CAZy Family GH18

CAZy ~ Carbohydrate-Active enZymes

Families

Glycoside Hydrolases

GlycosylTransferases

Polysaccharide Lyases

Carbohydrate Esterases

Carbohydrate-Binding Modules


Glycoside Hydrolase Family 18


Known Activities	chitinase (EC 3.2.1.14); endo--N-acetylglucosaminidase (EC 3.2.1.96); xylanase inhibitor; concanavalin B; narbonin

Mechanism	Retaining

Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate

Catalytic Proton Donor	Glu (experimental)

3D Structure Status	Fold: ( / ) ₈

Clan	GH-K

Note	Contains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin

Relevant Links	HOMSTRAD InterPro PFAM PROSITE

Statistics	CAZy Entries (2366); GenBank/GenPept (3351); Swissprot (720); 3D(31) : PDB(155); cryst(2);

Taxonomy	Archaea(10); Bacteria(1314); Eukaryota(979); Viruses(52); unclassified(11);

3D Display	GH18_3D


Archaea
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
Kcr_0727	n.d.	Candidatus Korarchaeum cryptofilum OPF8	CP000968	ACB07477.1
Mboo_2180	n.d.	Candidatus Methanoregula boonei 6A8	CP000780	ABS56694.1
OE2205F (Chia2)	n.d.	Halobacterium salinarum R1	AM774415	CAP13544.1
OE2201F (Chia1)	n.d.	Halobacterium salinarum R1	AM774415	CAP13543.1
chitinase (ChiN1;Chi;VNG_0816G;Vng0816g)	3.2.1.14	Halobacterium sp. NRC-1; ATCC 700922	AE005023 NC_002607	AAG19274.1 NP_279794.1	Q9HR84
Vng0818c	n.d.	Halobacterium sp. NRC-1; ATCC 700922	AE005023 NC_002607	AAG19275.1 NP_279795.1	Q9HR83
chitinase (PF1233;ChiB) - Chi18B	3.2.1.14	Pyrococcus furiosus DSM 3638	AE010230 NC_003413	AAL81357.1 NP_578962.1	Q8U1H5	2DSK	[A]
chitinase (PF1234;ChiA) (frameshift) - Chi18A	3.2.1.14	Pyrococcus furiosus DSM 3638	AE010230 NC_003413	AAL81358.1 NP_578963.1	Q8U1H4
chitinase (fragment)	n.d.	Thermococcus chitonophagus	AY438583	AAR13021.1
chitinase A (TK1765)	3.2.1.14	Thermococcus kodakaraensis KOD1	AP006878	BAD85954.1	Q9UWR7


