cellulose.
 
Relevant LinksHOMSTRAD   InterPro   PFAM   PRINTS   
 
StatisticsCAZy Entries (316);  GenBank/GenPept (402);  Swissprot (61);  3D(7) : PDB(32); cryst(1);
 
TaxonomyEukaryota(316);  
 
3D DisplayGH7_3D
 
        
        Eukaryota          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
unnamed protein product n.d.Acremonium sp.AX657621
CAD79794.1
   
unnamed protein product n.d.Acremonium thermophilumAX657569
CAD79778.1
   
cellobiohydrolase - Cel7B3.2.1.-
Acremonium thermophilum ALKO4245AM711861
CAM98446.1
   
cellobiohydrolase - Cel7A3.2.1.-
Acremonium thermophilum ALKO4245AM711860
CAM98445.1
   
cellobiohydrolase I (Cel2) 3.2.1.-
Agaricus bisporus D649Z50094
CAA90422.1
Q92400
  
exoglucanase C1 (AaC1) n.d.Alternaria alternataAF176571
AAF05699.1
Q9UVP4
  
exoglucanase C2 (AaC2) (fragment) n.d.Alternaria alternataAF282320
AAK69517.1
   
cellobiohydrolase I / chitosanase (CBHI) 3.2.1.-

3.2.1.132		Aspergillus aculeatus F-50AB002821
BAA25183.1
O59843
  
AN5176.2 n.d.Aspergillus nidulans FGSC A4AACD01000089
DQ490495
EAA62357.1
ABF50871.1
   
cellobiohydrolase (CbhB;AN0494.2) 3.2.1.-
Aspergillus nidulans FGSC A4AACD01000007
EAA66593.1
   
endo--1,4-glucanase (EglB;AN3418.2) 3.2.1.4
Aspergillus nidulans FGSC A4AACD01000055
EAA63386.1
   
cellobiohydrolase B (CbhB;An01g11660) 3.2.1.-
Aspergillus niger CBS 513.88AF156269
-
AM269981
CS475859
AAF04492.1
AAP66264.1
CAK44068.1
CAM35324.1
Q9UVS8
  
cellobiohydrolase A (CbhA; An07g09330) 3.2.1.-
Aspergillus niger CBS 513.88AF156268
-
-
AM270149
AAF04491.1
AAP66263.1
AAR79028.1
CAK39699.1
Q9UVS9
  
endo-1,4-glucanase (CelB) 3.2.1.4
Aspergillus oryzae KBN616D83732
BAA22589.1
O13455
  
cellobiohydrolase C (CelC) n.d.Aspergillus oryzae KBN616AB089436
BAC07255.1
Q8NK82
  
cellobiohydrolase D (CelD) n.d.Aspergillus oryzae KBN616AB089437
BAC07256.1
Q8NK81
  
endo-1,4-glucanase (CelB;AO090010000314) 3.2.1.4
Aspergillus oryzae RIB 40AP007175
BAE66197.1
   
cellobiohydrolase D (CelD;AO090012000941) n.d.Aspergillus oryzae RIB 40AP007161
BAE61042.1
   
cellobiohydrolase C (CelC;AO090001000348) n.d.Aspergillus oryzae RIB 40AP007154
BAE56877.1
   
cellobiohydrolase (fragment) n.d.Aspergillus terreus SUK-1AY864863
AAW68437.1
   
cellobiohydrolase (Cbh-1) n.d.Athelia rolfsiiAB103461
BAC81967.1
   
unnamed protein product n.d.Botryosphaeria rhodinaAX657605
CAD79786.1
   
unnamed protein product n.d.Chaetomidium pingtungiumAX657623
CAD79795.1
   
unnamed protein product n.d.Chaetomium thermophilumAX657571
CAD79779.1
   
cellobiohydrolase - Cel7A3.2.1.-
Chaetomium thermophilum ALKO4265AM711862
-
CAM98448.1
ACE10217.1
   
cellobiohydrolase (Cbh1) n.d.Chaetomium thermophilum CT2AY861347
AAW64926.1
   
cellobiohydrolase (Cbh3) n.d.Chaetomium thermophilum CT2DQ085790
EF222284
AAY89412.2
ABN13116.1
   
CBHI (fragment) n.d.Chaetomium thermophilum var. thermophilum DSM1495AY653226
AAT84320.1
   
