GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC; UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC; glycogenin glucosyltransferase (EC; inositol 1-α-galactosyltransferase (galactinol synthase) (EC; homogalacturonan α-1,4-galacturonosyltransferase (EC; UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-); UDP-Gal:glucoside α-1,3-galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (15460); Uniprot accession (1209); PDB accession (46); 3D entries (11); cryst (0)
All (13857) Archaea (10) Bacteria (11785) Eukaryota (1870) Viruses (189) unclassified (3) Structure (11) Characterized (52)
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BKD89_02640   Candidatus Methanomethylophilus alvus Mx-05 AYQ54704.1    
 MMALV_05390   Candidatus Methanomethylophilus alvus Mx1201 AGI85280.1    
 DV733_08450   Halapricum salinum CBA1105 QCC51274.1    
 GWK26_02820   haloarchaeon 3A1-DGR QHS16169.1    
 CHINAEXTREME_14340   Halobiforma lacisalsi AJ5 APW98880.1    
 MB9_1724 (fragment)   Methanobacterium formicicum isolate Mb9 CEL25359.1    
 sm9_1528   Methanobrevibacter millerae SM9 ALT69301.1    
 AR505_0559   methanogenic archaeon ISO4-H5 AMH94280.1    
 AR505_0557   methanogenic archaeon ISO4-H5 AMH94278.1    
 AUP07_1465   methanogenic archaeon mixed culture ISO4-G1 AMK14500.1    

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