Known Activities	hyaluronan lyase (EC 4.2.2.1).
3D Structure Status	triple strand β-helix
Note	Formerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657.
Commercial Enzyme Provider(s)	PROZOMIX;
Statistics	GenBank accession (64); Uniprot accession (23); PDB accession (9); 3D entries (4); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
ACPL_3843 (fragment)		Actinoplanes sp. SE50/110	AEV84738.1
SEQ_2045		Streptococcus equi subsp. equi 4047	CAW95336.1	C0M9W4
hyaluronate lyase (HylP2)	4.2.2.1	Streptococcus pyogenes 10403	AAA86895.1	Q54699	2DP5[A] 3EKA[A]	2
SPYALAB49_001176		Streptococcus pyogenes Alab49	AEQ24773.1			3
SPYALAB49_000995		Streptococcus pyogenes Alab49	AEQ24593.1
SPYALAB49_001308 (fragment)		Streptococcus pyogenes Alab49	AEQ24901.1
hyaluronan lyase (HylP3)		Streptococcus pyogenes M1 GAS SF370	AAK34249.1 NP_269528.1	Q99Z19	2WB3[A]	3
hyaluronate lyase (HylP2)		Streptococcus pyogenes M1 GAS SF370	AAK33900.1 NP_269179.1	Q99ZZ7	2WH7[A]	3
hyaluronate lyase (HylP1;SPy0701)	4.2.2.1	Streptococcus pyogenes M1 GAS SF370	AAK33657.1 NP_268936.1		2C3F[A] 2PK1[A] 2YVV[A] 2YW0[A] 2YX2[A]	2
MGAS10270_Spy0590 or MGAS10270_Spy1310		Streptococcus pyogenes MGAS10270	ABF33655.1 ABF34375.1	Q1CQ53		1
M6_Spy1203		Streptococcus pyogenes MGAS10394	AAT87338.1			3
M6_Spy0993		Streptococcus pyogenes MGAS10394	AAT87128.1
M6_Spy1550		Streptococcus pyogenes MGAS10394	AAT87685.1			2
M6_Spy0059		Streptococcus pyogenes MGAS10394	AAT86194.1			1
M6_Spy1348		Streptococcus pyogenes MGAS10394	AAT87483.1
MGAS10750_Spy0615		Streptococcus pyogenes MGAS10750	ABF37565.1	Q1CPE4		1
MGAS10750_Spy1285		Streptococcus pyogenes MGAS10750	ABF38235.1	Q1CP68		3
HylP.1		Streptococcus pyogenes MGAS315	AAM79332.1 NP_664529.1			1
HylP.2 (fragment)		Streptococcus pyogenes MGAS315	AAM79536.1 NP_664733.1
HylP.3		Streptococcus pyogenes MGAS315	AAM79708.1 NP_664905.1	Q8K6W4		3
HylP.4		Streptococcus pyogenes MGAS315	AAM79821.1 NP_665018.1			2
HylP.6		Streptococcus pyogenes MGAS315	AAM80025.1 NP_665222.1			1
SpyM3_0928 (short fragment)		Streptococcus pyogenes MGAS315	AAM79535.1			2
HylP		Streptococcus pyogenes MGAS8232	AAL97134.1 NP_606635.1	Q8P2E9		1
HylP		Streptococcus pyogenes MGAS8232	AAL97438.1 NP_606939.1	Q8P1N7		1
HylP		Streptococcus pyogenes MGAS8232	AAL97860.1 NP_607361.1	Q8P0R1		1
HylP		Streptococcus pyogenes MGAS8232	AAL98032.1 NP_607533.1	Q8P0B1		1
HylP		Streptococcus pyogenes MGAS8232	AAL98283.1 NP_607784.1	Q8NZS7
MGAS9429_Spy0586		Streptococcus pyogenes MGAS9429	ABF31774.1	Q1CQV7		1
MGAS9429_Spy0843		Streptococcus pyogenes MGAS9429	ABF32031.1	Q1CQQ0		3
Spy49_0785		Streptococcus pyogenes NZ131	ACI61098.1	B5XL86		3
Spy49_1465c		Streptococcus pyogenes NZ131	ACI61737.1	B5XI75		1
SPs0763		Streptococcus pyogenes SSI-1	BAC63858.1 NP_802025.1			3
SPs0927		Streptococcus pyogenes SSI-1	BAC64022.1 NP_802189.1
SPs0447		Streptococcus pyogenes SSI-1	BAC63542.1 NP_801709.1			1
SPs1127 (fragment)		Streptococcus pyogenes SSI-1	BAC64222.1 NP_802389.1
SPs0648		Streptococcus pyogenes SSI-1	BAC63743.1 NP_801910.1			2
SpyM50524		Streptococcus pyogenes str. Manfredo	CAM29863.1	A2RDD8		1
SpyM50680		Streptococcus pyogenes str. Manfredo	CAM30013.1	A2RDT8		2
SpyM51031		Streptococcus pyogenes str. Manfredo	CAM30356.1	A2RET0		3
SpyM51271		Streptococcus pyogenes str. Manfredo	CAM30596.1	A2RDD8		1

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