CAZy ~ Carbohydrate-Active enZymes


   
Glycoside Hydrolase Family 33
  
Known Activitiessialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-).
 
MechanismRetaining
 
Catalytic Nucleophile/BaseTyr+Glu
 
Catalytic Proton DonorNot known
 
3D Structure StatusFold: 6-fold -propeller
 
ClanGH-E
 
Relevant LinksHOMSTRAD   InterPro   PFAM   
 
StatisticsCAZy Entries (319);  GenBank/GenPept (506);  Swissprot (112);  3D(10) : PDB(67);
 
TaxonomyBacteria(143);  Eukaryota(171);  Viruses(5);  
 
3D DisplayGH33_3D
 
        
        Bacteria          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
ABSDF1049 n.d.Acinetobacter baumannii SDFCU468230
CAP00401.1
   
ABSDF0702 n.d.Acinetobacter baumannii SDFCU468230
CAP00078.1
   
sialidase (NanH) 3.2.1.18
Actinomyces viscosusL06898
AAA21932.1
Q44562
  
Amuc_1835 n.d.Akkermansia muciniphila ATCC BAA-835CP001071
ACD05653.1
   
Amuc_0625 n.d.Akkermansia muciniphila ATCC BAA-835CP001071
ACD04462.1
   
NanP n.d.Arcanobacterium pyogenesAY045771
AAK98800.1
Q8VPE8
  
sialidase (NanH) 3.2.1.18
Arcanobacterium pyogenesAF298154
AAK15462.1
Q9AHP2
  
AAur_3540 n.d.Arthrobacter aurescens TC1CP000474
ABM08108.1
   
AAur_0636 n.d.Arthrobacter aurescens TC1CP000474
ABM09704.1
   
Arth_0189 n.d.Arthrobacter sp. FB24CP000454
ABK01590.1
   
Arth_0543 n.d.Arthrobacter sp. FB24CP000454
ABK01942.1
   
sialidase (Si-AU) n.d.Arthrobacter ureafaciens IFO 12140AB193297
AY934539
BAD66680.2
AAX22758.1
   
BF3709 n.d.Bacteroides fragilis NCTC 9343 ATCC 25285 = NCTC 9343CR626927
CAH09389.1
   
BF4051 (Nanh2) n.d.Bacteroides fragilis NCTC 9343 ATCC 25285 = NCTC 9343CR626927
CAH09725.1
   
BF1806 (Nanh) n.d.Bacteroides fragilis NCTC 9343 ATCC 25285 = NCTC 9343CR626927
CAH07505.1
   
sialidase 3.2.1.18
Bacteroides fragilis TM4000M31663
AF031639
D28493
AAA22912.1
AAD01937.1
BAA05853.1
P31206
Q45145
  
BF3936 n.d.Bacteroides fragilis YCH46AP006841
BAD50678.1
   
BF4242 n.d.Bacteroides fragilis YCH46AP006841
BAD50984.1
   
BF1729 (NanH) n.d.Bacteroides fragilis YCH46AP006841
AB102772
AB102772
BAD48476.1
BAC56895.2
BAC56895.1
   
BT0455 n.d.Bacteroides thetaiotaomicron VPI-5482AE016927
NC_004663
AAO75562.1
NP_809368.1
   
BT1013 n.d.Bacteroides thetaiotaomicron VPI-5482AE016930
NC_004663
AAO76120.1
NP_809926.1
   
BVU_4143 n.d.Bacteroides vulgatus ATCC 8482CP000139
ABR41745.1
   
BVU_2645 n.d.Bacteroides vulgatus ATCC 8482CP000139
ABR40297.1
   
exo--sialidase (NanJ;CPE0553) 3.2.1.18
Clostridium perfringens 13AP003187
NC_003366
BAB80259.1
NP_561469.1
Q8XMY5
  
exo--sialidase (NanI;CPE0725) n.d.Clostridium perfringens 13AP003187
NC_003366
BAB80431.1
NP_561641.1
Q8XMG4
2BF6
2VK5
2VK6
2VK7
[A]
[A]
[A]
[B]
exo--sialidase (NanH) 3.2.1.18
Clostridium perfringens A99X87369
CAA60796.1
   
sialidase 1 3.2.1.18
Clostridium perfringens A99Y00963
CAA68780.1
P10481
  
sialidase 2 (nanH) 3.2.1.18
Clostridium perfringens ATCC 10543X71123
CAA50436.1
Q59311
  
