GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8766); Uniprot accession (1210); PDB accession (41); 3D entries (9); cryst (0)
All (7156) Archaea (7) Bacteria (5752) Eukaryota (1256) Viruses (138) unclassified (3) Structure (9) Characterized (52)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 13 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 galactinol synthase (Gols3)   Manihot esculenta AIE11288.1    
 galactinol synthase (Gols6)   Manihot esculenta AIE11285.1    
 GolS7   Manihot esculenta AIJ00873.1    
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96176.1 D9IFZ6  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96177.1 D9IFZ7  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96178.1 D9IFZ8  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96179.1 D9IFZ9  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96180.1 D9IG00  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96181.1 D9IG01  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96195.1 D9IG15  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96196.1 D9IG16  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96197.1 D9IG17  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96198.1 D9IG18  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96199.1 D9IG19  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96200.1 D9IG20  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96201.1 D9IG21  
 LARGE-2 (fragment)   Mastomys kollmannspergeri ADI96166.1 D9IFY6  
 LARGE-2 (fragment)   Mastomys kollmannspergeri ADI96167.1 D9IFY7  
 LARGE-2 (fragment)   Mastomys kollmannspergeri ADI96168.1 D9IFY8  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96184.1 D9IG04  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96185.1 D9IG05  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96186.1 D9IG06  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96187.1 D9IG07  
 LARGE-2 (fragment)   Mastomys natalensis ADI96169.1 D9IFY9  
 LARGE-2 (fragment)   Mastomys natalensis ADI96170.1 D9IFZ0  
 LARGE-2 (fragment)   Mastomys natalensis ADI96171.1 D9IFZ1  
 LARGE-2 (fragment)   Mastomys natalensis ADI96172.1 D9IFZ2  
 LARGE-2 (fragment)   Mastomys natalensis ADI96173.1 D9IFZ3  
 LARGE-2 (fragment)   Mastomys natalensis ADI96174.1 D9IFZ4  
 LARGE-2 (fragment)   Mastomys natalensis ADI96175.1 D9IFZ5  
 LARGE-1 (fragment)   Mastomys natalensis ADI96188.1 D9IG08  
 LARGE-1 (fragment)   Mastomys natalensis ADI96189.1 D9IG09  
 LARGE-1 (fragment)   Mastomys natalensis ADI96191.1 D9IG11  
 LARGE-1 (fragment)   Mastomys natalensis ADI96192.1 D9IG12  
 LARGE-1 (fragment)   Mastomys natalensis ADI96193.1 D9IG13  
 LARGE-1 (fragment)   Mastomys natalensis ADI96194.1 D9IG14  
 galactinol synthase (CorF)   Medicago falcata ACM50915.1 B9VV96  
 galactinol synthase (CorF) 2.4.1.123 Medicago sativa AAM97493.1 Q84MZ5  
 galactinol synthase 2 (GolS2) (fragment)   Medicago sativa CAF21715.1 Q703J2  
 MTYFL_FM_FN_FO1G-L-16 (fragment)   Medicago truncatula ACJ83784.1 B7FGC6  
 MTYFD_FE_FF_FG1G-F-3 (fragment)   Medicago truncatula ACJ85290.1 B7FKK6  
 MTYFL_FM_FN_FO1G-L-16 (fragment)   Medicago truncatula ACJ85766.1 B7FLY3  
 unknown (fragment)   Medicago truncatula AFK37519.1    
 unknown   Medicago truncatula AFK39430.1    
 unknown (fragment)   Medicago truncatula AFK41072.1    
 MtrDRAFT_AC147483g3v1 or MtrDRAFT_AC137839g25v1   Medicago truncatula ABE80667.2
ABE78500.1
ABE80667.1
ABO82396.1
   
 MtrDRAFT_AC145329g1v1   Medicago truncatula ABE91008.1 G7KSQ7  
 MtrDRAFT_AC146721g10v1   Medicago truncatula ABE89660.1 G7ZV05  
 MtrDRAFT_AC151424g8v1   Medicago truncatula ABE88904.1 G7I3L2  
 MtrDRAFT_AC151424g7v1   Medicago truncatula ABE88903.1 G7I3L3  
 MtrDRAFT_AC135465g9v1   Medicago truncatula ABE87756.1 G7KTP3  
 MtrDRAFT_AC155898g16v1   Medicago truncatula ABE87702.1
ABO83841.1
   
 MtrDRAFT_AC138087g9v1   Medicago truncatula ABE80888.1
CAW96603.1
CAW96805.1
CAX04122.1
CAX05902.1
CBD13108.1
G7JIW7  
 MtrDRAFT_AC137832g30v2   Medicago truncatula ABE86959.1
AFK41069.1
G7KJH6  
 MtrDRAFT_AC155890g1v2   Medicago truncatula ABN08312.1 A2Q3W2  
 MtrDRAFT_AC161399g30v2   Medicago truncatula ABN08854.1 A2Q5F4  
 MtrDRAFT_AC137701g1v2   Medicago truncatula ABO79665.1    
 MtrDRAFT_AC154090g8v1+ MtrDRAFT_AC154090g16v1 (fragments)   Medicago truncatula ABO83708.1
ABO83709.1
   
