GlycosylTransferase Family 8

Activities in FamilyHexosyltransferases (EC 2.4.1.-);
UDP-Gal α-galactosyltransferase (EC 2.4.1.-);
UDP-Gal:glucoside α-1,3-galactosyltransferase (EC 2.4.1.-);
UDP-Glc: LOS α-1,3-glucosyltransferase (EC 2.4.1.-);
UDP-GlcA: inositol phosphorylceramide α-glucuronosyltransferase (EC 2.4.1.-);
UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-);
UDP-GlcNAc: α-N-acetylglucosaminyltransferase (EC 2.4.1.-);
α-1,3-galactosyltransferase (EC 2.4.1.-);
α-glucosyltransferase (EC 2.4.1.-);
β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-);
Chiro-inositol 1-α-galactosyltransferase / fagopyritol synthase (EC 2.4.1.-);
Homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.-);
UDP-Gal: myo-inositol 3-α-galactosyltransferase (EC 2.4.1.123);
[retaining] glycogenin α-glucosyltransferase (EC 2.4.1.186);
LPS 3-α-galactosyltransferase (EC 2.4.1.44);
UDP-Glc: LPS α-glucosyltransferase (EC 2.4.1.58);
UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (EC 2.4.2.-);
[inverting] UDP-Xyl: protein O-β-xylosyltransferase (EC 2.4.2.-);
[retaining] UDP-Xyl: aDXylp-1,3-aDGlcp-O-Ser α-1,3-xylosyltransferase (EC 2.4.2.62);
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (23958); Uniprot accession (107); PDB accession (63); 3D entries (12); cryst (0)
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Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 MAMA_R825   Acanthamoeba castellanii mamavirus Hal-V AEQ60918.1    
 ORF   Acanthamoeba castellanii mimivirus Mimivirus kasaii BAV61838.1    
 ORF   Acanthamoeba castellanii mimivirus Mimivirus shirakomae BAV62824.1    
 ORF   Acanthamoeba polyphaga mimivirus AVG47094.1    
 ORF   Acanthamoeba polyphaga mimivirus AVG45993.1    
 MIMI_R707   Acanthamoeba polyphaga mimivirus AAV50967.1
ADO18804.1
AEJ34951.1
   
 ORF   Acanthamoeba polyphaga mimivirus UMZ07743.1    
 m4_igs_716   Acanthamoeba polyphaga mimivirus UTE96604.1    
 ORF   Acanthamoeba polyphaga mimivirus Amazonia AKI81384.1    
 ORF   Acanthamoeba polyphaga mimivirus Kroon AKI80447.1    
 ORF   Acanthamoeba polyphaga mimivirus Oyster AKI79493.1    
 Moumou_00188   Acanthamoeba polyphaga moumouvirus M10A AGC01732.1    
 P13-like protein   Adoxophyes honmai nucleopolyhedrovirus ADN001 BAC67338.1
NP_818734.1
   
 P13   Adoxophyes orana granulovirus AAP85675.1
NP_872492.1
   
 P13   Adoxophyes orana granulovirus Miyazaki AJA91678.1    
 P13   Adoxophyes orana nucleopolyhedrovirus ACF05376.1    
 agip70 (P13)   Agrotis ipsilon multiple nucleopolyhedrovirus Illinois ACI28772.1    
 AsGV042   Agrotis segetum granulovirus AAS82696.1    
 AsGV048   Agrotis segetum granulovirus DA AKN63322.1    
 AsGV048   Agrotis segetum granulovirus L1 AHN92087.1    
 ORF-64   Agrotis segetum nucleopolyhedrovirus AAZ38230.1    
 p13   Agrotis segetum nucleopolyhedrovirus B AIZ48617.1    
 p13 (Mabr_orf69)   Alphabaculovirus mabrassicae QD WNA17448.1    
 ORF   Bandra megavirus AUV58201.1    
 UNVERIFIED: glycosyltransferase   Borely moumouvirus QID05905.1    
 Catovirus_1_815   Catovirus CTV1 ARF08765.1    
 Catovirus_1_915   Catovirus CTV1 ARF08865.1    
 P13   Choristoneura occidentalis granulovirus ABC61168.1    
 P13 (ORF-102)   Chrysodeixis chalcites nucleopolyhedrovirus AAY84033.1    
 P13 protein   Chrysodeixis chalcites nucleopolyhedrovirus TF1 AGE61363.1
AGE61508.1
AGE61662.1
AGE61811.1
   
