GlycosylTransferase Family 4

Activities in Familysucrose synthase (EC 2.4.1.13); sucrose-phosphate synthase (EC 2.4.1.14); α-glucosyltransferase (EC 2.4.1.52); lipopolysaccharide N-acetylglucosaminyltransferase (EC 2.4.1.56); phosphatidylinositol α-mannosyltransferase (EC 2.4.1.57); GDP-Man: Man1GlcNAc2-PP-dolichol α-1,3-mannosyltransferase (EC 2.4.1.132); GDP-Man: Man3GlcNAc2-PP-dolichol/Man4GlcNAc2-PP-dolichol α-1,2-mannosyltransferase (EC 2.4.1.131); digalactosyldiacylglycerol synthase (EC 2.4.1.141); 1,2-diacylglycerol 3-glucosyltransferase (EC 2.4.1.157); diglucosyl diacylglycerol synthase (EC 2.4.1.208); trehalose phosphorylase (EC 2.4.1.231); NDP-Glc: α-glucose α-glucosyltransferase / α,α-trehalose synthase (EC 2.4.1.245); GDP-Man: Man2GlcNAc2-PP-dolichol α-1,6-mannosyltransferase (EC 2.4.1.257); UDP-GlcNAc: 2-deoxystreptamine α-N-acetylglucosaminyltransferase (EC 2.4.1.283); UDP-GlcNAc: ribostamycin α-N-acetylglucosaminyltransferase (EC 2.4.1.285); UDP-Gal α-galactosyltransferase (EC 2.4.1.-); UDP-Xyl α-xylosyltransferase (EC 2.4.2.-); UDP-GlcA α-glucuronyltransferase (EC 2.4.1.-); UDP-Glc α-glucosyltransferase (EC 2.4.1.-); UDP-GalNAc: GalNAc-PP-Und α-1,3-N-acetylgalactosaminyltransferase (EC 2.4.1.306); UDP-GalNAc: N,N'-diacetylbacillosaminyl-PP-Und α-1,3-N-acetylgalactosaminyltransferase (EC 2.4.1.290); ADP-dependent α-maltose-1-phosphate synthase (2.4.1.342); [retaining] UDP-GlcNAc: polypeptide α-N-acetylglucosaminyltransferase (EC 2.4.1.-); UDP-GlcNAc: α-N-acetylglucosaminyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-B
External resourcesGlymap; GPI:PIG-A;
Statistics GenBank accession (254067); Uniprot accession (331); PDB accession (90); 3D entries (35); cryst (0)
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 AF0043 (WbaZ-1)   Archaeoglobus fulgidus DSM 4304 AAB91187.1
NP_068884.1
 
2F9F[A] 1.80
 NDP-Glc: α-glucose α-glucosyltransferase / a,α-trehalose synthase (TreT;PhGT;PH1035) 2.4.1.245 Pyrococcus horikoshii OT3 BAA30133.1
NP_142946.1
O58762
2X6Q[A,B] 2.20
2X6R[A,B] 2.20
2XA1[A,B] 2.47
2XA2[A,B] 2.50
2XA9[A,B] 2.50
2XMP[A,B] 2.50
 TUZN_0976 2.4.1.245 Thermoproteus uzoniensis 768-20 AEA12458.1 F2L613
6ZJ4[AAA]
6ZJ7[AAA]
6ZJH[AAA]
6ZMZ[AAA]
6ZN1[AAA]
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 UDP-GlcNAc: L-malate α-N-acetylglucosaminyltransferase (BshA;BA1558) 2.4.1.- Bacillus anthracis str. Ames AAP25494.1
NP_844008.1
Q81ST7
2JJM[A,B,C,D,E,F,G,H,I,J, 3.10
 UDP-GlcNAc: L-malate α-N-acetylglucosaminyltransferase (BshA;BAS1445) 2.4.1.- Bacillus anthracis str. Sterne AAT53765.1
AJH48342.1
Q81ST7
3MBO[A,B,C,D,E,F,G,H] 3.31
 UDP-GlcNAc: L-malate α-N-acetylglucosaminyltransferase (BshA; YpjH; JojH; BSU22460) 2.4.1.- Bacillus subtilis subsp. subtilis str. 168 AIY93568.1
AAA92877.1
AQR82256.1
AQR86470.1
CAB14162.1
NP_390127.1
A0A6M3ZDL5
P42982
5D00[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
2.15
5D01[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
2.02
