CAZy ~ Carbohydrate-Active enZymes


   
Glycoside Hydrolase Family 56
  
Known Activitieshyaluronidase (EC 3.2.1.35); chondroitin hydrolase (EC 3.2.1.-)
 
MechanismRetaining
 
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
 
Catalytic Proton DonorGlu
 
3D Structure StatusFold: ( / ) 7
 
Clannone
 
Relevant LinksInterPro   PFAM   PRINTS   
 
StatisticsCAZy Entries (92);  GenBank/GenPept (231);  Uniprot (49);  3D(3) : PDB(6);
 
TaxonomyEukaryota(92);  
 
3D DisplayGH56_3D
 
        
        Eukaryota          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
HyaL n.d.Anoplius samariensisAB304459
BAF93867.1
   
hyaluronidase 2 n.d.Apis cerana ceranaAF351623
AAK51798.2
Q95PD7
  
hyaluronidase (HYA;Api m 2;Apim2;LOC406146) 3.2.1.35
Apis melliferaL10710
-
-
-
NM_001011619
AAA27730.1
AAB45920.1
AAR78242.1
ABH87698.1
NP_001011619.1
Q08169
1FCQ
1FCU
1FCV
2J88
[A]
[A]
[A]
[A]
hyaluronidase (fragment) n.d.Bitis arietansDQ840256
DQ840257
DQ840258
DQ840259
DQ840260
ABI33944.1
ABI33945.1
ABI33946.1
ABI33947.1
ABI33948.1
   
HYAL1 (fragment) n.d.Bos taurusBT020775
AAX08792.1
   
hyaluronidase PH-20 n.d.Bos taurusBC110183
AY297029
AY781776
AAI10184.1
AAP55713.1
AAV41022.1
Q7YS45
  
HYAL1 n.d.Bos taurusBT021035
BC102473
AAX09052.1
AAI02474.1
   
Hyal2 n.d.Bos taurusBC102042
AF411973
BT021754
BT021810
BT026155
NM_174347
AAI02043.1
AAL78385.1
AAX46601.1
AAX46657.1
ABG66994.1
NP_776772.1
Q8SQG8
  
chondroitin hydrolase / chondroitinase (T22C8.2) 3.2.1.-
Caenorhabditis elegans Bristol N2AB361565.1
Z49071
NM_063429
BAG48551.1
CAA88874.1
NP_495830.1
Q22675
  
PH-20 (fragment) n.d.Callimico goeldiiDQ437090
ABD94489.1
   
HYAL3-like protein (fragment) n.d.Callithrix jacchusEF215176
ABQ22669.1
   
sperm membrane protein (PH-20) (fragment) n.d.Capra hircusDQ862554
ABI31753.1
   
hyaluronidase PH-20 3.2.1.35
Cavia porcellus-
X56332
AAB45922.1
CAA39768.1
P23613
  
hyaluronidase (fragment) n.d.Cerastes cerastesDQ840250
DQ840251
DQ840252
ABI33938.1
ABI33939.1
ABI33940.1
   
PH-20 (fragment) n.d.Cercopithecus mitisDQ437094
ABD94493.1
   
ORF (probable fragment) n.d.Culex pipiens quinquefasciatus Vero BeachAY388556
AAR18444.1
   
ORF (fragment) n.d.Culicoides sonorensisAY603562
AAU06477.1
   
Unknown (protein for MGC:136804) n.d.Danio rerioBC114277
AAI14278.1
   
DKEY-20D21.13-001 n.d.Danio rerioCR847503
CAP19590.1
   
DKEY-72L14.3-001 n.d.Danio rerioBX784025
CAK11158.1
   
Unknown (protein for MGC:158626) n.d.Danio rerioBC129330
AAI29331.1
   
DKEY-42I9.14-001 n.d.Danio rerioBX465868
CAK11026.1
   
Unknown (protein for MGC:158668) (fragment) n.d.Danio rerioBC129367
BC152241
AAI29368.1
AAI52242.1
   
hyaluronidase 3.2.1.35
Dolichovespula maculataL34548
-
-
CS284681
AAA68279.1
AAR78243.1
ABH87699.1
CAJ98548.1
P49371
  
hyaluronidase (fragment) n.d.Echis carinatus sochurekiDQ840261
ABI33949.1
   
hyaluronidase (fragment) n.d.Echis carinatus sochurekiDQ840262
ABI33950.1
   
hyaluronidase (fragment) n.d.Echis ocellatusDQ840249
ABI33937.1
   
hyaluronidase (fragment) n.d.Echis pyramidum leakeyiDQ840253
ABI33941.1
   
hyaluronidase (fragment) n.d.Echis pyramidum leakeyiDQ840254
DQ840255
ABI33942.1
ABI33943.1
   
