CAZy ~ Carbohydrate-Active enZymes


   
Glycoside Hydrolase Family 6
  
Known Activitiesendoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91)
 
MechanismInverting
 
Catalytic Nucleophile/BaseAsp (experimental)
 
Catalytic Proton DonorAsp (experimental)
 
Clannone
 
Noteformerly known as cellulase family B. The cellobiohydrolases of this family are widely believed to act processively from the non-reducing ends of cellulose chains to generate cellobiose.
 
Relevant LinksHOMSTRAD   InterPro   PFAM   PRINTS   PROSITE   
 
StatisticsCAZy Entries (163);  GenBank/GenPept (221);  Swissprot (60);  3D(5) : PDB(28);
 
TaxonomyBacteria(79);  Eukaryota(82);  unclassified(2);  
 
3D DisplayGH6_3D
 
        
        Bacteria          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
endoglucanase (GuxA) 3.2.1.4
Acidothermus cellulolyticus-
-
-
-
-
-
-
-
ABH87623.1
ABH87626.1
ABH87625.1
ABH87627.1
ABH87628.1
ABH87629.1
ABH87630.1
ABH87635.1
   
Acel_0135 n.d.Acidothermus cellulolyticus 11B; ATCC 43068CP000481
ABK51910.1
   
Acel_0615 n.d.Acidothermus cellulolyticus 11B; ATCC 43068CP000481
ABK52388.1
   
endo-1,4-glucanase A (CenA) - Cel6A3.2.1.4
Cellulomonas fimiM15823
-
AAA23084.1
AAE59939.1
P07984
  
cellobiohydrolase A (CbhA) - Cel6B3.2.1.91
Cellulomonas fimiL25809
-
AAC36898.1
ABH87631.1
P50401
  
cellobiohydrolase A (CflA) (fragment) n.d.Cellulomonas flavigena CDBB-531AF172344
AAD48493.1
Q9S3V4
  
endo-1,4-glucanase - Cel6An.d.Cellulomonas pachnodaeAF113404
AAD54679.1
Q9RQE6
  
CJA_2473 - Cel6An.d.Cellvibrio japonicus Ueda107CP000934
ACE85978.1
   
FRAAL4955 n.d.Frankia alni ACN14aCT573213
CAJ63596.1
   
FRAAL4956 n.d.Frankia alni ACN14aCT573213
CAJ63597.2
   
Franean1_1657 n.d.Frankia sp. EAN1pecCP000820
ABW11095.1
   
Franean1_7197 n.d.Frankia sp. EAN1pecCP000820
ABW16516.1
   
HCH_00086 n.d.Hahella chejuensis KCTC 2396CP000155
ABC27007.1
   
Haur_2136 n.d.Herpetosiphon aurantiacus ATCC 23779CP000875
ABX04776.1
   
Krad_4622 n.d.Kineococcus radiotolerans SRS30216CP000751
ABS06081.1
   
endo-1,4-glucanase A 3.2.1.4
Microbispora bispora  P26414
  
endo-1,4-glucanase 3.2.1.4
Micromonospora cellulolyticumS76408
AAC60491.1
Q53488
  
MAB_4777c n.d.Mycobacterium abscessusCU458896
CAM64845.1
   
MAV_0326 n.d.Mycobacterium avium 104CP000479
ABK66869.1
   
MAP0280 (CelA) n.d.Mycobacterium avium subsp. paratuberculosis str. k10AE017227
NC_002944
AAS02597.1
NP_959214.1
   
Mb0063 (CelA1) n.d.Mycobacterium bovis AF2122/97BX248334
NC_002945
CAD92925.1
NP_853732.1
Q7U2Y0
  
