CAZy Family GH63

CAZy ~ Carbohydrate-Active enZymes

Families

Glycoside Hydrolases

GlycosylTransferases

Polysaccharide Lyases

Carbohydrate Esterases

Carbohydrate-Binding Modules


Glycoside Hydrolase Family 63


Known Activities	processing -glucosidase (EC 3.2.1.106); -1,3-glucosidase (EC 3.2.1.84); -glucosidase (EC 3.2.1.20)

Mechanism	Inverting

Catalytic Nucleophile/Base	Not known

Catalytic Proton Donor	Not known

3D Structure Status	Fold: ( / ) ₆

Clan	GH-G

Relevant Links	InterPro PFAM

Statistics	CAZy Entries (101); GenBank/GenPept (157); Uniprot (25); 3D(2) : PDB(6);

Taxonomy	Archaea(1); Bacteria(62); Eukaryota(38);

3D Display	GH63_3D


Archaea
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
Cmaq_1011	n.d.	Caldivirga maquilingensis IC-167	CP000852	ABW01842.1


Bacteria
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
AHA_3116	n.d.	Aeromonas hydrophila subsp. hydrophila ATCC 7966	CP000462	ABK38145.1
Amuc_1260	n.d.	Akkermansia muciniphila ATCC BAA-835	CP001071	ACD05085.1
BF1757	n.d.	Bacteroides fragilis YCH46	AP006841	BAD48504.1
BVU_1364	n.d.	Bacteroides vulgatus ATCC 8482	CP000139	ABR39053.1
BVU_0302	n.d.	Bacteroides vulgatus ATCC 8482	CP000139	ABR38022.1
BAPKO_0390	n.d.	Borrelia afzelii PKo	CP000395	ABH01646.1
BB0381	n.d.	Borrelia burgdorferi	U49938 AE001143	AAC44714.1 AAC66759.1	P94250 O50167
BG0380	n.d.	Borrelia garinii PBi	CP000013	AAU07233.1
BH0381	n.d.	Borrelia hermsii DAH	CP000048	AAX16890.1
BT0381	n.d.	Borrelia turicatae 91E135	CP000049	AAX17711.1
CPR_0360	n.d.	Clostridium perfringens SM101	CP000312	ABG85323.1
Dshi_1356	n.d.	Dinoroseobacter shibae DFL 12	CP000830	ABV93098.1
Sequence 430 from patent US 6448043 (fragment)	n.d.	Enterococcus faecalis EF040	- -	AAN89168.1 AAN89169.1
EF0071	n.d.	Enterococcus faecalis V583	AE016947 NC_004668 -	AAO79950.1 NP_813878.1 AAR60064.1
Sequence 430 from patent US 6913907 (probable fragment)	n.d.	Enterococcus faecalis V586	-	ABA13264.1
Sequence 432 from patent US 6913907 (fragment)	n.d.	Enterococcus faecalis V586	-	ABA13265.1
ECP_3171	n.d.	Escherichia coli 536	CP000247	ABG71153.1
APECO1_3336	n.d.	Escherichia coli APEC O1	CP000468	ABJ02590.1
EcolC_0620	n.d.	Escherichia coli C str. ATCC 8739	CP000946	ACA76296.1
YgjK	n.d.	Escherichia coli CFT073	AE016767 NC_004431	AAN82283.1 NP_755709.1
EcE24377A_3547	n.d.	Escherichia coli E24377A	CP000800	ABV19243.1
EcHS_A3262	n.d.	Escherichia coli HS	CP000802	ABV07491.1
-glucosidase (YgjK;b3080)	3.2.1.- 3.2.1.20 3.2.1.84	Escherichia coli K12	U18997 AE000390 NC_000913	AAA57881.1 AAC76115.1 NP_417551.1	P42592	2DS3 3C67 3C68 3C69 3D3I	[B] [A] [B] [B] [B]
YgjK	n.d.	Escherichia coli O157:H7 EDL933	AE005537 NC_002655	AAG58213.1 NP_289654.1
