GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8505); Uniprot accession (1210); PDB accession (41); 3D entries (9); cryst (0)
All (6962) Archaea (7) Bacteria (5588) Eukaryota (1232) Viruses (132) unclassified (3) Structure (9) Characterized (52)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 13 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Unknown (protein for MGC:103525)   Danio rerio AAH85543.1 Q5U3H3  
 Glt8d3 (CH211-155A11.6-001)   Danio rerio CAI11646.1
AAI63763.1
AAI63768.1
B3DK90
Q5SP46
 
 Unknown (protein for MGC:136873)   Danio rerio AAI14298.1
CAK10718.1
CAK10718.2
Q29RA8  
 Glt8d4 (MGC:162285)   Danio rerio AAI34948.1 A4QN62  
 ORF (MGC:194962 IMAGE:9037444) LOC561803   Danio rerio AAI63132.1
CAX14549.1
B3DIH8  
 DEHA0C07513g   Debaryomyces hansenii CBS767 CAG86035.1 Q6BUZ2  
 DEHA0D16445g   Debaryomyces hansenii CBS767 CAG87308.1
CAY34854.1
Q6BRN3  
 DEHA0F18579g   Debaryomyces hansenii CBS767 CAG89488.1
CAR66364.1
CAY34855.1
   
 ORF   Dendrobium catenatum AID53187.1    
 ORF   Dendrobium catenatum AIL52750.1    
 ORF   Dendrobium catenatum AIL52751.1    
 unknown   Dendroctonus ponderosae AEE62999.1    
 DLA_It03940 (Glt8d4)   Dicentrarchus labrax CBN80969.1    
 DLA_XVIII02630 (GlyG)   Dicentrarchus labrax CBN82005.1    
 DDB_0231974 (Gtr3)   Dictyostelium discoideum AX4 XP_637479.1    
 galactinol synthase (Gols1)   Dorcoceras hygrometricum ACI62176.1 B6UYJ2  
 Dbus_chr2Rg2224   Drosophila busckii ALC42645.1    
 Dbus_chr2Rg1634 (fragment)   Drosophila busckii ALC42055.1    
 Dbus_chr3Rg2690   Drosophila busckii ALC47940.1    
 CG11388   Drosophila melanogaster AAF47138.1
AEX91658.1
NP_611871.2
Q9W1D1  
 CG44244 (CG9480)   Drosophila melanogaster AAM51981.1
AAF46696.3
ACN63477.1
ACZ94504.1
ACZ94504.2
AFH08199.1
AGB93653.1
AHN56462.1
AHN56463.1
NP_726040.1
Q9W2J6  
 CG9996   Drosophila melanogaster AAF56394.2
AAF56394.1
AAS15686.1
ABY20490.1
NP_651334.1
Q9VBY3  
 ORF (fragment)   Elaeis guineensis AEZ00853.1    
 Glycogenin-1 (fragment)   Epinephelus coioides AEG78410.1    
 ORF (fragment)   Equus caballus AEP99996.1    
 ORF (fragment)   Equus caballus AEQ00392.1    
 Ecym_5197   Eremothecium cymbalariae DBVPG#7215 AET39968.1    
 ACR254C   Eremothecium gossypii ATCC 10895 AAS51480.1 Q75BL7  
 FAGOS_FACR254C   Eremothecium gossypii FDAG1 AEY95772.1    
 AW171_hschr2216   Eremothecium sinecaudum ATCC 58844 AMD18702.1    
 AW171_hschr84543   Eremothecium sinecaudum ATCC 58844 AMD22497.1    
 galactinol synthase-like protein   Eutrema halophilum AAM19710.1 Q8S2S0  
 fagopyritol synthase 1 (FeGolS-1) (fagopyritol B1 synthase) 2.4.1.- Fagopyrum esculentum AAM96870.1 Q7XZ05  
 fagopyritol synthase 2 (FeGolS-2) (fagopyritol A1/B1 synthase) 2.4.1.- Fagopyrum esculentum AAM96868.1 Q7XZ07  
 FeGolS-3 (fragment)   Fagopyrum esculentum AAM96869.1 Q7XZ06  
 glycosyltransferase 8-1, partial (Gt8) (fragment)   Fraxinus mandshurica AKF02846.1    
 glycosyltransferase 8-2, partial (Gt8)   Fraxinus mandshurica AKF02847.1    
 glycosyltransferase 8-3, partial (Gt8) (fragment)   Fraxinus mandshurica AKF02848.1    
 glycosyltransferase 8-4, partial (Gt8) (fragment)   Fraxinus mandshurica AKF02849.1    
 FFUJ_02205   Fusarium fujikuroi IMI 58289 CCT65272.1    
 FFUJ_02521   Fusarium fujikuroi IMI 58289 CCT65566.1    
 FFUJ_07165   Fusarium fujikuroi IMI 58289 CCT68386.1    
 FFUJ_08252   Fusarium fujikuroi IMI 58289 CCT71655.1    
 FFUJ_08234   Fusarium fujikuroi IMI 58289 CCT71672.1    
 FFUJ_12198   Fusarium fujikuroi IMI 58289 CCT72342.1    
 FFUJ_10895   Fusarium fujikuroi IMI 58289 CCT74825.1    
 FGRAMPH1_01T04553   Fusarium graminearum PH-1 SCB64319.1    
 FGRAMPH1_01T20841   Fusarium graminearum PH-1 SCB64974.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF75665.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF83000.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF86021.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF78020.1    
 glycosyltransferase-like 1A   Gallus gallus AAU12250.1 Q66PG3  
 Gyltl1b   Gallus gallus AAU12249.1 Q66PG4  
 RCJMB04_16h16   Gallus gallus CAG32043.1 Q5ZJQ0  
 RCJMB04_10i5   Gallus gallus CAG31757.1 Q5ZKI6  
 glycogenin (fragment)   Gillichthys mirabilis ACO57577.1 C1J0J7  
 glycogenin (fragment)   Gillichthys seta ACO57578.1 C1J0J8  
 glycogenin   Glossina morsitans morsitans ADD18784.1 D3TM56  
 ORF   Glossina morsitans morsitans ADD19890.1 D3TQB2  
 unnamed protein product   Glycine max CAW42705.1
CAW42734.1
CAW78070.1
CAW78099.1
CBC08234.1
CBC74593.1
   
