Polysaccharide Lyase Family 7

Activities in Familypoly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); α-L-guluronate lyase / G-specific alginate lyase (EC 4.2.2.11); poly-(MG)-lyase / MG-specific alginate lyase (EC 4.2.2.-); endo-β-1,4-glucuronan lyase (EC 4.2.2.14); oligoalginate lyase / exo-alginate lyase (EC 4.2.2.26)
Mechanism b-elimination
3D Structure Statusβ-jelly roll
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (2649); Uniprot accession (46); PDB accession (27); 3D entries (13); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 poly(α-L-guluronate) lyase / G-specific alginate lyase (alyPG) 4.2.2.11 Corynebacterium sp. ALY-1 BAA83339.1
ACK10589.1
Q9RB42
1UAI[A] 1.20
3
 Alginate lyase AlgAT5   Defluviitalea    
5ZQI[A] 1.50
3
 alginate lyase (AlyA;FlAlyA) 4.2.2.3 Flavobacterium sp. UMI-01 BAP05660.1 A0A068PC91
5Y33[A] 1.54
 poly(α-L-guluronate) lyase (AlyA) 4.2.2.11 Klebsiella pneumoniae subsp. aerogenes AAA25049.1
ACK10577.1
Q59478
4OZX[A] 1.88
5
 alginate lyase (AlyQ) 4.2.2.3 Persicobacter sp. CCB-QB2 WP_053404615.1 A0A3B6UEP6
5XNR[A] 2.30
3
 poly-MG alginate lyase (PA1167) 4.2.2.- Pseudomonas aeruginosa PAO1 AAG04556.1
NP_249858.1
Q9I4H0
1VAV[A,B] 2.00
1
 alginate lyase (alyC3) 4.2.2.3 Psychromonas sp.   A0A7M4DUG8
A0A7M4DUG9
7C8F[B] β-D-ManpA-(1-4)-β-D-ManpA
1.46
7C8G[A,B] 2.10
7C8F[A] β-D-ManpA-(1-4)-β-D-ManpA
1.46
 poly(α-L-guluronate) lyase / G-specific alginate lyase (A1-II';Aly) 4.2.2.11 Sphingomonas sp. A1 BAD16656.1 Q75WP3
2CWS[A] 1.00
2Z42[A] 1.60
2ZA9[A] 2.10
2ZAA[A] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA
1.80
2ZAB[A] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA
1.66
2ZAC[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-α-L-GulpA
1.50
 CBM32_AlyB   Vibrio splendidus    
5ZU5[A] 1.60
5
 exo-alginate lyase (AlyA5;zobellia_4131) 4.2.2.26 Zobellia galactanivorans DsijT CAZ98266.1 G0L2Y1
4BE3[A,B] 1.75
5
 endo-guluronate lyase (AlyA1;zobellia_1182) 4.2.2.11 Zobellia galactanivorans DsijT CAZ95239.1 G0LAE1
3ZPY[A,B] 1.43
3
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 alginate lyase (PsAlg7A) 4.2.2.3 Paradendryphiella salina VFY81779.1 A0A485PVH1
6YWF[A] 1.90
7NCZ[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA
1.64
7NL3[A] 1.70
7NM6[A] β-D-ManpA-(1-4)-β-D-ManpA
1.78
7NPP[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA
1.45
7NY3[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA
1.82
7O6H[A] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA
1.66
7OOF[A]
 endo-β-1,4-glucuronan lyase (TpPL7A; A9Z42_0012760) 4.2.2.14 Trichoderma parareesei OTA00986.1  
7NDE[A] 1.45
4
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