GlycosylTransferase Family 6

Known Activities	α-1,3-galactosyltransferase (EC 2.4.1.87); α-1,3 N-acetylgalactosaminyltransferase (EC 2.4.1.40); α-galactosyltransferase (EC 2.4.1.37); globoside α-N-acetylgalactosaminyltransferase (EC 2.4.1.88).
Mechanism	Retaining
3D Structure Status	GT-A
External resources	CFG(Core1); CFG(Glycosphingolipid); CFG(Terminal); InterPro; PFAM;
Statistics	GenBank accession (472); Uniprot accession (181); PDB accession (85); 3D entries (3); cryst (0)

Summary

All (154) Bacteria (13) Eukaryota (139) Viruses (1) unclassified (1) Structure (3 ) Characterized (13)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
UDP-GalNAc: 2'-fucosyl lactose α-N-acetylgalactosaminyltransferase (BoGT6a;BACOVA_01932) (23696)	2.4.1.40	Bacteroides ovatus ATCC 8483	ZP_02064961.1	A7LVT2
α-1,3-galactosyltransferase (WbnI)	2.4.1.87	Escherichia coli O86:H2	AAV80756.1	Q5JBG6
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
UDP-Gal: β-galactoside α-1,3-galactosyltransferase (GGTA1)	2.4.1.87	Bos taurus	AAA30558.1 AAT23491.1 AAX04504.1 CAD19039.1 NP_803477.1	P14769.1	1FG5[N] 1G8O[A] 1G93[A] 1GWV[A,B] 1GWW[A,B] 1GX0[A,B] 1GX4[A,B] 1K4V[A,B] 1O7O[A,B] 1O7Q[A,B] 1VZT[A,B] 1VZU[A,B] 1VZX[A,B] 2JCF[A,B] 2JCJ[A] 2JCK[A] 2JCL[A,B] 2JCO[A] 2VFZ[A,B] 2VS3[A,B] 2VS4[A,B] 2VS5[A,B] 2VXL[A] 2VXM[A,B,C,D] 2WGZ[A,B]
α-1,3-galactosyltransferase	2.4.1.87	Callithrix sp.	AAM17885.1 AAT23488.1 AAT23494.1 ABA30201.1 CAD19040.1	Q28855
α-1,3-galactosyltransferase	2.4.1.87	Cebus apella	AAK56499.1	Q8SPR2
B-specific α-1,3-galactosyltransferase (GTB)	2.4.1.37	Homo sapiens	AAD26574.1 AAD26581.1 AAD26582.1 AAD26583.1 AAD26584.1 AAH69595.1 AAQ04663.1 AAS16482.1 AAT23487.1 AAX62274.1 AAX62275.1 AAZ32763.1 AAZ32764.1 AAZ67147.1 ABA30203.1 ABC41115.1 ABD66591.1 ABG81281.1 ABG81282.1 ABG81283.1 ABG81284.1 ABG81285.1 ABG81286.1 ABG81287.1 ABL63909.1 ABL75287.1 ABX84152.1 ABX84153.1 ABY61766.1 ABY61767.1 ABY61965.1 ACD93506.1 ACH41919.1 ACH86117.1 ACM69334.1 ACN94231.1 ACP27631.1 ACP27636.1 ADM63093.1 AEA07709.1 AEO14649.1 AER42120.1 BAA11590.2 BAA11591.2 BAA11592.2 BAD20723.1 BAD20724.1 BAD20725.1 BAD20726.1 BAD20727.1 BAG63563.1 CAB81779.1 CAD19819.1 CAD48796.1 CAD60222.1 CAD60223.1 CAD60224.1 CAD60225.1 CAD60226.1 CAD60239.1 CAD60240.1 CAJ13827.1 CAM28425.1 CAM28426.1 CAM28427.1 CAM34527.1 CBI62111.1 CBI62113.1 CCA28520.1 CCA28524.1	B0B1U2 P16442 Q53I57 Q8N3W8 Q9NY01 Q9UQ62 Q9UQ63 Q9UQ64	1LZ7[A] 1LZJ[A] 1R7U[A] 1R7X[A] 1R80[A] 1R82[A] 1ZIZ[A] 1ZJ0[A] 1ZJ1[A] 1ZJ2[A] 1ZJ3[A] 1ZJP[A] 2A8U[A] 2I7B[A] 2O1F[A] 2O1G[A] 2RIT[A] 2RIX[A] 2RIY[A] 2RIZ[A] 2RJ0[A] 2RJ1[A] 2RJ4[A] 2RJ5[A] 2RJ6[A] 2RJ7[A] 2RJ8[A] 2RJ9[A] 3I0C[A] 3I0D[A] 3I0E[A] 3I0F[A] 3I0G[A] 3I0H[A] 3I0I[X] 3I0J[A] 3I0K[A] 3I0L[A]
