GlycosylTransferase Family 64

Activities in FamilyUDP-GlcNAc: heparan α-N-acetylhexosaminyltransferase (EC 2.4.1.224)
Mechanism Retaining
3D Structure StatusGT-A
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain.
External resourcesGlymap;
Statistics GenBank accession (386); Uniprot accession (84); PDB accession (4); 3D entries (1); cryst (0)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 2_8443_01 (fragment)   Abies alba AFB33671.1
AFB33669.1
AFB33670.1
AFB33672.1
   
 CB5_LOCUS19099 (fragment)   Ananas comosus var. bracteatus VUW68514.1    
 CB5_LOCUS21602 (fragment)   Ananas comosus var. bracteatus VUW71017.1    
 CB5_LOCUS19772   Ananas comosus var. bracteatus VUW69187.1    
 CB5_LOCUS391 (fragment)   Ananas comosus var. bracteatus VUW49816.1    
 ACCB08353 (fragment)   Apis cerana AEY60334.1    
 ACCB07274 (fragment)   Apis cerana AEY60121.1    
 At3g55830/F27K19_10 (Epc1;AtEPC1)   Arabidopsis thaliana CAB87837.1
AEE79446.1
AHL38727.1
BAF00425.1
NP_191142.1
Q9LY62  
 At5g04500/T32M21_100   Arabidopsis thaliana NP_196070.2
AAO42055.1
AED90753.1
AHL38645.1
CAB85556.1
NP_196070.1
Q84WB7
Q9LZ75
 
 At1g80290/F5I6.4   Arabidopsis thaliana AAG52433.1
AAF27686.1
AAM61012.1
ABD59059.1
AEE36383.1
AEE36384.1
AKV71933.1
BAH20131.1
NP_565236.1
Q8LG66
Q9C975
 
 DS421_20g692710   Arachis hypogaea QHN82099.1    
 DS421_19g663300   Arachis hypogaea QHN78666.1
QHN78667.1
   
 DS421_15g494960   Arachis hypogaea QHO11065.1    
 DS421_5g166310   Arachis hypogaea QHO43861.1    
 DS421_5g163240   Arachis hypogaea QHO43493.1    
 DS421_5g166340   Arachis hypogaea QHO43864.1    
 DS421_15g510060   Arachis hypogaea QHO12808.1    
 DS421_10g298790   Arachis hypogaea QHO15887.1    
 DS421_15g521660   Arachis hypogaea QHO14145.1    
 ORF   Ascaris suum ADY41945.1    
 ORF   Ascaris suum ADY42536.1    
 Bathy17g01230 (probable fragment)   Bathycoccus prasinos RCC1105 CCO20567.1    
 Bathy19g00100   Bathycoccus prasinos RCC1105 CCO20744.1    
 Unknown (protein for MGC:137797)   Bos taurus AAI14731.1 Q1RMT0  
 Unknown (protein for MGC:155111)   Bos taurus AAI33541.1 A2VE26  
 Unknown (protein for MGC:151773)   Bos taurus AAI40569.1 A5D7I4  
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) 2.4.1.224
2.4.1.225
Bos taurus AAC35386.1
AAI26571.1
NP_803462.1
O77783  
 ORF (protein for MGC:160120)   Bos taurus AAI50062.1 A6QR03  
 BOLC8T50736H   Brassica oleracea VDD57507.1    
 BOLC9T59970H   Brassica oleracea VDD34647.1    
 BOLC2T10127H (fragment)   Brassica oleracea VDD24376.1    
 BOLC2T06153H   Brassica oleracea VDD18297.1    
 BOLC2T09755H   Brassica oleracea VDD23846.1    
 BRAA09T40335Z   Brassica rapa VDC62724.1    
 BRAA02T04815Z   Brassica rapa VDC84653.1    
 BRAA02T07360Z   Brassica rapa VDC89516.1    
 BRAA04T16136Z (fragment)   Brassica rapa VDD10785.1    
 BRAA10T45205Z   Brassica rapa VDD21080.1    
 Ext2 (K01G5.6/Rib2)   Caenorhabditis elegans Bristol N2 AAC47510.1
AAW12599.1
BAB83878.1
CAB07245.1
NP_499368.1
O01705  
 ORF   Callorhinchus milii AFO94815.1    
 ORF   Callorhinchus milii AFP01971.1    
 ORF (fragment)   Callorhinchus milii AFP02012.1    
 ORF (fragment)   Callorhinchus milii AFO98479.1    
 ORF (fragment)   Callorhinchus milii AFP03381.1    
 ORF (fragment)   Callorhinchus milii AFP04792.1    
 A3770_01p05250   Chloropicon primus CCMP1205 QDZ18007.1    
 A9K55_006602 (fragment)   Cordyceps militaris ATCC 34164 ATY61117.1    
 CSTEINMANNI_LOCUS3116402   Coregonus sp. balchen CAB1339283.1    
 CSTEINMANNI_LOCUS3550657 (fragment)   Coregonus sp. balchen CAB1342930.1    
 CSTEINMANNI_LOCUS3226745 (fragment)   Coregonus sp. balchen CAB1340287.1    
 CSTEINMANNI_LOCUS3226352   Coregonus sp. balchen CAB1339894.1    
 CSTEINMANNI_LOCUS3550658 (fragment)   Coregonus sp. balchen CAB1342931.1    
 CSTEINMANNI_LOCUS3226746 (fragment)   Coregonus sp. balchen CAB1340288.1    
 CSTEINMANNI_LOCUS3550807   Coregonus sp. balchen CAB1343080.1    
 CSTEINMANNI_LOCUS3550656 (fragment)   Coregonus sp. balchen CAB1342929.1    
 CSTEINMANNI_LOCUS641224   Coregonus sp. balchen CAB1317902.1    
 CSTEINMANNI_LOCUS1016472 (fragment)   Coregonus sp. balchen CAB1321349.1    
 CSTEINMANNI_LOCUS4563109 (fragment)   Coregonus sp. balchen CAB1351322.1    
 CSTEINMANNI_LOCUS4563008 (fragment)   Coregonus sp. balchen CAB1351221.1    
 CSTEINMANNI_LOCUS4563108 (fragment)   Coregonus sp. balchen CAB1351321.1    
 CSTEINMANNI_LOCUS1016214 (fragment)   Coregonus sp. balchen CAB1321091.1    
 CSTEINMANNI_LOCUS1016207 (fragment)   Coregonus sp. balchen CAB1321084.1    
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.224
2.4.1.225
Cricetulus griseus AAF71276.1 Q9JK82  
 ORF   Crotalus adamanteus AFJ50039.1    
 ORF   Crotalus adamanteus AFJ50038.1    
 ORF   Crotalus adamanteus AFJ50040.1    
 CYME_CMG174C   Cyanidioschyzon merolae strain 10D BAM79674.1    
 CYME_CMP307C   Cyanidioschyzon merolae strain 10D BAM81902.1    
 Ext2   Danio rerio AAV48783.1 Q5U7A7  
 exostosin-like 3 (Extl3)   Danio rerio AAV51343.1
AAI62406.1
Q5U7D2  
 EXT1b   Danio rerio AAW29034.1
AAI25901.1
AAI65657.1
Q5IGR7  
 EXT1c   Danio rerio AAW29035.1
AAI15217.1
AAI55813.1
Q5IGR6  
 EXT1a   Danio rerio AAW29033.1
AAI33118.1
Q5IGR8  
 Unknown (protein for MGC:153688) (OTTDARP00000010010)   Danio rerio AAI24427.1
CAP09235.1
Q08C36  
 Dbus_chr2Rg1704   Drosophila busckii ALC42125.1    
 Dbus_chr2Rg1360 (fragment)   Drosophila busckii ALC41781.1    
 Dbus_chr2Rg1995   Drosophila busckii ALC42416.1    
 CG8433 (Dext2;sotv)   Drosophila melanogaster AAD38573.1
AAF58055.2
AAF58056.1
AAO39548.1
AAO41379.1
NP_725536.1
NP_788367.1
NP_788368.1
A4UZJ2
Q9Y169
 
