 CAZy ~ Carbohydrate-Active enZymes
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| Glycoside Hydrolase Family 33 |
| Known Activities | sialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-). |
| Mechanism | Retaining |
| Catalytic Nucleophile/Base | Tyr+Glu |
| Catalytic Proton Donor | Not known |
| 3D Structure Status | Fold: 6-fold  -propeller |
| Clan | GH-E |
| Relevant Links | HOMSTRAD InterPro PFAM |
| Statistics | CAZy Entries (425); GenBank/GenPept (653); Uniprot (118); 3D(12) : PDB(68); |
| Taxonomy | Bacteria( 6 / 242 ) ; Eukaryota( 4 / 178 ); Viruses( 0 / 5 ); |
| Regular Display | GH33 |
Bacteria  | ||||||
| Protein | EC# | Organism | GenBank/GenPept | UniProt | PDB/3D | |
exo- -sialidase (NanI;CPE0725) | | Clostridium perfringens str. 13 | BAB80431.1 NP_561641.1 | Q8XMG4 | 2BF6 2VK5 2VK6 2VK7 | A A A B |
| sialidase (NedA) | 3.2.1.18 | Micromonospora viridifaciens | BAA00852.1 AAQ70871.1 | Q02834 | 1EUR 1EUS 1EUT 1EUU 1W8N 1W8O 1WCQ 2BER 2BQ9 2BZD | A A A A A A A A A A |
| sialidase (NanH) | 3.2.1.18 | Salmonella typhimurium TA262 | AAA27168.1 | P29768 | 1DIL 1DIM 2SIL 2SIM 3SIL | A A A A A |
| sialidase A (NanA) | | Streptococcus pneumoniae R6 | AAL00340.1 NP_359129.1 ACJ76904.1 | 2VVZ | A | |
| (trans-)sialidase B (NanB;SP1687) | 2.4.1.- 3.2.1.18 | Streptococcus pneumoniae TIGR4 | AAK75766.1 NP_346126.1 | 2JKB 2VW0 2VW1 2VW2 | A A A A | |
| sialidase | 3.2.1.18 | Vibrio cholerae 569B 395 | AAA27546.1 AAA27547.1 | P37060 | 1KIT 1W0O 1W0P | A A A |
| Eukaryota | ||||||
| Protein | EC# | Organism | GenBank/GenPept | UniProt | PDB/3D | |
| cytoplasmic sialidase (Neu2) | 3.2.1.18 | Homo sapiens | CAB41449.1 NP_005374.1 AAH69151.1 AAY24360.1 AAI07054.1 | Q9Y3R4 | 1SNT 1SO7 1VCU 2F0Z 2F10 2F11 2F12 2F13 2F24 2F25 2F26 2F27 2F28 2F29 | A A A A A A A A A A A A A A |
| sialidase L | 3.2.1.18 | Macrobdella decora | AAC47263.1 | Q27701 | 1SLI 1SLL 2SLI 3SLI 4SLI | A A A A A |
| trans-sialidase | 2.4.1.- | Trypanosoma cruzi | AAA66352.1 AAO30670.1 AAT21542.1 | Q26966 | 1MR5 1MS0 1MS1 1MS3 1MS4 1MS5 1MS8 1MS9 1S0I 1S0J 1S0K 2AH2 3B69 | A B A B A B B B A A A A A |
| sialidase | 3.2.1.18 | Trypanosoma rangeli | AAC95493.1 AAC95494.1 AAC95495.1 | O44049 | 1MZ5 1MZ6 1N1S 1N1T 1N1V 1N1Y 2A75 2AGS 2FHR | A A A A A A A A A |
| Last update: 2008 Dec 17 © Copyright 1998-2008 AFMB - CNRS - Universités Aix-Marseille I & II |