A-specific α-1,3-N-acetylgalactosaminyltransferase (GTA)	2.4.1.40	Homo sapiens	AAA36792.1 AAB86462.1 AAB86464.1 AAB86465.1 AAD26572.1 AAD26573.1 AAD26575.1 AAD26576.1 AAD26577.1 AAD26578.1 AAD26579.1 AAD26580.1 AAD51648.1 AAD51649.1 AAF07060.1 AAH69814.1 AAI11576.1 AAL37338.1 AAL37339.1 AAP03430.1 AAP97075.1 AAP97075.2 AAQ04662.1 AAR20996.1 AAR97889.1 AAR98522.1 AAS00500.1 AAT01605.1 AAT90439.1 AAU93390.1 AAW31606.1 AAW31606.1 AAW31607.1 AAW31607.1 AAX39009.1 AAX58609.1 AAX58612.1 AAX58613.1 AAY98421.1 AAY98422.1 AAY98423.1 AAZ28944.1 ABA30202.1 ABC41116.1 ABC41117.1 ABC41118.1 ABC59309.1 ABC59310.1 ABU55874.1 ABV59094.1 ABX71623.1 ABY61763.1 ABY61765.1 ACA21506.1 ACB47836.1 ACM84089.1 ACP27634.1 ACR56378.1 ACS44646.1 ACS44647.1 ACS44648.1 ADD38980.1 ADH94279.1 ADP08988.1 ADP08989.1 ADP08991.1 ADP08992.1 ADP08993.1 ADP08994.1 ADP08995.1 ADP08996.1 ADP08997.1 ADP08998.1 ADP08999.1 ADR80625.1 AEA76423.1 AEA76424.1 AEA76425.1 AEA76426.1 AEA76427.1 AEA76428.1 AEV45767.1 BAA11586.1 BAD20714.1 BAD20715.1 BAD20716.1 BAD20717.1 BAD20718.1 BAD20719.1 BAD20720.1 BAD20721.1 BAD20722.1 CAA59233.1 CAB81777.1 CAD22451.1 CAD48795.1 CAD60209.1 CAD60210.1 CAD60211.1 CAD60212.1 CAD60213.1 CAD60214.1 CAD60215.1 CAD60216.1 CAD60217.1 CAD60218.1 CAD60219.1 CAD60221.1 CAI79116.1 CAJ00555.1 CAL58696.1 CAM28424.1 CAM34526.1 CBI62112.1 CBM82401.1 CBM82402.1 CBX20982.1 CBX20983.1 CCA28519.1 CCA28521.1 CCA28522.1 CCA28523.1 CCA28526.1 CCA28528.1 CCA28529.1 NP_065202.2	O15512 P16442.2 Q15951 Q53I57 Q7Z535 Q8WWJ1 Q99479 Q9NY02 Q9UIR1 Q9UMY7 Q9UMY8 Q9UQ65 Q9UQ66 Q9UQ67	1LZ0[A] 1LZI[A] 1R7T[A] 1R7V[A] 1R7Y[A] 1R81[A] 1WSZ[A] 1WT0[A] 1WT1[A] 1WT2[A] 1WT3[A] 1XZ6[A] 1ZHJ[1] 1ZI1[A] 1ZI3[A] 1ZI4[A] 1ZI5[A] 1ZJO[A] 2A8W[A] 3IOH[A] 3IOI[A] 3IOJ[A,B]
Forssman synthetase (Gbgt1)	2.4.1.88	Homo sapiens	AAF06145.1 AAH32499.1 AAQ88542.1 AAZ38721.1 ACM84351.1 BAF84187.1 BAG36792.1 BAH14061.1 CAI13418.1 CAI13420.1 NP_068836.2	A8K633 Q8N5D6 Q8N5D6.2
Forssman synthetase (globoside α-N-acetylgalactosaminyltransferase)	2.4.1.88	Mus musculus	AAI06832.1 AAL37034.1 BAC23060.1 BAC23060.2 CAM24089.1 NP_631936.1	Q8VI38 Q8VI38.2
α-1,3-galactosyltransferase	2.4.1.87	Mus musculus	AAA37657.1 AAA37711.1 AAH06810.1 AAK97205.1 AAK97206.1 AAO31497.1 AAT23493.1 AAX04505.1 ABI05618.1 BAB23534.1 BAC40449.1 BAE34805.1 CAD19042.1 CAM24927.1 CAM24928.1 CAM24928.2 CAM24929.1 CAM24930.1 CAQ52127.1 NP_034413.1	P23336.1 Q3TXW0 Q8C2H7 Q91W00 Q9DBU1
α-1,3-galactosyltransferase (Alpha3GalT)	2.4.1.87	Rattus norvegicus	AAI66599.1 AAM74957.1 AAO49077.1 NP_663707.1	Q80WF5 Q8K3Z1
iGb3 synthase	2.4.1.87	Rattus norvegicus	AAF82757.1 AAH61714.1 NP_612533.1	A0A4Z3
α-1,3-galactosyltransferase	2.4.1.87	Sus scrofa	AAA58775.1 AAA73558.1 AAK01141.1 AAK01142.1 AAK28714.1 AAT23492.1 AAX04503.1 ACW02639.1 CAB42480.1 CAB42481.1 CAB42702.1 CAD19041.1	P50127 Q548W5

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.