CBHI (fragment) n.d.Chlorophyllum molybditesEU345459
ABY61352.1
   
CBHI (fragment) n.d.Chlorophyllum molybditesEU345457
ABY61350.1
   
CBHI (fragment) n.d.Chlorophyllum molybditesEU345460
ABY61353.1
   
CBHI (fragment) n.d.Chlorophyllum molybditesEU345458
ABY61351.1
   
CBHI (fragment) n.d.Chlorophyllum molybditesEU345456
ABY61349.1
   
CBHI (fragment) n.d.Chlorophyllum molybditesEU345461
ABY61354.1
   
EG I (fragment) - Cel7Cn.d.Chrysosporium lucknowense     
cellobiohydrolase (CBH Ib) (fragments) - Cel7B3.2.1.-
Chrysosporium lucknowense     
cellobiohydrolase Ia (Cbh1a;CBH I) - Cel7A3.2.1.-
Chrysosporium lucknowense-
AAQ38146.1
   
cellobiohydrolase I (Cel1) 3.2.1.-
Claviceps purpurea T5Y07550
CAA68840.1
O00082
  
CBHI (fragment) n.d.Clitocybe nudaEU345452
ABY61345.1
   
CBHI (fragment) n.d.Clitocybe nudaEU345455
ABY61348.1
   
CBHI (fragment) n.d.Clitocybe nudaEU345453
ABY61346.1
   
CBHI (fragment) n.d.Clitocybe nudaEU345451
ABY61344.1
   
CBHI (fragment) n.d.Clitocybe nudaEU345454
ABY61347.1
   
CBHI (fragment) n.d.Clitopilus prunulusEU345434
EU345435
EU345436
ABY61327.1
ABY61328.1
ABY61329.1
   
cellulase (Cel2) n.d.Cochliobolus carbonumAF336799
AAK19621.1
Q9C1F9
  
cellobiohydrolase I (Cel1) 3.2.1.-
Cochliobolus carbonumU25129
AAC49089.1
Q00328
  
unnamed protein product n.d.Coprinopsis cinereaAX657619
CAD79793.1
   
endo--1,4-glucanase (CLhgEG1) 3.2.1.4
Coptotermes lacteus symbiont WH2002AB089800
BAC07551.1
Q8MXY2
  
endo--1,4-glucanase (CLhgEG2) 3.2.1.4
Coptotermes lacteus symbiont WH2002AB089801
BAC07552.1
Q8MXY1
  
unnamed protein product n.d.Corynascus heterothallicusAX657609
CAD79788.1
   
endoglucanase n.d.Corynascus heterothallicus CBS 117.65-
AAE25067.1
   
cellobiohydrolase I (Cbh-1) 3.2.1.-
Cryphonectria parasitica EP155L43048
AAB00479.1
Q00548
  
endo-1,4--glucanase (EglB) 3.2.1.4
Emericella nidulansAF420021
AAM54071.1
Q8NK01
  
cellobiohydrolase (CbhA) 3.2.1.-
Emericella nidulansAF420019
AAM54069.1
Q8NK03
  
cellobiohydrolase (CbhB) 3.2.1.-
Emericella nidulansAF420020
AAM54070.1
Q8NK02
  
unnamed protein product n.d.Exidia glandulosaAX657615
CAD79791.1
   
unnamed protein product n.d.Exidia glandulosaAX657613
CAD79790.1
   
cellobiohydrolase-c (fragment) n.d.Fusarium chlamydosporumEU214557
ABY16677.1
   
cellobiohydrolase-c (fragment) n.d.Fusarium culmorumEU214552
ABY16674.1
   
Cbh-C (fragment) n.d.Fusarium lateritium CBS 73774AY188914
AAP31849.1
   
endo-1,4-glucanase I (EG I) - Cel7B3.2.1.4
Fusarium oxysporumL29378
-
AAA65586.1
AAE25069.1
P46237
1OVW
2OVW
3OVW
4OVW
[C]
[B]
[A]
[B]
cellobiohydrolase I - Cel7An.d.Fusarium oxysporumL29379
AAA93710
AAC10999
EU214547
AAA65587.1
AAA93710.1
AAC10999.1
ABY16672.1
P46238
  
Cbh-C (fragment) n.d.Fusarium oxysporum f. sp. melonisAF546138
AAQ12003.1
   
exoglucanase type C (Cbh-C) n.d.Fusarium poaeAY706934
AF546134
AAX60003.1
AAQ11999.1
   
cellobiohydrolase-c (fragment) n.d.Fusarium proliferatumEU214555
ABY16676.1
   
Cbh-C (fragment) n.d.Fusarium sp. F1AF490891
AAN07150.1
   
Cbh-C (fragment) n.d.Fusarium sporotrichioidesAF546136
AAQ12001.1
   
Cbh-C (fragment) n.d.Fusarium tricinctum 7AF490897
AAN07156.1
Q8J146
  
cellobiohydrolase-c (fragment) n.d.Fusarium udumEU214551
ABY16673.1
   
exoglucanase type C (Cbh-C) n.d.Fusarium venenatum 5AF490895
AY706932
AAN07154.1
AAX60001.1
   
cellobiohydrolase I (CbhI) 3.2.1.-
Fusicoccum sp. BCC4124EU038070
ABS82449.1
   
exoglucanase type C (CBH-C) n.d.Gibberella avenaceaAY502071
AAS82857.1
   
Cbh-C (fragment) n.d.Gibberella avenacea 12AF490902
AAN07161.1
Q8J144
  
cellobiohydrolase-c (fragment) n.d.Gibberella moniliformisEU214554
ABY16675.1
   
Cbh-C (fragment) n.d.Gibberella moniliformisAF546135
AAQ12000.1
   
Cbh-C (fragment) n.d.Gibberella pulicaris 10AF490900
AAN07159.1
Q8J145
  
Cbh-C (fragment) n.d.Gibberella pulicaris 11AF490901
AAN07160.1
   
exoglucanase type C (CBH-C) n.d.Gibberella pulicaris 2AF490892
AY502072
AY706931
EU214558
AAN07151.1
AAS82858.1
AAX60000.1
ABY16678.1
   
