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Polysaccharide Lyase Family 8

Known Activitieshyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20)
3D Structure Status(a/a)6 barrel + anti-parallel b-sheet
External resourcesInterPro; PFAM;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (375); Uniprot accession (191); PDB accession (44); 3D entries (9); cryst (1)
Summary
All (315) Archaea (1) Bacteria (314) Structure (9 - 1 cryst) Characterized (26) Subfamilies (174)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D Subf
 SA2981_2139 (HysA)   Staphylococcus aureus 04-02981 ADC38350.1 D3EYM7   1
 hyaluronate lyase (HysA) 4.2.2.1 Staphylococcus aureus 8325-4 AAA82984.1 Q59801   1
 SAB1663   Staphylococcus aureus RF122 CAI81352.1 Q2YTM9   1
 SAB2082   Staphylococcus aureus RF122 CAI81771.1 Q2YYI7   1
 MS7_2224   Staphylococcus aureus subsp. aureus 11819-97 AEW66178.1     1
 ST398NM01_1880   Staphylococcus aureus subsp. aureus 71193 AFH70038.1     1
 ST398NM01_2262   Staphylococcus aureus subsp. aureus 71193 AFH70453.1     1
 SA2194   Staphylococcus aureus subsp. aureus COL AAW37070.1 Q5HE02   1
 ECTR2_2063   Staphylococcus aureus subsp. aureus ECT-R 2 CBX35392.1 E5R9T7   1
 SAOV_2247   Staphylococcus aureus subsp. aureus ED133 ADI98688.1 D8HDV0   1
 SAAV_2263   Staphylococcus aureus subsp. aureus ED98 ACY12098.1 D0K7K4   1
 SAEMRSA15_21070 (Hysa2)   Staphylococcus aureus subsp. aureus HO 5096 0412 CCG16818.1     1
 SaurJH1_2271   Staphylococcus aureus subsp. aureus JH1 ABR53099.1 A6U3T1   1
 SaurJH9_2232   Staphylococcus aureus subsp. aureus JH9 ABQ50013.1 A5IUZ0   1
 SAA6159_01731   Staphylococcus aureus subsp. aureus JKD6159 ADL23664.1 D9RI92   1
 SAA6159_02114   Staphylococcus aureus subsp. aureus JKD6159 ADL24036.1 D9RC72   1
 SARLGA251_16860 (HysA)   Staphylococcus aureus subsp. aureus LGA251 CCC88453.1     1
 SARLGA251_19960 (HysA)   Staphylococcus aureus subsp. aureus LGA251 CCC88761.1     1
 M013TW_2169   Staphylococcus aureus subsp. aureus M013 AEV79162.1     1
 M013TW_1815 (fragment)   Staphylococcus aureus subsp. aureus M013 AEV78865.1     1
 SAR2292 (HysA2)   Staphylococcus aureus subsp. aureus MRSA252 CAG41271.1 Q6GEM7   1
 SAR1892 (HysA1)   Staphylococcus aureus subsp. aureus MRSA252 CAG40881.1 Q6GFP8   1
 SAMSHR1132_20330   Staphylococcus aureus subsp. aureus MSHR1132 CCE59861.1     1
 SAS2103   Staphylococcus aureus subsp. aureus MSSA476 CAG43912.1 Q6G7B1   1
 SAHV_2186   Staphylococcus aureus subsp. aureus Mu3 BAF79069.1 A7X590   1
 SAV2202 (HysA)   Staphylococcus aureus subsp. aureus Mu50 BAB45130.1
BAB58364.1
NP_372726.1		 Q99S67   1
 MW2129 (HysA)   Staphylococcus aureus subsp. aureus MW2 BAB95994.1
NP_646946.1		 Q8NVC3   1
 SA2003 (HysA)   Staphylococcus aureus subsp. aureus N315 BAB43294.1
NP_375315.1		 Q7A486   1