 UDP-GalNAc: α-1,4-N-acetylgalactosyltransferase (PglH;WlaC;Cj1129c)   Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 CAB73384.1
CAA04329.1
CAL35246.1
NP_282277.1
O52905
O86151
Q0P9C5
Q9PNG5
6EJI[A,B] 2.30
6EJJ[A,B] 2.70
6EJK[A,B] 3.30
 UDP-GlcNAc: 1L-myo-inositol-1-P α-N-acetylglucoaminyltransferase (MshA;cg0481;NCgl0389) 2.4.1.- Corynebacterium glutamicum ATCC 13032 CAF19117.1
ACC03816.1
BAB97794.1
CCH23610.1
NP_599648.1
Q8NTA6
3C48[A,B] 2.10
3C4Q[A,B] 2.80
3C4V[A,B] <carb_like_LIP>
2.60
 α-mannosyltransferase (PimB;NCgl2106;RXN02148) 2.4.1.- Corynebacterium glutamicum ATCC 13032 BAB99579.1
CAC26525.1
CAF20527.1
CAJ85352.1
CCH25326.1
NP_601390.1
Q8NNK8
3OKA[A,B] 2.20
3OKC[A] 2.40
3OKP[A] 2.00
 UDP-GalNAc: GalNAc-PP-Und α-1,3-N-acetylgalactosaminyltransferase (WbnH)   Escherichia coli O86:H2 AAV80749.1  
4XYW[A] 2.20
 UDP-Glc: L-glycero-D-manno-heptose II α-1,3-glucosyltransferase I (WaaG,RfaG)   Escherichia coli str. K-12 substr. MG1655 AAC76655.1
AAA03743.1
AAA24082.1
AAB18608.1
AAD43826.1
AIZ93568.1
ALI38680.1
AMC96519.1
AUG18343.1
AVI53799.1
AYG17425.1
NP_418088.1
P25740
2IV7[A] 1.6
2IW1[A] 1.5
2N58[A] NMR
 FTT1235c (LpcC)   Francisella tularensis subsp. tularensis SCHU S4 CAG45868.1  
5I45[A] 1.35
 dTDP-β-L-Rha; S-Layer glycoprotein β-1,2-rhamnosyltransferase (WsaF;Orf7) 2.4.1.- Geobacillus stearothermophilus NRS 2004/3A AAR99609.1 Q7BG50
2X0D[A,B] 2.28
2X0E[A,B] 2.81
2X0F[A,B] 2.55
 sucrose phosphate synthase (SpsA) 2.4.1.14 Halothermothrix orenii ACB11221.1 B2CCB8
B8CZ51
2R60[A] 1.80
2R66[A] 2.80
2R68[A] P-(0-6)-β-D-Fruf-(2-1)-α-D-Glcp
2.40
 cholesterol α-glucosyltransferase (HP0421) 2.4.1.- Helicobacter pylori 26695 AAD07485.1
AFV41644.1
CAP40180.1
NP_207219.1
O25175
3QHP[A,B] 1.50
 phosphatidylinositol mannosyltransferase (PimA;MSMEG_2935) 2.4.1.57 Mycolicibacterium smegmatis MC2 155 ABK72422.1
AAG17338.1
AFP39325.1
AIU08092.1
A0QWG6
Q9F7Y7
2GEJ[A] 2.60
2GEK[A] 2.40
4N9W[A] 1.94
4NC9[A] 3.19
 ADP-Glc-dependent α-maltose-1-phosphate synthase (GlgA;MSMEG_5080) 2.4.1.342 Mycolicibacterium smegmatis MC2 155 ABK70457.1
AFP41398.1
AIU10118.1
A0R2E2
6TVP[A,B] 1.90
 sucrose synthase (Ss2;SuSyNe;NE1214) 2.4.1.13 Nitrosomonas europaea ATCC 19718 CAD85125.1
NP_841269.1
Q820M5
4RBN[A,B,C,D] 3.05
 UDP-Glc: [heterocyst envelope polysaccharide] mannoside glucosyltransferase (HepE;Alr3699) 2.4.1.- Nostoc sp. PCC 7120 = FACHB-418 BAB75398.1
NP_487739.1
Q8YQW3
4XSO[A,B] 2.01
4XSP[A,B] 2.15
4XSR[A,B] 2.39
4XSU[A,B] α-D-Glcp
2.48
 RAF_ORF0434   Rickettsia africae ESF-5 ACP53366.1  
7MI0[A] 2.90
 LPS 1,6-galactosyltransferase (RfaB)   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL22578.1
AAC16413.1
Q06994
5N7Z[A] 1.81
5N80[A] 1.92
6Y6G[A] 1.81
6Y6I[A] 1.92
 UDP-GlcNAc: teichoic acid α-N-acetylglucosaminyltransferase (TarM;SA21178_0837) 2.4.1.- Staphylococcus aureus subsp. aureus 21178 EHM57698.1 A0A0H2WWV6
4X6L[A,B,C,D] 3.19
4X7M[A,B] 2.40
4X7P[A,B] 3.40
4X7R[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
