CAZy ~ Carbohydrate-Active enZymes


   
Glycoside Hydrolase Family 12
  
Known Activitiesendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); -1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
 
MechanismRetaining
 
Catalytic Nucleophile/BaseGlu (experimental)
 
Catalytic Proton DonorGlu (experimental)
 
3D Structure StatusFold: -jelly roll
 
ClanGH-C
 
Noteformerly known as cellulase family H.
 
Relevant LinksHOMSTRAD   InterPro   PFAM   
 
StatisticsCAZy Entries (151);  GenBank/GenPept (289);  Uniprot (46);  3D(9) : PDB(21); cryst(1);
 
TaxonomyArchaea(11);  Bacteria(64);  Eukaryota(76);  
 
3D DisplayGH12_3D
 
       
        Archaea          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
Cmaq_1621  

Caldivirga maquilingensis IC-167 ABW02444.1
   
Cmaq_0847  

Caldivirga maquilingensis IC-167 ABW01682.1
   
Cmaq_1988  

Caldivirga maquilingensis IC-167 ABW02804.1
   
Cmaq_0848  

Caldivirga maquilingensis IC-167 ABW01683.1
   
endo-1,4-glucanase A (EglA;PF0854) - Cel123.2.1.4
Pyrococcus furiosus DSM 3638 AAD54602.1
AAE50601.1
AAL80978.1
NP_578583.1
AAM56799.1
AAW12536.1
ABJ38334.1
Q9V2T0
  
Saci_1852  

Sulfolobus acidocaldarius DSM 639 AAY81158.1
   
cellulase (CelS) 3.2.1.4
Sulfolobus solfataricus MT4CAC39483.1
   
endoglucanase / xylanase (SSO1354) 3.2.1.4

3.2.1.8
Sulfolobus solfataricus P2 AAK41590.1
NP_342800.1
Q97YG7
  
endo-1,4-glucanase (SSO1949) 3.2.1.4
Sulfolobus solfataricus P2 AAK42142.1
NP_343352.1
Q97X08
  
cellulase (CelB;SSO2534) 3.2.1.4
Sulfolobus solfataricus P2 CAC24331.1
AAK42663.1
NP_343873.1
   
Tpen_1681  

Thermofilum pendens Hrk 5 ABL79076.1
   
       
        Bacteria          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
endoglucanase (GuxA) 3.2.1.4
Acidothermus cellulolyticus ABH87623.1
ABH87625.1
ABH87626.1
ABH87627.1
ABH87628.1
ABH87629.1
ABH87630.1
ABH87635.1
   
Acel_0615  

Acidothermus cellulolyticus 11B ATCC 43068ABK52388.1
   
Acel_0619  

Acidothermus cellulolyticus 11B ATCC 43068ABK52392.1
   
Sequence 21 from patent US 7094588  

Actinomycetales ABJ29232.1
   
endo--1,4-glucanase (Cel12A) - Cel12A3.2.1.4
Bacillus licheniformis GXN151AAP44491.1
Q7X4S4
  
endo--1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) - Cel12A3.2.1.151

3.2.1.4
Bacillus licheniformis ATCC 14580AAU24774.1
AAU42138.1
 2JEM
2JEN
A
A
blr1656  

Bradyrhizobium japonicum USDA 110 USDA110BAC46921.1
NP_768296.1
Q89TW7
  
blr1964  

Bradyrhizobium japonicum USDA 110 USDA110AAG60937.1
BAC47229.1
NP_768604.1
Q9AN41
  
Bphy_7773  

Burkholderia phymatum STM815 ACC76656.1
   
Cphy_1640  

Clostridium phytofermentans ISDg ABX42012.1
   
pRALTA_0250  

Cupriavidus taiwanensis LMG 19424CAP63926.1
   
cellulase  

Dictyoglomus AAE50602.1
   
DICTH_0465  

Dictyoglomus thermophilum H-6-12 H-6-12; ATCC 35947ACI19111.1
   
Dtur_0628  

Dictyoglomus turgidum DSM 6724 ACK41916.1
   
Mb1120 (CelA2b) (fragment)  

Mycobacterium bovis AF2122/97 CAD93981.1
NP_854776.1
   
BCG_1150 (fragment)  

