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GlycosylTransferase Family 2

Activities in Familycellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate β-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate β-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); β-1,3-glucan synthase (EC 2.4.1.34); β-1,4-mannan synthase (EC 2.4.1.-); β-mannosylphosphodecaprenol-mannooligosaccharide α-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol β-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol β-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol α-1,3-L-rhamnosyltransferase (EC 2.4.1.289); alternating β-1,3/4-N-acetylmannan synthase (2.4.1.-); UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225); [inverting] UDP-Glc: glycocin S-β-glucosyltransferase (EC 2.4.1.-); [inverting] UDP-Glc: protein O-β-glucosyltransferase (EC 2.4.1.-)
Mechanism Inverting
3D Structure StatusGT-A
NoteDistant similarity to families GT12, GT21, GT27, GT55, GT81 etc.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (303948); Uniprot accession (382); PDB accession (54); 3D entries (21); cryst (0)
Summary
Download GT2 (301318) Taxonomic display Structure (21) Characterized (277)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
  cellulose synthase (CESA7) 2.4.1.12 pubmed
 Gossypium hirsutum AFB18636.1
AIE38017.1		   7D5K[A,B,C]
 dolichol-phosphate β-glucosyltransferase (Alg5) 2.4.1.117   Homo sapiens AAD41465.1
AAF29113.1
AAG09682.1
AAH12531.1
AAQ51358.1
AAY11281.1
ABH87395.1
BAG61149.1
BAG61179.1
CAI14011.1
CAI14012.1
NP_037470.1
XP_035926.1
XP_057367.1		 B4DR67
Q5TBA6
Q9HC03
Q9Y673		  
 dolichol-phosphate mannosyltransferase (Dpm1) 2.4.1.83   Homo sapiens AAH07073.1
AAC98797.1
AAH08466.1
AAH16322.1
ACM84791.1
ALQ33902.1
ALQ33903.1
ALQ33904.1
BAA25646.1
BAA25647.1
BAF82258.1
CAB53749.1
CAG33207.1
CAI23324.1
CAI23325.1
CAI23326.1
CAI23326.2
CAI23327.1
CAI23327.2
NP_003850.1		 A0A0S2Z4U1
A0A0S2Z4Y5
O60762
Q5QPK2
Q6IB78
Q96HK0		  
 hyaluronan synthase 1 (HAS1;HAS) 2.4.1.212   Homo sapiens AAC50706.1
AAE61835.1
AAH35837.1
AAN23418.1
AAY52131.1
AAY52132.1
ACM86032.1
ACP87615.1
BAA12351.1
CAJ87377.1
CAL40918.1
CAL44782.1
CAL47699.1
NP_001514.1
XP_031079.1		 Q4VHE4
Q4VHE5
Q8IYH3
Q92839		  
 hyaluronan synthase 3 (Has3) 2.4.1.212   Homo sapiens AAF36984.1
AAC51209.1
AAH21853.1
AAK73797.1
ACM84101.1
BAF84089.1
CAJ87375.1
CAL40916.1
CAL44780.1
CAL47697.1
NP_005320.2
NP_619515.1		 O00219
Q8WTZ0
Q96RV2		  
