GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8505); Uniprot accession (1210); PDB accession (41); 3D entries (9); cryst (0)
All (6962) Archaea (7) Bacteria (5588) Eukaryota (1232) Viruses (132) unclassified (3) Structure (9) Characterized (52)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 13 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycosyltransferase family 8 protein (Bofut4_p128880.1) (fragment)   Botrytis cinerea T4 CCD54188.1    
 gtl-1   Brachypodium sylvaticum CAJ26362.1 Q2L3C5  
 gtl-2   Brachypodium sylvaticum CAJ75629.1 Q2L3A3  
 inositol 1-α-galactosyltransferase (GS) 2.4.1.123 Brassica napus AAD26116.1
ABC15006.1
ACJ15472.1
ADG03603.1
Q9XEJ7  
 glycogenin (GyG) (fragment)   Bubalus bubalis ABI35900.1 Q0GA56  
 M116.2 (fragment)   Caenorhabditis elegans Bristol N2 AAB94141.2
AAB94141.3
AAB94141.4
CCD68522.1
NP_501428.1
O44521  
 glycogenin α-glucosyltransferase (Gyg-1;Uvt-5;CeGN;CELE_F56B6.4) 2.4.1.186 Caenorhabditis elegans Bristol N2 NP_741749.1
AAB04562.1
AAL11464.1
AAM69110.1
CCD64318.1
CCD64319.1
CCD64320.1
NP_508608.1
NP_508609.1
H2KYQ5
Q95Q50
4QLB[E,F,G,H]
 T10B10.8   Caenorhabditis elegans Bristol N2 CAO78709.1
CAA96680.2
CAA96680.3
NP_510518.1
Q22375  
 T25E12.5   Caenorhabditis elegans Bristol N2 CAB04823.1
NP_507238.1
O45819  
 Y73F8A.31 (probably fragment)   Caenorhabditis elegans Bristol N2 CAB60560.1
NP_502866.1
Q9NA45  
 K09C8.4 (Lge-1)   Caenorhabditis elegans Bristol N2 CAA91997.3
CAA91997.2
CAA91997.4
NP_509833.1
Q21389  
 glycogenin-1 (fragment)   Callorhinchus milii AFM90753.1    
 glycogenin-1   Callorhinchus milii AFK11151.1
AFP02050.1
   
 ORF (fragment)   Callorhinchus milii AFP12755.1    
 ORF   Callorhinchus milii AFO95554.1    
 ORF   Callorhinchus milii AFO98212.1    
 ORF   Callorhinchus milii AFP02563.1    
 ORF (fragment)   Callorhinchus milii AFP09084.1    
 ORF (fragment)   Callorhinchus milii AFP12772.1    
 ORF (fragment)   Callorhinchus milii AFP12931.1    
 ORF (fragment)   Callorhinchus milii AFO99418.1    
 ORF   Callorhinchus milii AFP03597.1    
 ORF (fragment)   Callorhinchus milii AFP05052.1    
 ORF (fragment)   Callorhinchus milii AFP02385.1    
 galactinol synthase 3   Camellia sinensis AKS29171.1    
 galactinol synthase 2   Camellia sinensis AKS29170.1    
 eukaryotic galactinol synthase (fragment)   Camellia sinensis AFR79417.1    
 galactinol synthase   Camellia sinensis AGQ44777.1    
 galactinol synthase 1 (Gs1)   Camellia sinensis AHA36621.1    
 Sequence 16155 from patent US 6747137   Candida albicans AAV04198.1    
 CAALFM_C205050CA   Candida albicans SC5314 AOW27523.1    
 CAALFM_C101360CA   Candida albicans SC5314 AOW25829.1    
 unnamed protein product   Candida albicans SC5314 CAY34857.1
AOW28652.1
   
 CD36_01260   Candida dubliniensis CD36 CAX44388.1 B9W6T2  
 CD36_86420   Candida dubliniensis CD36 CAX43138.1 B9WEM6  
 CAGL0I09922g   Candida glabrata CBS 138 CAG60616.1 Q6FQ15  
 CAGL0H02695g   Candida glabrata CBS 138 CAY34852.1
CAG59845.1
   
 SAMEA4029010_CIC11G00000002077   [Candida] intermedia CBS 141442 SGZ50383.1    
 SAMEA4029010_CIC11G00000003307   [Candida] intermedia CBS 141442 SGZ57658.1    
 SAMEA4029010_CIC11G00000003755   [Candida] intermedia CBS 141442 SGZ53751.1    
 SAMEA4029009_CIC11G00000005576   [Candida] intermedia PYCC 4715 SGZ56746.1    
 SAMEA4029009_CIC11G00000002858   [Candida] intermedia PYCC 4715 SGZ48902.1    
 CORT_0A09300   Candida orthopsilosis Co 90-125 CCG21314.1    
 CORT_0B10230   Candida orthopsilosis Co 90-125 CCG22727.1    
 CPAR2_109160   Candida parapsilosis CDC317 CCE40878.1    
 CPAR2_210040   Candida parapsilosis CDC317 CCE43359.1    
 ORF (fragment)   Capsella grandiflora ADG38156.1 D6PP74  
 ORF (fragment)   Capsella grandiflora AEN81719.1    
 ORF (fragment)   Capsella rubella AEN81392.1    
 ORF (fragment)   Capsella rubella AEN81724.1    
 galactinol synthase (GS)   Capsicum annuum ABQ44212.1 A5JSY8  
 galactinol synthase (GolS;GolS1;CsGOLS;CsGolS1)   Castanea sativa AAU43781.1
AGN88979.1
   
