Activities in Family	cellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289); alternating β-1,3/4-N-acetylmannan synthase (2.4.1.-)
Mechanism	Inverting
3D Structure Status	GT-A
Note	Distant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resources	Glymap; HOMSTRAD;
Commercial Enzyme Provider(s)	CHEMILY;
Statistics	GenBank accession (245852); Uniprot accession (17577); PDB accession (42); 3D entries (16); cryst (0)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Pcal_0472	2.4.1.-	Pyrobaculum calidifontis JCM 11548	ABO07903.1	A3MTD6	6YV7[A,B] 2.11 6YV8[A,B] 1.85 6YV9[A,B] 2.80
PF0058		Pyrococcus furiosus DSM 3638	NP_577787.1 AAL80182.1	Q8U4M3	5MLZ[A] 1.10 5MM0[A] 2.30 5MM1[A] 2.20
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
SpsA (BSU37910)		Bacillus subtilis subsp. subtilis str. 168	CAB15817.1 AIY95105.1 AQR83830.1 AQR88045.1 CAA51619.1 NP_391670.1	P39621	1H7L[A] 2.00 1H7Q[A] 1.70 1QG8[A] 2.28 1QGQ[A] 1.60 1QGS[A] 2.23
BF2801		Bacteroides fragilis NCTC 9343	CAH08495.1	Q5LBM4	3BCV[A,B] 2.20
AKN41_3848		Escherichia coli GE3	ASO85436.1		6YG8[A,B,C,D,E]
chondroitin polymerase (KfoC;K4CP)	2.4.1.175 2.4.1.226	Escherichia coli K4	BAC00523.1 CAD87418.1 CAD87419.1 CAV13380.1 CAV13381.1	Q8L0V4	2Z86[A,B,C,D] 2.02 2Z87[A,B] 3.50
chondroitin polymerase (KfoC;K4CP)	2.4.1.175 2.4.1.226	Escherichia coli K4	BAC00523.1 CAD87418.1 CAD87419.1 CAV13380.1 CAV13381.1	Q8L0V4	2Z86[A,B,C,D] 2.02 2Z87[A,B] 3.50
LBJ_1113		Leptospira borgpetersenii serovar Hardjo-bovis str. JB197	ABJ75726.1	Q04TP4	6P61[A,B,C,D] 1.90
UDP-Galf; galactan b-(1,5)- / b-(1,6)-galactofuranosyltransferase (GlfT2;GlfT;Rv3808c)	2.4.1.288	Mycobacterium tuberculosis H37Rv	CAA17872.1 ACS09801.1 AFN51834.1 CCP46637.1 NP_218325.1	O53585	4FIX[A,B] 1.70 4FIY[A,B] 1.10
cellulose synthase subunit A (BcsA;RSP_0333)	2.4.1.12	Rhodobacter sphaeroides 2.4.1	ABA79509.1 AXC61721.1	Q3J125	4HG6[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.50 4P00[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp 1.70 4P02[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp 1.80 5EIY[A] β-D-Galp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.03 5EJ1[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.55 5EJZ[A] β-D-Glcp2F-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.50
UDP-GlcNAc: teichoic acid β-N-acetylglucosaminyltransferase (TarS;SAV0258)	2.4.1.-	Staphylococcus aureus subsp. aureus Mu50	BAB56420.1 NP_370782.1	Q99WW5	5TZ8[A,B,C] 2.07 5TZE[C,E] 2.00 5TZI[C] 2.30 5TZJ[A,C] 1.90 5TZK[C] 1.90 5U02[A] 2.35
SA1808		Staphylococcus aureus subsp. aureus N315	BAB43088.1 NP_375109.1	Q99SP1	6H1J[A,B,C] 1.90 6H21[A,B,C] 1.17 6H2N[A,B,C] 1.10 6H4F[A,B,C,D,E,F,G,H,I,O, 1.45 6H4M[A,B,C,D,E,F,G,H,I,O, 2.50 6HNQ[A,B,C,D,E,F,G,H,I,O, 3.70
bimodular dual β-glycosyltransferase, N-term GT101 transfers β-Glc; C-term GT2 transfers β-GlcNAc (?dGT1;Spaf_1933)	2.4.1.- 2.4.1.-	Streptococcus parasanguinis FW213	ACF35268.1 AFJ26875.1	B5A7M0	5HEA[A,B,C] 1.85 5HEC[A,B] 1.35
UDP-Glc: undecaprenyl-P β-glucosyltransferase (GtrB;GtrBSyn;sll0501)	2.4.1.-	Synechocystis sp. PCC 6803	BAA10834.1 AGF53125.1 ALJ69004.1 BAK51619.1 NP_442763.1	Q55487	5EKE[A,B,C,D] 1.80 5EKP[A,B,C,D] 1.45
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Os07g0208500 (OsCesA8)		Oryza sativa Japonica Group	BAC57282.1 AAQ41474.1 BAD30175.1 BAF21076.1 BAG92935.1 BAT00571.1 CAW90431.1 CAW91297.1 CAW93006.1 CAW94112.1 CAW96299.1 CAW96907.1 CAW97564.1 CBC98617.1 NP_001059162.1	B7EKN8 Q84ZN6	5JNP[A,B] NMR
cellulose synthase (CesA3-1)	2.4.1.12	Populus tremula x Populus tremuloides	AAT09896.2 CAW90509.1 CAW91364.1 CAW93080.1 CAW94177.1 CAW96333.1 CAW96941.1 CAW97636.1 CBC98685.1	Q6J8X0	6WLB[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.55
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