GlycosylTransferase Family 47

Activities in Familyheparan β-glucuronyltransferase (EC 2.4.1.225); xyloglucan β-galactosyltransferase (EC 2.4.1.-); heparan synthase (EC 2.4.1.-); arabinan α-L-arabinosyltransferase (EC 2.4.2.-).
Mechanism Inverting
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase.
External resourcesGlymap;
Statistics GenBank accession (1008); Uniprot accession (236);
All (462) Bacteria (3) Eukaryota (457) Viruses (2) Characterized (13)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF (fragment)   Dicamptodon aterrimus AGQ56493.1    
 Dbus_chr2Rg1704   Drosophila busckii ALC42125.1    
 Dbus_chr2Rg1360 (fragment)   Drosophila busckii ALC41781.1    
 Dbus_chr2Rg1363 (fragment)   Drosophila busckii ALC41784.1    
 Dbus_chr2Rg1995   Drosophila busckii ALC42416.1    
 CG8433 (Dext2;sotv)   Drosophila melanogaster AAD38573.1
AAF58055.2
AAF58056.1
AAO39548.1
AAO41379.1
NP_725536.1
NP_788367.1
NP_788368.1
A4UZJ2
Q9Y169
 
 tout-velu (CG10117;Dext1;ttv)   Drosophila melanogaster AAC32397.1
AAF58236.1
AAX33551.1
ADG57806.1
AGB93503.1
AGB93504.1
BAE78509.1
NP_477231.1
Q5BI21
Q9V730
Q9V730
 
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225
Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1
Q9XZ08  
 ORF (fragment)   Ensatina eschscholtzii AIW46896.1    
 ORF (fragment)   Equus caballus AEP99427.1    
 xyloglucan galactosyltransferase (Mur3;EgMUR3)   Eucalyptus grandis ACY08857.1 D0V2A6  
 ORF (fragment)   Eurycea bislineata AGQ56494.1    
 ORF (fragment)   Eurycea quadridigitata AIW46897.1    
 RCJMB04_7p22 (fragment) (fragment)   Gallus gallus CAH65209.1 Q5F3S5  
 unknown   Glycine max ACU18220.1 C6T8R8  
 unknown (fragment)   Glycine max ACU17292.1 C6T680  
 unknown (fragment)   Glycine max ACU21295.1 C6THJ3  
 unknown (fragment)   Glycine max ACU22716.1 C6TIH6  
 ORF (fragment)   Hemidactylium scutatum AIW46899.1    
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225
Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
BAH12417.1
NP_000392.1
B2R5Z6
Q93063
 
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224
2.4.1.225
Homo sapiens AAB62283.1
AAC51154.1
AAH01174.1
ACS08204.1
ADI56520.1
AGT15863.1
BAG35949.1
NP_000118.1
B2R7V2
Q16394
 
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223
2.4.1.225
Homo sapiens AAC39598.1
AAB67602.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12589.1
ACW32787.1
BAA24080.1
BAA25445.2
BAA25445.3
NP_001431.1
D3DST8
O43909
Q53XT3
 
 exostosin-like 1 (Extl1) 2.4.1.224 Homo sapiens AAC51141.1
AAD02840.1
AAF73172.1
AAH65528.1
CAI17130.1
NP_004446.1
Q92935  
 predicted protein   Hordeum vulgare subsp. vulgare BAK08342.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK04795.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK01402.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAJ93013.1    
 predicted protein   Hordeum vulgare subsp. vulgare BAK00715.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK07897.1    
 HvGT47   Hordeum vulgare subsp. vulgare BAJ98063.1    
 ORF (fragment)   Hydromantes italicus AIW46898.1    
 ORF (fragment)   Hydromantes shastae AIW46900.1    
 ORF (fragment)   Hynobius amjiensis AIR08357.1    
 ORF (fragment)   Hynobius chinensis AIR08358.1    
 ORF (fragment)   Hynobius guabangshanensis AIR08359.1    
 ORF (fragment)   Hynobius kimurae AIR08350.1    
 ORF (fragment)   Hynobius leechii AIR08360.1    
 ORF (fragment)   Hynobius nigrescens AIR08362.1    
 ORF (fragment)   Hynobius retardatus AIR08349.1    
 ORF (fragment)   Hynobius tokyoensis AIR08361.1    
 ORF (fragment)   Ichthyophis bannanicus AGQ56495.1    
 ORF (Ext1C)   Ictalurus punctatus AHH42126.1    
 JHL07K02.4   Jatropha curcas Palawan BAJ53114.1    
 ORF (fragment)   Karsenia koreana AIW46901.1    
 LRAMOSA00164   Lichtheimia ramosa CDS02760.1    
 ORF (fragment)   Liua shihi AIR08347.1    
 ORF (fragment)   Liua tsinpaensis AIR08346.1    
 LmIRX10   Lolium multiflorum BAU61510.1    
 ORF (fragment)   Lolium perenne AFA26188.1    
 unknown (fragment)   Lotus japonicus AFK39820.1    
 unknown (fragment)   Lotus japonicus AFK34982.1    
 unknown (fragment)   Lotus japonicus AFK44235.1    
 unnamed protein product (fragment)   Macaca fascicularis BAE89111.1    
 ORF   Macaca mulatta AFE77124.1
AFH31465.1
AFI34959.1
   