Mycobacterium bovis BCG str. Pasteur 1173P2 CAL71137.1
   
MT1122 (fragment)  

Mycobacterium tuberculosis CDC1551 AAK45379.1
NP_335565.1
   
TBFG_11111 (fragment)  

Mycobacterium tuberculosis F11 ABR05454.1
   
MRA_1101 (fragment)  

Mycobacterium tuberculosis H37Ra ABQ72837.1
   
Rv1090 (fragment)  

Mycobacterium tuberculosis H37Rv CAA17206.1
NP_215606.1
O53438
  
endo-cellulase (Eg003)  

Paenibacillus sp. EC003 BAG68846.1
   
ECA2827 (CelB)  

Pectobacterium atrosepticum SCRI1043 CAG75727.1
   
endo-1,4-glucanase S 3.2.1.4
Pectobacterium carotovorum SCC3193AAA24817.1
AAR63651.1
AAR67704.1
ABJ29235.1
P16630
  
endo-1,4-glucanase B (CelB) 3.2.1.4
Pectobacterium carotovorum subsp. carotovorum LY34AAC02965.2
O31030
  
cellulase A (CelA) - Cel12A3.2.1.4
Rhodothermus marinus ITI378AAB65594.1
AAR63650.1
AAR67703.1
ABJ29234.1
O33897
1H0B
2BW8
2BWA
2BWC
3B7M
A
A
A
A
D
Sare_4899  

Salinispora arenicola CNS-205 ABW00649.1
   
Strop_4424  

Salinispora tropica CNB-440 ABP56852.1
   
ORF Orf70 (fragment)  

Sinorhizobium meliloti SM11ABN47076.1
   
ORF51  

Sinorhizobium meliloti ABA56022.1
   
sce5731  

Sorangium cellulosum 'So ce 56' SO CE56CAN95894.1
   
SAML1173  

Streptomyces ambofaciens ATCC 23877 CAJ90159.1
   
SAV2568 (CelA4)  

Streptomyces avermitilis MA-4680 BAC70279.1
NP_823744.1
   
SAV2571  

Streptomyces avermitilis MA-4680 BAC70282.1
NP_823747.1
   
SAV555 (CelA1)  

Streptomyces avermitilis MA-4680 BAC68265.1
NP_821730.1
   
SCO5691 or SC5H4.15  

Streptomyces coelicolor A3(2) CAB91127.1
NP_629819.1
Q9KYS4
  
SCO1187 (CelB;SCG11A.18)  

Streptomyces coelicolor A3(2) CAB61599.1
NP_625477.1
Q9RJY3
  
endo-1,4-glucanase (CelA2;Cel2) 3.2.1.4
Streptomyces halstedii JM8AAC45429.1
O08468
  
endo-1,4-glucanase 3.2.1.4
Streptomyces lividans 1326AAB71950.1
AAR63649.1
AAR67702.1
ABH87634.1
ABJ29233.1
Q54331
1NLR
2NLR
A
A
cellulase (11AG8) 3.2.1.4
Streptomyces lividans TK23AAQ31831.1
ABH87633.1
   
endo-1,4-glucanase S (EglS) 3.2.1.4
Streptomyces rochei A2CAA52139.1
Q59963
  
cellulase 12A - Cel12A3.2.1.4
Streptomyces sp. 11AG8 AAF91283.1
AAE59731.1
AAQ25310.1
AAQ31830.1
AAR63648.1
AAR67701.1
Q9KIH1
1OA4
A
endo-1,4-glucanase S1 (CelS1) 3.2.1.4
Streptomyces viridosporus T7AAAD25090.1
Q9X602
  
endo-1,4-glucanase A (CelA;TM1524) - Cel12A3.2.1.4
Thermotoga maritima MSB8 CAA93273.1
AAD36591.1
NP_229324.1
Q60032
Q9S5X8
  
endo-1,4-glucanase B (CelB;TM1525) - Cel12B3.2.1.4
Thermotoga maritima MSB8 CAA93274.1
AAD36592.1
NP_229325.1
Q60033
  
endo-1,4-glucanase A (CelA) 3.2.1.4
Thermotoga neapolitana CAB06783.1
AAC95059.1
P96491
O08428
  
endo-1,4-glucanase B (CelB) 3.2.1.4
Thermotoga neapolitana CAB06782.1
AAC95060.1
P96492
  