 galactinol synthase 2 splice variant 1 (Gols2) (fragment)   Cicer arietinum AMP59730.1    
 galactinol synthase 1 (Gols1)   Cicer arietinum AMP59727.1    
 galactinol synthase 2 splice variant 2 (Gols2) (fragment)   Cicer arietinum AMP59731.1    
 galactinol synthase 1 splice variant (Gols1) (fragment)   Cicer arietinum AMP59728.1    
 galactinol synthase 2 (Gols2)   Cicer arietinum AMP59729.1    
 ORF1   Cicer arietinum CAB81547.1 Q9M3Y6  
 GAS1 (fragment)   Citrullus lanatus AAQ74879.1 Q6U2N2  
 galactinol synthase (GolS2)   Coffea arabica ADM92590.1 E0X629  
 galactinol synthase (GolS1)   Coffea arabica ADM92588.1 E0X627  
 galactinol synthase (GolS3)   Coffea arabica ADM92589.1 E0X628  
 MA29G21.16 (fragment)   Coffea arabica ADY38797.1    
 GLGEN   Coprinellus disseminatus C345.1 AAZ14921.1 Q1WMS0  
 galactinol synthase (GolS;CjGolS)   Coptis japonica BAF99254.1 B0I373  
 ORF   Crotalus adamanteus AFJ50201.1    
 CGB_C6190C   Cryptococcus gattii WM276 ADV21194.1    
 CGB_I4330W   Cryptococcus gattii WM276 ADV24480.1    
 CGB_L0660W   Cryptococcus gattii WM276 ADV25383.1    
 CGB_D2640W   Cryptococcus gattii WM276 ADV21646.1    
 CGB_D2670C   Cryptococcus gattii WM276 ADV21652.1    
 CNAG_02790   Cryptococcus neoformans var. grubii H99 AFR93902.1    
 CNAG_05188   Cryptococcus neoformans var. grubii H99 AFR94453.1
AFR94453.2
AGV14250.1
   
 CNAG_05293   Cryptococcus neoformans var. grubii H99 AFR94554.1    
 CNAG_05430   Cryptococcus neoformans var. grubii H99 AFR98858.1    
 CNAG_05184   Cryptococcus neoformans var. grubii H99 AFR94449.2
AFR94449.1
   
 CNL04420   Cryptococcus neoformans var. neoformans JEC21 AAW46475.1
AAW46475.2
Q5K8U9  
 CNL04390   Cryptococcus neoformans var. neoformans JEC21 AAW46473.1
AAW46473.2
Q5K8V2  
 CNH03380   Cryptococcus neoformans var. neoformans JEC21 AAW45199.1 Q5KD57  
 CNC04080   Cryptococcus neoformans var. neoformans JEC21 AAW42342.1 Q5KK67  
 CNH00960   Cryptococcus neoformans var. neoformans JEC21 AAW44983.1
AAW44984.1
Q5KCG9  
 galactinol synthase (GAS2)   Cucumis melo AAL78686.1 Q8S9H2  
 galactinol synthase (GAS1)   Cucumis melo AAL78687.1 Q8S9H1  
 ORF   Cucumis melo ABR67414.1 A6YTD3  
 galactinol synthase   Cucumis melo subsp. melo ADN33831.1 E5GBI9  
 galactinol synthase (GolS)   Cucumis sativus AAO84915.1 Q84V66  
 GAS1 (fragment)   Cucurbita pepo AAQ74885.1 Q6U2M6  
 CYME_CMG174C   Cyanidioschyzon merolae strain 10D BAM79674.1    
 CYME_CMJ262C   Cyanidioschyzon merolae strain 10D BAM80368.1    
 CYME_CMK020C   Cyanidioschyzon merolae strain 10D BAM80419.1    
 CYME_CMR358C (fragment)   Cyanidioschyzon merolae strain 10D BAM82555.1    
 CYFA0S_01e10748g   Cyberlindnera fabianii YJS4271 CDR37447.1    
 CYFA0S_08e03994g   Cyberlindnera fabianii YJS4271 CDR42135.1    
 CYFA0S_19e01904g   Cyberlindnera fabianii YJS4271 CDR45694.1    
 CYFA0S_37e00628g   Cyberlindnera fabianii YJS4271 CDR47787.1    
 CYFA0S_01e04764g   Cyberlindnera fabianii YJS4271 CDR36819.1    
 ORF   Danio rerio AAH44387.1
AAH68329.1
AAH97080.1
AAI64360.1
CAQ15008.1
Q803Q1  
 Unknown (protein for MGC:86679)   Danio rerio AAH71363.1 Q6IQP1  
 Gyltl1b   Danio rerio AAU12252.1
AAI62103.1
CAK04442.1
CAK04901.1
B3DFN1
Q66PG1
 
 glycosyltransferase-like 1A   Danio rerio AAU12251.1
AAI62096.1
B3DFM4
Q66PG2
 
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