Bacteria
Protein	EC#	Organism	GenBank/GenPept		UniProt	PDB/3D
ACL_1282 (possible fragments)	n.d.	Acholeplasma laidlawii PG-8A	CP000896	ABX81877.1
Acid345_3523	n.d.	Acidobacteria bacterium Ellin345	CP000360	ABF42524.1
Acid345_0397	n.d.	Acidobacteria bacterium Ellin345	CP000360	ABF39402.1
Acel_0603	n.d.	Acidothermus cellulolyticus 11B; ATCC 43068	CP000481	ABK52376.1
Acel_1460	n.d.	Acidothermus cellulolyticus 11B; ATCC 43068	CP000481	ABK53232.1
Acel_1458 (probable fragment)	n.d.	Acidothermus cellulolyticus 11B; ATCC 43068	CP000481	ABK53230.1
Acel_0424	n.d.	Acidothermus cellulolyticus 11B; ATCC 43068	CP000481	ABK52198.1
Acel_2033	n.d.	Acidothermus cellulolyticus 11B; ATCC 43068	CP000481	ABK53805.1
Acel_1459 (possible fragment)	n.d.	Acidothermus cellulolyticus 11B; ATCC 43068	CP000481	ABK53231.1
Aave_3442	n.d.	Acidovorax avenae subsp. citrulli AAC00-1	CP000512	ABM33999.1
chitinase	3.2.1.14	Aeromonas hydrophila 11	AF099928	AAF00578.1	Q9RQJ3
chitinase A (ChiA) (fragment)	n.d.	Aeromonas hydrophila ATCC7966	AF059494	AAF37580.1	Q9LB35
chitinase (ChiA)	3.2.1.14	Aeromonas hydrophila JMP636	- AF251793	AAE36542 AAF70180.1	Q9L5D5
chitinase 92 (Chi92)	3.2.1.14	Aeromonas hydrophila JP101	AF181852	AAG09437.1	Q9F9Q8
extracellular chitinase (ChiA) (fragment)	n.d.	Aeromonas hydrophila SSU	DQ398103	ABD59013.1
AHA_3440	n.d.	Aeromonas hydrophila subsp. hydrophila ATCC 7966	CP000462	ABK38659.1
chitinase (Chi-A;AHA_0977)	3.2.1.14	Aeromonas hydrophila subsp. hydrophila ATCC 7966	CP000462	ABK39408.1
chitinase (ChiA)	3.2.1.14	Aeromonas hydrophila SUWA-9	AB253741 - -	BAE87051.1 ABE17219.1 ABE17695.1
Chi1	n.d.	Aeromonas punctata CB101	AJ534329	CAD58828.1	Q8GHI4
chitinase A (ChiA)	3.2.1.14	Aeromonas punctata K1	U09139 -	AAA93130.1 ABH92219.1	Q43919
chitinase	n.d.	Aeromonas punctata WS7b	AJ431785	CAD24484.1	Q8RQE5
ASA_0873	n.d.	Aeromonas salmonicida subsp. salmonicida A449	CP000644	ABO89008.1
chitinase (pCA8)	3.2.1.14	Aeromonas sp. 10S-24	AB014768	BAA36459.1	Q9ZNJ2
chitinase (ORF1)	3.2.1.14	Aeromonas sp. 10S-24	- - - - - - D63139	ABE17211.1 ABE17213.1 ABE17687.1 ABE17689.1 ABH92211.1 ABH92213.1 BAA09626.1	Q59141
chitinase (ORF3)	3.2.1.14	Aeromonas sp. 10S-24	D63139	BAA09628.1	Q59143
chitinase (ORF2)	3.2.1.14	Aeromonas sp. 10S-24	D63139	BAA09627.1	Q59142
chitinase II	3.2.1.14	Aeromonas sp. 10S-24	- - - - - - D31818	ABE17208.1 ABE17212.1 ABE17684.1 ABE17688.1 ABH92208.1 ABH92212.1 BAA06605.1	Q59145
Amuc_2164	n.d.	Akkermansia muciniphila ATCC BAA-835	CP001071	ACD05971.1
Amet_3685	n.d.	Alkaliphilus metalliredigens QYMF	CP000724	ABR49805.1
Amet_1089	n.d.	Alkaliphilus metalliredigens QYMF	CP000724	ABR47301.1
Clos_1547	n.d.	Alkaliphilus oremlandii OhILAs	CP000853	ABW19090.1