 tout-velu (CG10117;Dext1;ttv)   Drosophila melanogaster AAC32397.1
AAF58236.1
AAX33551.1
AGB93503.1
BAE78509.1
NP_477231.1
QCD26199.1
Q5BI21
Q9V730
Q9V730
 
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225
Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1
Q9XZ08  
 ORF (fragment)   Equus caballus AEP99427.1    
 UDP-glycosyltransferase   Fallopia multiflora ATO91431.1    
 CEK26_012913   Fusarium fujikuroi Augusto2 QGI99844.1    
 CEK26_001916   Fusarium fujikuroi Augusto2 QGI90701.1    
 CEK27_012926   Fusarium fujikuroi CSV1 QGI68955.1    
 CEK27_001913   Fusarium fujikuroi CSV1 QGI59788.1    
 CEK25_001896   Fusarium fujikuroi I1.3 QGI76990.1    
 CEK25_013055   Fusarium fujikuroi I1.3 QGI86326.1    
 FFUJ_00029   Fusarium fujikuroi IMI 58289 CCT63336.1    
 FFUJ_09875   Fusarium fujikuroi IMI 58289 CCT74021.1    
 FGRAMCML3066_01t15267.1 (fragment)   Fusarium graminearum CZS82691.1    
 FGRAMCML3066_01t22189.1   Fusarium graminearum CZS86151.1    
 unnamed protein product (fragment)   Fusarium graminearum PH-1 CEF79406.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF88455.1    
 FVRRES_10901   Fusarium venenatum A3/5 CEI70824.1    
 FVRRES_07505 (fragment)   Fusarium venenatum A3/5 CEI63069.1    
 RCJMB04_7p22 (fragment) (fragment)   Gallus gallus CAH65209.1 Q5F3S5  
 unknown   Glycine max ACU19532.1 C6TCI0  
 unknown   Glycine max ACU20418.1 C6TF16  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225
Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
NP_000392.1
B2R5Z6
Q93063
 
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