GlycosylTransferase Family 2

Activities in Familycellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289)
Mechanism Inverting
3D Structure StatusGT-A
NoteDistant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (118847); Uniprot accession (17782); PDB accession (28); 3D entries (11); cryst (0)
All (113414) Archaea (3300) Bacteria (103522) Eukaryota (5990) Viruses (534) unclassified (68) Structure (11) Characterized (277)
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 PF0058   Pyrococcus furiosus DSM 3638 AAL80182.1
NP_577787.1
Q8U4M3
5MLZ[A] 2.00
5MM0[A] 2.30
5MM1[A] 2.60
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 SpsA (BSU37910)   Bacillus subtilis subsp. subtilis str. 168 CAB15817.1
AIY95105.1
AQR83830.1
AQR88045.1
CAA51619.1
NP_391670.1
P39621
1H7L[A] 1.98
1H7Q[A] 2.0
1QG8[A] 1.50
1QGQ[A] 1.50
1QGS[A] 2.00
 BF2801   Bacteroides fragilis NCTC 9343 CAH08495.1 Q5LBM4
3BCV[A,B] 2.35
 chondroitin polymerase (KfoC;K4CP) 2.4.1.175
2.4.1.226
Escherichia coli K4 BAC00523.1
CAD87418.1
CAD87419.1
CAV13380.1
CAV13381.1
Q8L0V4
2Z86[A,B,C,D] 2.40
2Z87[A,B] 3.00
 chondroitin polymerase (KfoC;K4CP) 2.4.1.175
2.4.1.226
Escherichia coli K4 BAC00523.1
CAD87418.1
CAD87419.1
CAV13380.1
CAV13381.1
Q8L0V4
2Z86[A,B,C,D] 2.40
2Z87[A,B] 3.00
 UDP-Galf; galactan b-(1,5)- / b-(1,6)-galactofuranosyltransferase (GlfT2;GlfT;Rv3808c) 2.4.1.288 Mycobacterium tuberculosis H37Rv CAA17872.1
ACS09801.1
AFN51834.1
CCP46637.1
NP_218325.1
O53585
4FIX[A,B] 2.45
4FIY[A,B] 3.10
 cellulose synthase subunit A (BcsA;RSP_0333) 2.4.1.12 Rhodobacter sphaeroides 2.4.1 ABA79509.1 Q3J125
4HG6[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
3.25
5EIY[A] β-D-Galp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.95
5EJ1[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
3.40
5EJZ[A] β-D-Glcp2F-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
2.94
 UDP-GlcNAc: teichoic acid β-N-acetylglucosaminyltransferase (TarS;SAV0258) 2.4.1.- Staphylococcus aureus subsp. aureus Mu50 BAB56420.1
NP_370782.1
Q99WW5
5TZ8[A,B,C] 4.00
5TZE[C,E] 2.33
5TZI[C] 2.30
5TZJ[A,C] 1.90
5TZK[C] 2.22
5U02[A] 2.30
 bimodular dual glycosyltransferase, N-term GT101 transfers Glc; C-term GT2 transfers GlcNAc (?dGT1;Spaf_1933) 2.4.1.-
2.4.1.-
Streptococcus parasanguinis FW213 ACF35268.1
AFJ26875.1
B5A7M0
5HEA[A,B,C] 2.00
5HEC[A,B] 2.40
 UDP-Glc: undecaprenyl-P β-glucosyltransferase (GtrB;GtrBSyn;sll0501) 2.4.1.- Synechocystis sp. PCC 6803 BAA10834.1
AGF53125.1
ALJ69004.1
BAK51619.1
NP_442763.1
Q55487
5EKE[A,B,C,D] 3.00
5EKP[A,B,C,D] 3.19
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Os07g0208500 (OsCesA8)   Oryza sativa Japonica Group BAC57282.1
AAQ41474.1
BAD30175.1
BAF21076.1
BAG92935.1
BAT00571.1
CAW90431.1
CAW91297.1
CAW93006.1
CAW94112.1
CAW96299.1
CAW96907.1
CAW97564.1
CBC98617.1
NP_001059162.1
B7EKN8
Q84ZN6
5JNP[A,B] 2.40
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