Polysaccharide Lyase Family 16

Activities in Familyhyaluronan lyase (EC 4.2.2.1).
3D Structure Statustriple strand β-helix
NoteFormerly known as glycoside hydrolase family GH69; assigned to a PL family following papers by Baker, J. R., Dong, S. and Pritchard, D. G. (2002) Biochem J 365, 317-322 and Smith et al (2005) PNAS 102: 17652-17657. Subfamilies have been deleted in this family (December 2012).
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (143); Uniprot accession (29); PDB accession (10); 3D entries (5); cryst (0)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACPL_3843 (probable fragment)   Actinoplanes sp. SE50/110 AEV84738.1
SLM00537.1
   
 KSE_55340 (probable fragment)   Kitasatospora setae KM-6054 BAJ31309.1 E4NIH9  
 SEQ_2045   Streptococcus equi subsp. equi 4047 CAW95336.1 C0M9W4  
 SE071780_02165   Streptococcus equi subsp. equi ATCC 39506 ASB97711.1    
 SE071780_00215   Streptococcus equi subsp. equi ATCC 39506 ASB95834.1    
 SE071780_01756   Streptococcus equi subsp. equi ATCC 39506 ASB97343.1    
 hyaluronate lyase (HylP2) 4.2.2.1 Streptococcus pyogenes 10403 AAA86895.1 Q54699 2DP5[A]
3EKA[A]
 SPYALAB49_001176   Streptococcus pyogenes Alab49 AEQ24773.1    
 SPYALAB49_000995   Streptococcus pyogenes Alab49 AEQ24593.1    
 SPYALAB49_001308 (fragment)   Streptococcus pyogenes Alab49 AEQ24901.1    
 SPAP1_06950   Streptococcus pyogenes AP1 AKG28345.1    
 SPAP1_05545   Streptococcus pyogenes AP1 AKG28083.1    
 SPAP1_02840   Streptococcus pyogenes AP1 AKG27558.1    
 SPAP1_03565   Streptococcus pyogenes AP1 AKG27701.1    
 AUQ45_0607 (HylP)   Streptococcus pyogenes AP53 AMY97168.1    
 AUQ45_1317 (fragment)   Streptococcus pyogenes AP53 AMY97871.1    
 AUQ45_1187 (HylP)   Streptococcus pyogenes AP53 AMY97741.1    
 AUQ45_1011 (HylP)   Streptococcus pyogenes AP53 AMY97567.1    
 DP15_245 (Hylp2)   Streptococcus pyogenes ATCC 19615 AIL10687.1    
 DP15_676 (Hylp2)   Streptococcus pyogenes ATCC 19615 AIL11612.1    
 SpyM6D471_07290   Streptococcus pyogenes D471 AKI78395.1    
 SpyM6D471_05370   Streptococcus pyogenes D471 AKI78041.1    
 SpyM6D471_06095   Streptococcus pyogenes D471 AKI78183.1    
 AL510_07135   Streptococcus pyogenes FDAARGOS_149 AMH03618.1    
 B2G65_03235   Streptococcus pyogenes GUR ASO73760.1    
 B2G65_05975   Streptococcus pyogenes GUR ASO75021.1    
 B2G65_01855   Streptococcus pyogenes GUR ASO73519.1    
 B2G65_03940   Streptococcus pyogenes GUR ASO73894.1    
 CFA72_01855   Streptococcus pyogenes GURSA1 ASO67801.1    
 CFA72_03940   Streptococcus pyogenes GURSA1 ASO68178.1    
 CFA72_03235   Streptococcus pyogenes GURSA1 ASO68044.1    
 CFA72_05975   Streptococcus pyogenes GURSA1 ASO69307.1    
 HKU360_00797   Streptococcus pyogenes HKU360 AIW24615.1    
 L897_04975   Streptococcus pyogenes HSC5 AGQ28519.1    
 L897_07515   Streptococcus pyogenes HSC5 AGQ28627.1    
 L897_05855   Streptococcus pyogenes HSC5 AGQ28574.1    
 JMUB1235_0575   Streptococcus pyogenes JMUB1235 BAV54834.1    
 SPYJRS4_1277 (HylP)   Streptococcus pyogenes JRS4 BAR44777.1
AKI76512.1
   
