GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8923); Uniprot accession (1210); PDB accession (43); 3D entries (9); cryst (0)
All (7313) Archaea (7) Bacteria (5892) Eukaryota (1272) Viruses (139) unclassified (3) Structure (9) Characterized (52)
| 1 | ... | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 RO10_03885   Streptococcus mutans KCOM 1054 (= ChDC YM3) ARS62388.1    
 SMULJ23_0993   Streptococcus mutans LJ23 BAL69327.1    
 APQ13_03080   Streptococcus mutans NG8 AMF85444.1    
 SmuNN2025_0994   Streptococcus mutans NN2025 BAH88020.1 C6SQM8  
 SMU.1039c   Streptococcus mutans UA159 AAN58738.1
NP_721432.1
   
 SMUFR_0905   Streptococcus mutans UA159-FR AJD55376.1    
 STO1_004130 (GtfB)   Streptococcus oralis subsp. tigurinus osk_001 BBA08017.1    
 STO1_004060   Streptococcus oralis subsp. tigurinus osk_001 BBA08010.1    
 STO1_004050   Streptococcus oralis subsp. tigurinus osk_001 BBA08009.1    
 SOR_1574   Streptococcus oralis Uo5 CBZ01226.1    
 SOR_1581   Streptococcus oralis Uo5 CBZ01233.1    
 SOR_1582   Streptococcus oralis Uo5 CBZ01234.1    
 A0O21_01940   Streptococcus pantholopis TA 26 AND78871.1    
 A0O21_04260   Streptococcus pantholopis TA 26 AND79295.1    
 HMPREF0833_11287   Streptococcus parasanguinis ATCC 15912 AEH56318.1    
 HMPREF0833_11298   Streptococcus parasanguinis ATCC 15912 AEH56329.1    
 HMPREF0833_11304   Streptococcus parasanguinis ATCC 15912 AEH56335.1    
 HMPREF0833_11305   Streptococcus parasanguinis ATCC 15912 AEH56336.1    
 HMPREF0833_11307   Streptococcus parasanguinis ATCC 15912 AEH56338.1    
 Spaf_1325 (fragment)   Streptococcus parasanguinis FW213 AFJ26306.1    
 glycosyltransferase (Gtf2;Spaf_1924) 2.4.1.- Streptococcus parasanguinis FW213 ABL74005.1
AFJ26866.1
A1C3M0  
 STP_0572 (fragment)   Streptococcus parauberis KCTC 11537 AEF25020.1    
 CTY44_00824 (Gtf2_1) (fragment)   Streptococcus parauberis SpOF 3k ATX05897.1    
 CTY44_00825 (Gtf2_2) (fragment)   Streptococcus parauberis SpOF 3k ATX05898.1    
 SGPB_0869   Streptococcus pasteurianus ATCC 43144 BAK29947.1    
 Sequence 3992 from patent US 6699703 (fragment)   Streptococcus pneumoniae AAT16622.1
AAW09229.1
ABI03953.1
ABI08994.1
ABJ32510.1
ABJ50123.1
ABL17866.1
ACG91286.1
ACK14412.1
ACW45131.1
Q8VU29  
 Sequence 3888+3887 from patent US 7074914 (fragment)   Streptococcus pneumoniae ABI03848.1
ABI03849.1
ABI08889.1
ABI08890.1
ABJ32405.1
ABJ32406.1
ABJ50018.1
ABJ50019.1
ABL17761.1
ABL17762.1
ACG91182.1
ACK14307.1
ACK14308.1
ACW45026.1
ACW45027.1
   
 wciN (fragment)   Streptococcus pneumoniae BAN83022.1
BAN83014.1
BAN83018.1
BAN83026.1
BAN83034.1
BAN83042.1
BAN83046.1
   
