Activities in Family	cellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289); alternating β-1,3/4-N-acetylmannan synthase (2.4.1.-); UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225); [inverting] UDP-Glc: glycocin S-β-glucosyltransferase (EC 2.4.1.-); [inverting] UDP-Glc: protein O-β-glucosyltransferase (EC 2.4.1.-)
Mechanism	Inverting
3D Structure Status	GT-A
Note	Distant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resources	Glymap; HOMSTRAD;
Commercial Enzyme Provider(s)	CHEMILY;
Statistics	GenBank accession (301251); Uniprot accession (382); PDB accession (54); 3D entries (21); cryst (0)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Pcal_0472	2.4.1.-	Pyrobaculum calidifontis JCM 11548	ABO07903.1	A3MTD6	6YV7[A,B] 2.70 6YV8[A,B] 2.60 6YV9[A,B] 2.70
PF0058		Pyrococcus furiosus DSM 3638	NP_577787.1 AAL80182.1		5MLZ[A] 2.00 5MM0[A] 2.30 5MM1[A] 2.60
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
SpsA (BSU37910)		Bacillus subtilis subsp. subtilis str. 168	CAB15817.1 AIY95105.1 AQR83830.1 AQR88045.1 CAA51619.1 NP_391670.1		1H7L[A] 1.98 1H7Q[A] 2.0 1QG8[A] 1.50 1QGQ[A] 1.50 1QGS[A] 2.00
UDP-Glc: (sublancin 168) S-β-glucosyltransferase / sublancin S-glycosyltransferase (SunS; YolJ; BSU21450)	2.4.1.-	Bacillus subtilis subsp. subtilis str. 168	CAB14063.1 AAC12995.1 AAC38304.1 AIY93467.1 AQR82152.1 AQR86366.1 NP_390028.1	A0A6M3ZIB3 O31986 O64036	7MSN[A] 3.00 7MSP[A] 2.10
[inverting] UDP-Glc: glycocin S/O-β-glucosyltransferase (ThusS; bthur0009_56280)	2.4.1.- 2.4.1.-	Bacillus thuringiensis serovar andalousiensis BGSC 4AW1	EEM68351.1		7MSK[A] 2.06
BF2801		Bacteroides fragilis NCTC 9343	CAH08495.1		3BCV[A,B] 2.35
cellulose synthase subunit A (BcsA;RSP_0333)	2.4.1.12	Cereibacter sphaeroides 2.4.1	ABA79509.1 AXC61721.1	Q3J125	4HG6[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 3.25 4P00[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp 3.20 4P02[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp 2.65 5EIY[A] β-D-Galp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.95 5EJ1[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 3.40 5EJZ[A] β-D-Glcp2F-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.94
AKN41_3848	2.4.1.12	Escherichia coli GE3	ASO85436.1		7LBY[A] 4.20
chondroitin polymerase (KfoC; K4CP)	2.4.1.226	Escherichia coli K4	BAC00523.1 CAD87418.1 CAD87419.1 CAV13380.1 CAV13381.1	Q8L0V4	2Z86[A,B,C,D] 2.40 2Z87[A,B] 3.00
chondroitin polymerase (KfoC; K4CP)	2.4.1.175	Escherichia coli K4	BAC00523.1 CAD87418.1 CAD87419.1 CAV13380.1 CAV13381.1	Q8L0V4	2Z86[A,B,C,D] 2.40 2Z87[A,B] 3.00
LBJ_1113		Leptospira borgpetersenii serovar Hardjo-bovis str. JB197	ABJ75726.1		6P61[A,B,C,D] 1.95
UDP-Galf; galactan b-(1,5)- / b-(1,6)-galactofuranosyltransferase (GlfT2;GlfT;Rv3808c)	2.4.1.288	Mycobacterium tuberculosis H37Rv	CAA17872.1 ACS09801.1 AFN51834.1 CCP46637.1 NP_218325.1	O53585	4FIX[A,B] 2.45 4FIY[A,B] 3.10
UDP-GlcNAc: teichoic acid β-N-acetylglucosaminyltransferase (TarS;SAV0258)	2.4.1.-	Staphylococcus aureus subsp. aureus Mu50	BAB56420.1 NP_370782.1	A0A0H3JPC6 Q99WW5	5TZ8[A,B,C] 4.00 5TZE[C,E] 2.33 5TZI[C] 2.30 5TZJ[A,C] 1.90 5TZK[C] 2.22 5U02[A] 2.30
SA1808		Staphylococcus aureus subsp. aureus N315	BAB43088.1 NP_375109.1		6H1J[A,B,C] 1.86 6H21[A,B,C] 1.80 6H2N[A,B,C] 1.95 6H4F[A,B,C,D,E,F,G,H,I,O, 2.18 6H4M[A,B,C,D,E,F,G,H,I,O, 2.73 6HNQ[A,B,C,D,E,F,G,H,I,O, 2.40
bimodular dual β-glycosyltransferase, N-term GT101 transfers β-Glc; C-term GT2 transfers β-GlcNAc (?dGT1;Spaf_1933)	2.4.1.-	Streptococcus parasanguinis FW213	ACF35268.1 AFJ26875.1	B5A7M0 I1ZPA1	5HEA[A,B,C] 2.00 5HEC[A,B] 2.40
UDP-Glc: undecaprenyl-P β-glucosyltransferase (GtrB;GtrBSyn;sll0501)	2.4.1.-	Synechocystis sp. PCC 6803	BAA10834.1 AGF53125.1 ALJ69004.1 BAK51619.1 NP_442763.1 QWO80272.1	Q55487	5EKE[A,B,C,D] 3.00 5EKP[A,B,C,D] 3.19
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
At5g05170 (cellulose synthase A3;CesA3;Cev1;Rsw5) (AtCesA3)	2.4.1.12	Arabidopsis thaliana	AAC39336.1 AAN86168.1 AAO95208.1 AAY06383.1 AED90836.1 AHL38644.1 BAB09693.1 BAF01916.1 CAC09627.1 CAC09633.1 CAW91425.1 CAW94243.1 CBC96120.1 NP_196136.1	A0A384K963 O48948 Q941L0 W8Q6G0	7CK1[A] 2.35 7CK2[A] 2.05 7CK3[A] 2.90
cellulose synthase (CESA7)	2.4.1.12	Gossypium hirsutum	AFB18636.1 AIE38017.1		7D5K[A] β-D-Glcp-(1-4)-β-D-Glcp 3.50
Os07g0208500 (OsCesA8)		Oryza sativa Japonica Group	BAC57282.1 AAQ41474.1 BAD30175.1 BAF21076.1 BAG92935.1 BAT00571.1 CAW90431.1 CAW91297.1 CAW93006.1 CAW94112.1 CAW96299.1 CAW96907.1 CAW97564.1 CBC98617.1 NP_001059162.1		5JNP[A,B] 2.40
cellulose synthase (CesA3-1)	2.4.1.12	Populus tremula x Populus tremuloides	AAT09896.2 CAW90509.1 CAW91364.1 CAW93080.1 CAW94177.1 CAW96333.1 CAW96941.1 CAW97636.1 CBC98685.1	Q6J8X0	6WLB[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 3.50
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
hyaluronan synthase (PBCVCZ2_118R;Cz-2_118R)	2.4.1.212	Paramecium bursaria Chlorella virus CZ-2	AGE52748.1		7SP6[A] 3.10 7SP7[A] 3.10 7SP8[A] 2.70 7SP9[C] β-D-GlcpNAc 2.90 7SPA[C] β-D-GlcpNAc 2.80
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