GlycosylTransferase Family 47

Activities in Familyheparan β-glucuronyltransferase (EC 2.4.1.225); xyloglucan β-galactosyltransferase (EC 2.4.1.-); heparan synthase (EC 2.4.1.-); arabinan α-L-arabinosyltransferase (EC 2.4.2.-).
Mechanism Inverting
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase.
External resourcesGlymap;
Statistics GenBank accession (1151); Uniprot accession (236);
All (604) Bacteria (3) Eukaryota (599) Viruses (2) Characterized (13)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF (fragment)   Bufo gargarizans AUD44298.1    
 Ext2 (K01G5.6/Rib2)   Caenorhabditis elegans Bristol N2 AAC47510.1
BAB83878.1
CAB07245.1
NP_499368.1
O01705  
 Ext-1 / Riβ-1   Caenorhabditis elegans Bristol N2 CAB61014.1
AAC47509.1
BAF48989.1
NP_502180.1
A4F1W7
O01704
O01704
 
 ORF   Callorhinchus milii AFO94815.1    
 ORF (fragment)   Callorhinchus milii AFP02012.1    
 ORF (fragment)   Callorhinchus milii AFO98479.1    
 ORF (fragment)   Callorhinchus milii AFP03381.1    
 ORF (fragment)   Callorhinchus milii AFP04792.1    
 ORF (fragment)   Callulina kreffti AUD44280.1    
 ORF (fragment)   Calyptocephallela gayi AUD44255.1    
 Cr_42180   Capsella rubella ABA18105.1 Q287V3  
 ORF (fragment)   Ceratophrys cornuta AUD44302.1    
 ORF (fragment)   Chiasmocleis ventrimaculata AUD44229.1    
 ORF (fragment)   Conraua crassipes AUD44303.1    
 ORF (fragment)   Cophixalus cheesmanae AUD44288.1    
 ORF (fragment)   Cophixalus sp. TNHC-GDC 31221 AUD44240.1    
 ORF (fragment)   Cornufer pelewensis AUD44343.1    
 ORF (fragment)   Craugastor augusti AUD44312.1    
 ORF (fragment)   Craugastor fitzingeri AUD44263.1    
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.224
2.4.1.225
Cricetulus griseus AAF71276.1 Q9JK82  
 ORF (fragment)   Crinia signifera AUD44305.1    
 ORF (fragment)   Crocodylus siamensis AIW46892.1    
 ORF   Crotalus adamanteus AFJ50039.1    
 ORF   Crotalus adamanteus AFJ50038.1    
 ORF (fragment)   Cryptobatrachus sp. TNHC-GDC 451 AUD44304.1    
 CGB_G5240C   Cryptococcus gattii WM276 ADV23625.1    
 CNAG_03480   Cryptococcus neoformans var. grubii H99 AFR96705.1    
 CKF44_003107   Cryptococcus neoformans var. grubii KN99 AUB26654.1    
 CNG01130   Cryptococcus neoformans var. neoformans JEC21 AAW44475.1 Q5KEB0  
 Exo   Cucumis melo AAU04753.1 Q5DMX2  
 glucuronoxylan glucuronosyltransferase   Cucumis melo subsp. melo ADN33853.1 E5GBL2  
 ORF (fragment)   Cynops orientalis AGQ56492.1    
 Ext2   Danio rerio AAV48783.1 Q5U7A7  
 exostosin-like 3 (Extl3)   Danio rerio AAV51343.1
AAI62406.1
Q5U7D2  
 EXT1b   Danio rerio AAW29034.1
AAI25901.1
AAI65657.1
Q5IGR7  
 EXT1c   Danio rerio AAW29035.1
AAI15217.1
AAI55813.1
CAX13427.1
CAX13428.1
Q5IGR6  
 EXT1a   Danio rerio AAW29033.1
AAI33118.1
CAM12981.1
Q5IGR8  
 ORF (fragment)   Dendropsophus parviceps AUD44252.1    
 ORF (fragment)   Desmognathus fuscus AIW46893.1    
 ORF (fragment)   Desmognathus quadramaculatus AIW46894.1    
 ORF (fragment)   Desmognathus wrighti AIW46895.1    
 ORF (fragment)   Dicamptodon aterrimus AGQ56493.1    
 ORF (fragment)   Discoglossus pictus AUD44233.1    
 Dbus_chr2Rg1704   Drosophila busckii ALC42125.1    
 Dbus_chr2Rg1360 (fragment)   Drosophila busckii ALC41781.1    
 Dbus_chr2Rg1363 (fragment)   Drosophila busckii ALC41784.1    
 Dbus_chr2Rg1995   Drosophila busckii ALC42416.1    
 CG8433 (Dext2;sotv)   Drosophila melanogaster AAD38573.1
AAF58055.2
AAF58056.1
AAO39548.1
AAO41379.1
NP_725536.1
NP_788367.1
NP_788368.1
A4UZJ2
Q9Y169
 
 tout-velu (CG10117;Dext1;ttv)   Drosophila melanogaster AAC32397.1
AAF58236.1
AAX33551.1
ADG57806.1
AGB93503.1
AGB93504.1
BAE78509.1
NP_477231.1
Q5BI21
Q9V730
Q9V730
 
