GlycosylTransferase Family 2

Activities in Familycellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289)
Mechanism Inverting
3D Structure StatusGT-A
NoteDistant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (118847); Uniprot accession (17782); PDB accession (28); 3D entries (11); cryst (0)
All (113414) Archaea (3300) Bacteria (103522) Eukaryota (5990) Viruses (534) unclassified (68) Structure (11) Characterized (277)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 chitin synthase class I (Chs1) 2.4.1.16 Fusarium graminearum CAC41025.1 Q96VK2  
 Chitin synthase 2.4.1.16 Glomus versiforme CAA08762.1 O93962  
 cellulose synthase (CesA1;CelA1) 2.4.1.12 Gossypium hirsutum AAB37766.1
AAQ41472.1
AAT64028.1
ABG06122.1
ABR14737.1
ADY68800.1
CAW90440.1
CAW91306.1
CAW93014.1
CAW94123.1
CAW96303.1
CAW96911.1
CAW97572.1
CBC98625.1
P93155  
 dolichyl-phosphate β-glucosyltransferase (Gdt1) 2.4.1.117 Histoplasma capsulatum AAF01464.1 Q9UUT0  
 dolichol-phosphate β-glucosyltransferase (Alg5) 2.4.1.117 Homo sapiens AAD41465.1
AAF29113.1
AAG09682.1
AAH12531.1
AAQ51358.1
AAY11281.1
ABH87395.1
BAG61149.1
BAG61179.1
CAI14011.1
CAI14012.1
NP_037470.1
XP_035926.1
XP_057367.1
Q5TBA6
Q9HC03
Q9Y673
 
 dolichol-phosphate mannosyltransferase (Dpm1) 2.4.1.83 Homo sapiens AAH07073.1
AAC98797.1
AAH08466.1
AAH16322.1
ACM84791.1
ALQ33902.1
ALQ33903.1
ALQ33904.1
BAA25646.1
BAA25647.1
BAF82258.1
CAB53749.1
CAG33207.1
CAI23324.1
CAI23325.1
CAI23326.1
CAI23326.2
CAI23327.1
CAI23327.2
NP_003850.1
O60762
Q6IB78
Q96HK0
 
 hyaluronan synthase 1 (HAS1;HAS) 2.4.1.212 Homo sapiens AAC50706.1
AAE61835.1
AAH35837.1
AAN23418.1
AAY52131.1
AAY52132.1
ACM86032.1
ACP87615.1
BAA12351.1
CAJ87377.1
CAL40918.1
CAL44782.1
CAL47699.1
NP_001514.1
XP_031079.1
Q8IYH3
Q92839
 
 hyaluronan synthase 3 (Has3) 2.4.1.212 Homo sapiens AAF36984.1
AAC51209.1
AAH21853.1
AAK73797.1
ACM84101.1
BAF84089.1
CAJ87375.1
CAL40916.1
CAL44780.1
CAL47697.1
NP_005320.2
NP_619515.1
O00219
Q8WTZ0
Q96RV2
 
 hyaluronan synthase 2 (Has2) 2.4.1.212 Homo sapiens AAC50692.1
AAH69353.1
AAI09072.1
AAI09073.1
ACM81110.1
BAG60078.1
CAJ87378.1
CAL40919.1
CAL44783.1
CAL47700.1
NP_005319.1
Q92819  
 β-1,3;1,4-glucan synthase (CslF6) 2.4.1.- Hordeum vulgare ABZ01578.1
AKJ66175.1
B1P2T4  
 β-1,3-1,4-glucan synthase (HvCslH1) 2.4.1.- Hordeum vulgare subsp. vulgare ACN67534.1 C3U576  
 dolichol-phosphate β-mannosyltransferase (Dpms) 2.4.1.83 Leishmania mexicana MNYC/BZ/62/M379 CAA10541.1 O96795  
 chitin synthase 1 2.4.1.16 Lucilia cuprina AAG09712.1 Q9GU17  
 Csm1 2.4.1.16 Magnaporthe grisea BAA74449.1 O93809  
 MG09962.4 (chitin synthase) 2.4.1.16 Magnaporthe oryzae 70-15 XP_365117.1
AAB71411.1
O13353  
 chitin synthase 1 (MsCHS1;Chs1;cs-1;Chs-1;Chs-A) 2.4.1.16 Manduca sexta AAL38051.2
CAD11802.1
Q8T4U2
Q95PQ5
 
 chitin synthase 2 (MsCHS2;Chs2;cs-2;Chs-2;Chs-B) 2.4.1.16 Manduca sexta AAX20092.1
AAX20091.1
Q530Z6  
 chitin synthase (Csh1) 2.4.1.16 Mucor circinelloides CAA67797.1 Q12632  
 Dolichol-phosphate mannosyltransferase 2.4.1.83 Mus musculus BAA25759.1
AAH61151.1
BAB23602.1
BAB23920.1
BAB25735.1
CAM22975.1
CAM22976.1
NP_034202.1
A2BDX1
O70152
 
