CAZy Family GH5

CAZy ~ Carbohydrate-Active enZymes

Families

Glycoside Hydrolases

GlycosylTransferases

Polysaccharide Lyases

Carbohydrate Esterases

Carbohydrate-Binding Modules


Glycoside Hydrolase Family 5


Known Activities	chitosanase (EC 3.2.1.132); -mannosidase (EC 3.2.1.25); Cellulase (EC 3.2.1.4); glucan 1,3--glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); glucan endo-1,6--glucosidase (EC 3.2.1.75); mannan endo-1,4--mannosidase (EC 3.2.1.78); Endo-1,4--xylanase (EC 3.2.1.8); cellulose 1,4--cellobiosidase (EC 3.2.1.91); endo-1,6--galactanase (EC 3.2.1.-); -1,3-mannanase (EC 3.2.1.-); xyloglucan-specific endo--1,4-glucanase (EC 3.2.1.151)

Mechanism	Retaining

Catalytic Nucleophile/Base	Glu (experimental)

Catalytic Proton Donor	Glu (experimental)

3D Structure Status	Fold: ( / ) ₈

Clan	GH-A

Note	formerly known as cellulase family A.

Relevant Links	HOMSTRAD InterPro PFAM PROSITE

Statistics	CAZy Entries (1422); GenBank/GenPept (2328); Uniprot (335); 3D(32) : PDB(73); cryst(2);

Taxonomy	Archaea( 1 / 8 ); Bacteria( 17 / 866 ); Eukaryota( 7 / 519 ); unclassified( 0 / 29 );

Regular Display	GH5


Archaea
Protein	EC#	Organism	GenBank/GenPept	UniProt	PDB/3D

endoglucanase (PH1171)	3.2.1.4	Pyrococcus horikoshii OT3	BAA30271.1 NP_143072.1 AAQ31832.1 AAQ31833.1	O58925	cryst


Bacteria
Protein	EC#	Organism	GenBank/GenPept	UniProt	PDB/3D

endo-1,4-glucanase E1 (Acel_0614) - Cel5A	3.2.1.4	Acidothermus cellulolyticus 11B ATCC 43068	AAA75477.1 CAD42489.1 ABH84883.1 ABK52387.1 CAR96693.1	P54583	1C0D 1ECE 1VRX	B A A
endo-1,4-glucanase 5A - Cel5A	3.2.1.4	Bacillus agaradhaerens	AAC19169.1	O85465	1A3H 1E5J 1H11 1H2J 1H5V 1HF5 1HF6 1HF7 1OCQ 1QHZ 1QI0 1QI2 1W3K 1W3L 2A3H 2V38 3A3H 4A3H 5A3H 6A3H 7A3H 8A3H	A A A A A A A A A A A A A A A A A A A A A A
cellulase	3.2.1.4	Bacillus sp. CBS 670.93	CAB58698.1 CAB59165.1 CAD82873.1 AAV25061.1		1LF1	A
-mannanase - Man5A		Bacillus sp. JAMB-602	BAD99527.1		1WKY	A
endo-1,4-glucanase K	3.2.1.4	Bacillus sp. KSM-635	AAA22304.1	P19424	1G01 1G0C	A A
BF1510		Bacteroides fragilis NCTC 9343 ATCC 25285 = NCTC 9343	CAH07216.1		3CLW	F
-mannosidase 5A - Man5A	3.2.1.25	Cellvibrio mixtus	AAS19695.1		1UUQ 1UZ4	A A
endo-1,4-glucanase A (CelA;Cca;CelCCA;EgA) - Cel5A	3.2.1.4	Clostridium cellulolyticum ATCC 35319	AAA23221.1 AAA51444.1	P17901	1EDG	A
endo-1,4-glucanase C (CelC;EgC) - Cel5B	3.2.1.4	Clostridium thermocellum NCIB 10682EL	AAA23220.1	P07985	1CEC 1CEN 1CEO	A A A
endo-1,4-glucanase Z (CelZ) - Cel5A	3.2.1.4	Erwinia chrysanthemi 3937	CAA68604.1	P07103	1EGZ	B
glucuronoxylan xylanohydrolase (xylanase) (XynA)	3.2.1.136 3.2.1.8	Erwinia chrysanthemi D1	AAB53151.1	Q46961	1NOF	A
xyloglucanase (XG5)	3.2.1.151	Paenibacillus pabuli	AAR65335.1		2JEP 2JEQ	A A
endoglucanase (CelG) - Cel5G	3.2.1.4	Pseudoalteromonas haloplanktis A23	CAA76775.1	O86099	1TVN 1TVP	A A
endoglycoceramidase II (EGC)	3.2.1.123	Rhodococcus sp. M-777	AAB67050.1	O33853	2OSW 2OSX 2OSY 2OYK 2OYL 2OYM	A A A A A A
-mannanase (Man)	3.2.1.78	Thermobifida fusca KW3	CAA06924.1	Q9ZF13	1BQC 2MAN 3MAN	A A A
endo-1,4-glucanase (E5;Tfu_0901) - Cel5A	3.2.1.4	Thermobifida fusca YX	AAC09379.1 AAZ54939.1	Q01786	1US9 1USA 2CKR 2CKS	A A
endo-mannanase (TM1752) - Cel5B	3.2.1.78	Thermotoga maritima MSB8	AAD36817.1 NP_229550.1	Q9X274	1VJZ	A


Eukaryota
Protein	EC#	Organism	GenBank/GenPept	UniProt	PDB/3D

exo--1,3-glucanase (Xog;Xog1;Exg;Ca49c10.05)	3.2.1.58	Candida albicans	CAA39908.1 CAA21969.1 AAV05307.1	P29717	1CZ1 1EQC 1EQP 2PB1 2PBO 2PC8 2PF0	A A A A A A A
exo-xylanase IV (XYN IV)	3.2.1.-	Hypocrea jecorina	AAP64786.1 AAV25955.1		cryst
-mannanase - Man5A	3.2.1.78	Hypocrea jecorina RUTC-30	AAA34208.1 ABJ41268.1	Q99036	1QNO 1QNP 1QNQ 1QNR 1QNS	A A A A A
endo-1,4--mannanase - Man5A	3.2.1.78	Mytilus edulis	CAC81056.1	Q8WPJ2	2C0H	A
exo-1,3-glucanase 1 (Exg1;Bgl1;Scw6;YLR300W)	3.2.1.58	Saccharomyces cerevisiae S288C	AAA34599.1 AAB67345.1 NP_013403.1 AAT93088.1	P23776	1H4P	A
endo--mannanase 4a (LeMAN4a;LeMAN4i)	3.2.1.78	Solanum lycopersicum	AAK97760.1 AAK97759.2	Q8RVL3 Q93WT4	1RH9	A
-1,4-glucanase (Eg1;Eng1)	3.2.1.4	Thermoascus aurantiacus IFO 9748	AAL16412.1 AAL88714.2 ACE10214.1 CAT02251.1	Q96UI5 Q8TG26	1GZJ 1H1N	B A