PH-20 (fragment) n.d.Erythrocebus patasDQ437093
ABD94492.1
   
GIP_L1_00710 n.d.Glyptapanteles indiensisAC191960
ABK57057.1
   
hyaluronidase (PH-20;SPAM1;HYAL3;PH20) (sperm) 3.2.1.35
Homo sapiensAC004690
S67798
BC026163
AC004690
AY920278
AY920279
AY920280
AY920281
-
-
AK292229
X84347
NM_003117
NM_153189
AAC16482.1
AAC60607.2
AAH26163.1
AAQ96882.1
AAX13985.1
AAX13986.1
AAX13987.1
AAX13988.1
AAY03322.1
ABJ38775.1
BAF84918.1
CAA59086.1
NP_003108.2
NP_694859.1
P38567
Q8TC30
  
ENSP00000194108 (fragment) n.d.Homo sapiensAC006029
XM_069745
XM_069745
-
XP_069745.1
XP_069745.2
   
hyaluronidase 2 (HYAL2;LUCA2;LUCA-2) 3.2.1.35
Homo sapiensAC002455
AF070608
U09577
BC000692
-
AK092449.1
AK127945.1
AJ000099
NM_003773
NM_033158
AAB67045.1
AAC28656.1
AAC62823.1
AAH00692.1
ABA82488.1
BAG52554.1
BAG54602.1
CAA03924.1
NP_003764.3
NP_149348.2
Q12891
O15177
Q9BW29
  
hyaluronidase 3 (HYAL3;LUCA-3;LUCA14.2) 3.2.1.35
Homo sapiensU73167
AF040710
AF036035
BC005896
BC012892
AF502909
AF502910
AF502911
AF502912
-
AK313455
NM_003549
AAC02729.1
AAC70915.1
AAD04257.1
AAH05896.1
AAH12892.1
AAM60775.1
AAM60776.1
AAM60777.1
AAM60778.1
ABA67787.1
BAG36242.1
NP_003540.2
O60540
O43820
Q8NFK2
Q8NFK4
Q9BRW9
Q96E56
Q8NFK3
  
hyaluronoglucosaminidase 4 (HYAL4) 3.2.1.35
Homo sapiensAF009010
BC104788
BC104790
NM_012269
AAC98883.1
AAI04789.1
AAI04791.1
NP_036401.1
Q9UL99
  
hyaluronidase 1 (HYAL1;Hyal-1;LUCA1;LUCA-1) 3.2.1.35
Homo sapiensAC002455
U73167
U96078
U03056
AF173154
-
AAE60459
BC025774
BC035695
AF502904
AF502905
AF502906
AF502907
AF502908
-
-
AK290816
AK097287
AX207167
CR541933
NM_007312
NM_033159
NM_153281
NM_153282
NM_153283
NM_153284
NM_153285
NM_153286
AAB67046.1
AAC02730.1
AAD04190.1
AAD09137.2
AAD53277.1
AAE60457.1
AAE60459.1
AAH25774.1
AAH35695.1
AAM60770.1
AAM60771.1
AAM60772.1
AAM60773.1
AAM60774.1
ABJ38770.1
ABJ38772.1
BAF83505.1
BAG53447.1
CAC60225.1
CAG46731.1
NP_009296.1
NP_149349.2
NP_695013.1
NP_695014.1
NP_695015.1
NP_695016.1
NP_695017.1
NP_695018.1
Q12794
Q6FH23
Q6PIZ6
Q7KYU2
Q7LE34
Q8NFK5
Q8NFK6
Q8NFK7
Q8NFK8
Q8NFK9
Q93013
Q9UKD5
Q9UNI8
2PE4
[A]
PH-20 (fragment) n.d.Hylobates larDQ437098
ABD94497.1
   
PH-20 (fragment) n.d.Lemur cattaDQ437084
ABD94483.1
   
v-hyaluronidase-Lio1 (fragment) n.d.Liophis poecilogyrusEU091710
ABU68570.1
   
PH-20 (fragment) n.d.Lophocebus aterrimusDQ437096
ABD94495.1
   
HYAL n.d.Lutzomyia longipalpisAF132515
AAD32195.1
Q9XZ48
  
hyaluronidase 3.2.1.35
Macaca fascicularisDQ437095
AB169283
ABD94494.1
BAE01371.1
P38568
  
hyaluronidase (Hya1;BmHYA1) (fragment) 3.2.1.35
Mesobuthus martensii     
PH-20 (fragment) n.d.Microcebus murinusDQ437087
ABD94486.1
   
hyaluronoglucosaminidase 1 3.2.1.35
Mus musculusAF011567
BC021636
AF422176
AK028942
AL672219
AL672219
AL672219
AL672219
NM_008317
AAC15949.1
AAH21636.1
AAL17822.1
BAC26206.1
CAP19319.1
CAP19320.1
CAP19321.1
CAP19322.1
NP_032343.2
O70229
Q8VDK0
Q91ZJ9
Q8CE62
  
hyaluronidase 3.2.1.35
Mus musculusU33958
AY228460
AY920282
AY920283
AK005638
AB085676
NM_009241
AAA76603.1
AAP49832.1
AAX13989.1
AAX13990.1
BAB24161.1
BAC55070.1
NP_033267.1
P48794
Q9DAQ1
Q7TSD6
  
hyaluronidase 2 (Hyal2;Hyal-2) n.d.Mus musculusBC060047
AF302843
AF302844
AF422177
AF535140
AK087358
AK088806
AK133886
AJ000059
AJ000060
NM_010489
AAH60047.1
AAK28481.1
AAK28482.1
AAL17823.1
AAO49503.1
BAC39851.1
BAC40583.1
BAE21913.1
CAA03888.1
CAA03889.1
NP_034619.1
O35632
O35631
Q99MS9
Q99MT0
Q8C309
  
