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GlycosylTransferase Family 2

Activities in FamilyGDP-Man α-mannosyltransferase (EC 2.4.1.-);
GDP-Man: β-mannosyltransferase (EC 2.4.1.-);
GDP-β-L-Fuc : D-Glc-β-1,3-D-GalNAc-PP-Ph α-1,4-L-fucosyltransferase (EC 2.4.1.-);
Hexosyltransferases (EC 2.4.1.-);
LOS β-1,4-glucosyltransferase (EC 2.4.1.-);
N-acetylgalactosaminyltransferase (EC 2.4.1.-);
N-acetylglucosaminyltransferase (EC 2.4.1.-);
UDP-Gal: α-GlcNAc-PP-lipid β-1,3-galactosyltransferase (EC 2.4.1.-);
UDP-Gal:queuosine β-galactosyltransferase (EC 2.4.1.-);
UDP-GalNAc: β-1,3-N-acetylgalactosaminyltrasferase (EC 2.4.1.-);
UDP-GalNAc: undecaprenyl-P β-N-acetylgalactosaminyltransferase (EC 2.4.1.-);
UDP-Glc : GalNAc-PP-Und β-1,3-glucosyltransferase (EC 2.4.1.-);
UDP-Glc: β-1,6-glucan synthase (EC 2.4.1.-);
UDP-Glc: β-glucosyltransferase (EC 2.4.1.-);
UDP-Glc: bactoprenol β-glucosyltransferase (EC 2.4.1.-);
UDP-Glc: teichoic acid β-glucosyltransferase (EC 2.4.1.-);
UDP-GlcA: LOS β-glucuronyltransferase (EC 2.4.1.-);
UDP-GlcA: [hyaluronan] β-1,4-glucuronyltransferase (EC 2.4.1.-);
UDP-GlcNAc: [hyaluronan] β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-);
[inverting] UDP-Glc: glycocin S-β-glucosyltransferase (EC 2.4.1.-);
[inverting] UDP-Glc: protein O-β-glucosyltransferase (EC 2.4.1.-);
[inverting] UDP-GlcNAc: [chitooligosaccharide] β-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.-);
[inverting] UDP-GlcNAc: teichoic acid β-N-acetylglucosaminyltransferase (EC 2.4.1.-);
[inverting] β-1,6-glucosyltransferase (EC 2.4.1.-);
[inverting] dTDP-spectinose: β-spectinosyltransferase (EC 2.4.1.-);
[inverting] glucomannan synthase (EC 2.4.1.-);
α-1,3-rhamnosyltransferase (unspecified donor) (EC 2.4.1.-);
α-1,4-L-fucosyltransferase (EC 2.4.1.-);
α-1,6-L-fucosyltransferase (EC 2.4.1.-);
Alternating β-1,3/4-N-acetylmannan synthase (EC 2.4.1.-);
Arabinoglucan synthase (EC 2.4.1.-);
β-1,3-1,4-glucan synthase (EC 2.4.1.-);
β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-);
β-1,3-galactosyltransferase (EC 2.4.1.-);
β-1,3-glucosyltransferase (EC 2.4.1.-);
β-1,4-galactosyltransferase (EC 2.4.1.-);
β-1,4-glucosyltransferase (EC 2.4.1.-);
Chlorobactene β-glucosyltransferase (EC 2.4.1.-);
DTDP-L-Rha: α-L-rhamnosyltransferase (EC 2.4.1.-);
Poly-β-1,6-N-acetylglucosamine synthase (EC 2.4.1.-);
Staphyloxanthin β-glucosyltransferase (EC 2.4.1.-);
Xyloglucan β-1,4-glucan synthase (EC 2.4.1.-);
UDP-Glc: dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117);
UDP-Glc: β-1,4-glucan synthase / cellulose synthase (UDP-forming) (EC 2.4.1.12);
UDP-Glc: 1,2-diacylglycerol 3-glucosyltransferase (EC 2.4.1.157);
Chitin transglycosylase (EC 2.4.1.16);
UDP-GlcA: β-glucuronosyltransferase (EC 2.4.1.17);
UDP-GalNAc: β-1,3-glucuronyl-N-acetylgalactosaminyl-proteoglycan β-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.175);
β-Man-P-decaprenol: α-1,6-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199);
Hyaluronan synthase (EC 2.4.1.212);
UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225);
UDP-GlcA: N-acetylgalactosaminyl-proteoglycan β-1,3-glucuronosyltransferase (EC 2.4.1.226);
UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287);
UDP-Galf: [galactan] Galf-Galf-Rhα-GlcNAc-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288);
DTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289);