 WciN (fragment)   Streptococcus pneumoniae AAK20686.1
AAL68409.1
AAL68421.1
AAL68433.1
AEE38297.1
AEE38333.1
AEE38369.1
AEE38373.1
AEO88287.1
AEO88315.1
AEO88343.1
AEO88357.1
AEO88385.1
AEO88413.1
AEO88427.1
AEO88455.1
AEO88469.1
AEO88483.1
AEO88497.1
AEO88511.1
AEO88525.1
AEO88539.1
AEO88553.1
AEO88567.1
AEO88581.1
BAN83030.1
BAN83038.1
Q8VU29
Q9AHB5
 
 BUM80_11300 (fragment)   Streptococcus pneumoniae 11A AUC46841.1    
 CWI64_09295 (fragment)   Streptococcus pneumoniae 19F AUB33763.1    
 CWI64_09290 (fragment)   Streptococcus pneumoniae 19F AUB33762.1    
 SPC06B_0009 (WciN) (fragment)   Streptococcus pneumoniae 2616/39 CAI32839.1 Q9AHB5  
 SPC06A_0009 (WciN) (fragment)   Streptococcus pneumoniae 34351=Rodriques CAI32819.1 Q9AHB5  
 ORF   Streptococcus pneumoniae 557B CCG14121.1    
 SP670_0422 (fragment)   Streptococcus pneumoniae 670-6B ADM90497.1 E0TRN4  
 SP670_0515 (short fragment)   Streptococcus pneumoniae 670-6B ADM90586.1 E0TSA1  
 Cps6aP (fragment)   Streptococcus pneumoniae 6A AAL82783.1 Q9AHB5  
 WciN (fragment)   Streptococcus pneumoniae 6A AEO88301.1
AEO88329.1
AEO88371.1
   