Tpet_1267  

Thermotoga petrophila RKU-1 ABQ47281.1
   
Tpet_1268  

Thermotoga petrophila RKU-1 ABQ47282.1
   
TRQ2_1188  

Thermotoga sp. RQ2 ACB09532.1
   
TRQ2_1187  

Thermotoga sp. RQ2 ACB09531.1
   
XAC3507 + XAC3506 (CelS) (two fragments)  

Xanthomonas axonopodis pv. citri str. 306 AAM38349.1
AAM38350.1
NP_643813.1
NP_643814.1
   
xcc-b100_0819  

Xanthomonas campestris pv. campestris B100CAP50160.1
   
xcc-b100_0818  

Xanthomonas campestris pv. campestris B100CAP50159.1
   
XC_0784  

Xanthomonas campestris pv. campestris str. 8004 AAY47862.1
   
XC_0783  

Xanthomonas campestris pv. campestris str. 8004 AAY47861.1
   
CelS  

Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42651.1
NP_638727.1
   
XCC3380  

Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42650.1
NP_638726.1
   
XCV3634 (CelS)  

Xanthomonas campestris pv. vesicatoria str. 85-10 CAJ25365.1
   
XOO1077  

Xanthomonas oryzae pv. oryzae KACC10331 AAW74331.1
   
XOO1076 (CelS)  

Xanthomonas oryzae pv. oryzae KACC10331 AAW74330.1
   
XOO0977  

Xanthomonas oryzae pv. oryzae MAFF 311018 BAE67732.1
   
XOO0976  

Xanthomonas oryzae pv. oryzae MAFF 311018 BAE67731.1
   
PXO_02431  

Xanthomonas oryzae pv. oryzae PXO99A ACD60719.1
   
PXO_02432 (probable fragment)  

Xanthomonas oryzae pv. oryzae PXO99A ACD60720.1
   
       
        Eukaryota          
ProteinEC#OrganismGenBank/GenPeptUniProtPDB/3D
endo-1,4-glucanase 1 (FI CM-cellulase;FI-CMCase) 3.2.1.4
Aspergillus aculeatus F-50CAA36757.1
BAA00435.1
AAR63632.1
AAR67685.1
ABJ29216.1
P22669
cryst 
endo-1,4-glucanase (xyloglucan-specific) (XEG1) 3.2.1.151
Aspergillus aculeatus KSM 510AAD02275.1
O94218
  
xyloglucanase 2 (XEG2) (fragment)  

Aspergillus aculeatus AAO20340.1
   
endoglucanase - Cel12B3.2.1.4
Aspergillus kawachii IFO 4308AAM77715.1
AAR63634.1
AAR67687.1
ABJ29218.1
Q8NJY2
  
endo-1,4-glucanase (CekA) 3.2.1.4
Aspergillus kawachii IFO 4308BAA02297.1
AAR63633.1
AAR67686.1
ABJ29217.1
Q12679
  
endo-1,4-glucanase (xyloglucan-specific) (AN0452.2) 3.2.1.151
Aspergillus nidulans FGSC A4 EAA66551.1
ABF50842.1
   
endo-1,4-glucanase (EglA) 3.2.1.4
Aspergillus niger CBS 120.49 / N400CAA03652.1
CAA03657.1
CAA11964.1
AAE60101.1
AAE84291.1
CAG17891.1
O74705
1KS4
1KS5
A
A
xyloglucan-specific endo--1,4-glucanase - Xeg12A3.2.1.151
Aspergillus niger N402ABF46829.1
   
An01g03340  

Aspergillus niger CBS 513.88 CAK36874.1
   
An14g02760 (EglA) 3.2.1.4
Aspergillus niger CBS 513.88 CAK46524.1
   
An03g05530  

Aspergillus niger CBS 513.88 CAG17892.1
CAK38314.1
   
An03g05380  

Aspergillus niger CBS 513.88 CAK38300.1
   
endo-1,4-glucanase (CelA;AO090026000102) 3.2.1.4
Aspergillus oryzae RIB 40BAE59597.1
   