 MtrDRAFT_AC151426g12v1   Medicago truncatula ABP03325.1    
 BN887_00734   Melanopsichium pennsylvanicum 4 CDI52045.1    
 BN887_00256   Melanopsichium pennsylvanicum 4 CDI54499.1    
 galactinol synthase, partial (Gols1) (fragment)   Mentha sp. MC-2012 AFD50394.1    
 galactinol synthase, partial (Gols1) (fragment)   Micromeria hyssopifolia AFD50392.1    
 galactinol synthase, partial (Gols1) (fragment)   Micromeria lanata AFD50389.1    
 galactinol synthase, partial (Gols1) (fragment)   Micromeria tenuis AFD50395.1    
 galactinol synthase, partial (Gols1) (fragment)   Micromeria varia AFD50390.1    
 galactinol synthase, partial (Gols1) (fragment)   Micromeria varia AFD50393.1    
 galactinol synthase, partial (Gols1) (fragment)   Micromeria varia AFD50396.1    
 GNLVRS01_PISO0N00959g (Piso0_004779)   Millerozyma farinosa CBS 7064 CCE86296.1    
 GNLVRS01_PISO0M00804g (Piso0_004779)   Millerozyma farinosa CBS 7064 CCE85197.1    
 GAS1 (fragment)   Momordica charantia AAQ74882.1 Q6U2M9  
 ORF (fragment)   Mucor racemosus PTCC 5305 ABW74133.1 A8W7G8  
 xyloside xylosyltransferase 1 (MGC:19367)   Mus musculus AAH31419.1
BAE32468.1
BAE38667.1
NP_941028.1
Q3U4G3
Q8K2I0
4WLG[B]
4WLM[A,B]
4WLZ[B]
4WM0[A]
4WMA[A]
4WMB[A]
4WMI[A]
4WMK[A]
4WN2[A]
4WNH[A]
 LARGE (MKIAA0609)   Mus musculus AAI00400.1
AAH61506.1
AAI25488.1
AAI25490.1
ADI96202.1
BAC65610.1
CAA06945.1
Q059X9
Q80TW0
Q9Z1M7
 
 Glt8d4   Mus musculus AAH49816.1
NP_941014.1
Q810K9  
 Glycogenin-1 (Gyg;Gyg1) 2.4.1.186 Mus musculus AAH29903.1
AAD48901.1
BAE35197.1
NP_038783.1
Q3TWR9
Q9R062
 
 ORF   Mus musculus AAU95213.1
AAH96655.1
AAI16716.1
AAU95214.1
ADI96182.1
BAC36913.1
CAM20617.1
CAM20618.1
CAM20619.1
CAM20620.1
NP_766258.1
A2AHG8
Q5XPT3
Q8BJZ8
 
 Glt8d3   Mus musculus C57BL/6J AAI71972.1
AAI41303.1
BAE27879.1
Q3UHH8  
 2410004H05Rik   Mus musculus C57BL/6J BAB26903.1
AAH55709.1
AAH58731.1
AAH69873.1
BAE35802.1
NP_083902.1
Q6NSU3
Q7TNU1
Q9CWT8
 
 ORF   Mus musculus C57BL/6J BAC30718.1
AAH82561.1
BAB23061.1
Q8BLY8
Q9D163
 
 ORF   Musa AAB Group ANY40120.1    
 ORF   Musca domestica ALHF AFP61716.1    
 ORF (fragment)   Musca domestica ALHF AFP63307.1    
 glycosyltransferase 8 domain containing 1, partial (fragment)   Mustela putorius furo AER99128.1    
 glycosyltransferase 8 domain containing 3, partial (fragment)   Mustela putorius furo AER99528.1    
 glucoside xylosyltransferase 2, partial (fragment)   Mustela putorius furo AER99529.1    
 ORF   Mustela putorius furo AER99530.1    
 ORF (fragment)   Mustela putorius furo AER99531.1    
 ORF (fragment)   Mustela putorius furo AER99533.1    
 ORF (fragment)   Mustela putorius furo AER99129.1    
 ORF   Mustela putorius furo AER99130.1    
 ORF (fragment)   Mustela putorius furo AES12096.1    
 NCAS_0C00690 (Ncas0c00690)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC69059.1    
 NCAS_0B00960 (Ncas0b00960)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC68180.1    
 NCAS_0B08120   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC68896.1    
 NDAI_0K00720 (Ndai0k00720)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD27263.1    
 NDAI_0B05430   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD23576.1    
 NCLIV_054485   Neospora caninum Liverpool CBZ55023.1    
 ORF (fragment)   Neslia paniculata ADG38162.1 D6PP80  
 glycogenin (GNN;NCU06698.1;7F4.180) 2.4.1.186 Neurospora crassa OR74A CAD70922.1
AAS68518.1
CAY34861.1
XP_326984.1
Q1K740
Q871S1
 
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