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225
Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1
Q9XZ08  
 ORF (fragment)   Duttaphrynus melanostictus AUD44300.1    
 ORF (fragment)   Dyscophus antongilii AUD44306.1    
 ORF (fragment)   Elachistocleis ovalis AUD44307.1    
 ORF (fragment)   Eleutherodactylus planirostris AUD44274.1    
 ORF (fragment)   Engystomops pustulosus AUD44227.1    
 ORF (fragment)   Ensatina eschscholtzii AIW46896.1    
 ORF (fragment)   Equus caballus AEP99427.1    
 xyloglucan galactosyltransferase (Mur3;EgMUR3)   Eucalyptus grandis ACY08857.1 D0V2A6  
 ORF (fragment)   Eupsophus calcaratus AUD44246.1    
 ORF (fragment)   Eurycea bislineata AGQ56494.1    
 ORF (fragment)   Eurycea quadridigitata AIW46897.1    
 ORF (fragment)   Fejervarya limnocharis AUD44309.1    
 RCJMB04_7p22 (fragment) (fragment)   Gallus gallus CAH65209.1 Q5F3S5  
 ORF (fragment)   Gastrophryne olivacea AUD44310.1    
 ORF (fragment)   Gastrotheca pseustes AUD44311.1    
 ORF (fragment)   Gastrotheca weinlandii AUD44237.1    
 unknown   Glycine max ACU18220.1 C6T8R8  
 unknown (fragment)   Glycine max ACU17292.1 C6T680  
 unknown (fragment)   Glycine max ACU21295.1 C6THJ3  
 unknown (fragment)   Glycine max ACU22716.1 C6TIH6  
 ORF (fragment)   Heleophryne purcelli AUD44316.1    
 ORF (fragment)   Hemidactylium scutatum AIW46899.1    
 ORF (fragment)   Hemisus marmoratus AUD44315.1    
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225
Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
BAH12417.1
NP_000392.1
B2R5Z6
Q93063
 
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224
2.4.1.225
Homo sapiens AAB62283.1
AAC51154.1
AAH01174.1
ACS08204.1
ADI56520.1
AGT15863.1
BAG35949.1
NP_000118.1
B2R7V2
Q16394
 
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223
2.4.1.225
Homo sapiens AAC39598.1
AAB67602.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12589.1
ACW32787.1
BAA24080.1
BAA25445.2
BAA25445.3
NP_001431.1
D3DST8
O43909
Q53XT3
 
 exostosin-like 1 (Extl1) 2.4.1.224 Homo sapiens AAC51141.1
AAD02840.1
AAF73172.1
AAH65528.1
CAI17130.1
NP_004446.1
Q92935  
 predicted protein   Hordeum vulgare subsp. vulgare BAK08342.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK04795.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK01402.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAJ93013.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAK00715.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK07897.1    
 HvGT47   Hordeum vulgare subsp. vulgare BAJ98063.1    
 ORF (fragment)   Hydromantes italicus AIW46898.1    
 ORF (fragment)   Hydromantes shastae AIW46900.1    
 ORF (fragment)   Hyla chinensis AUD44314.1    
 ORF (fragment)   Hylarana sp. TNHC-GDC 31226 AUD44262.1    
 ORF (fragment)   Hylomantis lemur AUD44224.1    
 ORF (fragment)   Hyloscirtus lindae AUD44251.1    
 ORF (fragment)   Hyloxalus jacobuspetersi AUD44272.1    
 ORF (fragment)   Hymenochirus sp. CAS 249965 AUD44317.1    
 ORF (fragment)   Hynobius amjiensis AIR08357.1    
 ORF (fragment)   Hynobius chinensis AIR08358.1    
 ORF (fragment)   Hynobius guabangshanensis AIR08359.1    
 ORF (fragment)   Hynobius kimurae AIR08350.1    
 ORF (fragment)   Hynobius leechii AIR08360.1    
 ORF (fragment)   Hynobius nigrescens AIR08362.1    
 ORF (fragment)   Hynobius retardatus AIR08349.1    
 ORF (fragment)   Hynobius tokyoensis AIR08361.1    
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