BCG_0093 n.d.Mycobacterium bovis BCG str. Pasteur 1173P2AM408590
CAL70077.1
   
Mflv_1003 n.d.Mycobacterium gilvum PYR-GCKCP000656
ABP43486.1
   
MMAR_0107 n.d.Mycobacterium marinum MCP000854
ACC38578.1
   
MSMEG_6752 n.d.Mycobacterium smegmatis str. MC2 155CP000480
ABK75770.1
   
Mjls_5680 n.d.Mycobacterium sp. JLSCP000580
ABO01444.1
   
Mkms_5390 n.d.Mycobacterium sp. KMSCP000518
ABL94576.1
   
Mmcs_5301 n.d.Mycobacterium sp. MCSCP000384
ABG11402.1
   
MT0067 n.d.Mycobacterium tuberculosis CDC1551AE006919
NC_002755
AAK44291.1
NP_334477.1
   
TBFG_10061 n.d.Mycobacterium tuberculosis F11CP000717
ABR04404.1
   
MRA_0064 n.d.Mycobacterium tuberculosis H37RaCP000611
ABQ71783.1
   
endoglucanase (CelA;Rv0062;MTV030.05) - Cel63.2.1.4
Mycobacterium tuberculosis H37RvAL021428
NC_000962
BX842572
CAA16243.1
NP_214576.1
CAE55238.1
O53607
1UOZ
1UP0
1UP2
1UP3
[A]
[A]
[A]
[A]
Mvan_5837 n.d.Mycobacterium vanbaalenii PYR-1CP000511
ABM16602.1
   
MXAN_4837 (CelA) n.d.Myxococcus xanthus DK 1622CP000113
ABF91186.1
   
CelA n.d.Myxococcus xanthus DK101-
X76640
AAW97562.1
CAA54086.1
Q50901
  
Noca_4617 n.d.Nocardioides sp. JS614CP000509
ABL84112.1
   
Noca_1251 n.d.Nocardioides sp. JS614CP000509
ABL80765.1
   
Noca_3501 n.d.Nocardioides sp. JS614CP000509
ABL83001.1
   
RSp0583 (CbhA) n.d.Ralstonia solanacearum GMI1000AL646079
NC_003296
CAD17734.1
NP_522144.1
Q8XS97
  
Sde_2272 - Cel6An.d.Saccharophagus degradans 2-40CP000282
ABD81532.1
   
SACE_6060 n.d.Saccharopolyspora erythraea NRRL 2338AM420293
CAM05233.1
   
Sequence 2 from patent US 6207436 n.d.Saccharothrix australiensis-
AAE63612.1
   
Sare_3983 n.d.Salinispora arenicola CNS-205CP000850
ABV99773.1
   
Strop_3602 n.d.Salinispora tropica CNB-440CP000667
ABP56033.1
   
sce8077 n.d.Sorangium cellulosum So ce56AM746676
CAN98247.1
   
endo-1,4-glucanase (fragment) 3.2.1.4
Stigmatella aurantiacaX76726
CAA54143.1
Q53652
  
SAV6896 (CelA5) n.d.Streptomyces avermitilis MA-4680AP005048
NC_003155
BAC74607.1
NP_828072.1
   
SAV1853 (GuxA2) n.d.Streptomyces avermitilis MA-4680AP005028
NC_003155
BAC69564.1
NP_823029.1
   
SAV5217 n.d.Streptomyces avermitilis MA-4680AP005042
NC_003155
BAC72929.1
NP_826394.1
   
SAV557 (GuxA1) n.d.Streptomyces avermitilis MA-4680AP005023
NC_003155
BAC68267.1
NP_821732.1
Q82QF2
  
SCO2838 (SCE20.12c) n.d.Streptomyces coelicolor A3(2)AL136058
NC_003888
CAB65568.1
NP_627067.1
Q9RDB3
  
SCO1451 (SCL6.08c) n.d.Streptomyces coelicolor A3(2)AL159139
NC_003888
CAB76873.1
NP_625732.1
Q9L108
  
SCO6548 (SC5C7.33) n.d.Streptomyces coelicolor A3(2)AL031515
NC_003888
CAA20645.1
NP_630629.1
O86730
  
