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GlycosylTransferase Family 64

Known ActivitiesUDP-GlcNAc: heparan α-N-acetylhexosaminyltransferase (EC 2.4.1.224)
Mechanism Retaining
3D Structure StatusGT-A
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs have a single domain.
Statistics GenBank accession (196); Uniprot accession (74); PDB accession (4); 3D entries (1); cryst (0)
Summary
All (69) Eukaryota (69) Structure (1 ) Characterized (10)
Eukaryota
Protein NameEC#OrganismGenBankUniprotPDB/3D
 At3g55830/F27K19_10 (Epc1)   Arabidopsis thaliana BAF00425.1
CAB87837.1
NP_191142.1		 Q9LY62  
 At5g04500/T32M21_100   Arabidopsis thaliana AAO42055.1
CAB85556.1
NP_196070.1
NP_196070.2		 Q84WB7
Q9LZ75		  
 At1g80290/F5I6.4   Arabidopsis thaliana AAF27686.1
AAG52433.1
AAM61012.1
ABD59059.1
BAH20131.1
NP_565236.1		 Q8LG66
Q9C975		  
 ORF (protein for MGC:160120)   Bos taurus AAI50062.1 A6QR03  
 Unknown (protein for MGC:137797)   Bos taurus AAI14731.1 Q1RMT0  
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) 2.4.1.224
2.4.1.225		 Bos taurus AAC35386.1
AAI26571.1
NP_803462.1		 O77783.1  
 Unknown (protein for MGC:155111)   Bos taurus AAI33541.1 A2VE26  
 Unknown (protein for MGC:151773)   Bos taurus AAI40569.1 A5D7I4  
 Ext2 (K01G5.6/Rib2)   Caenorhabditis elegans Bristol N2 AAC47510.1
AAW12599.1
BAB83878.1
CAB07245.1
NP_499368.1		 O01705.2  
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.224
2.4.1.225		 Cricetulus griseus AAF71276.1 Q9JK82  
 Ext2   Danio rerio AAV48783.1 Q5U7A7  
 EXT1b   Danio rerio AAI25901.1
AAI65657.1
AAW29034.1		 Q5IGR7  
 Unknown (protein for MGC:153688) (OTTDARP00000010010)   Danio rerio AAI24427.1
CAP09235.1		 Q08C36  
 EXT1c   Danio rerio AAI15217.1
AAI55813.1
AAW29035.1		 Q5IGR6  
 EXT1a   Danio rerio AAI33118.1
AAW29033.1		 Q5IGR8  
 exostosin-like 3 (Extl3)   Danio rerio AAI62406.1
AAV51343.1		 Q5U7D2  
 CG8433 (Dext2;sotv)   Drosophila melanogaster AAD38573.1
AAF58055.2
AAF58056.1
AAO39548.1
AAO41379.1
NP_725536.1
NP_788367.1
NP_788368.1		 A4UZJ2
Q9Y169		  
 tout-velu (CG10117;Dext1;ttv)   Drosophila melanogaster AAC32397.1
AAF58236.1
AAX33551.1
BAE78509.1
NP_477231.1		 Q5BI21
Q9V730
Q9V730.1		  
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225		 Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1		 Q9XZ08  
 RCJMB04_7p22 (fragment)   Gallus gallus CAH65209.1 Q5F3S5  
 unknown   Glycine max ACU19532.1    
 unknown   Glycine max ACU20418.1    
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224
2.4.1.225		 Homo sapiens AAB62283.1
AAH01174.1
ACS08204.1
BAG35949.1
NP_000118.1		 B2R7V2
Q16394.2		  
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223
2.4.1.225		 Homo sapiens AAB67602.1
AAC39598.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12594.1
ACW32787.1
BAA24080.1
BAA25445.2
BAG57702.1
NP_001431.1		 D3DST8
O43909.1
Q53XT3		  
 exostosin-like 1 (Extl1) 2.4.1.224 Homo sapiens AAC51141.1
AAD02840.1
AAF73172.1
AAH65528.1
AAW12597.1
CAI17130.1
NP_004446.1		 Q92935  
 UDP-GlcNAc: α-1,4-N-acetylglucosaminyltransferase (Exotosin-like 2) (Extl2;Extr2) 2.4.1.223 Homo sapiens AAC02898.1
AAH14910.1
AAH36015.1
AAH45681.1
AAR61360.1
AAW12598.1
BAA24081.1
BAC04893.1
BAG60404.1
NP_001430.1		 B2R795
D3DT60
Q8IYF4
Q8N8F1
Q9UBQ6		  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225		 Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