CPF_0721 n.d.Clostridium perfringens ATCC 13124CP000246
ABG83208.1
   
CPF_0985 n.d.Clostridium perfringens ATCC 13124CP000246
ABG84018.1
   
CPF_0532 n.d.Clostridium perfringens ATCC 13124CP000246
ABG84247.1
   
CPR_0877 n.d.Clostridium perfringens SM101CP000312
ABG86307.1
   
sialidase 3.2.1.18
Clostridium septicumX63266
CAA44916.1
P29767
  
sialidase 3.2.1.18
Clostridium sordelliiM31584
AAA23280.1
P15698
  
sialidase 3.2.1.18
Clostridium sordellii G12U77592
AAB38297.1
P94675
  
sialidase 3.2.1.18
Clostridium sordellii G39U77593
AAB38298.1
P94676
  
sialidase 3.2.1.18
Clostridium sordellii G5U77591
AAB38296.1
P94674
  
sialidase 3.2.1.18
Clostridium tertiumY08695
CAA69951.1
P77848
  
DIP0543 n.d.Corynebacterium diphtheriae NCTC 13129BX248355
NC_002935
CAE49054.1
NP_938919.1
   
DIP0330 n.d.Corynebacterium diphtheriae NCTC 13129BX248354
NC_002935
CAE48837.1
NP_938718.1
   
RXN02478 n.d.Corynebacterium glutamicumAX065903
CAC26191.1
Q8NMC8
  
FRXA02513 / RXN02513 (fragment) n.d.Corynebacterium glutamicum-
AX065893
AX065895
CS360239
CS360241
AAW20926.1
CAC26186.1
CAC26187.1
CAL31683.1
CAL31684.1
   
RXA00984 (fragment) n.d.Corynebacterium glutamicumAX065891
CS360237
CAC26185.1
CAL31682.1
   
cg1756 (NanH) n.d.Corynebacterium glutamicum ATCC 13032AP005278
BX927152
NC_003450
BAB98949.1
CAF21565.1
NP_600771.1
   
cg2935 (NanP) n.d.Corynebacterium glutamicum ATCC 13032AP005282
NC_003450
BX927155
-
CS360249
BAC00044.1
NP_601849.1
CAF21311.1
ABC13268.1
CAL31688.1
   
sialidase (NanH) n.d.Erysipelothrix rhusiopathiae FujisawaAB019122
BAB40435.1
Q9AJR8
  
neuraminidase (NanH) n.d.Mannheimia haemolytica CECT924-Reglero-BHIB/AEF215852
ABN42196.1
   
sialidase (NedA) 3.2.1.18
Micromonospora viridifaciens-
D01045
AAQ70871.1
BAA00852.1
Q02834
1EUR
1EUS
1EUT
1EUU
1W8N
1W8O
1WCQ
2BER
2BQ9
2BZD
 
 
 
 
[A]
[A]
[A]
[A]
[A]
[A]
sialidase (NanI) n.d.Mycoplasma alligatoris A21JP2AY515695
AAR98792.1
   
MGA_0329 n.d.Mycoplasma gallisepticum RAE016969
NC_004829
AAP56911.1
NP_853343.1
   
MS53_0199 (NanI;MS_0199) n.d.Mycoplasma synoviae 53AE017245
AE017245
AAZ43618.1
AAZ43618.2
   
neuraminidase (NanH) n.d.Mycoplasma synoviae B27/00EU245031
ABX90098.1
   
sialidase (NanH) n.d.Mycoplasma synoviae K1968EU532615.1
ACB47934.1
   
neuraminidase (NanH) n.d.Mycoplasma synoviae K2426DEU015400
EU015400
ABS50356.1
ABS50356.2
   
neuraminidase (NanH) n.d.Mycoplasma synoviae K2581EU245025
ABX90092.1
   
neuraminidase (NanH) n.d.Mycoplasma synoviae K3009/37EU245030
ABX90097.1
   
neuraminidase (NanH) n.d.Mycoplasma synoviae K4463BEU245028
ABX90095.1
   
neuraminidase (NanH) n.d.Mycoplasma synoviae ULB02/P4EU245029
ABX90096.1
   
sialidase (NanH) n.d.Mycoplasma synoviae ULB07/P5EU532616.1
ACB47935.1
   
neuraminidase (NanH) n.d.Mycoplasma synoviae ULB9122EU245027
ABX90094.1
   
sialidase (NanH) (fragment) n.d.Mycoplasma synoviae ULB925EU532617
ACB47936.1
   
neuraminidase (NanH) n.d.Mycoplasma synoviae WVU1853EU245026
ABX90093.1
   
BDI_2946 n.d.Parabacteroides distasonis ATCC 8503CP000140
ABR44654.1
   
sialidase NanH 3.2.1.18
Pasteurella multocida 86-1913AF274869
AAG35310.1
Q9EZV6
  
sialidase NanB 3.2.1.18
Pasteurella multocida 86-1913AF274868
AAG35309.1
Q9EZV7
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 10AY153799
AAN74546.1
Q8GJQ4
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 11AY153800
AAN74547.1
Q8GJQ3
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 12AY153801
AAN74548.1
Q8GJQ2
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 13AY153802
AAN74549.1
Q8GJQ1
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 15AY153803
AAN74550.1
Q8GJQ0
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 16AY153804
AAN74551.1
Q8GJP9
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 3AY153793
AAN74540.1
Q8GJQ8
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 4AY153794
AAN74541.1
   
