GlycosylTransferase Family 97

Activities in FamilyCMP-Neu5Ac:α-galactoside α-2,6-sialyltransferase (EC 2.4.99.-); CMP-Neu5Ac:α-glucoside α-2,6-sialyltransferase (EC 2.4.99.-);
Mechanism Inverting
NoteCreated after Romanow et al., J. Biol. Chem., 289:33945-33957 [PMID=25342753] who have shown that the C-terminal domains of bi-functional capsule polymerases from Neisseria meningitidis W and Y function as a-2,6-sialyltransferases that utilize CMP-beta-Neu5Ac as the sugar donor to build the alternating capsular polysaccharides [->6)-a-D-Gal-(1->4)-a-Neu5Ac-(2->)]n and [->6)-a-D-Glc-(1->4)-a-Neu5Ac-(2->)]n, respectively.
Statistics GenBank accession (87); Uniprot accession (22);
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 A4Z71_06140   Candidatus Rhodoluna planktonica MWH-Dar1 AOY56524.1    
 DAD186_20510   Dermabacter vaginalis AD1-86 ANP28601.1    
 polysialyltransferase (SiaD)   Neisseria meningitidis 2004-038 ABW08129.1
ABW08138.1
B3FHD9  
 DE10444_0069   Neisseria meningitidis DE10444 ANW88596.1    
 A6L17_06810   Neisseria meningitidis M07149 ANX30216.1    
 A6L20_08765   Neisseria meningitidis M07161 ANX82499.1    
 A6L21_11280   Neisseria meningitidis M07162 ANX18416.1    
 A6L22_05835   Neisseria meningitidis M07165 AOA34861.1    
 A6L23_07165   Neisseria meningitidis M07999 AOA37287.1    
 A6L24_02210   Neisseria meningitidis M08000 ANX93895.1    
 A6L25_09245   Neisseria meningitidis M08001 ANX34786.1    
 A6L26_04115   Neisseria meningitidis M09261 ANX60934.1    
 A6L27_03415   Neisseria meningitidis M09293 ANX25484.1    
 polysialyltransferase (SiaD)(fragment)   Neisseria meningitidis M1000 AAO85296.1 Q83TN1  
 polysialyltransferase (SiaD)(fragment)   Neisseria meningitidis M1013 AAO85295.1 Q83Z67  
 LD07_05000   Neisseria meningitidis M10208 AIZ26250.1    
 A6L28_00855   Neisseria meningitidis M12752 ANX18763.1    
 polysialyltransferase (SiaD) (fragment)   Neisseria meningitidis M2190 AAO85292.1 Q83Z70  
 A6L29_00415   Neisseria meningitidis M22160 ANX79023.1    
 A6L30_06850   Neisseria meningitidis M22189 ANX28060.1    
 A6L31_05430   Neisseria meningitidis M22191 ANX98630.1    
 A6L32_03395   Neisseria meningitidis M22718 ANX14989.1    
 A6L33_06010   Neisseria meningitidis M22722 ANX57132.1    
 A6L34_09785   Neisseria meningitidis M22740 ANX91025.1    
 A6L35_06880   Neisseria meningitidis M22745 ANX44798.1    
 A6L36_04260   Neisseria meningitidis M22747 AOA38858.1    
 A6L37_08435   Neisseria meningitidis M22748 ANX36700.1    
 A6L38_00275   Neisseria meningitidis M22759 ANX68593.1    
 A6L40_05060   Neisseria meningitidis M22769 ANX42409.1    
 A6L41_09265   Neisseria meningitidis M22772 ANX41045.1    
 A6L42_09045   Neisseria meningitidis M22783 ANX74233.1    
 A6L43_11025   Neisseria meningitidis M22790 AOA41994.1    
 A6L44_01195   Neisseria meningitidis M22797 AOA42429.1    
 A6L45_10410   Neisseria meningitidis M22801 ANX49535.1    
 A6L46_09260   Neisseria meningitidis M22804 ANX51410.1    
 A6L47_08790   Neisseria meningitidis M22809 ANX24295.1    
 A6L48_00570   Neisseria meningitidis M22811 ANX37451.1    
 A6L49_02670   Neisseria meningitidis M22819 ANX21147.1    
 A6L50_08805   Neisseria meningitidis M22822 ANX92924.1    
 A6L51_02015   Neisseria meningitidis M22828 ANX75110.1    
 A6L52_04215   Neisseria meningitidis M23413 ANX54752.1    
 A6L58_02455   Neisseria meningitidis M24705 ANX96011.1    