 hyaluronan synthase 2 (Has2) 2.4.1.212   Homo sapiens AAC50692.1
AAH69353.1
AAI09072.1
AAI09073.1
ACM81110.1
BAG60078.1
CAJ87378.1
CAL40919.1
CAL44783.1
CAL47700.1
NP_005319.1		 B4DN16
Q92819		  
 β-1,3;1,4-glucan synthase (CslF6) 2.4.1.-   Hordeum vulgare ABZ01578.1
AKJ66175.1		 B1P2T4  
 β-1,3-1,4-glucan synthase (HvCslH1) 2.4.1.-   Hordeum vulgare subsp. vulgare ACN67534.1 C3U576  
 dolichol-phosphate β-mannosyltransferase (Dpms) 2.4.1.83   Leishmania mexicana MNYC/BZ/62/M379 CAA10541.1 O96795  
 chitin synthase 1 2.4.1.16   Lucilia cuprina AAG09712.1 Q9GU17  
 chitin synthase 1 (MsCHS1;Chs1;cs-1;Chs-1;Chs-A) 2.4.1.16   Manduca sexta AAL38051.2
CAD11802.1		 Q8T4U2
Q95PQ5		  
 chitin synthase 2 (MsCHS2;Chs2;cs-2;Chs-2;Chs-B) 2.4.1.16   Manduca sexta AAX20092.1
AAX20091.1		 Q530Z6  
 chitin synthase (Csh1) 2.4.1.16   Mucor circinelloides CAA67797.1 Q12632  
 Dolichol-phosphate mannosyltransferase 2.4.1.83   Mus musculus BAA25759.1
AAH61151.1
BAB23602.1
BAB23920.1
BAB25735.1
CAM22975.1
CAM22976.1
NP_034202.1		 A2BDX1
O70152		  
 Hyaluronan synthase 1 (Has1;Has ) 2.4.1.212   Mus musculus AAO93602.1
AAI25425.1
AAI25427.1
AAR39742.1
BAA11654.1
BAC35492.1
BAE23579.1
CAJ87380.1
CAL40921.1
CAL44785.1
CAL47702.1
NP_032241.1		 Q05A37
Q3UUP6
Q61647
Q8BPN0		  
 chitin synthase 2 (Chs2;NcChs2;Chs-2;NCU05239.1) 2.4.1.16   Neurospora crassa OR74A CAA54816.1
AAA33582.1
XP_324596.1		 P30589  
 chitin synthase 3 (NCU03611.1/B11H24.170) 2.4.1.16   Neurospora crassa OR74A AAA33568.1
CAD21286.1
XP_322913.1		 P29070
P29070		  
 Chitin synthase 4 (NCU09324.1) 2.4.1.16   Neurospora crassa OR74A AAB03563.1
XP_332016.1		 Q01285  
 hyaluronan synthase 2 (Has2) 2.4.1.212   Oryctolagus cuniculus BAB63264.1
ABA69792.1
CAJ87386.1
CAL40927.1
CAL44791.1
CAL47708.1		 Q95M16  
 β-1,3-1,4-glucan synthase (OsCslF4) (OsCslF4) 2.4.1.-   Oryza sativa AAL25134.1 Q6ZF86
Q944D9		  
 β-1,3-1,4-glucan synthase (OsCslF1) (OsCslF1) 2.4.1.-   Oryza sativa AAL25131.1 Q6ZF89
Q944E2		  
 β-1,3-1,4-glucan synthase (Os07g0552800) (OsCslF2) 2.4.1.-   Oryza sativa Japonica Group AAL25132.1
AAL38536.1
BAC65378.1
BAD30521.1
BAF21860.1
BAT02064.1
BAT02065.1
BAT02067.1		 A0A0P0X7S3
A0A0P0X843
Q84S11		  
 UDP-Glc: β-1,3-1,4-glucan synthase (CslF6;Os08g0160500) (OsCslF6) 2.4.1.-   Oryza sativa Japonica Group BAC66734.1
BAC99567.1
BAC99779.1
BAC99781.1
BAF22962.1
BAT03930.1
BAT03932.1		 A0A0P0XC63
Q7EYE9
Q84UP7		  
 β-1,3-1,4-glucan synthase (P0013G11.2) (OsCslF1) 2.4.1.-   Oryza sativa Japonica Group BAC83318.1 Q6ZF89  