 SAOUHSC_02463   Staphylococcus aureus subsp. aureus NCTC 8325 ABD31483.1 Q59801   1
 SAPIG1880   Staphylococcus aureus subsp. aureus ST398 CAQ50304.1 D2N8F6   1
 SAPIG2262   Staphylococcus aureus subsp. aureus ST398 CAQ50642.1 D2N9E4   1
 SAA6008_02243 (HysA)   Staphylococcus aureus subsp. aureus str. JKD6008 ADL66257.1 D9RPN3   1
 NWMN_2106   Staphylococcus aureus subsp. aureus str. Newman BAF68378.1 A6QJ46   1
 SAT0131_02378   Staphylococcus aureus subsp. aureus T0131 AEB89302.1     1
 HMPREF0772_10989 (HysA)   Staphylococcus aureus subsp. aureus TCH60 ADQ76451.1 E5QQN6   1
 HMPREF0772_11345 (Hysa2)   Staphylococcus aureus subsp. aureus TCH60 ADQ76807.1 E5QTA9   1
 SATW20_23400 (HysA)   Staphylococcus aureus subsp. aureus TW20 CBI50206.1 D1GRH5   1
 SAUSA300_2161   Staphylococcus aureus subsp. aureus USA300 FPR3757 ABD22109.1     1
 USA300HOU_2197   Staphylococcus aureus subsp. aureus USA300_TCH1516 ABX30190.1 A8Z313   1
 SAVC_09900   Staphylococcus aureus subsp. aureus VC40 AEZ38132.1     1
 SAG1197   Streptococcus agalactiae 2603V/R serotype V AAN00079.1
NP_688206.1		     1
 hyaluronate lyase (HylB) 4.2.2.1 Streptococcus agalactiae 4755 CAA75865.1 O86478   1
 SAK_1284 (HylB)   Streptococcus agalactiae A909 ABA45106.1     1
 Gbs1270   Streptococcus agalactiae NEM316 serovar III CAD46929.1
NP_735714.1		     1
 hyaluronate lyase 4.2.2.1 Streptococcus agalactiae TYPE III / GBS 3502 AAA56749.1 Q53591 1F1S[A]
1I8Q[A]
1LXM[A]		 1
 hyaluronate lyase (Hyl) (fragment)   Streptococcus agalactiae VMC-57 AEV45786.1     1
 hyaluronate lyase, partial (HylB) (fragment)   Streptococcus agalactiae VMC17 AEV45782.1     1
 hyaluronate lyase (Hyl) (fragment)   Streptococcus agalactiae VMC31 AEV45787.1     1
 hyaluronate lyase (HylB) (fragment)   Streptococcus agalactiae VMC55 AEK20863.1     1
 hyaluronate lyase (HylB) (fragment)   Streptococcus agalactiae VMC90 AEL88241.1     1
 ORF   Streptococcus anginosus MAS624 AAQ73521.1 Q6W9E0   1
 hyaluronate lyase 4.2.2.1 Streptococcus constellatus subsp. constellatus ATCC 27823 AAK67165.1 Q934I5   1
 ORF   Streptococcus constellatus subsp. pharyngis MM9889A AAQ73523.1 Q6W9D8   1
 SDE12394_03510   Streptococcus dysgalactiae subsp. equisimilis ATCC 12394 ADX24222.1     1
 SDEG_0654 (HylB)   Streptococcus dysgalactiae subsp. equisimilis GGS_124 BAH81156.1 C5WFJ1   1
 hyaluronidase (Hyl)   Streptococcus equi subsp. zooepidemicus ACT33447.1 C7E667   1
 hyaluronidase   Streptococcus equi subsp. zooepidemicus ATCC 35246 ACH78324.1 B5TE63   1
 hyaluronidase (Hyl) 4.2.2.1 Streptococcus equi subsp. zooepidemicus CVCC23362 ABV69920.1 A8HJR5   1
 SZO_06680   Streptococcus equi subsp. zooepidemicus H70 CAW98747.1     1
 Sez_1299   Streptococcus equi subsp. zooepidemicus MGCS10565 ATCC BAA1716 ACG62635.1 B4U3R8   1
 hyaluronate lyase 4.2.2.1 Streptococcus intermedius ATCC 27335 AAK67167.1 Q934I4   1