β-1,3-glucosyltransferase (EC 2.4.1.305);
[inverting] GDP-Man: β-mannan β-1,4-mannosyltransferase / glucomannan synthase (EC 2.4.1.32);
Mannuronan synthase (EC 2.4.1.33);
UDP-Glc: β-1,3-glucan synthase / callose synthase (EC 2.4.1.34);
GDP-Man: Dol-P β-mannosyltransferase (EC 2.4.1.83);
UDP-L-Arap-4N-formyl : undecaprenyl-P α-L-4N-formylarabinosyltransferase (EC 2.4.2.-);
Mechanism Inverting
3D Structure StatusGT-A
NoteDistant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (363603); Uniprot accession (389); PDB accession (82); 3D entries (27); cryst (0)
Summary
Download GT2 (377694) Taxonomic display Structure (27) Characterized (286)
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 GDP-Man : mannosyltransferase (PcManGT; Pcal_0472) 2.4.1.- Pyrobaculum calidifontis JCM 11548 ABO07903.1 A3MTD6
6YV7[A,B] 2.70
6YV8[A,B] 2.60
6YV9[A,B] 2.70
 GDP-Man: dolichyl-phosphate β-mannosyltransferase / dolichylphosphate mannose synthase (PfDPMS; PF0058) 2.4.1.83 Pyrococcus furiosus DSM 3638 NP_577787.1
AAL80182.1		  
5MLZ[A] 2.00
5MM0[A] 2.30
5MM1[A] 2.60
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 SpsA (BSU37910)   Bacillus subtilis subsp. subtilis str. 168 CAB15817.1
AIY95105.1
AQR83830.1
AQR88045.1
CAA51619.1
NP_391670.1		  
1H7L[A] 1.98
1H7Q[A] 2.0
1QG8[A] 1.50
1QGQ[A] 1.50
1QGS[A] 2.00
 UDP-Glc: (sublancin 168) S-β-glucosyltransferase / sublancin S-glycosyltransferase (SunS; YolJ; BSU21450) 2.4.1.- Bacillus subtilis subsp. subtilis str. 168 CAB14063.1
AAC12995.1
AAC38304.1
AIY93467.1
AQR82152.1
AQR86366.1
NP_390028.1		 A0A6M3ZIB3
O31986
O64036
7MSN[A,B] 3.00
7MSP[A,B] 2.10
 [inverting] UDP-Glc: glycocin S/O-β-glucosyltransferase (ThusS; bthur0009_56280) 2.4.1.-
2.4.1.-		 Bacillus thuringiensis serovar andalousiensis BGSC 4AW1 EEM68351.1 C3GCL5
7MSK[A,B] 2.06
 BF2801   Bacteroides fragilis NCTC 9343 CAH08495.1  
3BCV[A,B] 2.35
 cellulose synthase subunit A (BcsA;RSP_0333) 2.4.1.12 Cereibacter sphaeroides 2.4.1 ABA79509.1
AXC61721.1		 Q3J125
4HG6[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 3.25
4P00[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp
 3.20
4P02[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-D-1-deoxy-Glcp
 2.65
5EIY[A] β-D-Galp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.95
5EJ1[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 3.40
5EJZ[A] β-D-Glcp2F-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 2.94
 UDP-Glc: β-1,4-glucan synthase / cellulose synthase (BcsA; AKN41_3848) 2.4.1.12 Escherichia coli GE3 ASO85436.1 P37652
P37653
7LBY[A] 4.20
 chondroitin polymerase (KfoC; K4CP) 2.4.1.226 Escherichia coli K4 BAC00523.1
CAD87418.1
CAD87419.1
CAV13380.1
CAV13381.1		 Q8L0V4
2Z86[A,B,C,D] 2.40
2Z87[A,B] 3.00
 chondroitin polymerase (KfoC; K4CP) 2.4.1.175 Escherichia coli K4 BAC00523.1
CAD87418.1
CAD87419.1
CAV13380.1
CAV13381.1		 Q8L0V4
2Z86[A,B,C,D] 2.40
2Z87[A,B] 3.00
 LBJ_1113   Leptospira borgpetersenii serovar Hardjo-bovis str. JB197 ABJ75726.1  
6P61[A,B,C,D] 1.95
 IFI78_03440   Listeria monocytogenes FSL F6-0367 QOF60318.1  
7X9R[A] 2.25
 JKV74_08865   Listeria monocytogenes LM26 QQX72823.1  
8BZ4[A,B] 2.52
8BZ5[A,B,C,D] 2.30
8BZ6[A,B,C,D,E,F] 2.40
8BZ7[A,B,C,D,E,F] 2.20
8BZ8[A,B,C,D,E,F] 2.52
 UDP-Galf; galactan b-(1,5)- / b-(1,6)-galactofuranosyltransferase (GlfT2;GlfT;Rv3808c) 2.4.1.288 Mycobacterium tuberculosis H37Rv CAA17872.1
ACS09801.1
AFN51834.1