 Hyaluronan synthase 1 (Has1;Has ) 2.4.1.212 Mus musculus AAO93602.1
AAI25425.1
AAI25427.1
AAR39742.1
BAA11654.1
BAC35492.1
BAE23579.1
CAJ87380.1
CAL40921.1
CAL44785.1
CAL47702.1
NP_032241.1
Q61647
Q8BPN0
 
 chitin synthase 2 (Chs2;NcChs2;Chs-2;NCU05239.1) 2.4.1.16 Neurospora crassa OR74A CAA54816.1
AAA33582.1
XP_324596.1
P30589  
 chitin synthase 3 (NCU03611.1/B11H24.170) 2.4.1.16 Neurospora crassa OR74A AAA33568.1
CAD21286.1
XP_322913.1
P29070
P29070
 
 Chitin synthase 4 (NCU09324.1) 2.4.1.16 Neurospora crassa OR74A AAB03563.1
XP_332016.1
Q01285  
 hyaluronan synthase 2 (Has2) 2.4.1.212 Oryctolagus cuniculus BAB63264.1
ABA69792.1
CAJ87386.1
CAL40927.1
CAL44791.1
CAL47708.1
Q95M16  
 β-1,3-1,4-glucan synthase (OsCslF4) (OsCslF4) 2.4.1.- Oryza sativa AAL25134.1 Q944D9  
 β-1,3-1,4-glucan synthase (OsCslF1) (OsCslF1) 2.4.1.- Oryza sativa AAL25131.1 Q944E2  
 β-1,3-1,4-glucan synthase (Os07g0552800) (OsCslF2) 2.4.1.- Oryza sativa Japonica Group AAL25132.1
AAL38536.1
BAC65378.1
BAD30521.1
BAF21860.1
BAT02064.1
BAT02065.1
BAT02067.1
Q84S11  
 UDP-Glc: β-1,3-1,4-glucan synthase (CslF6;Os08g0160500) (OsCslF6) 2.4.1.- Oryza sativa Japonica Group BAC66734.1
BAC99567.1
BAC99779.1
BAC99781.1
BAF22962.1
BAT03930.1
BAT03932.1
Q84UP7  
 β-1,3-1,4-glucan synthase (P0013G11.2) (OsCslF1) 2.4.1.- Oryza sativa Japonica Group BAC83318.1 Q6ZF89  
 β-1,3-1,4-glucan synthase (Os07g0553300) (OsCslF4) 2.4.1.- Oryza sativa Japonica Group BAC83321.1
BAF21861.1
Q6ZF86  
 β-1,4-mannan synthase / glucomannan synthase (CslA1;Os02g0192500) (OsCslA1) 2.4.1.- Oryza sativa Japonica Group DAA01743.1
BAA82375.1
BAD15390.1
BAD34025.1
BAF08078.1
BAG95675.1
BAS77418.1
BAS77419.1
B7ETH8
Q7PC76
 