 STP_1167   Streptococcus parauberis KCTC 11537 AEF25615.1     1
 Sequence 4843 from patent US 6800744   Streptococcus pneumoniae AAW09447.1
ABI03997.1
ABI09038.1
ABJ32554.1
ABJ50167.1
ABL17910.1		     1
 SP670_0382   Streptococcus pneumoniae 670-6B ADM90457.1 E0TRJ4   1
 SP70585_0379   Streptococcus pneumoniae 70585 ACO16655.1 C1CB94   1
 SPAP_0347   Streptococcus pneumoniae AP200 ADM83940.1 E0SVG1   1
 SPN23F02890   Streptococcus pneumoniae ATCC 700669 CAR68147.1 B8ZL35   1
 SPCG_0322   Streptococcus pneumoniae CGSP14 ACB89574.1 B2ISN7   1
 SPD_0287   Streptococcus pneumoniae D39 ABJ54273.1 Q04ME3   1
 SPG_0285 (HyL)   Streptococcus pneumoniae G54 ACF54992.1 B5E6X4   1
 SPH_0426   Streptococcus pneumoniae Hungary19A-6 ACA36441.1 B1I936   1
 INV104_02610   Streptococcus pneumoniae INV104 CBW35945.1 E1XPE8   1
 SPNINV200_02820   Streptococcus pneumoniae INV200 CBW33916.1 E1XHX5   1
 SPJ_0310   Streptococcus pneumoniae JJA ACO18875.1 C1CC91   1
 SPP_0350   Streptococcus pneumoniae P1031 ACO21275.1 C1CII1   1
 hyaluronate lyase (HysA) 4.2.2.1 Streptococcus pneumoniae R6 AAA53685.1
AAA53686.1
AAK99090.1
AAT16666.1
ACK14456.1
ACW45175.1
NP_357880.1		 Q8CWU3 1C82[A]
1EGU[A]
1F9G[A]
1LOH[A]
1LXK[A]
1N7N[A]
1N7O[A]
1N7P[A]
1N7Q[A]
1N7R[A]
1OJM[A]
1OJN[A]
1OJO[A]
1OJP[A]
1W3Y[A]
2BRP[A]
2BRV[X]
2BRW[A,B]		 1
 MYY_0397   Streptococcus pneumoniae ST556 AFC94059.1     1
 SPT_0364   Streptococcus pneumoniae Taiwan19F-14 ACO22630.1 C1CPJ1   1
 HMPREF0837_10617   Streptococcus pneumoniae TCH8431/19A ADI68845.1 D6ZQF6   1
 hyaluronate lyase (SP0314) 4.2.2.1 Streptococcus pneumoniae TIGR4 AAK74491.1
NP_344851.1		 Q54873.2   1
 hyaluronate lyase (HylA) 4.2.2.1 Streptococcus pyogenes AAF29533.1 Q9L7W9   1
 HylA   Streptococcus pyogenes 1020 ABU63951.1 A7XFV6   1
 HylA   Streptococcus pyogenes 1055 ABU63942.1 A7XFU7   1
 HylA   Streptococcus pyogenes 2397 ABU63950.1 A7XFV5   1
 HylA   Streptococcus pyogenes 3200 ABU63939.1 A7XFU4   1
 HylA   Streptococcus pyogenes 350 ABU63943.1 A7XFU8   1
 HylA   Streptococcus pyogenes 3779 ABU63952.1 A7XFV7   1
 HylA   Streptococcus pyogenes 422 ABU63944.1 A7XFU9   1
 HylA   Streptococcus pyogenes 4282 ABU63947.1 A7XFV2   1
 HylA   Streptococcus pyogenes 4283 ABU63940.1 A7XFU5   1
 HylA   Streptococcus pyogenes 437 ABU63946.1 A7XFV1   1
 HylA   Streptococcus pyogenes 445 ABU63941.1 A7XFU6   1
 HylA   Streptococcus pyogenes 4786 ABU63945.1 A7XFV0   1
 HylA   Streptococcus pyogenes 6219 ABU63938.1 A7XFU3   1
 HylA   Streptococcus pyogenes 872 ABU63948.1 A7XFV3   1
 HylA   Streptococcus pyogenes 94146 ABU63949.1 A7XFV4   1
 SPYALAB49_000782   Streptococcus pyogenes Alab49 AEQ24382.1     1
 SPY1032 (HylA)   Streptococcus pyogenes M1 GAS SF370 AAK33924.1
NP_269203.1		 Q99ZX4   1
 MGAS10270_Spy0874 (HylA)   Streptococcus pyogenes MGAS10270 ABF33939.1 Q1JH55   1