 WciN (fragment)   Streptococcus pneumoniae 6A AEO88399.1    
 UDP-Gal: α-Glc-PP-lipid α-1,3-galactosyltransferase (WciN) 2.4.1.44 Streptococcus pneumoniae 6B AEO88441.1    
 glycosyl_transferase wciN (fragment)   Streptococcus pneumoniae 6E SBT85379.1    
 SP70585_1806   Streptococcus pneumoniae 70585 ACO15925.1 C1C901  
 SP70585_1812 (partial)   Streptococcus pneumoniae 70585 ACO17198.1 C1C906  
 SP70585_1807 (fragment)   Streptococcus pneumoniae 70585 ACO17676.1 C1C902  
 SP70585_1797   Streptococcus pneumoniae 70585 ACO17736.1 C1C8Z4  
 SP70585_1808   Streptococcus pneumoniae 70585 ACO17796.1 C1C903  
 SPC33C_0009   Streptococcus pneumoniae 7098/41 CAI34212.1 Q4JZL5  
 A66_00419 (fragment)   Streptococcus pneumoniae A66 CRI61130.1    
 A66_00418 (fragment)   Streptococcus pneumoniae A66 CRI61129.1    
 SPAP_0455 (fragment)   Streptococcus pneumoniae AP200 ADM84048.1 E0SW66  
 SPN23F17740   Streptococcus pneumoniae ATCC 700669 CAR69540.1 B8ZMU2  
 SPN23F17750   Streptococcus pneumoniae ATCC 700669 CAR69541.1 B8ZMU3  
 SPN23F17800   Streptococcus pneumoniae ATCC 700669 CAR69546.1 B8ZMU8  
 SPN23F17810   Streptococcus pneumoniae ATCC 700669 CAR69547.1 B8ZMU9  
 SPN23F04130 (fragment)   Streptococcus pneumoniae ATCC 700669 CAR68262.1 B8ZLK4  
 SPN23F17660   Streptococcus pneumoniae ATCC 700669 CAR69532.1 B8ZMT4  
 SPN23F17770   Streptococcus pneumoniae ATCC 700669 CAR69543.1 B8ZMU5  
 SPCG_1749   Streptococcus pneumoniae CGSP14 ACB91001.1 B2ISC6  
 SPCG_1733   Streptococcus pneumoniae CGSP14 ACB90985.1 B2ISB0  
 SPCG_1741   Streptococcus pneumoniae CGSP14 ACB90993.1 B2ISB8  
 SPCG_1742   Streptococcus pneumoniae CGSP14 ACB90994.1 B2ISB9  
 SPCG_1743   Streptococcus pneumoniae CGSP14 ACB90995.1 B2ISC0  
 SPCG_1745   Streptococcus pneumoniae CGSP14 ACB90997.1 B2ISC2  
 SPCG_1747 (fragment)   Streptococcus pneumoniae CGSP14 ACB90999.1 B2ISC4  
 SPC33D_0009   Streptococcus pneumoniae CSF/79 CAI34230.1 Q4JZJ9  
 SPD_0400 (fragment)   Streptococcus pneumoniae D39 ABJ53884.1 Q04M38  
 WciN (fragment)   Streptococcus pneumoniae DS2212-94 ALV85456.1    
 SPC33B_0009   Streptococcus pneumoniae E294 CAI34192.1 Q4JZN3  
 HMPREF1038_00482 (fragment)   Streptococcus pneumoniae gamPNI0373 AFS42555.1    
 WciN (fragment)   Streptococcus pneumoniae HK02-14 AEE38329.1    
 SPNHU15_00504 (fragment)   Streptococcus pneumoniae Hu15 ARD36315.1    
 SPNHU15_01770   Streptococcus pneumoniae Hu15 ARD37530.1    
 SPNHU15_01782   Streptococcus pneumoniae Hu15 ARD37541.1    
 SPNHU15_00503 (fragment)   Streptococcus pneumoniae Hu15 ARD36314.1    
 SPNHU15_01785 (fragment)   Streptococcus pneumoniae Hu15 ARD37544.1    
 SPNHU15_01780   Streptococcus pneumoniae Hu15 ARD37539.1    
 SPNHU15_01779   Streptococcus pneumoniae Hu15 ARD37538.1    
 SPNHU15_01787 (fragment)   Streptococcus pneumoniae Hu15 ARD37545.1    
 SPNHU17_01799   Streptococcus pneumoniae Hu17 ARD35351.1    
 SPNHU17_01787   Streptococcus pneumoniae Hu17 ARD35340.1    
 SPNHU17_01802 (fragment)   Streptococcus pneumoniae Hu17 ARD35354.1    
 SPNHU17_01796   Streptococcus pneumoniae Hu17 ARD35348.1    
 SPNHU17_00499 (fragment)   Streptococcus pneumoniae Hu17 ARD34112.1    
 SPNHU17_01804 (fragment)   Streptococcus pneumoniae Hu17 ARD35355.1    
 SPNHU17_00500 (fragment)   Streptococcus pneumoniae Hu17 ARD34113.1    
 SPNHU17_01797   Streptococcus pneumoniae Hu17 ARD35349.1    
 SPH_1876   Streptococcus pneumoniae Hungary19A-6 ACA36319.1 B1I7M8  
 SPH_1877   Streptococcus pneumoniae Hungary19A-6 ACA36830.1 B1I7M9  
 SPH_1879   Streptococcus pneumoniae Hungary19A-6 ACA37207.1 B1I7N1  
 SPH_1868   Streptococcus pneumoniae Hungary19A-6 ACA37545.1 B1I7M0  
 INV104_15010   Streptococcus pneumoniae INV104 CBW37182.1 E1XSS2  
 INV104_15100   Streptococcus pneumoniae INV104 CBW37191.1 E1XST1  
 INV104_15110   Streptococcus pneumoniae INV104 CBW37192.1 E1XST2  
 INV104_15090   Streptococcus pneumoniae INV104 CBW37190.1 E1XST0  
 INV104_15140 (fragment)   Streptococcus pneumoniae INV104 CBW37195.1 E1XST5  
 SPNINV200_15800   Streptococcus pneumoniae INV200 CBW35213.1 E1XLG3  
 SPNINV200_15880   Streptococcus pneumoniae INV200 CBW35221.1 E1XLH1  
 SPNINV200_15880   Streptococcus pneumoniae INV200 CBW35221.1 E1XLH1  
 SPNINV200_15890   Streptococcus pneumoniae INV200 CBW35222.1 E1XLH2  
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