Clos_0408	n.d.	Alkaliphilus oremlandii OhILAs	CP000853	ABW17970.1
chitinase C (ChiC)	3.2.1.14	Alteromonas sp. O-7	AB004557	BAA24795.1	O50590
chitinase A (ChiA)	3.2.1.14	Alteromonas sp. O-7	ABE17216 ABE17692 - D13762 AB063629	ABE17216.1 ABE17692.1 ABH92216.1 BAA02908.1 BAB79620.1	P32823
chitinase D (ChiD)	n.d.	Alteromonas sp. O-7	AB063629	BAB79618.1
chitinase B (ChiB)	n.d.	Alteromonas sp. O-7	AB086847	BAC53628.1	Q8GI52
chitinase (ChiA) (fragment)	n.d.	Amycolatopsis methanolica	U31277	AAB01684.1	Q44094
AAur_3218	n.d.	Arthrobacter aurescens TC1	CP000474	ABM07757.1
Arth_1229	n.d.	Arthrobacter sp. FB24	CP000454	ABK02623.1
chitinase (ChitiA)	3.2.1.14	Arthrobacter sp. TAD20	AJ250585	CAB62382.1	Q9RMB8
chitinase (ChiC)	3.2.1.14	Arthrobacter sp. TAD20	AJ504427	CAD43215.1
chitinase (ChitiB)	3.2.1.14	Arthrobacter sp. TAD20	AJ250586	CAB62499.1	Q9REI6	1KFW	[A]
AZC_2901	n.d.	Azorhizobium caulinodans ORS 571	AP009384	BAF88899.1
AZC_4417	n.d.	Azorhizobium caulinodans ORS 571	AP009384	BAF90415.1
chitinase	n.d.	Bacillus amyloliquefaciens AVWX-1	EF088513	ABO15008.1
RBAM_000210	n.d.	Bacillus amyloliquefaciens FZB42	CP000560	ABS72465.1
RBAM_013100	n.d.	Bacillus amyloliquefaciens FZB42	CP000560	ABS73673.1
BA_4327	n.d.	Bacillus anthracis str. A2012	NC_003995	NP_657687.1
BA_0961	n.d.	Bacillus anthracis str. A2012	NC_003995	NP_654321.1
BA_4156	n.d.	Bacillus anthracis str. A2012	NC_003995	NP_657516.1
BA3668	n.d.	Bacillus anthracis str. Ames	AE017035 NC_003997	AAP27417.1 NP_845931.1	Q81Y89
BA0385 (chitinase B)	n.d.	Bacillus anthracis str. Ames	AE017025 NC_003997	AAP24415.1 NP_842929.1	Q81Z87
BA3854 (Chi36)	n.d.	Bacillus anthracis str. Ames	AE017036 NC_003997	AAP27590.1 NP_846104.1	Q81WW1
GBAA0385	n.d.	Bacillus anthracis str. Ames 0581	AE017334	AAT29480.1
GBAA3668	n.d.	Bacillus anthracis str. Ames 0581	AE017334	AAT32777.1
GBAA3854 (Chi36)	n.d.	Bacillus anthracis str. Ames 0581	AE017334	AAT32966.1
BAS0371	n.d.	Bacillus anthracis str. Sterne	AE017225	AAT52702.1
BAS3402	n.d.	Bacillus anthracis str. Sterne	AE017225	AAT55709.1
BAS3571	n.d.	Bacillus anthracis str. Sterne	AE017225	AAT55875.1
chitinase CH (ChiCH)	3.2.1.14	Bacillus cereus 28-9	AF510723	AAP47142.1	Q7X4L4
chitinase CW (ChiCW)	3.2.1.14	Bacillus cereus 28-9	AF416570	AAM48520.2	Q8KVU8
BCE0497	n.d.	Bacillus cereus ATCC 10987	AE017265 NC_003909	AAS39432.1 NP_976824.1
BCE3627	n.d.	Bacillus cereus ATCC 10987	AE017275 NC_003909	AAS42532.1 NP_979924.1
BCE3753 (Chi36)	n.d.	Bacillus cereus ATCC 10987	AE017276 NC_003909	AAS42658.1 NP_980050.1
exochitinase (BC3725)	3.2.1.14	Bacillus cereus ATCC 14579	AE017010 NC_004722	AAP10651.1 NP_833450.1	Q81A65
endochitinase (BC0429)	n.d.	Bacillus cereus ATCC 14579	AE016999 NC_004722	AAP07469.1 NP_830268.1	Q81IF9
