CAZy Family GH18

CAZy ~ Carbohydrate-Active enZymes

Families

Glycoside Hydrolases

GlycosylTransferases

Polysaccharide Lyases

Carbohydrate Esterases

Carbohydrate-Binding Modules


Glycoside Hydrolase Family 18


Known Activities	chitinase (EC 3.2.1.14); endo--N-acetylglucosaminidase (EC 3.2.1.96); xylanase inhibitor; concanavalin B; narbonin

Mechanism	Retaining

Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate

Catalytic Proton Donor	Glu (experimental)

3D Structure Status	Fold: ( / ) ₈

Clan	GH-K

Note	Contains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin

Relevant Links	HOMSTRAD InterPro PFAM PROSITE

Statistics	CAZy Entries (2489); GenBank/GenPept (3515); Uniprot (682); 3D(33) : PDB(156); cryst(3);

Taxonomy	Archaea( 1 / 10 ); Bacteria( 13 / 1343 ); Eukaryota( 19 / 1068 ); Viruses( 0 / 57 ); unclassified( 0 / 11 );

Regular Display	GH18


Archaea
Protein	EC#	Organism	GenBank/GenPept	UniProt	PDB/3D

chitinase (PF1233;ChiB) - Chi18B	3.2.1.14	Pyrococcus furiosus DSM 3638	AAL81357.1 NP_578962.1	Q8U1H5	2DSK	A


Bacteria
Protein	EC#	Organism	GenBank/GenPept	UniProt	PDB/3D

chitinase (ChitiB)	3.2.1.14	Arthrobacter sp. TAD20	CAB62499.1	Q9REI6	1KFW	A
chitinase (ChiNCTU2)	3.2.1.14	Bacillus cereus NCTU2			cryst
chitinase A1 (ChiA;ChiA1)	3.2.1.14	Bacillus circulans WL-12	AAA81528.1 ABE17206.1 ABE17682.1 ABH92206.1	P20533	1ITX	A
BSU05710 (YdhD)		Bacillus subtilis subsp. subtilis str. 168	CAB12390.1 NP_388452.1		3CZ8	B
chitinase (BT2825)		Bacteroides thetaiotaomicron VPI-5482	AAO77931.1 NP_811737.1		3CO4	A
endo-N-acetylglucosaminidase F3 (EndoF3)	3.2.1.96	Elizabethkingia meningoseptica ATCC 33958	AAA24924.1	P36913	1EOK 1EOM	A A
endo-N-acetylglucosaminidase F1 (EndoF1)	3.2.1.96	Elizabethkingia meningoseptica ATCC 33958	AAA24922.1	P36911	2EBN	A
chitinase F1 (ChiF1)		Nocardiopsis sp. F96	BAC98349.1		cryst
chitinase A (ChiA)	3.2.1.14	Serratia marcescens 2170 / 27117 / BJL200 / ATCC990 / QMB1466	CAA27292.1 AAA26551.1 CAA85291.1 BAA31567.1 AAR10884.1	P07254 O83008	1CTN 1EDQ 1EHN 1EIB 1FFQ 1FFR 1K9T 1NH6 1RD6 1X6L 1X6N	A A A A A A A A A A A
chitinase B (ChiB)	3.2.1.14	Serratia marcescens QMB1466	CAA33278.1 CAA85292.1 BAA31568.1 AAL57855.1 ABE17214.1 ABE17690.1 ABH92214.1	Q54276 P11797	1E15 1E6N 1E6P 1E6R 1E6Z 1GOI 1GPF 1H0G 1H0I 1O6I 1OGB 1OGG 1UR8 1UR9 1W1P 1W1T 1W1V 1W1Y	A B A B A A A A A B A A A A A A A A
chitinase A (ChiA;Chi18bA;SCK15.05c;SCO5003) - Chi18A	3.2.1.14	Streptomyces coelicolor A3(2)	BAA75642.1 CAB92596.1 NP_629155.1	Q9Z9M9 Q9KY99	3EBV	A
endo-N-acetylglucosaminidase H (EndoH;Endo-H)	3.2.1.96	Streptomyces plicatus	AAA26738.1 AAX00996.1 AAY74563.1 ABA35708.1	P04067	1C3F 1C8X 1C8Y 1C90 1C91 1C92 1C93 1EDT	A A A A A A A A
chitinase A (ChiA)	3.2.1.14	Vibrio harveyi	AAK11576.1	Q9AMP1	3B8S 3B9A 3B9D 3B9E	B A A A