 SPYJRS4_1529 (Hylp2)   Streptococcus pyogenes JRS4 BAR45029.1
AKI76724.1
   
 SPYJRS4_1119 (Hylp3)   Streptococcus pyogenes JRS4 BAR44619.1
AKI76370.1
   
 hyaluronan lyase (HylP3)   Streptococcus pyogenes M1 GAS AAK34249.1
NP_269528.1
Q99Z19 2WB3[A]
 hyaluronate lyase (HylP2)   Streptococcus pyogenes M1 GAS AAK33900.1
NP_269179.1
Q99ZZ7 2WH7[A]
 hyaluronate lyase (HylP1;SPy0701) 4.2.2.1 Streptococcus pyogenes M1 GAS AAK33657.1
NP_268936.1
  2C3F[A]
2PK1[A]
2YVV[A]
2YW0[A]
2YX2[A]
 FE90_0215   Streptococcus pyogenes M23ND AIQ00984.1    
 FE90_0641 (HylP)   Streptococcus pyogenes M23ND AIQ01408.1    
 FE90_0460 (HylP)   Streptococcus pyogenes M23ND AIQ01229.1    
 FE90_0882 (fragment)   Streptococcus pyogenes M23ND AIQ01645.1    
 FE90_0883 (HylP) (fragment)   Streptococcus pyogenes M23ND AIQ01646.1    
 M3B_0843   Streptococcus pyogenes M3-b BAU60212.1    
 M3B_0510 (fragment)   Streptococcus pyogenes M3-b BAU59891.1    
 M3B_0511 (fragment)   Streptococcus pyogenes M3-b BAU59892.1    
 M3B_0729   Streptococcus pyogenes M3-b BAU60098.1    
 M3B_1017   Streptococcus pyogenes M3-b BAU60386.1    
 AWM58_02775   Streptococcus pyogenes MEW427 AMA68626.1    
 AWM58_05790   Streptococcus pyogenes MEW427 AMA69164.1    
 MGAS10270_Spy0590 or MGAS10270_Spy1310   Streptococcus pyogenes MGAS10270 ABF33655.1
ABF34375.1
Q1CQ53  
 M6_Spy1203   Streptococcus pyogenes MGAS10394 AAT87338.1    
 M6_Spy0993 (fragment)   Streptococcus pyogenes MGAS10394 AAT87128.1    
 M6_Spy1550   Streptococcus pyogenes MGAS10394 AAT87685.1    
 M6_Spy0059   Streptococcus pyogenes MGAS10394 AAT86194.1    
 M6_Spy1348   Streptococcus pyogenes MGAS10394 AAT87483.1    
 MGAS10750_Spy0615   Streptococcus pyogenes MGAS10750 ABF37565.1 Q1CPE4  
 MGAS10750_Spy1285   Streptococcus pyogenes MGAS10750 ABF38235.1 Q1CP68  
 MGAS11027_0588   Streptococcus pyogenes MGAS11027 ANC23593.1    
 MGAS1882_1115   Streptococcus pyogenes MGAS1882 AFC68322.1    
 MGAS27061_0575   Streptococcus pyogenes MGAS27061 ANC26858.1    
 HylP.1   Streptococcus pyogenes MGAS315 AAM79332.1
NP_664529.1
   
 HylP.2 (fragment)   Streptococcus pyogenes MGAS315 AAM79536.1
NP_664733.1
   
 HylP.3   Streptococcus pyogenes MGAS315 AAM79708.1
NP_664905.1
Q8K6W4  
 HylP.4   Streptococcus pyogenes MGAS315 AAM79821.1
NP_665018.1
   
 HylP.6   Streptococcus pyogenes MGAS315 AAM80025.1
NP_665222.1
   
 SpyM3_0928 (short fragment)   Streptococcus pyogenes MGAS315 AAM79535.1    
 HylP   Streptococcus pyogenes MGAS8232 AAL97134.1
NP_606635.1
Q8P2E9  
 HylP   Streptococcus pyogenes MGAS8232 AAL97438.1
NP_606939.1
Q8P1N7  
 HylP   Streptococcus pyogenes MGAS8232 AAL97860.1
NP_607361.1
Q8P0R1  
 HylP   Streptococcus pyogenes MGAS8232 AAL98032.1
NP_607533.1
Q8P0B1  
 HylP   Streptococcus pyogenes MGAS8232 AAL98283.1
NP_607784.1
Q8NZS7  
 MGAS9429_Spy0586   Streptococcus pyogenes MGAS9429 ABF31774.1 Q1CQV7  
 MGAS9429_Spy0843   Streptococcus pyogenes MGAS9429 ABF32031.1 Q1CQQ0  
 ERS445054_01453   Streptococcus pyogenes NCTC8198 CKH05333.1    
 ERS445054_00613   Streptococcus pyogenes NCTC8198 CKG82209.1    
 ERS445054_01307 (HylP)   Streptococcus pyogenes NCTC8198 CKH01474.1    
 ERS445054_00899   Streptococcus pyogenes NCTC8198 CKG90139.1    
 SD89_06270   Streptococcus pyogenes NGAS322 AKZ50707.1    
 SD89_06945   Streptococcus pyogenes NGAS322 AKZ50836.1    
 SD89_05005   Streptococcus pyogenes NGAS322 AKZ50471.1    
 DK93_03885   Streptococcus pyogenes NGAS327 AKI38591.1    
 DK92_05065   Streptococcus pyogenes NGAS596 AKI37192.1    
 SD90_04815   Streptococcus pyogenes NGAS638 AKZ52250.1    
 DI45_04145   Streptococcus pyogenes NGAS743 AKI35205.1    
 DI45_03205   Streptococcus pyogenes NGAS743 AKI35031.1    
 Spy49_0785   Streptococcus pyogenes NZ131 ACI61098.1 B5XL86  
 Spy49_1465c   Streptococcus pyogenes NZ131 ACI61737.1 B5XI75  
 SPs0763   Streptococcus pyogenes SSI-1 BAC63858.1
NP_802025.1
Q878Y7  
 SPs0927   Streptococcus pyogenes SSI-1 BAC64022.1
NP_802189.1
Q878T2  
 SPs0447   Streptococcus pyogenes SSI-1 BAC63542.1
NP_801709.1
F7ITM1  
 SPs1127 (fragment)   Streptococcus pyogenes SSI-1 BAC64222.1
NP_802389.1
Q878N5  
 SPs0648   Streptococcus pyogenes SSI-1 BAC63743.1
NP_801910.1
Q79XT2  
 B4W66_05875   Streptococcus pyogenes STAB090229 ASQ21424.1    
 B5D85_06210   Streptococcus pyogenes STAB120304 ASQ23235.1    
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