 β-1,3-1,4-glucan synthase (Os07g0553300) (OsCslF4) 2.4.1.-   Oryza sativa Japonica Group BAC83321.1
BAF21861.1		 Q6ZF86  
 β-1,4-mannan synthase / glucomannan synthase (CslA1;Os02g0192500) (OsCslA1) 2.4.1.-   Oryza sativa Japonica Group DAA01743.1
BAA82375.1
BAD15390.1
BAD34025.1
BAF08078.1
BAG95675.1
BAS77418.1
BAS77419.1		 A0A0P0VFW6
B7ETH8
Q7PC76		  
 chitin synthase 2 (Chs2;PbrCHS2) 2.4.1.16   Paracoccidioides brasiliensis CAA70433.1
ABI49154.1
ABI49156.1
ABU55050.1
ABU55051.1
ABU55052.1
ABU55053.1
ABU55054.1
ABU55055.1
ABU55056.1
ABU55057.1
ABU55058.1
ABU55059.1
ABU55060.1
ABU55061.1
ABU55062.1
ABU55063.1
ABU55064.1
ABU55065.1
ABU55066.1
ABU55067.1
ABU55068.1
ABU55069.1
ABU55070.1
BAF62690.1
BAF62691.1
BAF62692.1
BAF62693.1
BAF62694.1
BAF62695.1
BAF62696.1
BAF62697.1
BAF62698.1
BAF62699.1
BAF62700.1
BAF62701.1
BAF62702.1
BAF62703.1
BAF62704.1
BAF62705.1
BAF62706.1
BAF62707.1
BAF62708.1
BAF62709.1
BAF62710.1
BAF62711.1
BAF62712.1
BAF62713.1
BAF62714.1
BAF62715.1
BAF62716.1
BAF62717.1
BAF62718.1
BAF62719.1
BAF62720.1
BAF62721.1
BAF62722.1
BAF62723.1
BAF62724.1		 Q92444  
 chitin synthase (CHS4) 2.4.1.16   Penicillium chrysogenum KCTC6052; ATCC 10106 AAF04828.1
AAC49554.1		 Q01749  
 chitin synthase 1 (Chs1) 2.4.1.16   Phycomyces blakesleeanus NRRL 1555(-) BAA19857.1 P87073  
 arabinoglucan synthase (Pp3c12_24670; PHYPA_016708) 2.4.1.-   Physcomitrium patens PNR44324.1 A0A2K1JS17  
 cellulose synthase (CesA5;PpCesA5) (fragment) 2.4.1.12   Physcomitrium patens AAT48372.1 Q6GVL8  
 β-1,4-mannan synthase / glucomannan synthase (CslA1) (PpCslA1) 2.4.1.-   Physcomitrium patens ABD79099.1 Q1ZZG0  
 β-1,4-mannan synthase / glucomannan synthase (CslA2) (PpCslA2) 2.4.1.-   Physcomitrium patens ABD79100.1 Q1ZZF9  
 cellulose synthase 3 (CesA3;PcapCesA3) 2.4.1.12   Phytophthora capsici 188 AFB20353.1
AGA60312.1		 H6U2P7  
 cellulose synthase 1 (Ces1;CesA1) 2.4.1.12   Phytophthora infestans 88069 ABP96902.1 A5A5Z3  
 cellulose synthase 2 (Ces2;CesA2) 2.4.1.12   Phytophthora infestans 88069 ABP96903.1 A5A5Z4  
 cellulose synthase 4 (Ces4;CesA4) 2.4.1.12   Phytophthora infestans 88069 ABP96905.1 A5A5Z6  
 cellulose synthase 3 (Ces3;CesA3;PinfCesA3) 2.4.1.12   Phytophthora infestans 88069 / 96 ABP96904.1 A5A5Z5  
 cellulose synthase 3 (CesA3;PvitCesA3) 2.4.1.12   Plasmopara viticola D05 ADD84672.1 D4N2S7  
 cellulose synthase 2.4.1.12   Populus tremula x Populus alba 717 AAC78476.1
CAW90438.1