 M6_Spy0782   Streptococcus pyogenes MGAS10394 AAT86917.1     1
 MGAS10750_Spy0909 (HylA)   Streptococcus pyogenes MGAS10750 ABF37859.1 Q1J6X4   1
 MGAS15252_0784 (HylA)   Streptococcus pyogenes MGAS15252 AFC66130.1     1
 MGAS1882_0780 (HylA)   Streptococcus pyogenes MGAS1882 AFC67994.1     1
 MGAS2096_Spy0831 + MGAS2096_Spy0830 (HylA)   Streptococcus pyogenes MGAS2096 ABF35882.1
ABF35883.1		     1
 HylA   Streptococcus pyogenes MGAS315 AAM79272.1
NP_664469.1		 Q8K7S1   1
 M5005_Spy_0757 (HylA)   Streptococcus pyogenes MGAS5005 AAZ51375.1     1
 M28_Spy0736 (HylA)   Streptococcus pyogenes MGAS6180 AAX71849.1     1
 HylA   Streptococcus pyogenes MGAS8232 AAL97649.1
NP_607150.1		 Q8P183   1
 MGAS9429_Spy0871 (HylA)   Streptococcus pyogenes MGAS9429 ABF32059.1 Q1JM10   1
 Spy49_0811c (HylA)   Streptococcus pyogenes NZ131 ACI61121.1 B5XLA9   1
 hyaluronidase (HylA)   Streptococcus suis CAG27053.1 Q6H8Y0   1
 hyaluronidase (HylA)   Streptococcus suis CAG27052.1 Q6H8Y1   1
 hyaluronidase (HylA)   Streptococcus suis CAG27068.1 Q6A1P9   1
 SSUA7_1065 (fragment)   Streptococcus suis A7 AER44387.1     1
 SSUA7_1066 (fragment)   Streptococcus suis A7 AER44388.1     1
 SSUD9_1371   Streptococcus suis D9 AER17555.1     1
 hyaluronidase   Streptococcus suis HA1001111 ADO66679.1 E3UN55   1
 hyaluronidase   Streptococcus suis HA1001112 ADO66680.1 E3UN56   1
 SSUJS14_1182 + SSUJS14_1181 (fragments)   Streptococcus suis JS14 ADV70253.1
ADV70254.1		     1
 HylA 4.2.2.1 Streptococcus suis P5/11/88 CAC87663.1 Q8VLQ7   1
 hyaluronidase (HylA)   Streptococcus suis SEROTYPE 2 CAG27048.1
CAG27049.1		 Q6H8Y3
Q6H8Y4		   1
 hyaluronidase (HylA)   Streptococcus suis SEROTYPE 2 CAG27050.1 Q6H8Y2
Q6H8Y4		   1
 hyaluronidase (HylA) 4.2.2.1 Streptococcus suis SEROTYPE 7 CAC87662.1 Q8VLQ8   1
 SSUST1_0748   Streptococcus suis ST1 AER21132.1     1
 SSUST3_1226   Streptococcus suis ST3 AEB81651.1     1
 heparinase (Hep)   Bacillus circulans BAB91369.1 Q8KKH9   2
 Bache_0583   Bacteroides helcogenes P 36-108 ATCC 35417 ADV42608.1     2
 BT3324 4.2.2.20 Bacteroides thetaiotaomicron VPI-5482 AAO78430.1
NP_812236.1		 Q8A2I1   2
 lyase 2 (CsuB;BT3350)   Bacteroides thetaiotaomicron VPI-5482 AAA99039.1
AAO78456.1
NP_812262.1		 Q45773   2
 chondroitin sulfate ABC lyase 4.2.2.20 Bacteroides thetaiotaomicron WAL2926 ABV21364.1 C5G6D7 2Q1F[A,B] 2
 BXY_25910   Bacteriodes xylanisolvens XB1A CBK67635.1 D6CZN3   2
 BXY_26470   Bacteriodes xylanisolvens XB1A CBK67690.1 D6CZT8   2
 NT01EI_3294   Edwardsiella ictaluri 93-146 ACR70433.1 C5B905   2
 NT01EI_3295   Edwardsiella ictaluri 93-146 ACR70434.1 C5B906   2
 ETAE_2917   Edwardsiella tarda EIB202 ACY85750.1 D0ZDX1   2
 ETAE_2918   Edwardsiella tarda EIB202 ACY85751.1 D0ZDX2   2
 ETAF_2650   Edwardsiella tarda FL6-60 ADM42753.1 E0T7G9   2