SGR_4702 n.d.Streptomyces griseus subsp. griseus NBRC 13350AP009493
BAG21531.1
   
SGR_2125 n.d.Streptomyces griseus subsp. griseus NBRC 13350AP009493
BAG18954.1
   
SGR_6928 n.d.Streptomyces griseus subsp. griseus NBRC 13350AP009493
BAG23757.1
   
SGR_2445 n.d.Streptomyces griseus subsp. griseus NBRC 13350AP009493
BAG19274.1
   
endo-1,4-glucanase A (CelA1;Cel1;CMCASE I) 3.2.1.4
Streptomyces halstedii JM8Z12157
CAA78145.1
P33682
  
NanG8 n.d.Streptomyces nanchangensis NS3226AF521085
AAP42880.1
Q7WTD0
  
endo-1,4-glucanase A 3.2.1.4
Streptomyces sp. KSM-9L03218
M20921

X61008
AAA26713.1
AAA26776.1
AAE59941.1
CAA43330.1
P13933
  
exoglucanase (CbhII) 3.2.1.91
Streptomyces sp. M23AB078006
BAB83928.1
Q8VLR1
  
-1,4-endoglucanase / cellobiohydrolase (CelAB) 3.2.1.4

3.2.1.91		Teredinibacter turnerae T7902EF562510
ABS72374.1
   
cellulase (Ex) 3.2.1.4

3.2.1.91		Thermobifida fuscaAF268074
AAF75786.1
Q9KH72
  
cellobiohydrolase (E3;Tfu_0620) - Cel6B3.2.1.91
Thermobifida fusca YXU18978
CP000088
-
AAA62211.1
AAZ54658.1
ABH87632.1
Q60029
  
endo-1,4-glucanase (E2;CelB;Tfu_1074) - Cel6A3.2.1.4
Thermobifida fusca YXM73321
AAE59940
CP000088
AAC06388.1
AAE59940.1
AAZ55112.1
P26222
1TML
2BOD
2BOE
2BOF
2BOG
 
[X]
[X]
[X]
[X]
xcc-b100_1018 n.d.Xanthomonas campestris pv. campestris B100AM920689
CAP50366.1
   
xcc-b100_0661 n.d.Xanthomonas campestris pv. campestris B100AM920689
CAP50000.1
   
XC_0626 n.d.Xanthomonas campestris pv. campestris str. 8004CP000050
AAY47706.1
   
XC_1005 n.d.Xanthomonas campestris pv. campestris str. 8004CP000050
AAY48079.1
   
XCC3160 n.d.Xanthomonas campestris pv. campestris str. ATCC 33913AE012431
NC_003902
AAM42430.1
NP_638506.1
Q8P622
  
XCC3534 n.d.Xanthomonas campestris pv. campestris str. ATCC 33913AE012474
NC_003902
AAM42804.1
NP_638880.1
   
CbsA (fragment) n.d.Xanthomonas oryzae pv. oryzae BXO43AY627915
AAT35586.1
   
XOO4035 n.d.Xanthomonas oryzae pv. oryzae KACC10331AE013598
AAW77289.1
   
XOO3805 n.d.Xanthomonas oryzae pv. oryzae MAFF 311018AP008229
BAE70560.1
   
PXO_04176 n.d.Xanthomonas oryzae pv. oryzae PXO99ACP000967
ACD57472.1
   
XF1267 n.d.Xylella fastidiosa 9a5cAE003960
NC_002488
AAF84076.1
NP_298556.1
Q9PDW2
  
Xfasm12_0598 n.d.Xylella fastidiosa M12CP000941
ACA11602.1
   
XfasM23_0553 n.d.Xylella fastidiosa M23CP001011
ACB91997.1
   
PD0529 (GuxA) n.d.Xylella fastidiosa Temecula1AE012555
NC_004556
AAO28402.1
NP_778753.1
Q87E00
  
 
        
