Activities in Family	Alginate lyase (EC 4.2.2.-); Oligo-α-L-guluronate lyase / exo-acting α-L-guluronan lyase (EC 4.2.2.-); Poly-(MG)-lyase / MG-specific alginate lyase (EC 4.2.2.-); Poly(α-L-guluronate) lyase / G-specific alginate lyase (EC 4.2.2.11); Chondroitinase B (EC 4.2.2.19); Oligoalginate lyase / exo-alginate lyase (EC 4.2.2.26); Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3);
Mechanism	b-elimination
3D Structure Status	parallel β-helix
External resources	CAZypedia;
Statistics	GenBank accession (1042); Uniprot accession (24); PDB accession (19); 3D entries (10); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
polymannuronic acid-specific alginate lyase (BcelPL6; BACCELL_05351)	4.2.2.3	Bacteroides cellulosilyticus DSM 14838	EEF87057.1	E2NM07	6QPS[A,B] 1.29
poly-(G/MG)-specific exo-alginate lyase (BcAlyPL6)	4.2.2.-	Bacteroides clarus YIT 12056	WP_009122077.1	A0A1Y4JW59 F3PIZ9	7DMK[A,B,C,D] 2.21	1
exo-alginate lyase (polyG-specific) (AlyGC)	4.2.2.-	Paraglaciecola chathamensis S18K6T	WP_007984897.1	A0A1S4NYD7 A0A1S4NYD8 A0A656LHA2	5GKD[A,B,C,D] 2.19 5GKQ[A,B] β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA-(1-4)-β-D-ManpA 2.57	1
chondroitinase B (CslB;ChnB;Phep_0789)	4.2.2.19	Pedobacter heparinus DSM 2366	ACU03011.1 AAC83384.1 AAE46726.1 ABC06960.1 ABJ38857.1 ACK03140.1	Q46079	1DBG[A] 1.70 1DBO[A] β-D-4-deoxy-GlcpA-(1-3)-β-D-GalpNAc4SO3 1.70 1OFL[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3 β-D-4-deoxy-GlcpA-(1-3)-α-D-GalpNAc4SO3 1.70 1OFM[A] α-L-4-deoxy-IdopA-(1-3)-β-D-GalpNAc4SO3-(1-4)-β-D-GlcpA-(1-3)-β-D-GalpNAc4SO3 1.80
poly(α-L-guluronate) lyase / G-specific alginate lyase (Patl_3640)	4.2.2.11	Pseudoalteromonas atlantica T6c	ABG42142.1	Q15PP6	7O77[A] 2.32 7O7T[A] 2.05	1
AOG27_15850		Pseudoalteromonas lipolytica UCD-48B	KPM82556.1		8BWK[A,B,C,D] 2.29
chondroitinase B (Pedsa3807;Pedsa_3807)	4.2.2.19	Pseudopedobacter saltans DSM 12145	ADY54336.1	F0S763	7O78[A,B] 1.58
alginate lyase (Pedsa_0632)	4.2.2.11 4.2.2.-	Pseudopedobacter saltans DSM 12145	ADY51208.1	F0S7Y7	7O7A[A,B] 1.99 7O84[A,B] β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA β-D-4-deoxy-ManpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 2.18	1
poly-(MG)-lyase / MG-specific alginate lyase (Pedsa_3628)	4.2.2.-	Pseudopedobacter saltans DSM 12145	ADY54157.1	F0S4Y3	7O79[A] 1.93
polyG-specific alginate lyase	4.2.2.11	Vibrio splendidus	WP_116871951.1	A0A2S7V3I3	5Z9T[A,B] α-L-4-deoxy-AllpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 1.80 6A40[A] α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 1.80 6ITG[A,B] 1.42 7BZ0[A] α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA-(1-4)-α-L-GulpA 1.80
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