 exostosin-1, partial (Ext1) (fragment)   Macaca mulatta AFE68355.1    
 exostosin-1, partial (Ext1) (fragment)   Macaca mulatta AFE71593.1    
 ORF   Macaca mulatta AFE77122.1
AFE77123.1
   
 exostosin-1 (Ext1)   Macaca mulatta AFH28289.1
AFJ71363.1
   
 xyloglucan-specific galacturonosyltransferase 1   Marchantia polymorpha APT68030.1    
 unknown (fragment)   Medicago truncatula AFK36383.1    
 unknown (short fragment)   Medicago truncatula AFK42555.1    
 unknown (fragment)   Medicago truncatula AFK43167.1    
 MtrDRAFT_AC147481g21v1   Medicago truncatula ABC75371.1
ABN04853.1
ABN04854.1
G7JJY6  
 MtrDRAFT_AC148816g3v1   Medicago truncatula ABD28410.1
ABK28848.1
Q2HVN7  
 MtrDRAFT_AC144540g11v1 or MtrDRAFT_AC144657g20v2   Medicago truncatula ABE92993.1
ABE86351.1
ABE86351.2
ABP03873.1
   
 MtrDRAFT_AC149304g10v1 (fragment)   Medicago truncatula ABE79352.1    
 MtrDRAFT_AC144540g3v1   Medicago truncatula ABE92985.1
ABP03863.1
A4Q7L8
G7JFD7
 
 MtrDRAFT_AC148607g4v1   Medicago truncatula ABE92010.1 G7KYE9  
 MtrDRAFT_AC137546g35v1   Medicago truncatula ABE81272.1
ABP03600.1
   
 MtrDRAFT_AC119408g8v1   Medicago truncatula ABE86701.1 G7JHR7  
 MtrDRAFT_AC144657g12v2   Medicago truncatula ABE86352.1
ABE92992.1
ABP03872.1
A4Q7M7  
 MtrDRAFT_AC148405g21v1   Medicago truncatula ABE81786.1
ABE81786.2
G7JAG9  
 MICPUN_99882   Micromonas commoda sp. RCC299 ACO62879.1 C1E367  
 MICPUN_50255   Micromonas commoda sp. RCC299 ACO63376.1 C1E670  
 MICPUN_54821   Micromonas commoda sp. RCC299 ACO68681.1 C1FF42  
 exostosin-2 (Ext2)   Mus musculus AAB17006.1
AAC53143.1
AAH06597.1
ABY16664.1
ACW41681.1
BAC39274.1
BAE22143.1
BAE28510.1
BAE29346.1
BAE31083.1
BAE37749.1
CAM22097.1
CAM22098.1
CAM23880.1
CAM23881.1
CAM23882.1
CAM23883.1
NP_034293.1
P70428
Q8BUJ1
 
 exostosin-1 (Ext1)   Mus musculus AAB41728.1
AAH04741.1
ABY16663.1
ACW41680.1
BAE21106.1
CAA65443.1
NP_034292.1
P97464
Q3V1P4
 
 exostosin-like 1 (Extl1)   Mus musculus AAF61913.1
AAI20891.1
AAI20892.1
BAE36631.1
BAE43097.1
NP_062524.1
Q0VAW4
Q9JKV7
 
 α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) 2.4.1.224 Mus musculus AAD42040.1
AAH65073.1
AAW12587.1
BAE23506.1
NP_061258.2
Q9WVL6  
 MA4_54N07.34   Musa acuminata ABF70053.1 Q1EPA4  
 MBP_91N22.80   Musa balbisiana ABF70140.1 Q1EP17  
 ORF   Musca domestica ALHF AFP60311.1    
 exostoses 1 (partial)   Mustela putorius furo AER98199.1    
 exostoses 2   Mustela putorius furo AER98200.1    
 ORF (fragment)   Mustela putorius furo AER98203.1    
 ORF (fragment)   Necturus beyeri AGQ56496.1    
 glycosyltransferase   Nicotiana alata BAV19378.1    
 Naatkam3/mur3 (fragment)   Nicotiana alata BAO02560.1    
 pectin β-glucuronyltransferase (NpGUT1) (fragment) 2.4.1.- Nicotiana plumbaginifolia BAC20928.1 Q8GSQ4  
 NtGUT1 (fragment)   Nicotiana tabacum BAD04923.1 Q75SZ7  
 Irx10 (fragment)   Nicotiana tabacum BY-2::VND7-VP16-GR AFJ12118.1    
 Irx10 (fragment)   Nicotiana tabacum BY-2::VND7-VP16-GR AFJ12119.1    
 Op_42180   Olimarabidopsis pumila ABA18091.1 Q287W9  
 ORF (fragment)   Onychodactylus fischeri AGQ56497.1    
 ORF (fragment)   Onychodactylus zhangyapingi AIR08363.1    
 ORF   Oryza glaberrima AIE88283.1    
 ORF   Oryza glaberrima AIE88284.1    
 ORF   Oryza minuta AEV41028.1    
 ORF (fragment)   Oryza minuta AEV41075.1    
 ORF   Oryza officinalis AEV41121.1    
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