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 5AY153795
AAN74542.1
   
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 7AY153796
AAN74543.1
Q8GJQ7
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 8AY153797
AAN74544.1
Q8GJQ6
  
sialidase NanH (fragment) n.d.Pasteurella multocida serotype 9AY153798
AAN74545.1
Q8GJQ5
  
PM1000 n.d.Pasteurella multocida subsp. multocida str. PM70AE006139
NC_002663
AAK03084.1
NP_245937.1
Q9CM43
  
PM0663 n.d.Pasteurella multocida subsp. multocida str. PM70AE006102
NC_002663
AAK02747.1
NP_245600.1
Q9CMY7
  
PGN_1608 n.d.Porphyromonas gingivalis ATCC 33277AP009380.1
BAG34127.1
   
PG0352 n.d.Porphyromonas gingivalis W83AE017173
NC_002950
AAQ65563.1
NP_904664.1
   
PPA0684 n.d.Propionibacterium acnes KPA171202AE017283
AAT82440.1
   
sialidase (PPA1560) n.d.Propionibacterium acnes KPA171202AE017283
AAT83304.1
   
PPA0685 n.d.Propionibacterium acnes KPA171202AE017283
AAT82441.1
   
PSHAb0159 n.d.Pseudoalteromonas haloplanktis TAC125CR954247
CAI89205.1
   
RB3353 n.d.Rhodopirellula baltica SH 1BX294138
NC_005027
CAD73141.1
NP_865457.1
   
RB5143 n.d.Rhodopirellula baltica SH 1BX294141
CAD78312.1
   
RB3006 n.d.Rhodopirellula baltica SH 1BX294138
NC_005027
CAD72956.1
NP_865272.1
   
RB1257 n.d.Rhodopirellula baltica SH 1BX294135
CAD71993.1
   
RB11055 n.d.Rhodopirellula baltica SH 1BX294152
CAD77137.1
   
RB8895 (NanH) n.d.Rhodopirellula baltica SH 1BX294148
NC_005027
CAD75983.1
NP_868606.1
   
SACE_1663 n.d.Saccharopolyspora erythraea NRRL 2338AM420293
CAM00982.1
   
SACE_5159 n.d.Saccharopolyspora erythraea NRRL 2338AM420293
CAM04403.1
   
SPA1594 n.d.Salmonella enterica subsp. enterica serovar Paratypi A str. ATCC 9150CP000026
AAV77524.1
   
NanH n.d.Salmonella typhimurium LT2AE008739
NC_003197
AAL19864.1
NP_459905.1
   
sialidase (NanH) 3.2.1.18
Salmonella typhimurium TA262M55342
AAA27168.1
P29768
1DIL
1DIM
2SIL
2SIM
3SIL
 
 
 
 
 
Spea_1515 n.d.Shewanella pealeana ATCC 700345CP000851
ABV86840.1
   
Acid_0193 n.d.Solibacter usitatus Ellin6076CP000473
ABJ81207.1
   
SAG1932 n.d.Streptococcus agalactiae 2603V/RAE014279
NC_004116
AAN00794.1
NP_688921.1
   
SAK_1891 (possible fragment) n.d.Streptococcus agalactiae A909CP000114
ABA45464.1
   
Gbs1919 n.d.Streptococcus agalactiae NEM316AL766854
NC_004368
CAD47578.1
NP_736353.1
   
Sequence 3175 from patent US 7074914 n.d.Streptococcus pneumoniae-
-
-
-
-
ABI03136.1
ABI08177.1
ABJ31693.1
ABJ49306.1
ABL17049.1
   
Sequence 3166 from patent US 7074914 n.d.Streptococcus pneumoniae-
-
-
-
-
ABI03127.1
ABI08168.1
ABJ31684.1
ABJ49297.1
ABL17040.1
   
sialidase B (NanB) 3.2.1.18
Streptococcus pneumoniae 6U43526
-
AAC44396.1
AAW08718.1
Q54727
  
sialidase A (NanA) 3.2.1.18
Streptococcus pneumoniae 6U43526
X72967
AAC44391.1
CAA51473.1
Q59959
Q54722
  
SPCG_1665 n.d.Streptococcus pneumoniae CGSP14CP001033
ACB90917.1
   
SPCG_1660 (NanB) n.d.Streptococcus pneumoniae CGSP14CP001033.1
ACB90912.1
   
SPCG_0853 (NanC) n.d.Streptococcus pneumoniae CGSP14CP001033.1
ACB90105.1
   
neuraminidase (NanA) (fragment) n.d.Streptococcus pneumoniae Cl25 = 340 132217AJ968997
CAI94554.1
   
neuraminidase (NanA) (fragment) n.d.Streptococcus pneumoniae Cl37 = 162 GM123