ECs3962	n.d.	Escherichia coli O157:H7 str. Sakai	AP002564 NC_002695	BAB37385.1 NP_311989.1	Q8XAL1
EcSMS35_3374	n.d.	Escherichia coli SECEC SMS-3-5	CP000970	ACB17052.1
ECDH10B_3255	3.2.1.- 3.2.1.20 3.2.1.84	Escherichia coli str. K12 substr. DH10B	CP000948	ACB04164.1
UTI89_C3520	n.d.	Escherichia coli UTI89	CP000243	ABE08966.1
YgjK	3.2.1.- 3.2.1.20 3.2.1.84	Escherichia coli W3110	AP009048	BAE77130.1
Franean1_1236	n.d.	Frankia sp. EAN1pec	CP000820	ABW10690.1
orf1720	n.d.	Gramella forsetii KT0803	CU207366	CAL66706.1
orf1168	n.d.	Gramella forsetii KT0803	CU207366	CAL66155.1
Sequence 9385 from patent US 6610836	n.d.	Klebsiella pneumoniae	-	AAR49668.1
MAB_4920c	n.d.	Mycobacterium abscessus	CU458896	CAM64988.1
Mflv_0855	n.d.	Mycobacterium gilvum PYR-GCK	CP000656	ABP43339.1
Mjls_5762	n.d.	Mycobacterium sp. JLS	CP000580	ABO01526.1
Mvan_6050	n.d.	Mycobacterium vanbaalenii PYR-1	CP000511	ABM16803.1
BDI_3179	n.d.	Parabacteroides distasonis ATCC 8503	CP000140	ABR44885.1
PBPRB0230 (probable fragment)	n.d.	Photobacterium profundum SS9	CR378675	CAG22103.1
ORF3	n.d.	Pseudoalteromonas sp. S9	AF047839	AAC25988.1	O85169
Sde_0838	n.d.	Saccharophagus degradans 2-40	CP000282	ABD80100.1
Spro_1970	n.d.	Serratia proteamaculans 568	CP000826	ABV41073.1
Sama_3625	n.d.	Shewanella amazonensis SB2B	CP000507	ABM01828.1
Shal_0092	n.d.	Shewanella halifaxensis HAW-EB4	CP000931	ABZ74668.1
Shew_3745	n.d.	Shewanella loihica PV-4	CP000606	ABO25611.1
Spea_4151	n.d.	Shewanella pealeana ATCC 700345	CP000851	ABV89461.1
Ssed_4434	n.d.	Shewanella sediminis HAW-EB3	CP000821	ABV39036.1
SDY_3263 (YgjK)	n.d.	Shigella dysenteriae Sd197	CP000034	ABB63263.1
S3327 (YgjK)	n.d.	Shigella flexneri 2a str. 2457T	AE016989 NC_004741	AAP18405.1 NP_838594.1
YgjK	n.d.	Shigella flexneri 2a str. 301	AE015323 NC_004337	AAN44592.1 NP_708885.1
SSO_3125 (YgjK)	n.d.	Shigella sonnei Ss046	CP000038	AAZ89710.1
SAML0634	n.d.	Streptomyces ambofaciens ATCC 23877	AM238663	CAJ89620.1
Tlet_1295	n.d.	Thermotoga lettingae TMO	CP000812	ABV33853.1
TTHA0978	n.d.	Thermus thermophilus HB8	AP008226	BAD70801.1		2Z07	[B]
TDE0996	n.d.	Treponema denticola ATCC 35405	AE017249 NC_002967	AAS11486.1 NP_971605.1
TPASS_0931	n.d.	Treponema pallidum subsp. pallidum SS14	CP000805	ACD71347.1
TP0931	n.d.	Treponema pallidum subsp. pallidum str. Nichols	AE001261 NC_000919	AAC65884.1 NP_219367.1	O83901
VFA0338+VFA0337 (two fragments)	n.d.	Vibrio fischeri ES114	CP000021 CP000021	AAW87408.1 AAW87407.1
VIBHAR_06895	n.d.	Vibrio harveyi ATCC BAA-1116; BB120	CP000790	ABU74770.1
VPA0102	n.d.	Vibrio parahaemolyticus RIMD 2210633	AP005084 NC_004605	BAC61445.1 NP_799612.1
VV11763	n.d.	Vibrio vulnificus CMCP6	AE016802 NC_004459	AAO10174.1 NP_760647.1
VV2646	n.d.	Vibrio vulnificus YJ016	AP005340 NC_005139	BAC95410.1 NP_935439.1	Q7MI71