 A6L61_05090   Neisseria meningitidis M24730 ANX46564.1    
 A6L64_05145   Neisseria meningitidis M25070 ANX59045.1    
 A6L66_05810   Neisseria meningitidis M25073 AOA45286.1    
 A6L67_05800   Neisseria meningitidis M25074 AOA47407.1    
 A6L77_01420   Neisseria meningitidis M25087 ANX70869.1    
 A6L86_00885   Neisseria meningitidis M25419 ANX87389.1    
 A6L93_01895   Neisseria meningitidis M25438 ANX52278.1    
 A6L95_00825   Neisseria meningitidis M25456 ANX85306.1    
 A6L96_03845   Neisseria meningitidis M25459 ANX77513.1    
 A6L97_00645   Neisseria meningitidis M25462 ANX62435.1    
 A6M04_09295   Neisseria meningitidis M25472 ANX68033.1    
 A6M06_00485   Neisseria meningitidis M25474 ANX31212.1    
 A6M07_07075   Neisseria meningitidis M25476 ANX84319.1    
 SynF (fragment)   Neisseria meningitidis M2578 AAP34774.1 Q83TN1  
 A6M08_03430   Neisseria meningitidis M27559 ANX64989.1    
 polysialyltransferase (SiaD)(fragment)   Neisseria meningitidis M3027 AAO85297.1 Q83TN1  
 polysialyltransferase (SiaD)(fragment)   Neisseria meningitidis M3029 AAO85293.1 Q83Z69  
 polysialyltransferase (SiaD)(fragment)   Neisseria meningitidis M4440 AAO85298.1 Q83Z66  
 polysialyltransferase (SiaD) (fragment)   Neisseria meningitidis M5005 AAO85299.1 Q83TN1  
 polysialyltransferase (SiaD) (fragment)   Neisseria meningitidis M6477 AAO85294.1 Q83Z68  
 SynG (fragment)   Neisseria meningitidis M7034 AAP34773.1 Q7X5R1  
 LA24_01860   Neisseria meningitidis M7124 AIZ19528.1    
 LA58_00730   Neisseria meningitidis NM3682 AIZ21409.1    
 LC14_00085   Neisseria meningitidis NM3683 AIZ23362.1    
 LA50_06045   Neisseria meningitidis NM3686 AIZ18179.1    
 NEIS2162 (Csw)   Neisseria meningitidis ST-11 CCP19949.1    
 NEIS2163 (Csy)   Neisseria meningitidis ST-166 CCP19896.1    
 NEIS2162 (Csw)   Neisseria meningitidis ST-22 CCP19817.1    
 NEIS2163 (Csy)   Neisseria meningitidis ST-23 CCP19868.1    
 bifunctional alternating UDP-Gal: α-1,4-galactosyltransferase / CMP-Neu5Ac: α-2,6-sialyltransferase (SiaD-W-135) 2.4.1.-
2.4.99.-
Neisseria meningitidis W135 CAA74303.1 O33390  
 SiaD   Neisseria meningitidis W:2A:P1.7-2,4 ST-11 ABW93674.1 A8V8Z9  
 SiaD   Neisseria meningitidis W:NT:P1.18-1,3 ST-22 ABW93688.1 A8V935  
 capsule polymerase (Siad-w-135)   Neisseria meningitidis WUE 2138 CAQ42967.1 B5WYL1  
 capsule polymerase (Siad-w-135)   Neisseria meningitidis WUE 2143 CAQ42966.1 B5WYL0  
 capsule polymerase (Siad-w-135)   Neisseria meningitidis WUE 2144 CAQ42969.1 B5WYL3  
 capsule polymerase (Siad-Y)   Neisseria meningitidis WUE 2219 CAQ42973.1 B5WYL7  
 capsule polymerase (Siad-Y)   Neisseria meningitidis WUE 2223 CAQ42974.1 B5WYL8  
 capsule polymerase (Siad-Y)   Neisseria meningitidis WUE 2225 CAQ42971.1 B5WYL5  
 capsule polymerase (Siad-w-135)   Neisseria meningitidis WUE 2232 CAQ42970.1 B5WYL4  
 capsule polymerase (Siad-w-135)   Neisseria meningitidis WUE 2234 CAQ42968.1 B5WYL2  
 capsule polymerase (Siad-Y)   Neisseria meningitidis WUE 325 CAQ42972.1 B5WYL6  
 capsule polymerase (Siad-Y)   Neisseria meningitidis WUE 637 CAQ42975.1 B5WYL9  
 bifunctional alternating UDP-Glc: α-glucosyltransferase / CMP-Neu5Ac α-sialyltransferase (SiaD-Y) 2.4.1.-
2.4.99.-
Neisseria meningitidis Y:2A:P1.2,5 CAA74302.1 O33391  
 A0T30_15110   Pseudomonas alcaligenes NEB 585 AMR67629.1    
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