BC3607	n.d.	Bacillus cereus ATCC 14579	AE017009 NC_004722	AAP10540.1 NP_833339.1	Q81AG3
chitinase B	3.2.1.14	Bacillus cereus CH	AB041932	BAB16891.1	Q9FAC8
chitinase A	3.2.1.14	Bacillus cereus CH	AB041931	BAB16890.1	Q9FAC9
cortical fragment-lytic enzyme (CFLE;SleL)	n.d.	Bacillus cereus IFO13579	AB029921	BAA92376.1
chitinase (ChiNCTU2)	3.2.1.14	Bacillus cereus NCTU2				cryst
Bcer98_0373	n.d.	Bacillus cereus subsp. cytotoxis NVH 391-98	CP000764	ABS20731.1
Bcer98_2256	n.d.	Bacillus cereus subsp. cytotoxis NVH 391-98	CP000764	ABS22505.1
BTZK3314	n.d.	Bacillus cereus ZK	CP000001	AAU16950.1
BTZK3135	n.d.	Bacillus cereus ZK	CP000001	AAU17127.1
BTZK3483 (ChiA)	3.2.1.14 3.2.1.132	Bacillus cereus ZK	CP000001	AAU16783.1
BTZK0359 (ChiA)	3.2.1.14	Bacillus cereus ZK	CP000001	AAU19880.1
ChiS	n.d.	Bacillus cf. subtilis SG2	DQ355512	ABC86581.1
chitinase (Chi1)	3.2.1.14	Bacillus circulans C-2	AF265220	AAF74782.1	Q9KHB3
chitinase (Chi41)	3.2.1.14	Bacillus circulans No. 4.1	AF154827	AAF23368.1	Q9RG51
chitinase A1 (ChiA;ChiA1)	3.2.1.14	Bacillus circulans WL-12	M57601 - - -	AAA81528.1 ABE17206.1 ABE17682.1 ABH92206.1	P20533	1ITX	[A]
chitinase D (ChiD)	3.2.1.14	Bacillus circulans WL-12	- - - D10594	ABE17207.1 ABE17683.1 ABH92207.1 BAA34114.1	P27050
chitinase C1 (ChiC)	3.2.1.14	Bacillus circulans WL-12	D89568	BAA13974.1	P94289
ABC0646	n.d.	Bacillus clausii KSM-K16	AP006627	BAD63185.1
ABC3113	n.d.	Bacillus clausii KSM-K16	AP006627	BAD65647.1
chitinase (Chi55)	3.2.1.14	Bacillus ehimensis EAG3	AB110080	BAC76692.1	Q7X5M0
chitinase (Chi80)	n.d.	Bacillus ehimensis EAG3	AB110082	BAC76694.1	Q7X5L8
chitinase (Chi60)	n.d.	Bacillus ehimensis EAG3	AB110081	BAC76693.1	Q7X5L9
BH0916	n.d.	Bacillus halodurans C-125	AP001510 NC_002570	BAB04635.1 NP_241782.1	Q9KED7
BH2292	n.d.	Bacillus halodurans C-125	AP001515	BAB06011.1
unnamed protein product	n.d.	Bacillus licheniformis	AX930154	CAF03885.1
chitinase (Chi)	3.2.1.14	Bacillus licheniformis	U71214	AAB47847.1	P94339
unnamed protein product (probable fragment)	n.d.	Bacillus licheniformis	AX930152	CAF03884.1
chitinase B	n.d.	Bacillus licheniformis A1	EU314720	ABY40373.1
BLi00025 or BL02368 (YdhD)	n.d.	Bacillus licheniformis DSM 13 ATCC 14580	CP000002 AE017333	AAU21664.1 AAU39010.1
chitinase 1 (Chi;Chi1;BLi00338;BL01685)	3.2.1.14	Bacillus licheniformis DSM 13 ATCC 14580	CP000002 AE017333 CP000002 AX954773	AAU21943.1 AAU39296.1 AAU21943.2 CAF05579.1
BLi01952 or BL00455 (YdhD)	n.d.	Bacillus licheniformis DSM 13 ATCC 14580	CP000002 AE017333	AAU23483.1 AAU40846.1
BLi00339 or BL01686	n.d.	Bacillus licheniformis DSM 13 ATCC 14580	CP000002 AE017333	AAU21944.1 AAU39297.1
ChiA (fragment)	n.d.	Bacillus licheniformis F11	AM183794	CAJ70727.1