GlycosylTransferase Family 64

Activities in FamilyUDP-GlcNAc: heparan α-N-acetylhexosaminyltransferase (EC 2.4.1.224)
Mechanism Retaining
3D Structure StatusGT-A
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain.
External resourcesGlymap;
Statistics GenBank accession (353); Uniprot accession (84); PDB accession (4); 3D entries (1); cryst (0)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 2_8443_01 (fragment)   Abies alba AFB33671.1
AFB33669.1
AFB33670.1
AFB33672.1
   
 CB5_LOCUS19099 (fragment)   Ananas comosus var. bracteatus VUW68514.1    
 CB5_LOCUS21602 (fragment)   Ananas comosus var. bracteatus VUW71017.1    
 CB5_LOCUS19772   Ananas comosus var. bracteatus VUW69187.1    
 CB5_LOCUS391 (fragment)   Ananas comosus var. bracteatus VUW49816.1    
 ACCB08353 (fragment)   Apis cerana AEY60334.1    
 ACCB07274 (fragment)   Apis cerana AEY60121.1    
 At3g55830/F27K19_10 (Epc1;AtEPC1)   Arabidopsis thaliana CAB87837.1
AEE79446.1
AHL38727.1
BAF00425.1
NP_191142.1
Q9LY62  
 At5g04500/T32M21_100   Arabidopsis thaliana NP_196070.2
AAO42055.1
AED90753.1
AHL38645.1
CAB85556.1
NP_196070.1
Q84WB7
Q9LZ75
 
 At1g80290/F5I6.4   Arabidopsis thaliana AAG52433.1
AAF27686.1
AAM61012.1
ABD59059.1
AEE36383.1
AEE36384.1
AKV71933.1
BAH20131.1
NP_565236.1
Q8LG66
Q9C975
 
 ORF   Ascaris suum ADY41945.1    
 ORF   Ascaris suum ADY42536.1    
 Bathy17g01230 (probable fragment)   Bathycoccus prasinos RCC1105 CCO20567.1    
 Bathy19g00100   Bathycoccus prasinos RCC1105 CCO20744.1    
 Unknown (protein for MGC:137797)   Bos taurus AAI14731.1 Q1RMT0  
 Unknown (protein for MGC:155111)   Bos taurus AAI33541.1 A2VE26  
 Unknown (protein for MGC:151773)   Bos taurus AAI40569.1 A5D7I4  
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) 2.4.1.224
2.4.1.225
Bos taurus AAC35386.1
AAI26571.1
NP_803462.1
O77783  
 ORF (protein for MGC:160120)   Bos taurus AAI50062.1 A6QR03  
 BOLC8T50736H   Brassica oleracea VDD57507.1    
 BOLC9T59970H   Brassica oleracea VDD34647.1    
 BOLC2T10127H (fragment)   Brassica oleracea VDD24376.1    
 BOLC2T06153H   Brassica oleracea VDD18297.1    
 BOLC2T09755H   Brassica oleracea VDD23846.1    
 BRAA09T40335Z   Brassica rapa VDC62724.1    
 BRAA02T04815Z   Brassica rapa VDC84653.1    
 BRAA02T07360Z   Brassica rapa VDC89516.1    
 BRAA04T16136Z (fragment)   Brassica rapa VDD10785.1    
 BRAA10T45205Z   Brassica rapa VDD21080.1    
 Ext2 (K01G5.6/Rib2)   Caenorhabditis elegans Bristol N2 AAC47510.1
AAW12599.1
BAB83878.1
CAB07245.1
NP_499368.1
O01705  
 ORF   Callorhinchus milii AFO94815.1    
 ORF   Callorhinchus milii AFP01971.1    
 ORF (fragment)   Callorhinchus milii AFP02012.1    
 ORF (fragment)   Callorhinchus milii AFO98479.1    
 ORF (fragment)   Callorhinchus milii AFP03381.1    
 ORF (fragment)   Callorhinchus milii AFP04792.1    
 A3770_01p05250   Chloropicon primus CCMP1205 QDZ18007.1    
 A9K55_006602 (fragment)   Cordyceps militaris ATCC 34164 ATY61117.1    
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.224
2.4.1.225
Cricetulus griseus AAF71276.1 Q9JK82  
 ORF   Crotalus adamanteus AFJ50039.1    
 ORF   Crotalus adamanteus AFJ50038.1    
 ORF   Crotalus adamanteus AFJ50040.1    
 CYME_CMG174C   Cyanidioschyzon merolae strain 10D BAM79674.1    
 CYME_CMP307C   Cyanidioschyzon merolae strain 10D BAM81902.1    
 Ext2   Danio rerio AAV48783.1 Q5U7A7  
 exostosin-like 3 (Extl3)   Danio rerio AAV51343.1
AAI62406.1
Q5U7D2  
 EXT1b   Danio rerio AAW29034.1
AAI25901.1
AAI65657.1
Q5IGR7  
 EXT1c   Danio rerio AAW29035.1
AAI15217.1
AAI55813.1
Q5IGR6  
 EXT1a   Danio rerio AAW29033.1
AAI33118.1
Q5IGR8  
 Unknown (protein for MGC:153688) (OTTDARP00000010010)   Danio rerio AAI24427.1
CAP09235.1
Q08C36  
 Dbus_chr2Rg1704   Drosophila busckii ALC42125.1    
 Dbus_chr2Rg1360 (fragment)   Drosophila busckii ALC41781.1    
 Dbus_chr2Rg1995   Drosophila busckii ALC42416.1    
 CG8433 (Dext2;sotv)   Drosophila melanogaster AAD38573.1
AAF58055.2
AAF58056.1
AAO39548.1
AAO41379.1
NP_725536.1
NP_788367.1
NP_788368.1
A4UZJ2
Q9Y169
 