NP_000392.1		 B2R5Z6
Q93063.1		  
 unnamed protein product (fragment)   Macaca fascicularis BAE89111.1    
 MICPUN_70089 (fragment)   Micromonas sp. RCC299 ACO64184.1    
 exostosin-1 (Ext1)   Mus musculus AAB41728.1
AAH04741.1
ABY16663.1
ACW41680.1
BAE21106.1
CAA65443.1
NP_034292.1		 P97464.1
Q3V1P4		  
 exostosin-like 1 (Extl1)   Mus musculus AAF61913.1
AAI20891.1
AAI20892.1
BAE36631.1
BAE43097.1
NP_062524.1		 Q0VAW4
Q9JKV7		  
 α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) 2.4.1.224 Mus musculus AAD42040.1
AAH65073.1
AAW12587.1
BAE23506.1
NP_061258.2		 Q9WVL6  
 α-N-acetylhexosaminyltransferase (Extl2) 2.4.1.- Mus musculus AAG17542.1
AAH31438.1
AAH94444.1
BAB31683.2
BAC26062.1
BAC27649.1
BAE34959.1
BAE36615.1
NP_067363.1		 Q8C089
Q8C197
Q9ES89.1		 1OMX[A,B]
1OMZ[A,B]
1ON6[A,B]
1ON8[A,B]
 exostosin-2 (Ext2)   Mus musculus AAB17006.1
AAC53143.1
AAH06597.1
ABY16664.1
ACW41681.1
BAE22143.1
BAE28510.1
BAE29346.1
BAE31083.1
BAE37749.1
CAM22097.1
CAM22098.1
CAM23881.1
CAM23882.1
CAQ11719.1
NP_034293.1		 P70428.1  
 Os03g0684500   Oryza sativa Japonica Group AAK14423.1
BAF12834.1		 Q10F19  
 Os05g0540000   Oryza sativa Japonica Group AAS79703.1
AAT58698.1
AAV59411.1
BAF18092.1		 Q53WK1  
 P0018H04.8   Oryza sativa Japonica Group BAD53800.1
BAH01223.1		 Q5Z8V4  
 OSTLU_41697   Ostreococcus lucimarinus CCE9901 ABO99406.1 A4S6M1  
 OSTLU_36758   Ostreococcus lucimarinus CCE9901 ABP01200.1 A4S6M1  
 Ot13g02070   Ostreococcus tauri OTTH0595 CAL56535.1 Q00WX6  
 unknown   Picea sitchensis ADE77623.1    
 DKFZp459K2032   Pongo abelii CAH90611.1 Q5RC96  
 DKFZp468L2313   Pongo abelii CAH90937.1 Q5RBC3  
 Unknown (protein for IMAGE:7453681) (fragment)   Rattus norvegicus AAI05840.1 Q3B8R0  
 Unknown protein for MGC:188484   Rattus norvegicus AAI66748.1 B2RYE4  
 Reg receptor   Rattus norvegicus BAA92895.1
BAD90409.1
NP_064482.1		 Q9JMA8  
 Extl2 (MGC:187885;IMAGE:9091843)   Rattus norvegicus AAH91373.1
AAI62014.1		 B1WC59  
 ORF   Saccoglossus kowalevskii ACY92509.1    
 Ext2 (fragment)   Salmo salar ACN58692.1    
 EXTL2   Salmo salar ACN11111.1    
 SJCHGC08232 (fragment)   Schistosoma japonicum AAX26777.2 Q5C0P8  
 Smp_073220   Schistosoma mansoni CAZ34733.1    
 Smp_172060   Schistosoma mansoni CAZ36393.1    
 Smp_146320   Schistosoma mansoni CAZ32036.1
CAZ32037.1		    
 EXT1 (fragment)   Sus scrofa CAC67995.1 Q95KP6  
 VITISV_038958 (short fragment)   Vitis vinifera CAN76751.1 A5BDG3  
 VITISV_033101   Vitis vinifera CAN68561.1 A5C241  
 VITISV_017356 (fragment)   Vitis vinifera CAN79748.1 A5C7B3  
 Unknown (protein for MGC:185216)   Xenopus (Silurana) tropicalis AAI66243.1 B2GUE4  
 Unknown (protein for MGC:89702)   Xenopus (Silurana) tropicalis AAH80459.1
CAJ81810.1		 Q66KC7  
 Unknown (protein for MGC:79560)   Xenopus (Silurana) tropicalis AAH80918.1 Q66JH0  
 Unknown (protein for MGC:89315)   Xenopus (Silurana) tropicalis AAH75481.1 Q6DIQ4  
 Unknown (protein for MGC:80258)   Xenopus laevis AAH72858.1 Q6GQ89  
 ORF   Xenopus laevis AAH44703.1
AAH60367.1		 Q7ZTM7  
 Unknown (protein for MGC:80904)   Xenopus laevis AAH73424.1 Q6GNS9  
 Unknown (protein for MGC:83950)   Xenopus laevis AAH81133.1
AAH94483.1		 Q66IZ2  
 XEXT1   Xenopus laevis AAH77234.1
AAH94398.1
BAB87180.1		 Q8QGX3  
 exostosin   Xenopus laevis AAK15278.1
AAO84329.1		 Q98SV5  
 unknown   Zea mays ACG28807.1 B6SVC4