CAW91304.1
CAW93012.1
CAW94120.1
CAW96302.1
CAW96910.1
CAW97570.1
CBC98624.1		 O81649  
 cellulose synthase (CesA3-1) 2.4.1.12   Populus tremula x Populus tremuloides AAT09896.2
CAW90509.1
CAW91364.1
CAW93080.1
CAW94177.1
CAW96333.1
CAW96941.1
CAW97636.1
CBC98685.1		 Q6J8X0 6WLB[A,B,C]
 cellulose synthase (CelA) (secondary xylem) (PtCesA1) 2.4.1.12   Populus tremuloides AAD03417.1
ABH84874.1
CAW90435.1
CAW91301.1
CAW93010.1
CAW94117.1
CAW96301.1
CAW96909.1
CAW97568.1
CBC98622.1		 O81368  
 cellulose synthase 3 (CesA3;PcubCesA3) 2.4.1.12   Pseudoperonospora cubensis CH01 AEC45570.1 G1CDG2  
 Csm1 2.4.1.16   Pyricularia grisea BAA74449.1 O93809  
 MG09962.4 (chitin synthase) 2.4.1.16   Pyricularia oryzae 70-15 XP_365117.1
AAB71411.1		 O13353  
 hyaluronan synthase (Has2) 2.4.1.212   Rattus norvegicus AAB63209.1
CAJ87384.1
CAL40925.1
CAL44789.1
CAL47706.1
NP_037285.1		 O35776  
 chitin synthase 1 (Chs1) 2.4.1.16   Rhizopus microsporus var. oligosporus IFO 8631 BAA01023.1 P30594  
 chitin synthase 2 (Chs2) 2.4.1.16   Rhizopus microsporus var. oligosporus IFO 8631 BAA01024.1 P30595  
 chitin synthase 1 (Chs1;YNL192W;N1404) 2.4.1.16   Saccharomyces cerevisiae S288c AAA34491.1
ABC16980.1
CAA96086.1
CAL85381.1
NP_014207.1		 P08004  
 chitin synthase 2 (Chs2;YBR038W;YBR0407) 2.4.1.16   Saccharomyces cerevisiae S288c AAA34493.1
ABC16981.1
CAA84980.1
NP_009594.1		 P14180  
 chitin synthase 3 (Chs3;Cal1;Csd2;Kit2;YBR023C;YBR0305) 2.4.1.16   Saccharomyces cerevisiae S288c CAA53680.1
AAA34844.1
ABC16982.1
CAA40559.1
CAA84965.1
NP_009579.1		 P29465  
 dolichol-phosphate mannosyltransferase (Dpm1;Sed3;YPR183w;P9705.3) 2.4.1.83   Saccharomyces cerevisiae S288c AAA34578.1
AAB68116.1
NP_015509.1		 P14020  
 dolichyl-phosphate β-glucosyltransferase (Alg5;YPL227c) 2.4.1.117   Saccharomyces cerevisiae S288c CAA54680.1
CAA64260.1
CAA97942.1
NP_015097.1		 P40350  
 chitin synthase (Chs;Chs2) 2.4.1.16   Saprolegnia monoica AAC49743.1 P48017  
 cellulose synthase 3 (CesA3;SmonCesA3) 2.4.1.12   Saprolegnia monoica CBS 539.67 ACX56231.1 C9WPK0  
 chitin synthase 2 (Chs2;SPBC1709.01;SPBC1734.17) 2.4.1.16   Schizosaccharomyces pombe 972h- CAA21311.1
NP_595434.1		 O74756  
 chitin synthase 1 (Chs1;SPAC13G6.12C;SPAC24B11.01C) 2.4.1.16   Schizosaccharomyces pombe 972h- CAA91105.1
AAA35297.1
CAA91766.1
NP_592838.1		 P30597  
 dolichol-phosphate mannosyltransferase (Dpm1;SPAC31G5.16C) 2.4.1.83   Schizosaccharomyces pombe 972h- AAC98795.1
CAB11700.1