Eukaryota
Protein	EC#	Organism	GenBank/GenPept	UniProt	PDB/3D

chitinase B1 (ChiB1)	3.2.1.14	Aspergillus fumigatus ATCC 13073	AAO61686.1	Q873X9	1W9P 1W9U 1W9V 2A3A 2A3B 2A3C 2A3E 2IUZ 3CH9 3CHC 3CHD 3CHE 3CHF	A A A A A A A A A A A A A
chitinase (ChiB)	3.2.1.14	Aspergillus fumigatus YJ-407	AAP23218.1	Q870C0	1WNO	A
signal processing protein (Chi3L1;Spc-40)		Bos taurus	AAP41220.1 AAP41220.2	P30922	1OWQ 2ESC	A A
mammary gland protein 40 (SPB-40)		Bubalus bubalis	AAP42568.2	Q7YS85	1SV8 1TFV 2O9O 2QF8	A A A A
concanavalin B		Canavalia ensiformis	CAA58450.1	P49347	1CNV	A
signalling protein (SPG-40;MGP-40;BP40;CHI3L1)		Capra hircus	AAL87007.1	Q8SPQ0	1LJY 1QZO 1SYT 1ZBV 1ZBW 1ZU6 1ZU7 1ZU8 1ZU9 2A09 2A0O 2AOS 2B2Z 2B31 2B40 2B41 2DSZ 2DT0 2DT1 2DT2 2DT3 2O92 2OLH	A A A A A A A A A A A A A A A A A A A A A A A
complement fixation-chitinase	3.2.1.14	Coccidioides posadasii SILVEIRA	AAB48567.1 AAB48566.1		1D2K 1LL4 1LL6 1LL7	A A A A
imaginal disk growth factor 2 (CG4475)		Drosophila melanogaster	AAC99418.1 AAF45017.1 AAF53536.1 AAL28234.1 NP_477257.2	Q9V3D4 Q9V3D4	1JND 1JNE	A A
chitinase (hevamine A)	3.2.1.14	Hevea brasiliensis	AAB19633.1 CAA09110.1 CAA07608.1 ABI32402.1 ABI32402.2	P23472	1HVQ 1KQY 1KQZ 1KR0 1KR1 1LLO 2HVM	A A A A A A A
chitin-binding lectin / chitinase 3-like-1 (Chi3L1;gp-39;HC-gp39;HumGP39;YKL-40)		Homo sapiens	AAA16074.1 CAA69661.1 NP_001267.1 CAB76472.1 AAH08568.1 AAH38354.1 AAH39132.1 AAP35887.1 ABA82376.1 BAG35757.1	P30923 P36222	1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU	C A B A B A C C
chitinase (chitotriosidase)	3.2.1.14	Homo sapiens	AAC50246.1 NP_003456.1 AAG10644.1 CAC37767.1 CAC37768.1 AAE83140.1 AAE83141.1 AAH69614.1 AAY73903.1 AAY73904.1 AAI03696.1 ABE14345.1 AAI05683.1 AAI05681.1 AAI05682.1 BAG51478.1	Q13231	1GUV 1HKI 1HKJ 1HKK 1HKM 1LG1 1LG2 1LQ0 1WAW 1WB0	A A A A A A A A A A
ECF-L (CHI3L3;Ym1)		Mus musculus	AAB01230.1 BAA13458.2 NP_034022.1 AAB62394.2 AAH61154.1 AAX02313.1 BAE32572.1 BAE23385.1	O35744 O35744	1E9L 1VF8	A A
chitin-binding protein (Brp39)		Mus musculus	CAA63603.1 AAH03780.1 AAH04734.1 AAH05611.1 BAC34654.1 NP_031721.1 CAJ18491.1 BAE33251.1 ABY53363.1	Q61362 Q61362	cryst
signal processing protein (SPS-40;Chi3L1)		Ovis aries	AAQ94054.1	Q6TMG6	1R2V 1SR0 1ZBK 1ZL1 2AO8 2AOK 2B2L 2B2P 2DPE 2DSU 2DSV 2DSW 2FDM 2G41 2G8Z 2PI6	A A A A A A A A A A A A A A A A
endochitinase (Ppl2)	3.2.1.14	Parkia platycephala	CAO78600.1		2GSJ	A
chitinase (Cts1;YLR286C)	3.2.1.14	Saccharomyces cerevisiae S288C	AAB67331.1 NP_013388.1 AAT93059.1 ABC16985.1	P29028 P29029	2UY2 2UY3 2UY4 2UY5	A A A A
signal processing protein (Spp-40)		Sus scrofa	AAV30548.1		1XHG 1XRV 1ZB5 1ZBC	A A A A
xylanase inhibitor protein I (XipI;XIP-I)		Triticum aestivum	CAD19479.1	Q8L5C6	1OM0 1TA3 1TE1	A A A
narbonin		Vicia narbonensis	CAA80983.1 CAA80980.1 CAA80979.1	Q41675 Q08884	1NAR	A