        Eukaryota          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
cellobiohydrolase II (Acc2) 3.2.1.91
Acremonium cellulolyticus Y-94-
AB022429
AAE50824
BAA74458.1
O93837
  
cellobiohydrolase II (Cel3;Cel3A) 3.2.1.91
Agaricus bisporus D649L24519
L24520
-
Z34007
AAA50607.1
AAA50608.1
AAE59938.1
CAA83971.1
P49075
  
cellulase (CelA) 3.2.1.91
Anaeromyces sp. W-98AF529294
AAQ09258.1
   
cellobiohydrolase (AN5282.2) 3.2.1.91
Aspergillus nidulans FGSC A4DQ490497
AACD01000093
ABF50873.1
EAA62442.1
   
AN1273.2 n.d.Aspergillus nidulans FGSC A4AACD01000017
EAA65866.1
   
An08g01760 n.d.Aspergillus niger CBS 513.88AM270160
CAK39856.1
   
An12g02220 n.d.Aspergillus niger CBS 513.88AM270264
CAK41068.1
   
AO090038000439 n.d.Aspergillus oryzae RIB 40AP007169
BAE64227.1
   
unnamed protein product (fragment) n.d.Aspergillus sp.CQ838160
CAH05673.1
   
unnamed protein product (fragment) n.d.Aspergillus tubingensisCQ838164
-
CAH05675.1
ACC29925.1
   
unnamed protein product n.d.Chaetomium thermophilumCQ838150
CAH05669.1
   
cellobiohydrolase (Cbh2) 3.2.1.91
Chaetomium thermophilum CT2AY861348
DQ020255
AAW64927.1
AAY88915.1
   
cellobiohydrolase (EG6;CBH II) - Cel6An.d.Chrysosporium lucknowense-
AAQ38151.1
   
cellobiohydrolase IIb (CBH IIb) (fragments) - Cel6B3.2.1.91
Chrysosporium lucknowense     
EG VI (fragment) - Cel6Cn.d.Chrysosporium lucknowense     
CesA - CiCesAn.d.Ciona intestinalisAB104509
BAD10864.1
   
cellulose synthase 2.4.1.12
Ciona savignyiAY504665
AAR89623.1
   
cellobiohydrolase II (CEL7) n.d.Cochliobolus heterostrophus C4AY116307
AAM76664.1
Q8J215
  
endoglucanase B n.d.Fusarium oxysporumL29377
-
AAA65585.1
AAE59937.1
P46236
  
Cel6 - Cel6n.d.Gibberella zeae K59AY302753
AY336127
AAQ72468.1
AAR01213.1
   
unnamed protein product (fragment) n.d.Gloeophyllum trabeumCQ838166
CAH05676.1
   
endo-1,4-glucanase B (EG VI) - Cel6B3.2.1.4
Humicola insolens  Q7SIG5
1DYS
A
avicelase 2 (Avi2) n.d.Humicola insolens
AB048710
AAN19008.1
BAB39154.1
Q9C1S9
  
cellobiohydrolase (CBHII) - Cel6A3.2.1.91
Humicola insolens   1BVW
1GZ1
1OC5
1OC6
1OC7
1OCB
1OCJ
1OCN
2BVW
[A]
[A]
[A]
[A]
[A]
[A]
[A]
[A]
A
cellobiohydrolase II (CBHII;Cbh2) - Cel6A3.2.1.91
Hypocrea jecorina QM9414M16190
M55080
-
AF302657
-
AAA34210.1
AAA72922.1
AAE59936.1
AAG39980.1
AAR60513.1
P07987
Q9HEY8
1CB2
1HGW
1HGY
1LG8
1LLX
1QJW
1QK0
1QK2
3CBH
[B]
[B]
[A]


[B]
[B]
[A]
 
cellobiohydrolase II (Cbh2) 3.2.1.91
Hypocrea koningiiAF315681
AAK01367.1
   
cellobiohydrolase II (Cbh2;CbhII) n.d.Hypocrea koningii 3.2774DQ504304
ABF56208.1
   
cbh2 n.d.Hypocrea koningii AS3.2774DQ660372
ABG48766.1
   
cellobiohydrolase II (Cex3) n.d.Irpex lacteus MC-2AB370872