NP_594017.1		 O14466  
 chitin synthase B (Chs2;ChsB;Chs-B) 2.4.1.16   Spodoptera exigua ABI96087.1 Q06BR7  
 chitin synthase (CHS2;CHS-B) 2.4.1.16   Tribolium castaneum AAQ62692.1
AAQ55061.1
AAQ63455.1		 Q6USK5
Q6WD24		  
 chitin synthase (CHS1B;CHS1;CHS-A) 2.4.1.16   Tribolium castaneum AAQ55060.1
AAQ62694.1		 Q6WD22  
 dolichol-phosphate mannosyltransferase (DPM1) 2.4.1.83   Trichoderma reesei RUTC-30 AAG32629.1 Q9HGE2  
 GDP-Man: β-1,4-mannan synthase (ManS;TfManS) 2.4.1.-   Trigonella foenum-graecum AFV79650.1 K7RDG8  
 β-1,3-1,4-glucan synthase (Cslf6) 2.4.1.-   Triticum aestivum CAN84874.1 A6Q0E9  
 dolichol-phosphate mannosyltransferase 2.4.1.83   Trypanosoma brucei brucei 118 CAA90875.1 Q26732  
 chitin synthase (CHS5) 2.4.1.16   Ustilago maydis 518 AAB84284.1 O13394  
 chitin synthase 6 (Chs6) 2.4.1.16   Ustilago maydis 518 AAB84285.1 O13395  
 dolichol-phosphate mannosyltransferase (Dpm1) 2.4.1.83   Ustilago maydis H-156S AAC49401.1 P54856  
 chitin synthase 1 (CHS1) 2.4.1.16   Ustilago maydis RK32 / A2B3 CAA61027.1 Q99126  
 chitin synthase 2 (Chs2) 2.4.1.16   Ustilago maydis RK32 / A2B3 CAA61028.1 Q99127  
 hyaluronan synthase 1 (HAS1;DG42) 2.4.1.212   Xenopus laevis AAA49699.1
AAH47963.1
AAI08481.1
AAN23419.1
AAO93603.1
AAR39743.1
ABA69790.1
ABJ29054.1
CAJ87393.1
CAL40934.1
CAL44798.1
CAL47715.1		 P13563  
 hyaluronan synthase 2 (Has2) 2.4.1.212   Xenopus laevis AAD45813.1
AAB94540.1
ABA69797.1
CAJ87394.1
CAL40935.1
CAL44799.1
CAL47716.1		 O57427  
Viruses
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 hyaluronan synthase (Has;A98R;PBCV1_A98R) 2.4.1.212   Paramecium bursaria Chlorella virus 1 AAW91047.1
AAC96466.1
AAD26640.1
AAD26641.1
AAD26642.1
AAD26643.1
AAD26644.1
ABE19383.1
ABH92226.1
ABJ43064.1
ACP88141.1
CAJ87373.1
CAL40914.1
CAL44778.1
CAL47695.1
CAM90867.1
CAO00420.1
CAO00437.1
CAO00442.1
CAX69225.1
CAX87018.1
NP_048446.1		 Q84419
Q84419
Q9WFS9
Q9WFT0		  
 chitin synthase (Chs) 2.4.1.16   Paramecium bursaria Chlorella virus CVK2 BAB83509.1 Q8V735  
 hyaluronan synthase (PBCVCZ2_118R;Cz-2_118R) 2.4.1.212 pubmed
 Paramecium bursaria Chlorella virus CZ-2 AGE52748.1   7SP6[A]
7SP7[A]
7SP8[A]
7SP9[C]
7SPA[C]
 bactoprenol β-glucosyltransferase (GtrB;Bgt;SfII_28) 2.4.1.-   Shigella phage SfII AAC39272.1
AGQ45518.1		 O21943
P68668
S5FKN0		  
 UDP-Glc: bactoprenol glucosyltransferase (GtrB) 2.4.1.-   Shigella phage SfX AAF22454.1 Q9T1D6  
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