GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8766); Uniprot accession (1210); PDB accession (41); 3D entries (9); cryst (0)
All (7156) Archaea (7) Bacteria (5752) Eukaryota (1256) Viruses (138) unclassified (3) Structure (9) Characterized (52)
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-N-acetylglucosamine transferase (NagT)   uncultured organism AID69686.1    
 Sequence 2 from patent US 7476778.   unidentified ACN00702.1    
 Sequence 7 from patent US 7476778.   unidentified ACN00705.1    
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