 TF1A_00102   Chrysodeixis chalcites SNPV TF1-A AGC36316.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus AOL56677.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus AOL57243.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus AOL56960.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus AOL56535.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus AOL57102.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus AOL56818.1    
 P13   Chrysodeixis includens nucleopolyhedrovirus QED40618.1    
 P13 (ORF-94)   Clanis bilineata nucleopolyhedrosis virus ABF47435.1    
 p13 (Orf24)   Clostera anachoreta granulovirus AEB00312.1    
 CaLGV025   Clostera anastomosis granulovirus AGQ20284.1    
 clas35   Clostera anastomosis granulovirus ClasGV-B AKS25378.1    
 glycosyltransferase   Cotonvirus japonicus BCS82893.1    
 orf44   Cryptophlebia leucotreta granulovirus AAQ21639.1
NP_891891.1
   
 p13   Cryptophlebia peltastica nucleopolyhedrovirus AXS67754.1    
 ORF47 P13   Cydia pomonella granulosis virus (isolate Mexican) AAK70707.1
NP_148831.1
   
 p13 (Orf47)   Cydia pomonella granulovirus QDW81106.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGZ00020.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGY99311.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGY99595.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGY99452.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGZ00162.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGY99737.1    
 p13 (Orf47)   Cydia pomonella granulovirus QGY99878.1    
 KFGOHAPD_00118   Cydia pomonella granulovirus WOZ30660.1    
 IPEBKFLO_00112   Cydia pomonella granulovirus WOZ30403.1    
 HDNAPKKO_00023   Cydia pomonella granulovirus WOZ44797.1    
 GGGKFHNK_00021   Cydia pomonella granulovirus WOZ44933.1    
 NJLGDECI_00025   Cydia pomonella granulovirus WOZ47099.1    
 PPFHPHBJ_00021   Cydia pomonella granulovirus WOZ30176.1    
 AGHAAFNI_00114   Cydia pomonella granulovirus WOZ30528.1    
 IFEMGEHL_00115   Cydia pomonella granulovirus WOZ45299.1    
 ENACNPPH_00022   Cydia pomonella granulovirus WOZ46545.1    
 BGFFOGFG_00021   Cydia pomonella granulovirus WOZ45069.1    
 JEKDHOOB_00022   Cydia pomonella granulovirus WOZ46408.1    
 JPLFIAAO_00022   Cydia pomonella granulovirus WOZ45995.1    
 ICELHAMJ_00021   Cydia pomonella granulovirus WOZ46818.1    
 DDAPCIDK_00121   Cydia pomonella granulovirus WOZ45827.1    
 MEFDCDFN_00022   Cydia pomonella granulovirus WOZ46271.1    
 EKIODEHO_00019   Cydia pomonella granulovirus WOZ46957.1    
 AAGMHLIN_00019   Cydia pomonella granulovirus WOZ45590.1    
 NOENIHFE_00019   Cydia pomonella granulovirus WOZ45859.1    
 BJOIBEHA_00022   Cydia pomonella granulovirus WOZ46682.1    
 GKEABHAL_00018   Cydia pomonella granulovirus WOZ46136.1    
 JEDKAPMP_00121   Cydia pomonella granulovirus WOZ45433.1    
 NOPONELM_00049   Cydia pomonella granulovirus WOZ45495.1    
 ORF47 p13   Cydia pomonella granulovirus CpGV-E2 AIU37255.1    
 ORF47 p13   Cydia pomonella granulovirus CpGV-I07 AIU36835.1    
 ORF47 p13   Cydia pomonella granulovirus CpGV-I12 AIU37114.1    
 ORF47 p13   Cydia pomonella granulovirus CpGV-M AIU36972.1    
 ORF47 p13   Cydia pomonella granulovirus CpGV-S AIU36693.1    
 Datr000039   Darna trima granulovirus UYX49672.1    
 P13   Diatraea saccharalis granulovirus Parana-2009 AKN80719.1    
 ORF87   Ectropis obliqua nucleopolyhedrovirus A1 ABI35770.1    
 QF4000059   Ectropis obliqua nucleopolyhedrovirus QF4 QWV59645.1    
 transferase   Ectropis obliqua nucleopolyhedrovirus QV UYO72884.1    
 wdlz-06GM97   Ectropis obliqua nucleopolyhedrovirus unioasis 1 AGS47937.1    
 Edafosvirus41_2   Edafosvirus sp. AYV78866.1    
 Edafosvirus18_16   Edafosvirus sp. AYV78567.1    
 P13   Epinotia aporema granulovirus AER41471.1    
 EREL_040   Erinnyis ello granulovirus ARX72029.1    
 EREL_040   Erinnyis ello granulovirus ARX71639.1    
 EREL_040   Erinnyis ello granulovirus ARX71509.1    
 EREL_040   Erinnyis ello granulovirus ARX71379.1    
 EREL_040   Erinnyis ello granulovirus ARX71769.1    
 EREL_040   Erinnyis ello granulovirus ARX71899.1    
 P13   Erinnyis ello granulovirus AIS92040.1    
 Eudi_ORF104 (P13)   Euproctis digramma nucleopolyhedrovirus 424 QHB21763.1    
 Faunusvirus22_4   Faunusvirus sp. AYV79553.1    
 Faunusvirus41_4   Faunusvirus sp. AYV79713.1    
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