α-D-GlcpNSO36SO3-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNSO33SO36SO3-(1-4)-α-L-IdopA2SO3-(1-4)-α-D-GlcpNSO36SO3-(1-1)-methyl
2.15
 UDP-GlcNAc: teichoic acid α-N-acetylglucosaminyltransferase (TarM;SACOL1043;SA1043 ) 2.4.1.- Staphylococcus aureus subsp. aureus COL AAW36508.1 A0A0D6HUA0
A0A0H2WWV6
Q5HH49
4WAC[A] 2.40
4WAD[A] 2.80
 Serine-O-α-N-acetylglucosaminyltransferase (SdgB;SAUSA300_0550) 2.4.1.- Staphylococcus aureus subsp. aureus USA300_FPR3757 ABD21647.1 A0A0H2XGN0
7EC1[A,B] 1.85
7EC3[A,B] β-D-GlcpNAc
2.50
7EC4[A,C] 2.28
7EC6[A,B] 1.90
7EC7[A,B] 3.20
7VFK[A,B] 1.84
7VFL[A,B] β-D-GlcpNAc
2.45
7VFM[A,B] 2.28
7VFN[A,B] 1.90
7VFO[A,B] 3.20
 α-N-acetylglucosaminyltransferase (SdgA;SAUSA300_0549) 2.4.1.- Staphylococcus aureus subsp. aureus USA300_FPR3757 ABD21657.1 A0A0H2XI10
7EC2[A,B] 2.80
 UDP-GlcNAc: L-malate α-N?acetylglucosaminyltransferase (BshA;USA300HOU_1396) 2.4.1.- Staphylococcus aureus subsp. aureus USA300_TCH1516 ABX29406.1 A0A068A5A2
A8Z438
T1Y9F7
6D9T[A] 2.00
6N1X[A] α-D-GlcpNAc
2.35
 cytosolic O-glycosyltransferase / UDP-GlcNAc: [Ser/Thr] O-N-acetylglucosaminyltransferase - active subunit GtfA (Gtf1;Gtf;GtfA) 2.4.1.- Streptococcus gordonii M99 AAK17002.2 Q9AET5
5E9T[A,C] 2.92
5E9U[A,C,E,G] β-D-GlcpNAc
3.84
 UDP-GlcNAc: protein [Serine] α-N-acetylglucosaminyltransferase (GtfA;OGT;SP1758) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75833.1
NP_346193.1
A0A0H2URG7
Q97P84
4PQG[A,B] β-D-GlcpNAc
2.00
 eurekanate-attachment enzyme (AviGT4)   Streptomyces viridochromogenes TUE57 AAK83193.1 Q93KV2
2IUY[A,B] 2.1
2IV3[A,B,C,D] 2.3
 UDP-Glc: tetrahydrobiopterin α-glucosyltransferase (BGluT;Synpcc7942_1918) 2.4.1.- Synechococcus elongatus PCC 7942 = FACHB-805 AAK70860.1
ABB57948.1
Q31LX1
Q93EY3
5ZE7[A,B] 1.99
5ZER[A,B] 2.39
5ZES[A,B] 2.03
5ZFK[A,B] 1.75
  sucrose-phosphate synthase (TeSPS; Tll1590) 2.4.1.14 Thermosynechococcus vestitus BP-1 BAC09142.1
NP_682380.1
Q8DIJ5
6KIH[A,B,C,D,E,F,G,H,I,J, 3.00
6LDQ[A,B,C,D] 1.92
 UDP-Glc: α-1,2-glucosyltransferase (Tll1591) 2.4.1.- Thermosynechococcus vestitus BP-1 BAC09143.1
NP_682381.1
Q8DIJ4
7FG9[A,B] 2.66
7FGA[A,B,C,D] 3.20
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 sucrose synthase 1 (Sus1;AtSus1;At5g20830) 2.4.1.13 Arabidopsis thaliana NP_197583.1
AED92894.1
AED92895.1
ANM71045.1
BAD94975.1
BAH19538.1
CAA50317.1
NP_001031915.1
P49040
3S27[A,B,C,D,E,F,G,H] β-D-Fruf
2.91
3S28[A,B,C,D,E,F,G,H] D-1-deoxy-Glcp
2.80
3S29[A,B,C,D,E,F,G,H] β-D-Fruf
2.85
 digalactosyldiacylglycerol synthase (Dgd2;DGD2;At4g00550) 2.4.1.241 Arabidopsis thaliana BAF00170.1
AAC13625.1
AAL60504.1
AAQ22613.1
AAR76412.1
AEE81898.1
AHL38716.1
ANM67739.1
BAD94208.1
CAB80864.1
CAD5326714.1
NP_191964.1
A0A178V709
A0A7G2EWA5
Q8W1S1
2L7C[A] NMR
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 NY2A_B736L   Paramecium bursaria Chlorella virus NY2A ABT15135.1  
3OY2[A,B] 2.31
3OY7[A,B] 2.73
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