 tout-velu (CG10117;Dext1;ttv)   Drosophila melanogaster AAC32397.1
AAF58236.1
AAX33551.1
AGB93503.1
BAE78509.1
NP_477231.1
QCD26199.1
Q5BI21
Q9V730
Q9V730
 
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225
Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1
Q9XZ08  
 ORF (fragment)   Equus caballus AEP99427.1    
 UDP-glycosyltransferase   Fallopia multiflora ATO91431.1    
 FFUJ_00029   Fusarium fujikuroi IMI 58289 CCT63336.1    
 FFUJ_09875   Fusarium fujikuroi IMI 58289 CCT74021.1    
 unnamed protein product (fragment)   Fusarium graminearum PH-1 CEF79406.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF88455.1    
 FVRRES_10901   Fusarium venenatum A3/5 CEI70824.1    
 FVRRES_07505 (fragment)   Fusarium venenatum A3/5 CEI63069.1    
 RCJMB04_7p22 (fragment) (fragment)   Gallus gallus CAH65209.1 Q5F3S5  
 unknown   Glycine max ACU19532.1 C6TCI0  
 unknown   Glycine max ACU20418.1 C6TF16  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225
Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
NP_000392.1
B2R5Z6
Q93063
 
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224
2.4.1.225
Homo sapiens AAB62283.1
AAH01174.1
ACS08204.1
AGV77097.1
AHB20150.1
BAG35949.1
NP_000118.1
B2R7V2
Q16394
 
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223
2.4.1.225
Homo sapiens AAC39598.1
AAB67602.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12594.1
ACW32787.1
ADO22448.1
BAA24080.1
BAA25445.2
BAA25445.3
BAG57702.1
NP_001431.1
D3DST8
O43909
Q53XT3
 
 exostosin-like 1 (Extl1) 2.4.1.224 Homo sapiens AAC51141.1
AAD02840.1
AAF73172.1
AAH65528.1
AAW12597.1
CAI17130.1
NP_004446.1
Q92935  
 UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Exotosin-like 2) (Extl2;EXTL2;Extr2) 2.4.1.223 Homo sapiens AAC02898.1
AAH14910.1
AAH36015.1
AAH45681.1
AAR61360.1
AAW12598.1
BAA24081.1
BAC04893.1
BAG60404.1
NP_001430.1
B2R795
D3DT60
Q8IYF4
Q8N8F1
Q9UBQ6
 