CCP46637.1
NP_218325.1		 O53585
4FIX[A,B] 2.45
4FIY[A,B] 3.10
 UDP-GlcNAc: [wall teichoic acid] polyribitol phosphate β-1,4-N-acetylglucosaminyltransferase (TarS; SAV0258) 2.4.1.- Staphylococcus aureus subsp. aureus Mu50 BAB56420.1
NP_370782.1		 A0A0H3JPC6
Q99WW5
5TZ8[A,B,C] 4.00
5TZE[C,E] 2.33
5TZI[C] 2.30
5TZJ[A,C] 1.90
5TZK[C] 2.22
5U02[A] 2.30
 UDP-GlcNAc: [wall teichoic acid] polyribitol phosphate β-1,3-N-acetylglucosaminyltransferase (TarP; SA1808) 2.4.1.- Staphylococcus aureus subsp. aureus N315 BAB43088.1
NP_375109.1		  
6H1J[A,B,C] 1.86
6H21[A,B,C] 1.80
6H2N[A,B,C] 1.95
6H4F[A,B,C,D,E,F,G,H,I,O, 2.18
6H4M[A,B,C,D,E,F,G,H,I,O, 2.73
6HNQ[A,B,C,D,E,F,G,H,I,O, 2.40
 bimodular dual β-glycosyltransferase, N-term GT101 transfers β-Glc; C-term GT2 transfers β-GlcNAc (?dGT1;Spaf_1933) 2.4.1.- Streptococcus parasanguinis FW213 ACF35268.1
AFJ26875.1		 B5A7M0
I1ZPA1
5HEA[A,B,C] 2.00
5HEC[A,B] 2.40
 UDP-Glc: undecaprenyl-P β-glucosyltransferase (GtrB;GtrBSyn;sll0501) 2.4.1.- Synechocystis sp. PCC 6803 BAA10834.1
AGF53125.1
ALJ69004.1
BAK51619.1
NP_442763.1
QWO80272.1		 Q55487
5EKE[A,B,C,D] 3.00
5EKP[A,B,C,D] 3.19
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 At5g05170 (cellulose synthase A3;CesA3;Cev1;Rsw5) (AtCesA3) 2.4.1.12 Arabidopsis thaliana AAC39336.1
AAN86168.1
AAO95208.1
AAY06383.1
AED90836.1
AHL38644.1
BAB09693.1
BAF01916.1
CAC09627.1
CAC09633.1
CAW91425.1
CAW94243.1
CBC96120.1
NP_196136.1		 A0A384K963
O48948
Q941L0
W8Q6G0
7CK1[A,B] 2.35
7CK2[A,B] 2.05
7CK3[A,B] 2.90
 chitin transglycosylase (CAALFM_CR09020CA;Chs2) 2.4.1.16 Candida albicans SC5314 AOW31570.1 A0A1D8PTV3
7STL[A,B] 2.95
7STM[A,B] 3.02
7STN[A,B] 3.19
7STO[A,B] 3.15
  cellulose synthase (CESA7; GhCesA7) 2.4.1.12 Gossypium hirsutum AFB18636.1
AIE38017.1		 L7NUA2
7D5K[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp
 3.50
 β-1,3;1,4-glucan synthase (CslF6) 2.4.1.- Hordeum vulgare ABZ01578.1
AKJ66175.1		 B1P2T4
8DQK[A] 4.00
 Os07g0208500 (OsCesA8)   Oryza sativa Japonica Group BAC57282.1
AAQ41474.1
BAD30175.1
BAF21076.1
BAG92935.1
BAT00571.1
CAW90431.1
CAW91297.1
CAW93006.1
CAW94112.1
CAW96299.1
CAW96907.1
CAW97564.1
CBC98617.1
NP_001059162.1		  
5JNP[A,B] 2.40
 chitin synthase   Phytophthora sojae ARC77249.1  
7WJM[A,B] 3.30
7WJN[A,B] 3.30
7WJO[A,B] 3.20
7X05[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 3.90
7X06[A,B] 3.10
 cellulose synthase (CesA3-1; PttCesA8) 2.4.1.12 Populus tremula x Populus tremuloides AAT09896.2
CAW90509.1
CAW91364.1
CAW93080.1
CAW94177.1
CAW96333.1
CAW96941.1
CAW97636.1
CBC98685.1		 Q6J8X0
6WLB[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 3.50
8G27[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 3.30
8G2J[A,B,C] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 3.30
 chitin synthase 1 (Chs1;YNL192W;N1404) 2.4.1.16 Saccharomyces cerevisiae S288c AAA34491.1
ABC16980.1
CAA96086.1
CAL85381.1
NP_014207.1		 P08004
7XS6[A,B] 2.90
7XS7[A,B] 3.20
8K3P[A,B] 3.64
8K3Q[A,B] 2.60
8K3R[A,B] 3.51
8K3T[A,B] 3.57
8K3U[A,B] β-D-GlcpNAc
 3.06
8K3V[A,B] 3.10
8K3W[A,B] 2.91
8K3X[A,B] 2.86
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 hyaluronan synthase (PBCVCZ2_118R;Cz-2_118R) 2.4.1.212 Paramecium bursaria Chlorella virus CZ-2 AGE52748.1 M1H2Q1
7SP6[A] 3.10
7SP7[A] 3.10
7SP8[A] 2.70
7SP9[C] β-D-GlcpNAc
 2.90
7SPA[C] β-D-GlcpNAc
 2.80
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