Cbh-C (fragment) n.d.Gibberella pulicaris 6AF490896
AAN07155.1
   
Cbh-C (fragment) n.d.Gibberella pulicaris 8AF490898
AAN07157.1
   
Cbh-C (fragment) n.d.Gibberella zeae 3AF490893
AAN07152.1
   
Cbh-C (fragment) n.d.Gibberella zeae 4AF490894
AAN07153.1
   
Cbh-C (fragment) n.d.Gibberella zeae 9AF490899
AAN07158.1
   
cellobiohydrolase C (Cel7) - Cel7An.d.Gibberella zeae K59AY196784
AY196784
AY342396
AY706933
AAO42612.1
AAO42612.2
AAR02398.1
AAX60002.1
   
endoglucanase 2 (HmEG2) (fragment) 3.2.1.4
Holomastigotoides mirabileAB071012
BAB64564.1
   
endoglucanase 1 (HmEG1) (fragment) 3.2.1.4
Holomastigotoides mirabileAB071011
BAB64563.1
   
endoglucanase 3 (HmEG3) (fragment) 3.2.1.4
Holomastigotoides mirabileAB071013
BAB64565.1
   
endo-1,4-glucanase I (EG-I) 3.2.1.4
Humicola griseaD63516
BAA09786.1
Q12622
  
cellobiohydrolase (Cbh-1) 3.2.1.-
Humicola grisea var. thermoidea IFO9854D63515
BAA09785.1
Q12621
  
cellobiohydrolase I.2 (Cbh1.2) 3.2.1.-
Humicola grisea var. thermoideaU50594
AF123441
-
AAD11942.1
AAD31545.1
AAN19007.1
O94093
Q9UUS1
  
cellobiohydrolase I (Cbh1.1;Cbh1) - Cel7A3.2.1.-
Humicola grisea var. thermoideaX17258
CAA35159.1
P15828
  
cellobiohydrolase I (Exo1) 3.2.1.-
Humicola grisea var. thermoidea IFO9854AB003105
BAA74517.1
O93780
  
endoglucanase I (EG I;EG1) - Cel7B3.2.1.4
Humicola insolens-
-
AAE25068.1
AAE25070.1
P56680
1A39
1DYM
1OJI
1OJJ
1OJK
2A39
 
[A]
[A]
[A]
[B]
[B]
endo-1,4-glucanase I (EGI;Egl1) - Cel7B3.2.1.4
Hypocrea jecorinaM15665
-
-
-
-
-
AAA34212.1
AAE25071.1
AAQ24882.1
AAR60514.1
ABE22091.1
ABE22093.1
P07981
1EG1
[A]
cellobiohydrolase I / chitosanase (CBHI;Cbh1) - Cel7A3.2.1.-

3.2.1.132		Hypocrea jecorina L27-
-
CQ757626
CQ757626
CQ757626
CQ757626
AAE25072.1
AAR60512.1
CAF32516.1
CAF32517.1
CAF32518.1
CAH10320.1
P62694
P00725
1CEL
1DY4
1EGN
1EK7
1I5M
1Q2B
1Q2E
2CEL
2V3I
3CEL
4CEL
5CEL
6CEL
7CEL
8CEL
[B]
[A]
[A]


[A]
[A]
[A]
[A]
 
[A]
 
 
 
 
endo--1,4-glucanase (Egl1) 3.2.1.4
Hypocrea jecorina PTCC 5142AY928809
AAX28897.1
   
cellobiohydrolase (Cbh1) - Cel7A3.2.1.-
Hypocrea koningii G-39X69976
CAA49596.1
P62695
P00725
  
cellobiohydrolase (Cbh1) n.d.Hypocrea lixii FP 108AF223252
AAF36391.1
Q9P8P3
  
endoglucanase I n.d.Hypocrea pseudokoningiiEF185865
ABM90986.1
   
CBHI (fragment) n.d.Infundibulicybe gibbaEU345442
ABY61335.1
   
CBHI (fragment) n.d.Infundibulicybe gibbaEU345450
ABY61343.1
   
CBHI (fragment) n.d.Infundibulicybe gibbaEU345448
ABY61341.1
   
CBHI (fragment) n.d.Infundibulicybe gibbaEU345446
EU345447
ABY61339.1
ABY61340.1
   
CBHI (fragment) n.d.Infundibulicybe gibbaEU345443
ABY61336.1
   
CBHI (fragment) n.d.Infundibulicybe gibbaEU345437
EU345438
EU345439
EU345440
EU345441
ABY61330.1
ABY61331.1
ABY61332.1
ABY61333.1
ABY6