Polysaccharide Lyase Family 7

Activities in Familypoly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); α-L-guluronate lyase / G-specific alginate lyase (EC 4.2.2.11); poly-(MG)-lyase / MG-specific alginate lyase (EC 4.2.2.-); endo-β-1,4-glucuronan lyase (EC 4.2.2.14); oligoalginate lyase / exo-alginate lyase (EC 4.2.2.26)
Mechanism b-elimination
3D Structure Statusβ-jellyroll
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (1779); Uniprot accession (86); PDB accession (15); 3D entries (10); cryst (0)
All (1769) Bacteria (1753) Eukaryota (10) Viruses (6) Structure (10) Characterized (39)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 guluronate lyase (alyPG) 4.2.2.11 Corynebacterium sp. ALY-1 BAA83339.1
ACK10589.1
Q9RB42
1UAI[A] 1.20
3
 Alginate lyase AlgAT5   Defluviitalea    
5ZQI[A] 1.50
3
 alginate lyase (AlyA;FlAlyA) 4.2.2.3 Flavobacterium sp. UMI-01 BAP05660.1  
5Y33[A] 1.54
 poly(α-L-guluronate) lyase (AlyA) 4.2.2.11 Klebsiella pneumoniae subsp. aerogenes AAA25049.1
ACK10577.1
Q59478
4OZX[A] 1.88
5
 alginate lyase (AlyQ) 4.2.2.3 Persicobacter sp. CCB-QB2 WP_053404615.1  
5XNR[A] 2.30
3
 poly-MG alginate lyase (PA1167) 4.2.2.- Pseudomonas aeruginosa PAO1 AAG04556.1
NP_249858.1
Q9I4H0
1VAV[A,B] 2.00
1
 alginate lyase (A1-II';Aly) 4.2.2.- Sphingomonas sp. A1 BAD16656.1 Q75WP3
2CWS[A] 1.00
2Z42[A] 1.60
2ZA9[A] 2.10
2ZAA[A] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA
1.80
2ZAB[A] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA
1.66
2ZAC[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA
1.50
 CBM32_AlyB   Vibrio splendidus    
5ZU5[A] 1.60
5
 exo-alginate lyase (AlyA5;zobellia_4131) 4.2.2.26 Zobellia galactanivorans DsijT CAZ98266.1  
4BE3[A,B] 1.75
5
 endo-guluronate lyase (AlyA1;zobellia_1182) 4.2.2.11 Zobellia galactanivorans DsijT CAZ95239.1  
3ZPY[A,B] 1.43
3
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