 unnamed protein product   Glycine max CAW42733.1
CAW78098.1
CBC08262.1
CBC74647.1
   
 unnamed protein product   Glycine max CAW42704.1
CAW78069.1
CBC08233.1
CBC74591.1
   
 unnamed protein product   Glycine max CAW42706.1
CAW78071.1
CBC08235.1
CBC74595.1
   
 unnamed protein product   Glycine max CAW42729.1
CAW78094.1
CBC08258.1
CBC74640.1
   
 unnamed protein product   Glycine max CAW42730.1
CAW78095.1
CBC08259.1
CBC74642.1
   
 unnamed protein product   Glycine max CAW42731.1
CAW78096.1
CBC08260.1
CBC74644.1
   
 unnamed protein product   Glycine max CAW42732.1
CAW78097.1
CBC08261.1
CBC74646.1
   
 unnamed protein product   Glycine max CAW96594.1
CAX05893.1
CBD13091.1
   
 unknown (fragment)   Glycine max ACU19924.1 C6TDM2  
 unknown   Glycine max ACU20809.1 C6TG57  
 unnamed protein product   Glycine max CBD31754.1    
 unnamed protein product   Glycine max CBD34299.1    
 galactinol synthase (GmGolS) 2.4.1.123 Glycine max AAM96867.1 Q7XZ08  
 Sequence 2 from patent US 6967262   Glycine max ABC15004.1    
 Sequence 4 from patent US 6967262   Glycine max ABC15005.1
ACK26818.1
ACU18470.1
ACU23116.1
   
 ORF   Glycine max CAM33581.1    
 ORF   Glycine max CAM33582.1    
 ORF   Glycine max CAM33583.1    
 homogalacturonan α-1,4-galacturonosyltransferase (Gaut1)   Gossypium barbadense ABU43074.1    
 transferring glycosyl protein (GT) (fragment)   Gossypium hirsutum ABD65461.1 B9MST6  
 galactinol synthase (GolS)   Gossypium hirsutum AFG26331.1    
 UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (GXYLT2;GLT8D4;FLJ10539) 2.4.2.- Homo sapiens NP_001073862.1
AAI27734.1
CAK32330.1
XP_059527.1
A0PJZ3  
 FLJ35155   Homo sapiens BAC11694.1
AAH19036.1
AAH39067.1
AAH39067.2
ABE15385.1
ACH32828.1
BAB71355.1
BAG62725.1
CAC39844.1
CAI72215.1
NP_689744.3
D3DNW5
Q8NBI6
Q96ME0
 