 chitin synthase 2 (Chs2;PbrCHS2) 2.4.1.16 Paracoccidioides brasiliensis CAA70433.1
ABI49154.1
ABI49156.1
ABU55050.1
ABU55051.1
ABU55052.1
ABU55053.1
ABU55054.1
ABU55055.1
ABU55056.1
ABU55057.1
ABU55058.1
ABU55059.1
ABU55060.1
ABU55061.1
ABU55062.1
ABU55063.1
ABU55064.1
ABU55065.1
ABU55066.1
ABU55067.1
ABU55068.1
ABU55069.1
ABU55070.1
BAF62690.1
BAF62691.1
BAF62692.1
BAF62693.1
BAF62694.1
BAF62695.1
BAF62696.1
BAF62697.1
BAF62698.1
BAF62699.1
BAF62700.1
BAF62701.1
BAF62702.1
BAF62703.1
BAF62704.1
BAF62705.1
BAF62706.1
BAF62707.1
BAF62708.1
BAF62709.1
BAF62710.1
BAF62711.1
BAF62712.1
BAF62713.1
BAF62714.1
BAF62715.1
BAF62716.1
BAF62717.1
BAF62718.1
BAF62719.1
BAF62720.1
BAF62721.1
BAF62722.1
BAF62723.1
BAF62724.1
Q92444  
 chitin synthase (CHS4) 2.4.1.16 Penicillium chrysogenum KCTC6052; ATCC 10106 AAF04828.1
AAC49554.1
Q01749  
 chitin synthase 1 (Chs1) 2.4.1.16 Phycomyces blakesleeanus NRRL 1555(-) BAA19857.1 P87073  
 cellulose synthase (CesA5;PpCesA5) (fragment) 2.4.1.12 Physcomitrella patens AAT48372.1 Q6GVL8  
 β-1,4-mannan synthase / glucomannan synthase (CslA1) (PpCslA1) 2.4.1.- Physcomitrella patens ABD79099.1 Q1ZZG0  
 β-1,4-mannan synthase / glucomannan synthase (CslA2) (PpCslA2) 2.4.1.- Physcomitrella patens ABD79100.1 Q1ZZF9  
 cellulose synthase 3 (CesA3;PcapCesA3) 2.4.1.12 Phytophthora capsici 188 AFB20353.1
AGA60312.1
   