Hyal4 n.d.Mus musculusBC125402
BC132096
AK014599
AAI25403.1
AAI32097.1
BAB29454.1
Q9D660
  
hyaluronidase 3 (Hyal3) n.d.Mus musculusBC018457
AY048681
AL672219
NM_178020
AAH18457.1
AAL06145.1
CAP19324.1
NP_821139.1
Q8VEI3
  
4932701A20 or 4930503G08 n.d.Mus musculusAK016575
AK029715
BAB30316.1
BAC26578.1
Q8CDQ9
Q9D4E9
  
Hyal-5 n.d.Mus musculusBC145992
BC145994
AK017112
AK017112
AB085679
AK133387
AAI45993.1
AAI45995.1
BAB30602.2
BAB30602.3
BAC55071.1
BAE21628.1
Q9CUA5
  
hyaluronidase n.d.Orancistrocerus drewseniEU677844
ACD61711.1
   
hyaluronidase 2 (Hyal2) (fragment) n.d.Oryctolagus cuniculusAY603960
AAT35556.1
   
hyaluronidase (Hyal1;Spam1;PH20) 3.2.1.35
Oryctolagus cuniculusU09183
AAA88913.1
P38566
  
PH-20 (fragment) n.d.Otolemur crassicaudatusDQ437082
ABD94481.1
   
Hyal2 n.d.Ovis ariesAF411974
AAL78386.1
Q8SQG7
  
PH-20 (fragment) n.d.Pan troglodytesDQ437099
ABD94498.1
   
PH-20 (fragment) n.d.Papio hamadryasDQ437097
ABD94496.1
   
PH-20 (fragment) n.d.Perodicticus pottoDQ437083
ABD94482.1
   
hyaluronidase (fragment) 3.2.1.35
Polistes annularisAF174528
-
-
AAD52616.1
AAR78239.1
ABH87695.1
Q9U6V9
  
DKFZp469J0738 n.d.Pongo pygmaeusCR857468
CAH89756.1
   
PH-20 (fragment) n.d.Propithecus verreauxiDQ437086
ABD94485.1
   
PH-20 (fragment) n.d.Pygathrix nemaeusDQ437091
ABD94490.1
   
Unknown (protein for MGC:108951) n.d.Rattus norvegicusBC091219
AAH91219.1
   
hyaluronidase 3 (Hyal3) n.d.Rattus norvegicusBC097259
AB100602
AAH97259.1
BAD14370.1
   
2B1 antigen n.d.Rattus norvegicusBC081748
X89999
CH473959.1
NM_053967
AAH81748.1
CAA62016.1
EDM15179.1
NP_446419.1
Q62803
  
hyaluronidase 1 (Hyal1) n.d.Rattus norvegicusAB100600
BAD14368.1
   
Unknown (protein for MGC:94293) n.d.Rattus norvegicusBC082016
AAH82016.1
   
hyaluronidase 3.2.1.35
Rattus norvegicusAF034218
BC062410
AF535141
NM_172040
AAD01980.1
AAH62410.1
AAO49504.1
NP_742037.1
Q9Z2Q3
Q80ZC7
  
hyaluronidase 4 (Hyal4) (fragment) n.d.Rattus norvegicusAB100601
BAD14369.1
   
venom hyaluronidase n.d.Rhynchium brunneumEU624135
ACC93934.1
   
PH-20 (fragment) n.d.Saguinus fuscicollisDQ437089
ABD94488.1
   
PH-20 (fragment) n.d.Saimiri sciureusDQ437088
ABD94487.1
   
PH-20 (fragment) n.d.Semnopithecus entellusDQ437092
ABD94491.1
   
hyaluronoglucosaminidase 1 n.d.Sus scrofaAY497543
AAR91599.1
   
hyaluronoglucosaminidase 3 n.d.Sus scrofaAY472019
AY497545
AAR33037.1
AAR91601.1
   
sperm adhesion molecule 1 (SPAM-1) n.d.Sus scrofaAJ310675
CAC83973.2
Q8MI02
  
hyaluronoglucosaminidase 2 n.d.Sus scrofaAY497544
AAR91600.1
   
hyaluronidase (HYA1) 3.2.1.35
Synanceia horridaAY232496
AAO74499.1
Q801Z8