 ETAF_2651   Edwardsiella tarda FL6-60 ADM42754.1 E0T7H0   2
 PBPRB0153   Photobacterium profundum SS9 CAG22026.1     2
 Sequence 7112 from patent US 6605709   Proteus mirabilis AAR43842.1     2
 Sequence 7181 from patent US 6605709   Proteus mirabilis AAR43911.1     2
 PMI2127   Proteus mirabilis HI4320 CAR44246.1 B4F1D7   2
 PMI2128   Proteus mirabilis HI4320 CAR44248.1 B4F1D8   2
 chondroitin ABC lyase I 4.2.2.20 Proteus vulgaris 2109195A
ABE23097.1
ACN04689.1
ACQ12496.1
ACQ12497.1
ACW17440.1
ACW17441.1
ACY01450.1		 P59807 1HN0[A] 2
 chondroitin ABC lyase II (ChABCII) 4.2.2.20 Proteus vulgaris ATCC 6896 AAB43333.1
ABU46331.1		   cryst 2
 choindroitinase ABC   Proteus vulgaris ATCC 9920D ADK74774.1 E2J154   2
 SARI_02380   Salmonella enterica subsp. arizonae serovar 62:z4,z23:-- RSK2980 ABX22243.1 A9ML73   2
 A1122_00920   Yersinia pestis A1122 AEL70869.1     2
 YpAngola_A3277   Yersinia pestis Angola ABX86633.1 A9R2U7   2
 YPA_0445   Yersinia pestis Antiqua ABG12413.1 Q1CAV9   2
 YPC_0996   Yersinia pestis biovar Medievalis str. Harbin 35 ADV97673.1     2
 YP2832   Yersinia pestis biovar Microtus str. 91001 AAS63015.1
NP_994138.1		     2
 YPO0824   Yersinia pestis CO92 Biovar Orientalis CAC89673.1
CAL19496.1
NP_404448.1		 Q8ZHR1   2
 YPD4_0844   Yersinia pestis D106004 ACY57753.1 D0JGW4   2
 YPD8_0842   Yersinia pestis D182038 ACY61532.1 D0JR01   2
 Y3211   Yersinia pestis KIM AAM86761.1
NP_670510.1		     2
 YPN_3027   Yersinia pestis Nepal516 ABG19354.1 Q1CF76   2
 YPDSF_0688   Yersinia pestis Pestoides F ABP39094.1 A4TII2   2
 YPZ3_0887   Yersinia pestis Z176003 ADE63797.1 D5B2N0   2
 YpsIP31758_0946   Yersinia pseudotuberculosis IP 31758 ABS47913.1 A7FFA2   2
 YPTB3073   Yersinia pseudotuberculosis IP 32953 CAH22311.1     2
 YPTS_3194   Yersinia pseudotuberculosis PB1/+ ACC90149.1 B2JZU6   2
 YPK_0997   Yersinia pseudotuberculosis YPIII ACA67298.1 B1JPP9   2
 chondroitin sulfate lyase AC (CslA) 4.2.2.5 Bacteroides stercoris HJ-15 ABW87764.1 A9Y5J0   3
 BT2964   Bacteroides thetaiotaomicron VPI-5482 AAO78070.1
NP_811876.1		     3
 FCOL_08260   Flavobacterium columnare ATCC 49512 AEW86467.1     3
 chondroitin AC lyase (CslA;ChonAC) 4.2.2.5 Flavobacterium columnare G4 AAX07421.1 Q5EC33   3
 chondroitin AC lyase, partial (CslA)   Flavobacterium columnare MAC102 / G4 AFG23465.1     3
 Niako_2983   Niastella koreensis GR20-10 AEV99313.1     3
 chondroitin AC lyase (CslA;ChnAC;Phep_0786) 4.2.2.5 Pedobacter heparinus DSM 2366 AAC83383.1
ACU03008.1		 Q59288 1CB8[A]
1HM2[A]
1HM3[A]
1HMU[A]
1HMW[A]		 3
 Pedsa_3808   Pedobacter saltans DSM 12145 ADY54337.1     3
 VV21110   Vibrio vulnificus CMCP6 AAO08015.1
NP_763025.1		     3
 VVM_03164   Vibrio vulnificus MO6-24/O ADV89524.1     3
 VVA1636   Vibrio vulnificus YJ016 BAC97662.1
NP_937692.1		 Q7MBV1   3




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