 ORF   Hypocrella siamensis MTCC 10142 ANH56592.1    
 ORF (Ext1C)   Ictalurus punctatus AHH42126.1    
 2_8443_01 (fragment)   Larix decidua AFB33673.1    
 LSINAPIS_LOCUS11241   Leptidea sinapis VUZ00689.1    
 LSINAPIS_LOCUS7130 (fragment)   Leptidea sinapis VUY95445.1    
 LSINAPIS_LOCUS12393 (fragment)   Leptidea sinapis VUZ02161.1    
 LRAMOSA05113   Lichtheimia ramosa CDS12929.1    
 unnamed protein product (fragment)   Macaca fascicularis BAE89111.1    
 ORF   Macaca mulatta AFE77124.1
AFH31465.1
AFI34959.1
   
 ORF   Macaca mulatta AFE66170.1
AFH29959.1
AFI33826.1
   
 exostosin-1, partial (Ext1) (fragment)   Macaca mulatta AFE71593.1    
 ORF   Macaca mulatta AFE77122.1
AFE77123.1
   
 exostosin-1 (Ext1)   Macaca mulatta AFH28289.1
AFJ71363.1
   
 unknown (fragment)   Medicago truncatula AFK40363.1    
 MICPUN_70089 (fragment)   Micromonas commoda sp. RCC299 ACO64184.1 C1E8N5  
 exostosin-2 (Ext2)   Mus musculus AAB17006.1
AAC53143.1
AAH06597.1
ABY16664.1
ACW41681.1
BAE22143.1
BAE28510.1
BAE29346.1
BAE31083.1
BAE37749.1
CAM22097.1
CAM22098.1
CAM23881.1
CAM23882.1
CAQ11719.1
NP_034293.1
P70428  
 exostosin-1 (Ext1)   Mus musculus AAB41728.1
AAH04741.1
ABY16663.1
ACW41680.1
BAE21106.1
CAA65443.1
NP_034292.1
P97464
Q3V1P4
 
 exostosin-like 1 (Extl1)   Mus musculus AAF61913.1
AAI20891.1
AAI20892.1
BAE36631.1
BAE43097.1
NP_062524.1
Q0VAW4
Q9JKV7
 
 α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) 2.4.1.224 Mus musculus AAD42040.1
AAH65073.1
AAW12587.1
BAE23506.1
NP_061258.2
Q9WVL6  
 UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Extl2) 2.4.1.223 Mus musculus AAG17542.1
AAH31438.1
AAH94444.1
BAB31683.2
BAC26062.1
BAC27649.1
BAE34959.1
BAE36615.1
BAM48568.1
BAM48569.1
NP_067363.1
Q8C089
Q8C197
Q9ES89
1OMX[A,B]
1OMZ[A,B]
1ON6[A,B]
1ON8[A,B]
 ORF   Musca domestica ALHF AFP60311.1    
 exostoses 1 (partial)   Mustela putorius furo AER98199.1    
 exostoses 2   Mustela putorius furo AER98200.1    
 ORF   Mustela putorius furo AER98201.1    
 ORF (fragment)   Mustela putorius furo AER98203.1    
 NGATSA_2005600   Nannochloropsis gaditana CCMP526 AFJ69249.1    
 NYM_LOCUS28540   Nymphaea colorata VVW82837.1    
 Os05g0540000   Oryza sativa Japonica Group AAT58698.1
AAS79703.1
AAV59411.1
BAF18092.1
BAS95108.1
Q53WK1  
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