 cellulose synthase 1 (Ces1;CesA1) 2.4.1.12 Phytophthora infestans 88069 ABP96902.1 A5A5Z3  
 cellulose synthase 2 (Ces2;CesA2) 2.4.1.12 Phytophthora infestans 88069 ABP96903.1 A5A5Z4  
 cellulose synthase 4 (Ces4;CesA4) 2.4.1.12 Phytophthora infestans 88069 ABP96905.1 A5A5Z6  
 cellulose synthase 3 (Ces3;CesA3;PinfCesA3) 2.4.1.12 Phytophthora infestans 88069 / 96 ABP96904.1 A5A5Z5  
 cellulose synthase 3 (CesA3;PvitCesA3) 2.4.1.12 Plasmopara viticola D05 ADD84672.1 D4N2S7  
 cellulose synthase 2.4.1.12 Populus tremula x Populus alba 717 AAC78476.1
CAW90438.1
CAW91304.1
CAW93012.1
CAW94120.1
CAW96302.1
CAW96910.1
CAW97570.1
CBC98624.1
O81649  
 cellulose synthase (CelA) (secondary xylem) (PtCesA1) 2.4.1.12 Populus tremuloides AAD03417.1
ABH84874.1
CAW90435.1
CAW91301.1
CAW93010.1
CAW94117.1
CAW96301.1
CAW96909.1
CAW97568.1
CBC98622.1
O81368  
 cellulose synthase 3 (CesA3;PcubCesA3) 2.4.1.12 Pseudoperonospora cubensis CH01 AEC45570.1    
 hyaluronan synthase (Has2) 2.4.1.212 Rattus norvegicus AAB63209.1
CAJ87384.1
CAL40925.1
CAL44789.1
CAL47706.1
NP_037285.1
O35776  
 chitin synthase 1 (Chs1) 2.4.1.16 Rhizopus microsporus var. oligosporus IFO 8631 BAA01023.1 P30594  
 chitin synthase 2 (Chs2) 2.4.1.16 Rhizopus microsporus var. oligosporus IFO 8631 BAA01024.1 P30595  
 chitin synthase 1 (Chs1;YNL192W;N1404) 2.4.1.16 Saccharomyces cerevisiae S288c AAA34491.1
ABC16980.1
CAA96086.1
CAL85381.1
NP_014207.1
P08004  
 chitin synthase 2 (Chs2;YBR038W;YBR0407) 2.4.1.16 Saccharomyces cerevisiae S288c AAA34493.1
ABC16981.1
CAA84980.1
NP_009594.1
P14180  
 chitin synthase 3 (Chs3;Cal1;Csd2;Kit2;YBR023C;YBR0305) 2.4.1.16 Saccharomyces cerevisiae S288c CAA53680.1
AAA34844.1
ABC16982.1
CAA40559.1
CAA84965.1
NP_009579.1
P29465  
 dolichol-phosphate mannosyltransferase (Dpm1;Sed3;YPR183w;P9705.3) 2.4.1.83 Saccharomyces cerevisiae S288c AAA34578.1
AAB68116.1
NP_015509.1
P14020  
 dolichyl-phosphate β-glucosyltransferase (Alg5;YPL227c) 2.4.1.117 Saccharomyces cerevisiae S288c CAA54680.1
CAA64260.1
CAA97942.1
NP_015097.1
P40350  
 chitin synthase (Chs;Chs2) 2.4.1.16 Saprolegnia monoica AAC49743.1 P48017  
 cellulose synthase 3 (CesA3;SmonCesA3) 2.4.1.12 Saprolegnia monoica CBS 539.67 ACX56231.1 C9WPK0  
 chitin synthase 2 (Chs2;SPBC1709.01;SPBC1734.17) 2.4.1.16 Schizosaccharomyces pombe 972h- CAA21311.1
NP_595434.1
O74756  
 chitin synthase 1 (Chs1;SPAC13G6.12C;SPAC24B11.01C) 2.4.1.16 Schizosaccharomyces pombe 972h- CAA91105.1
AAA35297.1
CAA91766.1
NP_592838.1
P30597  
 dolichol-phosphate mannosyltransferase (Dpm1;SPAC31G5.16C) 2.4.1.83 Schizosaccharomyces pombe 972h- AAC98795.1
CAB11700.1
NP_594017.1
O14466  
 chitin synthase B (Chs2;ChsB;Chs-B) 2.4.1.16 Spodoptera exigua ABI96087.1 Q06BR7  
 chitin synthase (CHS2;CHS-B) 2.4.1.16 Tribolium castaneum AAQ62692.1
AAQ55061.1
AAQ63455.1
Q6WD24  
 chitin synthase (CHS1B;CHS1;CHS-A) 2.4.1.16 Tribolium castaneum AAQ55060.1
AAQ62694.1
Q6WD22  
 dolichol-phosphate mannosyltransferase (DPM1) 2.4.1.83 Trichoderma reesei RUTC-30 AAG32629.1 Q9HGE2  
 GDP-Man: β-1,4-mannan synthase (ManS;TfManS) 2.4.1.- Trigonella foenum-graecum AFV79650.1    
 β-1,3-1,4-glucan synthase (Cslf6) 2.4.1.- Triticum aestivum CAN84874.1 A6Q0E9  
 dolichol-phosphate mannosyltransferase 2.4.1.83 Trypanosoma brucei brucei 118 CAA90875.1 Q26732  
 chitin synthase (CHS5) 2.4.1.16 Ustilago maydis 518 AAB84284.1 O13394  
 chitin synthase 6 (Chs6) 2.4.1.16 Ustilago maydis 518 AAB84285.1 O13395  
 dolichol-phosphate mannosyltransferase (Dpm1) 2.4.1.83 Ustilago maydis H-156S AAC49401.1 P54856  
 chitin synthase 1 (CHS1) 2.4.1.16 Ustilago maydis RK32 / A2B3 CAA61027.1 Q99126  
 chitin synthase 2 (Chs2) 2.4.1.16 Ustilago maydis RK32 / A2B3 CAA61028.1 Q99127  
 hyaluronan synthase 1 (HAS1;DG42) 2.4.1.212 Xenopus laevis AAA49699.1
AAH47963.1
AAI08481.1
AAN23419.1
AAO93603.1
AAR39743.1
ABA69790.1
ABJ29054.1
CAJ87393.1
CAL40934.1
CAL44798.1
CAL47715.1
P13563  
 hyaluronan synthase 2 (Has2) 2.4.1.212 Xenopus laevis AAD45813.1
AAB94540.1
ABA69797.1
CAJ87394.1
CAL40935.1
CAL44799.1
CAL47716.1
O57427  
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 hyaluronan synthase (Has;A98R;PBCV1_A98R) 2.4.1.212 Paramecium bursaria Chlorella virus 1 AAW91047.1
AAC96466.1
AAD26640.1
AAD26641.1
AAD26642.1
AAD26643.1
AAD26644.1
ABE19383.1
ABH92226.1
ABJ43064.1
ACP88141.1
CAJ87373.1
CAL40914.1
CAL44778.1
CAL47695.1
CAM90867.1
CAO00420.1
CAO00437.1
CAO00442.1
CAX69225.1
CAX87018.1
NP_048446.1
Q84419
Q84419
Q9WFS9
Q9WFT0
 
 chitin synthase (Chs) 2.4.1.16 Paramecium bursaria Chlorella virus CVK2 BAB83509.1 Q8V735  
 bactoprenol β-glucosyltransferase (GtrB;Bgt;SfII_28) 2.4.1.- Shigella phage SfII AAC39272.1
AGQ45518.1
O21943
P68668
 
 UDP-Glc: bactoprenol glucosyltransferase (GtrB) 2.4.1.- Shigella phage SfX AAF22454.1 Q9T1D6  
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