AO090003000905  

Aspergillus oryzae RIB 40BAE58022.1
   
AO090701000185  

Aspergillus oryzae RIB 40BAE61926.1
   
AO090038000175  

Aspergillus oryzae RIB 40BAE64005.1
   
endo-1,4-glucanase (CelA) 3.2.1.4
Aspergillus oryzae KBN616BAA22588.1
AAR63635.1
AAR67688.1
ABJ29219.1
O13454
  
endoglucanase - Cel12D3.2.1.4
Bionectria ochroleuca 1003AAM77709.1
AAR63645.1
AAR67698.1
ABJ29229.1
Q8NJY8
  
endoglucanase - Cel12B3.2.1.4
Bionectria ochroleuca 1003AAM77707.1
AAR63643.1
AAR67696.1
ABJ29227.1
Q8NJZ0
  
cellulase 3.2.1.4
Bionectria ochroleuca AAR63642.1
AAR67695.1
ABJ29226.1
   
endoglucanase - Cel12A3.2.1.4
Bionectria ochroleuca 1003AAM77706.1
Q8NJZ1
  
endoglucanase - Cel12C3.2.1.4
Bionectria ochroleuca 1003AAM77708.1
AAR63644.1
AAR67697.1
ABJ29228.1
Q8NJY9
  
endoglucanase - Cel12A3.2.1.4
Chaetomium brasiliense CBS 140.50AAM77701.1
AAR63638.1
AAR67691.1
ABJ29222.1
Q8NJZ6
  
endoglucanase (EG3) 3.2.1.4
Chrysosporium lucknowense AAQ38148.1
ACH15006.1
   
mixed -1,3-1,4-glucanase (Mlg2) 3.2.1.73
Cochliobolus carbonum AAF65311.1
Q9P8N6
  
cellulase (C173)  

Thielavia heterothallica CBS 117.65AAN94974.1
   
orf  

Diaphorina citri ABG82005.1
   
endoglucanase - Cel12A3.2.1.4
Emericella desertorum CBS 653.73AAM77702.1
AAR63647.1
AAR67700.1
ABJ29231.1
Q8NJZ5
  
endoglucanase (EG35) - Cel123.2.1.4
Fomitopsis palustris FFPRI 0507BAF49602.1
   
endoglucanase - Cel12A3.2.1.4
Fusarium equiseti CBS 185.34AAM77703.1
AAR63639.1
AAR67692.1
ABJ29223.1
Q8NJZ4
  
endo-1,4--glucanase (fragments) - Cel12A3.2.1.4
Gloeophyllum trabeum  P84196
P84196
  
endoglucanase - Cel12A3.2.1.4
Humicola grisea ATCC 22081AAM77714.2
AAR63636.1
AAR63637.1
AAR67689.1
AAR67690.1
ABJ29220.1
ABJ29221.1
 1OLR
1UU4
1UU5
1UU6
1W2U
A
A
A
A
A
endo-1,4-glucanase III (Egl3;EGIII;EG III) - Cel12A3.2.1.4
Hypocrea jecorina QM9414BAA20140.1
AAE59774.1
AAE59775.1
AAN19479.1
AAN19480.1
AAO95538.1
AAO95539.1
AAQ24888.1
AAQ42100.1
AAQ42101.1
AAR60524.1
AAR63629.1
AAR63630.1
AAR67682.1
AAR67683.1
ABE22099.1
ABJ29213.1
ABJ29214.1
ABV71388.1
O00095
1H8V
1OA2
1OLQ
C
C
A
endoglucanase - Cel12A3.2.1.4
Hypocrea koningii ATCC 2613AAM77712.1
Q8NJY5
  
endogluanase III  

Hypocrea pseudokoningii ABM90985.1
   
endoglucanase - Cel12A3.2.1.4
Hypocrea schweinitzii ATCC 66965AAE59776.1
AAM77711.1
AAN19481.1
AAO95540.1
AAQ42102.1
AAR63631.1
AAR67684.1
ABJ29215.1
Q8NJY6
1OA3
C
xyloglucan endotransglycosylase (XET) 2.4.1.207
Macrophomina phaseolina AAN89225.1
AAS22565.1
   
MG08537.4  

Magnaporthe grisea 70-15 XP_362900.1
   
MG10972.4  

Magnaporthe grisea 70-15 XP_361895.1
   
MG00677.4  

Magnaporthe grisea 70-15