 glycogenin (Gyg;Gyg1;GYG1) 2.4.1.186 Homo sapiens AAH00033.1
AAB00114.1
AAB09752.1
AAD31084.1
AAD52093.1
AAH31096.2
AAV20877.1
ACM81895.1
BAG35212.1
BAG61788.1
CAA56073.1
CAC22472.1
CAG38784.1
NP_004121.2
XP_051426.1
XP_051427.1
XP_051428.2
D3DNH1
D3DNH2
P46976
Q6FHZ1
3Q4S[A]
3QVB[A]
3RMV[A]
3RMW[A]
3T7M[A,B]
3T7N[A,B]
3T7O[A,B]
3U2T[A]
3U2U[A,B]
3U2V[A,B]
3U2W[A,B]
3U2X[A,B]
 glycogenin 2 (Gyg2) 2.4.1.186 Homo sapiens AAB84377.1
AAB84374.1
AAB84375.1
AAB84376.1
AAB84378.1
AAB84379.1
AAF61855.1
AAH23152.1
BAF85185.1
BAG53568.1
NP_003909.1
XP_043483.1
O15488 4UEG[A,B]
 GLT8D1 (LOC55830)   Homo sapiens AAF67484.1
AAH01418.1
AAI19671.1
AAI19672.1
AAN98065.1
AAQ88942.1
ABA13538.1
ABA33415.1
ABC03794.1
ABC04712.1
ABC15889.1
ABE24477.1
ABE25290.1
ABH65832.1
ABH71938.1
ABH72382.1
ABH72759.1
ABH75497.1
ABH93174.1
ABH98398.1
ABI01862.1
ABI11302.1
ABI12153.1
ABJ35085.1
ABJ41631.1
ABJ43226.1
ABL13520.1
ABL21773.1
ABN29859.1
ABN30046.1
ABN30288.1
ABX93891.1
ABX96184.1
ABX96494.1
ABX96804.1
ABY04958.1
ABY18694.1
ABY19002.1
ACC28095.1
ACC33768.1
ACE08685.1
ACJ96364.1
ACM95002.1
ACN00234.1
ACP58254.1
ACP73757.1
ACS06383.1
ACW23750.1
BAB55170.1
BAC11363.1
CAC19666.1
CAD34736.1
CAE89295.1
CAF86225.1
CAH18681.1
NP_060916.1
NP_690909.1
XP_041217.1
Q68CQ7
Q8N2J6
 
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1) 2.4.1.-
2.4.2.-
Homo sapiens CAA07571.1
AAI17426.1
AAI26405.1
ACM81049.1
ACM83412.1
AHW56517.1
AHW56672.1
AHW56712.1
AHW56713.1
BAA25535.2
BAA25535.3
BAH11875.1
BAH12135.1
BAH13559.1
CAB62965.1
CAG30396.1
CAI17890.1
CAI17950.1
CAI18754.1
CAI18769.1
CAI18772.1
CAI18784.1
CAI18785.1
CAI18788.1
CAQ06854.1
CAQ06855.1
CAQ06856.1
CAQ08276.1
CAQ08280.1
CAQ08281.1
CAQ08796.1
CAQ08800.1
CAQ08801.1
CAQ09323.1
CAQ09433.1
CAQ09434.1
CAQ09435.1
CAQ09639.1
CAQ09894.1
CAQ09895.1
CAQ09896.1
CAQ10763.1
CAQ11002.1
CAX14873.1
CAX14874.1
CAX14935.1
CAX14936.1
CAX15214.1
CAX15215.1
NP_004728.1
NP_598397.1
O95461  
 GLT8D2 (LOC83468)   Homo sapiens CAC19667.1
AAH22343.1
AAQ89123.1
ABE14808.1
ABH82915.1
ABI02301.1
ABI12586.1
ABJ30812.1
ABJ38942.1
ABX91581.1
ABX91857.1
ABX92133.1
ABX92409.1
ABX92685.1
ABX93119.1
ABX93626.1
ABX94360.1
ABX95367.1
ABX95643.1
ABX95919.1
ABY04141.1
ABY04417.1
ABY04693.1
ABY05279.1
ABY16385.1
ABY17877.1
ABY18153.1
ABY18429.1
ACC18493.1
ACE07488.1
ACE09326.1
ACE10538.1
ACJ96101.1
ACN02367.1
ACN06777.1
ACP73492.1
ACP89020.1
ACR88970.1
ACR89522.1
ACW28612.1
BAB55033.1
BAB71085.1
CAD58278.1
CAE91995.1
NP_112592.1
Q96KA2
Q9H1C3
 
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE2) 2.4.1.-
2.4.2.-
Homo sapiens BAC04675.1
AAH37291.1
ABE14687.1
BAC03909.1
BAG51581.1
NP_689525.2
Q8N3Y3
Q8N8Y6
Q8NAK3
 
 UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (GXYLT1;GLT8D3) 2.4.2.- Homo sapiens XP_290597.4
AAH15597.2
AAH30023.1
AAH39145.1
BAG54154.1
XP_058509.1
XP_062319.1
XP_290597.3
B3KWJ2
Q4G148
Q8IXV1
 
 unnamed protein product (fragment)   Hordeum vulgare CAD89089.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAK01477.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAJ89181.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK04875.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAJ97858.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK01339.1    
 predicted protein (fragments)   Hordeum vulgare subsp. vulgare BAK01369.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAJ97300.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAK04525.1    
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