Eukaryota
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
-1,2-glucosidase / -glucosidase I (Gcs1;KNF;KNOPF;At1g67490 )	3.2.1.106	Arabidopsis thaliana	AC004393 AC011020 AY055858 AK118927 AJ278990 NC_003070 NM_105416	AAC18786.1 AAG52297.1 AAL17718.1 BAC43508.1 CAC34725.1 NP_176916.1 NP_176916.2	O64796 Q9CAG7 Q940D4 Q8GWC8 Q9C5B4
At1g24320/F3I6.26	n.d.	Arabidopsis thaliana	AC002396 BT006494 AK227426 NC_003070	AAC00593.1 AAP21302.1 BAE99430.1 NP_173842.1	O48699 Q84M89
glucosidase I	n.d.	Aspergillus fumigatus YJ-407	AY461807	AAR23808.1
AN6606.2	n.d.	Aspergillus nidulans FGSC A4	AACD01000110	EAA58135.1
An15g01420	n.d.	Aspergillus niger CBS 513.88	AM270336	CAL00956.1
AO090701000141	n.d.	Aspergillus oryzae RIB 40	AP007164	BAE61889.1
CBG05981	n.d.	Caenorhabditis briggsae	CAAC01000028	CAE61977.1
F13H10.4c	n.d.	Caenorhabditis elegans Bristol N2	Z68748 Z68748 Z68748 Z68748	CAA92954.1 CAL36499.1 CAL36500.1 CAN86588.1	Q19426
-glucosidase I (Cwh41)	3.2.1.106	Candida albicans SC5314	DQ295807	ABB97046.1
CAGL0A01452g	n.d.	Candida glabrata CBS138	CR380947	CAG57723.1
-glucosidase I (fragment)	n.d.	Cricetulus griseus	AB115503	BAC80205.1	Q7TNW2
Unknown (protein for MGC:158312)	n.d.	Danio rerio	BC129197	AAI29198.1
DEHA0D13486g	n.d.	Debaryomyces hansenii CBS767	CR382136	CAG87171.1
CG1597	n.d.	Drosophila melanogaster	AE003485 AE003485 AY061591 BT031284 NM_132479	AAF48028.2 AAF48028.3 AAL29139.1 ABY20525.1 NP_572707.2	Q9VZ04 Q95R68
gcs1b	n.d.	Enchytraeus japonensis	AB211190	BAE93518.1
gcs1a	n.d.	Enchytraeus japonensis	AB211189	BAE93517.1
AFR483C	n.d.	Eremothecium gossypii ATCC 10895	AE016903	AAS53854.1
-glucosidase (processing) (Gcs1)	3.2.1.106	Homo sapiens	BC028337 BC117250 BC117252 AK292553 AK292719 X87237 AJ422288 NM_006302	AAH28337.1 AAI17251.1 AAI17253.1 BAF85242.1 BAF85408.1 CAA60683.1 CAD19636.1 NP_006293.1	Q13724 Q8TCT5
KLLA0E10681g	n.d.	Kluyveromyces lactis NRRL Y-1140	CR382125	CAG99520.1
LbrM28_V2.2400	n.d.	Leishmania braziliensis	AM494965	CAM39770.1
LinJ28.2290	n.d.	Leishmania infantum JPCM5 (MCAN/ES/98/LLM-877)	AM502246	CAM69456.1
LmjF28.2200	n.d.	Leishmania major Friedlin	CT005266	CAJ05671.1
MG09721.4	n.d.	Magnaporthe grisea 70-15	AACU01001292 XM_364876	EAA49730.1 XP_364876.1
MG04045.4	n.d.	Magnaporthe grisea 70-15	AACU01001051 XM_361571	EAA50286.1 XP_361571.1
-glucosidase I (Gcs1)	3.2.1.106	Mus musculus	AF001797 BC051949 AK144946 AK151941 AK152127 AK157286 NM_020619	AAD00906.1 AAH51949.1 BAE26149.1 BAE30817.1 BAE30968.1 BAE34029.1 NP_065644.1	Q9Z2W5 Q80UM7
NCU03657.1 (B2F7.60)	n.d.	Neurospora crassa OR74A	AL451013 AABX01000294 XM_322958	CAC18158.1 EAA31501.1 XP_322959.1	Q9HE56
004-22	n.d.	Oikopleura dioica	AY449460	AAS21415.1
Os01g0921200	n.d.	Oryza sativa (japonica cultivar-group)	AP003707 AP008207	BAB86175.1 BAF07139.1
PICST_39865 (Cwh41)	n.d.	Pichia stipitis CBS 6054	AAVQ01000002	EAZ62766.2
unnamed protein product	n.d.	Podospora anserina	CU640366	CAP73192.1
-glucosidase (processing)	3.2.1.106	Rattus rattus	AF087431 NM_031749	AAC36477.1 NP_113937.1	O88941
-glucosidase I (Cwh41;Gls1;YGL027c;Der7)	3.2.1.106	Saccharomyces cerevisiae S288C	U35669 Z72549 NC_001139	AAC49157.1 CAA96728.1 NP_011488.1	P53008
SJCHGC04071 (fragment)	n.d.	Schistosoma japonicum	AY809831	AAX25720.2
ORF (fragment)	n.d.	Schistosoma japonicum	AY812600 AY812600	AAX28489.1 AAX28489.2
SJCHGC07586 (fragment)	n.d.	Schistosoma japonicum	AY811935	AAX27824.2
SPAC6G10.09 (Gls1)	n.d.	Schizosaccharomyces pombe 972h-	Z98603 NC_003424	CAB11295.1 NP_594106.1	O14255
Unknown (protein for IMAGE:6988934)	n.d.	Xenopus tropicalis	BC100610	AAI00611.1
YALI0F14927g	n.d.	Yarrowia lipolytica CLIB99	CR382132	CAG78244.1